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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:4035
Term: cyhalothrin
Definition: A carboxylic ester obtained by formal condensation between 3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylic acid and cyano(3-phenoxyphenyl)methanol.
Chemical ID: MESH:C037304
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfincreases expressionEXP 6480464CTDcyhalothrin results in increased expression of TNF mRNA; cyhalothrin results in increased expression of TNF proteinPMID:26645134 PMID:27348886 PMID:28058584 PMID:37060950
Tnfmultiple interactionsEXP 6480464CTDthymoquinone inhibits the reaction [cyhalothrin results in increased expression of TNF mRNA]; thymoquinone inhibits the reaction [cyhalothrin results in increased expression of TNF protein]PMID:26645134
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