GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tnf | decreases response to substance | ISO | TNF (Homo sapiens) | 6480464 | CTD | anacardic acid results in decreased susceptibility to TNF protein | PMID:18349320 | Tnf | multiple interactions | ISO | TNF (Homo sapiens) | 6480464 | CTD | [anacardic acid co-treated with TNF protein] results in increased cleavage of CASP3 protein; [anacardic acid co-treated with TNF protein] results in increased cleavage of CASP8 protein; [anacardic acid co-treated with TNF protein] results in increased cleavage of CASP9 protein; anacardic acid inhibits the reaction [4-octylphenol results in increased expression of and results in increased secretion of TNF protein]; anacardic acid inhibits the reaction [nonylphenol results in increased expression of and results in increased secretion of TNF protein]; anacardic acid inhibits the reaction [nonylphenol results in increased expression of TNF]; anacardic acid inhibits the reaction [TNF protein affects the localization of RELA protein]; anacardic acid inhibits the reaction [TNF protein results in increased acetylation of RELA protein]; anacardic acid inhibits the reaction [TNF protein results in increased activity of [RELA protein binds to NFKB1 protein]]; anacardic acid inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; anacardic acid inhibits the reaction [TNF protein results in increased expression of BCL2 protein]; anacardic acid inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]; anacardic acid inhibits the reaction [TNF protein results in increased expression of BIRC3 protein]; anacardic acid inhibits the reaction [TNF protein results in increased expression of BIRC5 protein]; anacardic acid inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; anacardic acid inhibits the reaction [TNF protein results in increased expression of CFLAR protein]; anacardic acid inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; anacardic acid inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; anacardic acid inhibits the reaction [TNF protein results in increased expression of MYC protein]; anacardic acid inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]; anacardic acid inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; anacardic acid inhibits the reaction [TNF protein results in increased expression of VEGFA protein]; anacardic acid inhibits the reaction [TNF protein results in increased expression of XIAP protein]; anacardic acid inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein] | PMID:18349320 PMID:20056579 PMID:24039973 | | ||||||||||||||||||||||
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