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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:27882
Term: (S)-colchicine
Definition: A colchicine that has (S)-configuration. It is a secondary metabolite, has anti-inflammatory properties and is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, and many other conditions.
Chemical ID: MESH:D003078
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfmultiple interactionsEXP 6480464CTDColchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; Colchicine inhibits the reaction [Ethanol results in increased expression of TNF protein]PMID:22446813 PMID:23146695
Tnfdecreases expressionISOTnf (Mus musculus)6480464CTDColchicine results in decreased expression of TNF mRNAPMID:33002524
Tnfdecreases expressionISOTNF (Homo sapiens)6480464CTDColchicine results in decreased expression of TNF proteinPMID:1553933
Tnfincreases expressionISOTnf (Mus musculus)6480464CTDColchicine results in increased expression of TNF proteinPMID:34453961
Tnfmultiple interactionsISOTnf (Mus musculus)6480464CTDColchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]PMID:37573684
Tnfmultiple interactionsISOTNF (Homo sapiens)6480464CTDColchicine inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Paclitaxel inhibits the reaction [Colchicine inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; Paclitaxel inhibits the reaction [Colchicine inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]]PMID:11154858
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