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Gene: Ripk1 (receptor (TNFRSF)-interacting serine-threonine kinase 1) Mus musculus
Symbol: Ripk1
Name: receptor (TNFRSF)-interacting serine-threonine kinase 1
Description: Exhibits protein homodimerization activity and protein serine/threonine kinase activity. Involved in several processes, including necroptotic process; negative regulation of cardiac muscle cell proliferation; and regulation of signal transduction. Predicted to localize to several cellular components, including death-inducing signaling complex; membrane raft; and ripoptosome. Is expressed in brain; heart; liver; lung; and spinal cord. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human RIPK1 (receptor interacting serine/threonine kinase 1); PARTICIPATES IN ceramide signaling pathway; FasL mediated signaling pathway; Toll-like receptor signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cell death protein RIP; D330015H01Rik; receptor-interacting protein 1; receptor-interacting serine/threonine-protein kinase 1; Rinp; RIP; RIP-1; Rip1; serine/threonine-protein kinase RIP
Homo sapiens (human) : RIPK1 (receptor interacting serine/threonine kinase 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ripk1 (receptor interacting serine/threonine kinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ripk1 (receptor interacting serine/threonine kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : RIPK1 (receptor interacting serine/threonine kinase 1)
Canis lupus familiaris (dog) : RIPK1 (receptor interacting serine/threonine kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ripk1 (receptor interacting serine/threonine kinase 1)
Sus scrofa (pig) : RIPK1 (receptor interacting serine/threonine kinase 1)
Chlorocebus sabaeus (African green monkey) : RIPK1 (receptor interacting serine/threonine kinase 1)
Heterocephalus glaber (naked mole-rat) : Ripk1 (receptor interacting serine/threonine kinase 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1334,002,363 - 34,037,147 (+)EnsemblGRCm38mm10GRCm38
GRCm381334,002,225 - 34,035,170 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371334,094,743 - 34,127,039 (+)NCBIGRCm37mm9NCBIm37
MGSCv361334,010,339 - 34,042,635 (+)NCBImm8
Celera1335,132,366 - 35,164,663 (+)NCBICelera
Cytogenetic Map13A3.3NCBI
cM Map1314.01NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Ripk1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1320897
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.