Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Ripk1 (receptor (TNFRSF)-interacting serine-threonine kinase 1) Mus musculus
Analyze
Symbol: Ripk1
Name: receptor (TNFRSF)-interacting serine-threonine kinase 1
Description: Exhibits protein homodimerization activity and protein serine/threonine kinase activity. Involved in several processes, including necroptotic process; negative regulation of cardiac muscle cell proliferation; and regulation of signal transduction. Predicted to localize to several cellular components, including death-inducing signaling complex; membrane raft; and ripoptosome. Is expressed in brain; heart; liver; lung; and spinal cord. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human RIPK1 (receptor interacting serine/threonine kinase 1); PARTICIPATES IN ceramide signaling pathway; FasL mediated signaling pathway; Toll-like receptor signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cell death protein RIP; D330015H01Rik; receptor-interacting protein 1; receptor-interacting serine/threonine-protein kinase 1; Rinp; RIP; RIP-1; Rip1; serine/threonine-protein kinase RIP
Orthologs:
Homo sapiens (human) : RIPK1 (receptor interacting serine/threonine kinase 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ripk1 (receptor interacting serine/threonine kinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ripk1 (receptor interacting serine/threonine kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : RIPK1 (receptor interacting serine/threonine kinase 1)
Canis lupus familiaris (dog) : RIPK1 (receptor interacting serine/threonine kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ripk1 (receptor interacting serine/threonine kinase 1)
Sus scrofa (pig) : RIPK1 (receptor interacting serine/threonine kinase 1)
Chlorocebus sabaeus (African green monkey) : RIPK1 (receptor interacting serine/threonine kinase 1)
Heterocephalus glaber (naked mole-rat) : Ripk1 (receptor interacting serine/threonine kinase 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl1334,002,363 - 34,037,147 (+)EnsemblGRCm38mm10GRCm38
GRCm381334,002,225 - 34,035,170 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371334,094,743 - 34,127,039 (+)NCBIGRCm37mm9NCBIm37
MGSCv361334,010,339 - 34,042,635 (+)NCBImm8
Celera1335,132,366 - 35,164,663 (+)NCBICelera
Cytogenetic Map13A3.3NCBI
cM Map1314.01NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Ripk1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1320897
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.