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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621237
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnfrsf1a
Name: TNF receptor superfamily member 1A
Acc ID: CHEBI:8809
Term: resiniferatoxin
Definition: A heteropentacyclic compound found in Euphorbia poissonii with molecular formula C37H40O9. It is an agonist of the transient receptor potential cation channel subfamily V member 1 (TrpV1).
Chemical ID: MESH:C024353
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfrsf1aincreases expressionISOTnfrsf1a (Mus musculus)6480464CTDresiniferatoxin results in increased expression of TNFRSF1A proteinPMID:19531269
Tnfrsf1amultiple interactionsISOTnfrsf1a (Mus musculus)6480464CTDcapsazepine inhibits the reaction [resiniferatoxin results in increased expression of TNFRSF1A protein]; phenyl-N-tert-butylnitrone inhibits the reaction [resiniferatoxin results in increased expression of TNFRSF1A protein]; TRPV1 gene mutant form inhibits the reaction [resiniferatoxin results in increased expression of TNFRSF1A protein]PMID:19531269
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