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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621237
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnfrsf1a
Name: TNF receptor superfamily member 1A
Acc ID: CHEBI:72583
Term: WR-1065
Definition: An alkanethiol that is the N-3-aminopropyl derivative of cysteamine. Used as the S-phosphorylated prodrug, amifostine, for cytoprotection in cancer chemotherapy and radiotherapy.
Chemical ID: MESH:C020174
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7342476480464CTD[TNFRSF1A protein co-treated with TNFRSF1B protein] affects the reaction [WR 1065 results in increased activity of SOD2], TNFRSF1A protein affects the reaction [WR 1065 results in increased activity of SOD2]

PMID:21945096
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.