RGD Reference Report - Genetic dissection of a rat model for rheumatoid arthritis: significant gender influences on autosomal modifier loci - Rat Genome Database

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Genetic dissection of a rat model for rheumatoid arthritis: significant gender influences on autosomal modifier loci

Authors: Furuya, T  Salstrom, JL  McCall-Vining, S  Cannon, GW  Joe, B  Remmers, EF  Griffiths, MM  Wilder, RL 
Citation: Furuya T, etal., Hum Mol Genet 2000 Sep 22;9(15):2241-50
RGD ID: 61067
Web Url: http://hmg.oupjournals.org/cgi/content/abstract/9/15/2241
Pubmed: (View Article at PubMed) PMID:11001927

Rheumatoid arthritis (RA) is a common, chronic, autoimmune, inflammatory disease that is influenced by genetic factors including gender. Many studies suggest that the genetic risk for RA is determined by the MHC, in particular class II alleles with a 'shared epitope' (SE), and multiple non-MHC loci. Other studies indicate that RA and other autoimmune diseases, in particular insulin-dependent diabetes mellitus (IDDM) and autoimmune thyroid disease (ATD), share genetic risk factors. Rat collagen-induced arthritis (CIA) is an experimental model with many features that resemble RA. The spontaneous diabetes-resistant bio-breeding rat, BB(DR), is of interest because it is susceptible to experimentally induced CIA, IDDM and ATD, and it has an SE in its MHC class II allele. To explore the genetics of CIA, including potential gender influences and the genetic relationships between CIA and other autoimmune diseases, we conducted a genome-wide scan for CIA regulatory loci in the F(2) progeny of BB(DR) and CIA-resistant BN rats. We identified 10 quantitative trait loci (QTLs), including 5 new ones (Cia15, Cia16*, Cia17, Cia18* and Cia19 on chromosomes 9, 10, 18 and two on the X chromosome, respectively), that regulated CIA severity. We also identified four QTLs, including two new ones (Ciaa4* and Ciaa5* on chromosomes 4 and 5, respectively), that regulated autoantibody titer to rat type II collagen. Many of these loci appeared to be gender influenced, and most co-localized with several other autoimmune trait loci. Our data support the view that multiple autoimmune diseases may share genetic risk factors, and suggest that many of these loci are gender influenced.


Disease Annotations    

Phenotype Annotations    

Mammalian Phenotype
Phenotype Values via PhenoMiner

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Objects Annotated

Cia1  (Collagen induced arthritis QTL 1)
Cia13  (Collagen induced arthritis QTL 13)
Cia15  (Collagen induced arthritis QTL 15)
Cia16  (Collagen induced arthritis QTL 16)
Cia17  (Collagen induced arthritis QTL 17)
Cia18  (Collagen induced arthritis QTL 18)
Cia19  (Collagen induced arthritis QTL 19)
Cia2  (Collagen induced arthritis QTL 2)
Cia5  (Collagen induced arthritis QTL 5)
Cia6  (Collagen induced arthritis QTL 6)
Cia7  (Collagen induced arthritis QTL 7)
Ciaa1  (CIA Autoantibody QTL 1)
Ciaa4  (CIA Autoantibody QTL 4)
Ciaa5  (CIA Autoantibody QTL 5)

BBDR/Rhw  (NA)

Objects referenced in this article
0 D18Mit5 D18Mit5 All species
0 D2Mit24 D2Mit24 All species
0 D20Arb2 D20Arb2 All species
0 D20Wox3 D20Wox3 All species
0 D2Mit17 D2Mit17 All species
0 D4Mit14 D4Mit14 All species
0 D2Mit23 D2Mit23 All species
0 D4Mit17 D4Mit17 All species
0 D8Mgh11 D8Mgh11 All species
0 DXMgh9 DXMgh9 All species
0 D5Mgh13 D5Mgh13 All species
0 D4Mgh18 D4Mgh18 All species
0 D9Mgh5 D9Mgh5 All species
0 D8Mgh4 D8Mgh4 All species
0 D4Mgh11 D4Mgh11 All species
0 D5Mgh8 D5Mgh8 All species
0 DXRat66 DXRat66 All species
0 D10Rat11 D10Rat11 All species
0 D10Rat49 D10Rat49 All species
0 D9Rat44 D9Rat44 All species
0 D10Rat95 D10Rat95 All species
0 D8Rat71 D8Rat71 All species
0 D18Rat82 D18Rat82 All species
0 D9Arb7 D9Arb7 All species
0 D5Wox3 D5Wox3 All species
0 DXWox3 DXWox3 All species
0 D9Wox19 D9Wox19 All species
0 DXWox2 DXWox2 All species
0 D20Arb8 D20Arb8 All species
0 BN BN All species
0 C3 complement C3 All species
0 Cd4 Cd4 molecule All species
0 Cd69 Cd69 molecule All species
0 Cia4 Collagen induced arthritis QTL 4 All species
0 Ciaa3 CIA Autoantibody QTL 3 All species
0 DA DA All species
0 F344/NRrrc null All species
0 Jun Jun proto-oncogene, AP-1 transcription factor subunit All species
0 Oia2 Oil induced arthritis QTL 2 All species
0 Pia7 Pristane induced arthritis QTL 7 All species
0 Tnfrsf1a TNF receptor superfamily member 1A All species
0 Vav1 vav guanine nucleotide exchange factor 1 All species

Additional Information