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Strain: DA

Symbol: DA
Strain: DA
Full Name: DA
RGD ID: 60997
RRID: RGD_60997
Ontology ID: RS:0000014
Alleles: Tnfrsf1a;   Ednrb
Type: inbred
Source: Not Available
Origin: Developed from stock of unstated origin by Dr. T.T. Odell, Jr. at Oak Ridge National Laboratory, Tennessee to F11, then by Dr. Darcy Wilson at the Wistar Institute, who named it DA because it expressed the 'd' blood group allele of Joy Palm, and it is 'a' agouti in colour (Wilson 1965). Inbreeding was completed in about 1965. Although Palm and Black (1971) suggest it may be related to COP, there is no real evidence that this is the case.
Genetic Markers: A,C,H.
Coat Color: Agouti .
Inbred Generations: F77 (Han1989)
Last Known Status: Unknown





References

References - curated
1. Backdahl L, etal., Arthritis Rheum 2003 Feb;48(2):551-9.
2. Berg SF, etal., Eur J Immunol 1998 Feb;28(2):444-50
3. Bergsteinsdottir K, etal., J Immunol 2000 Feb 1;164(3):1564-8
4. Cannon GW, etal., J Rheumatol 1993 Jan;20(1):7-11
5. Dahlman I, etal., Eur J Immunol 1998 Jul;28(7):2188-96
6. Dissen E, etal., J Exp Med 1996 May 1;183(5):2197-207
7. Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
8. Festing, MFW, Personal Communication Update, Feb-2000
9. Furuya T, etal., Hum Mol Genet 2000 Sep 22;9(15):2241-50
10. Griffiths MM, etal., Arthritis Rheum 2000 Jun;43(6):1278-89
11. Holm BC, etal., Hum Mol Genet 2001 Mar 15;10(6):565-72.
12. Hultqvist M, etal., Antioxid Redox Signal. 2011 Jun 15;14(12):2373-83. doi: 10.1089/ars.2010.3440. Epub 2011 Mar 31.
13. Jacob HJ, etal., Nat Genet 1992 Sep;2(1):56-60
14. Jagodic M, etal., J Immunol 2004 Jul 15;173(2):1366-73.
15. Jansson AM, etal., Transplant Proc 1999 May;31(3):1597-9.
16. Kawahito Y, etal., Immunogenetics 1998 Oct;48(5):335-8
17. Kawahito Y, etal., J Immunol 1998 Oct 15;161(8):4411-9
18. Kloting I, etal., Biochem Biophys Res Commun 1998 Apr 17;245(2):483-6
19. Lorentzen JC and Klareskog L, Scand J Immunol 1996 Dec;44(6):592-8.
20. Lorentzen JC Scand J Immunol 1999 Jan;49(1):45-50.
21. Lorentzen JC, etal., Proc Natl Acad Sci U S A 1998 May 26;95(11):6383-7
22. Nicholls SM, etal., Invest Ophthalmol Vis Sci. 1994 Jul;35(8):3260-7.
23. Remmers EF, etal., Nat Genet 1996 Sep;14(1):82-5
24. RGD Automated Pipelines
25. Tanuma J, etal., Cancer Res 1998 Apr 15;58(8):1660-4
26. Tanuma J, etal., Int J Cancer 2002 Dec 20;102(6):638-42.
27. Vingsbo C, etal., Am J Pathol 1996 Nov;149(5):1675-83
28. Vingsbo-Lundberg C, etal., Nat Genet 1998 Dec;20(4):401-4
29. Xu H, etal., Scand J Immunol 2002 Sep;56(3):248-53.

Region

Strain QTL Data
Symbol Name Trait
Aia1 Adjuvant induced arthritis QTL 1 joint integrity trait   (VT:0010548)    
Aia2 Adjuvant induced arthritis QTL 2 joint integrity trait   (VT:0010548)    
Aia3 Adjuvant induced arthritis QTL 3 joint integrity trait   (VT:0010548)    
Aia4 Adjuvant induced arthritis QTL 4 joint integrity trait   (VT:0010548)    
Apr1 Acute phase response QTL 1 orosomucoid 1 amount   (VT:0010541)    
Apr2 Acute phase response QTL 2 blood murinoglobulin 1 amount   (VT:0010597)    
Apr3 Acute phase response QTL 3 blood interleukin-6 amount   (VT:0008595)    
Apr4 Acute phase response QTL 4 orosomucoid 1 amount   (VT:0010541)    
Apr5 Acute phase response QTL 5 blood interleukin-6 amount   (VT:0008595)    
Apr6 Acute phase response QTL 6 blood interleukin-6 amount   (VT:0008595)    
Ciaa1 CIA Autoantibody QTL 1 blood autoantibody amount   (VT:0003725)    
Ciaa2 CIA Autoantibody QTL 2 blood autoantibody amount   (VT:0003725)    
Ciaa3 CIA Autoantibody QTL 3 blood autoantibody amount   (VT:0003725)    
Eae1 Experimental allergic encephalomyelitis QTL 1 nervous system integrity trait   (VT:0010566)    
Eae10 Experimental allergic encephalomyelitis QTL 10 nervous system integrity trait   (VT:0010566)    
Eae11 Experimental allergic encephalomyelitis QTL 11 nervous system integrity trait   (VT:0010566)    
Eae12 Experimental allergic encephalomyelitis QTL 12 nervous system integrity trait   (VT:0010566)    
Eae13 Experimental allergic encephalomyelitis QTL 13 nervous system integrity trait   (VT:0010566)    
Eae14 Experimental allergic encephalomyelitis QTL 14 nervous system integrity trait   (VT:0010566)    
Eae15 Experimental allergic encephalomyelitis QTL 15 nervous system integrity trait   (VT:0010566)    
Eae19 Experimental allergic encephalomyelitis QTL 19 nervous system integrity trait   (VT:0010566)    
Eae20 Experimental allergic encephalomyelitis QTL 20 nervous system integrity trait   (VT:0010566)    
Eae21 Experimental allergic encephalomyelitis QTL 21 body mass   (VT:0001259)    
Eae22 Experimental allergic encephalomyelitis QTL 22 nervous system integrity trait   (VT:0010566)    
Eae4 Experimental allergic encephalomyelitis QTL 4 nervous system integrity trait   (VT:0010566)    
Eae5 Experimental allergic encephalomyelitis QTL 5 nervous system integrity trait   (VT:0010566)    
Eae6 Experimental allergic encephalomyelitis QTL 6 body mass   (VT:0001259)    
Eae7 Experimental allergic encephalomyelitis QTL 7 body mass   (VT:0001259)    
Eae8 Experimental allergic encephalomyelitis QTL 8 nervous system integrity trait   (VT:0010566)    
Eae9 Experimental allergic encephalomyelitis QTL 9 body mass   (VT:0001259)    
Eaex Experimental allergic encephalomyelitis QTL x nervous system integrity trait   (VT:0010566)    
Eaey Experimental allergic encephalomyelitis QTL y nervous system integrity trait   (VT:0010566)    
Eaez Experimental allergic encephalomyelitis QTL z nervous system integrity trait   (VT:0010566)    
Iddm16 Insulin dependent diabetes mellitus QTL 16 blood glucose amount   (VT:0000188)    
Iddm4 Insulin dependent diabetes mellitus QTL 4 blood glucose amount   (VT:0000188)    
Iddm5 Insulin dependent diabetes mellitus QTL 5 blood glucose amount   (VT:0000188)    
Iddm6 Insulin dependent diabetes mellitus QTL 6 blood glucose amount   (VT:0000188)    
Nka1 Natural killer alloreactivity QTL 1 natural killer cell cytolysis trait   (VT:0005070)    
Oia2 Oil induced arthritis QTL 2 joint integrity trait   (VT:0010548)    
Pia1 Pristane induced arthritis QTL 1 joint integrity trait   (VT:0010548)    
Pia2 Pristane induced arthritis QTL 2 joint integrity trait   (VT:0010548)    
Pia3 Pristane induced arthritis QTL 3 joint integrity trait   (VT:0010548)    
Pia4 Pristane induced arthritis QTL 4 joint integrity trait   (VT:0010548)    
Pia5 Pristane induced arthritis QTL 5 joint integrity trait   (VT:0010548)    
Pia6 Pristane induced arthritis QTL 6 joint integrity trait   (VT:0010548)    
Tcas10 Tongue tumor susceptibility QTL 10 tongue integrity trait   (VT:0010553)    
Tcas11 Tongue tumor susceptibility QTL 11 tongue integrity trait   (VT:0010553)    
Tcas2 Tongue tumor susceptibility QTL 2 tongue integrity trait   (VT:0010553)    
Tcas3 Tongue tumor susceptibility QTL 3 tongue integrity trait   (VT:0010553)    
Tcas4 Tongue tumor susceptibility QTL 4 tongue integrity trait   (VT:0010553)    
Tcas5 Tongue tumor susceptibility QTL 5 tongue integrity trait   (VT:0010553)    
Tcas6 Tongue tumor susceptibility QTL 6 tongue integrity trait   (VT:0010553)    
Tcas8 Tongue tumor susceptibility QTL 8 tongue integrity trait   (VT:0010553)    
Tcas9 Tongue tumor susceptibility QTL 9 tongue integrity trait   (VT:0010553)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_drgs_chems Susceptible (1/7) to the development of 4-nitroquinoline 1-oxide induced squamous cell carcinomas of the tongue, with high proliferative response of the tongue epithelium (contrast WF)(Kitano et al, 1992). 1004
strain_drgs_chems Susceptible (1/7) to the development of 4-nitroquinoline 1-oxide induced squamous cell carcinomas of the tongue, with high proliferative response of the tongue epithelium (contrast WF)(Kitano et al, 1992). 61077
strain_drgs_chems Susceptible (1/7) to the development of 4-nitroquinoline 1-oxide induced squamous cell carcinomas of the tongue, with high proliferative response of the tongue epithelium (contrast WF)(Kitano et al, 1992). 634612
strain_drgs_chems Rats developed mild arthritis after injected with IFA emulsified with water but when arthritogenic adjuvants like pristane, mycobacteria, MDP, avridine were added arthritis incidence was increased from 50% to 100% and severity from 4-7 to 10-12. Beta glucan solution was able to induce arthritis when injected without IFA. 737660
strain_immunology Susceptible to the induction of autoimmune thyroiditis (Rose 1975). Develop severe collagen-induced arthritis following immunisation with bovine, chick or rat type II collagens. This is exacerbated by infection with rat cytomegalovirus. However, the congenic strain DA.1N(BN) is much more resistant (Griffiths et al, 1994). Develops arthritis after injection of Freunds incomplete adjuvent alone (oil-induced arthritis, OIA). This is a self-limiting acute disease whereas collagen-induced arthritis follows a chronic course (Holmdahl and Kvick, 1992, 1994). DA is sensitive whereas LEW are relatively resistant (Holmdahl et al, 1992). A strong local expression of TNF-alpha, induced by arthritogenic stimuli may be important for the induction of arthritis (Mussener et al, 1995). Susceptible to the development of experimental allergic encephalomyelitis upon treatment with a myelin basic protein-specific T cell line derived from an F1 hybrid between resistant AO and susceptible DA strain rats (Mostaricastrojkovic et al, 1992). Although DA andLEW are both highly susceptible to the development of EAE, there are marked differences in the array of myelin epitopes capable of inducing the disease as well as MHC restriction of these epitopes between the two strains (Stepaniak et al, 1995). Resistant to the development of experimental glomerulonephritis following injection of nephritogenic antigen from bovine renal basement membrane (10/10) (Naito et al, 1991).Met-enkephalin increased H2O2 production by macrophages (contrast AO) (Radulovic et al,1995). 1004
strain_immunology Susceptible to the induction of autoimmune thyroiditis (Rose 1975). Develop severe collagen-induced arthritis following immunisation with bovine, chick or rat type II collagens. This is exacerbated by infection with rat cytomegalovirus. However, the congenic strain DA.1N(BN) is much more resistant (Griffiths et al, 1994). Develops arthritis after injection of Freunds incomplete adjuvent alone (oil-induced arthritis, OIA). This is a self-limiting acute disease whereas collagen-induced arthritis follows a chronic course (Holmdahl and Kvick, 1992, 1994). DA is sensitive whereas LEW are relatively resistant (Holmdahl et al, 1992). A strong local expression of TNF-alpha, induced by arthritogenic stimuli may be important for the induction of arthritis (Mussener et al, 1995). Susceptible to the development of experimental allergic encephalomyelitis upon treatment with a myelin basic protein-specific T cell line derived from an F1 hybrid between resistant AO and susceptible DA strain rats (Mostaricastrojkovic et al, 1992). Although DA andLEW are both highly susceptible to the development of EAE, there are marked differences in the array of myelin epitopes capable of inducing the disease as well as MHC restriction of these epitopes between the two strains (Stepaniak et al, 1995). Resistant to the development of experimental glomerulonephritis following injection of nephritogenic antigen from bovine renal basement membrane (10/10) (Naito et al, 1991).Met-enkephalin increased H2O2 production by macrophages (contrast AO) (Radulovic et al,1995). 61077
strain_immunology Susceptible to the induction of autoimmune thyroiditis (Rose 1975). Develop severe collagen-induced arthritis following immunisation with bovine, chick or rat type II collagens. This is exacerbated by infection with rat cytomegalovirus. However, the congenic strain DA.1N(BN) is much more resistant (Griffiths et al, 1994). Develops arthritis after injection of Freunds incomplete adjuvent alone (oil-induced arthritis, OIA). This is a self-limiting acute disease whereas collagen-induced arthritis follows a chronic course (Holmdahl and Kvick, 1992, 1994). DA is sensitive whereas LEW are relatively resistant (Holmdahl et al, 1992). A strong local expression of TNF-alpha, induced by arthritogenic stimuli may be important for the induction of arthritis (Mussener et al, 1995). Susceptible to the development of experimental allergic encephalomyelitis upon treatment with a myelin basic protein-specific T cell line derived from an F1 hybrid between resistant AO and susceptible DA strain rats (Mostaricastrojkovic et al, 1992). Although DA andLEW are both highly susceptible to the development of EAE, there are marked differences in the array of myelin epitopes capable of inducing the disease as well as MHC restriction of these epitopes between the two strains (Stepaniak et al, 1995). Resistant to the development of experimental glomerulonephritis following injection of nephritogenic antigen from bovine renal basement membrane (10/10) (Naito et al, 1991).Met-enkephalin increased H2O2 production by macrophages (contrast AO) (Radulovic et al,1995). 634612
strain_infection Infection with Hymenolepsis diminuata cysticercoids results in significant mastocytosis six weeks post infection and low persistance of worms, in contrast with F344, where there was no worm loss and no mastocytosis (Ishih, 1992, 1994).Dahl R and Dahl S (Mollegard) Origin: see SR and SS and also DSS/1 to DSS/3 1004
strain_infection Infection with Hymenolepsis diminuata cysticercoids results in significant mastocytosis six weeks post infection and low persistance of worms, in contrast with F344, where there was no worm loss and no mastocytosis (Ishih, 1992, 1994).Dahl R and Dahl S (Mollegard) Origin: see SR and SS and also DSS/1 to DSS/3 61077
strain_infection Infection with Hymenolepsis diminuata cysticercoids results in significant mastocytosis six weeks post infection and low persistance of worms, in contrast with F344, where there was no worm loss and no mastocytosis (Ishih, 1992, 1994).Dahl R and Dahl S (Mollegard) Origin: see SR and SS and also DSS/1 to DSS/3 634612
strain_life_disease Urinary bladder tumours 54% in males and 14% in females, with a peak incidence at 25-30 months of age (Deerberg et al 1985). High incidence of hormone-dependent endometrial adenocarcinoma. A transplantable cell line (RUCA-I) derived from such a tumour in DA rats can produce these tumours in ectopic sites. The rate of proliferation is reduced by tamoxifen, and this cell line appears to be a suitable model for the study of molecular aspects of estrogen and tamoxifen-dependent gene expression. See also strain BDII/Han (Schutze et al, 1992).Urolithiasis found in 2/78 female rats at an average age of 118 days (Kunstyr et al 1982). 1004
strain_life_disease Urinary bladder tumours 54% in males and 14% in females, with a peak incidence at 25-30 months of age (Deerberg et al 1985). High incidence of hormone-dependent endometrial adenocarcinoma. A transplantable cell line (RUCA-I) derived from such a tumour in DA rats can produce these tumours in ectopic sites. The rate of proliferation is reduced by tamoxifen, and this cell line appears to be a suitable model for the study of molecular aspects of estrogen and tamoxifen-dependent gene expression. See also strain BDII/Han (Schutze et al, 1992).Urolithiasis found in 2/78 female rats at an average age of 118 days (Kunstyr et al 1982). 61077
strain_life_disease Urinary bladder tumours 54% in males and 14% in females, with a peak incidence at 25-30 months of age (Deerberg et al 1985). High incidence of hormone-dependent endometrial adenocarcinoma. A transplantable cell line (RUCA-I) derived from such a tumour in DA rats can produce these tumours in ectopic sites. The rate of proliferation is reduced by tamoxifen, and this cell line appears to be a suitable model for the study of molecular aspects of estrogen and tamoxifen-dependent gene expression. See also strain BDII/Han (Schutze et al, 1992).Urolithiasis found in 2/78 female rats at an average age of 118 days (Kunstyr et al 1982). 634612
strain_life_disease All DA rats which were injected with IFA (incomplete Freund's adjuvant) developed arthritis whereas only 17% of (DA x LEW.1AV1)F1 , 46% of (DA x LEW.1AV1)F2 and 75% of DA x F1 developed arthritis. 61087
strain_life_disease Animals developed severe arthritis with a sudden onset 2 to 3 weeks after being injected with pristane. This started in interphalangeal joints and spread to the ankles. 61088
strain_life_disease These animals are susceptible to arthritis induced by non-immunogenic mineral oil (Oia) and by rat collagen II and mineral oil (rOia). 737659
strain_life_disease Displays genetic susceptibility to induction of arthritis in experimental models of rheumatoid arthritis. 629560
strain_life_disease The F1 progeny when crossed with PVG.1AV1 were resistant to arthritis whereas 4% of F2 and 46%of DA(DA x PVG.1AV1) backcross had signs of arthritis. 737700
strain_other The F7 generation from a DA x PVG.1AV1 intercross were used for myelin oligodendrocyte glycoprotein-induced experimental allergic encephalomyelitis QTL mapping. 1302437
strain_phys_biochem Possible model for deficiency of debrisoquine hydroxylation due to a lack of Cyp2D1 activity,which is equivalent to human Cyp2D6 (Al-Dabbagh et al 1981), with the defect being due to a structurally altered db1 protein (Gonzalez et al 1987). At least one other isoform of P450 of the Cyp2C or Cyp3A families may also be missing. Although DA rats may be used as a preliminary screen to identify Cyp2D6 substrates, interspecies differences in metabolism means that this strain could not be used to provide quantitative information regarding the contribution of Cyp2D6 to anoxidation in humans (Barham et al, 1994) Defective bile acid transport found in females, which may be related to deficient debrisoquine hydroxylation (Reichen et al 1986). Hackbarth et al (1981) have described the glomerular filtration rate and renal plasma flow in DA and other strains, and haematological parameters and their relation to diet have been described by Hackbarth et al (1983). In studies of food intake andbody weight gain, DA rats ingested mainly proteins and fats, in contrast with outbred Wistar rats which ate about equal quantities of fat, protein and carbohydrate (Larueachagiotis et al, 1994). 1004
strain_phys_biochem Possible model for deficiency of debrisoquine hydroxylation due to a lack of Cyp2D1 activity,which is equivalent to human Cyp2D6 (Al-Dabbagh et al 1981), with the defect being due to a structurally altered db1 protein (Gonzalez et al 1987). At least one other isoform of P450 of the Cyp2C or Cyp3A families may also be missing. Although DA rats may be used as a preliminary screen to identify Cyp2D6 substrates, interspecies differences in metabolism means that this strain could not be used to provide quantitative information regarding the contribution of Cyp2D6 to anoxidation in humans (Barham et al, 1994) Defective bile acid transport found in females, which may be related to deficient debrisoquine hydroxylation (Reichen et al 1986). Hackbarth et al (1981) have described the glomerular filtration rate and renal plasma flow in DA and other strains, and haematological parameters and their relation to diet have been described by Hackbarth et al (1983). In studies of food intake andbody weight gain, DA rats ingested mainly proteins and fats, in contrast with outbred Wistar rats which ate about equal quantities of fat, protein and carbohydrate (Larueachagiotis et al, 1994). 61077
strain_phys_biochem Possible model for deficiency of debrisoquine hydroxylation due to a lack of Cyp2D1 activity,which is equivalent to human Cyp2D6 (Al-Dabbagh et al 1981), with the defect being due to a structurally altered db1 protein (Gonzalez et al 1987). At least one other isoform of P450 of the Cyp2C or Cyp3A families may also be missing. Although DA rats may be used as a preliminary screen to identify Cyp2D6 substrates, interspecies differences in metabolism means that this strain could not be used to provide quantitative information regarding the contribution of Cyp2D6 to anoxidation in humans (Barham et al, 1994) Defective bile acid transport found in females, which may be related to deficient debrisoquine hydroxylation (Reichen et al 1986). Hackbarth et al (1981) have described the glomerular filtration rate and renal plasma flow in DA and other strains, and haematological parameters and their relation to diet have been described by Hackbarth et al (1983). In studies of food intake andbody weight gain, DA rats ingested mainly proteins and fats, in contrast with outbred Wistar rats which ate about equal quantities of fat, protein and carbohydrate (Larueachagiotis et al, 1994). 634612
strain_phys_biochem Animals in which arthritis has been induced by immunization with incomplete Freund's adjuvant (IFA) show swelling in the ankles and in few peripheral interphalangeal joints. Animals suffering from rat-collagen induced arthritis (rCia) have their peripheral interphalangeal joints effected first and then all joints in the paws become inflamed. 737659
strain_reproduction Short gestation period (1/8) (Peters 1986). 1004
strain_reproduction Short gestation period (1/8) (Peters 1986). 634612