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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:34444
Term: 4-tert-butylphenol
Definition: A member of the class of phenols that is phenol substituted with a tert-butyl group at position 4.
Chemical ID: MESH:C006862
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfincreases expressionISORGD:13441926480464CTDbutylphen results in increased expression of TNF protein

PMID:28836394
Tnfmultiple interactionsISORGD:13441926480464CTDAcetylcysteine inhibits the reaction [butylphen results in increased expression of TNF protein] Acetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [butylphen results in increased expression of TNF protein]] PIK3R1 protein modified form inhibits the reaction [butylphen results in increased expression of TNF protein]

PMID:28836394
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