FADD (Fas associated via death domain) - Rat Genome Database

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Gene: FADD (Fas associated via death domain) Sus scrofa
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Symbol: FADD
Name: Fas associated via death domain
RGD ID: 14210438
Description: ENCODES a protein that exhibits death receptor binding (ortholog); protease binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN activation of cysteine-type endopeptidase activity (ortholog); apoptotic process (ortholog); behavioral response to cocaine (ortholog); PARTICIPATES IN ceramide signaling pathway; FasL mediated signaling pathway; Trail mediated signaling pathway; ASSOCIATED WITH abdominal obesity-metabolic syndrome 1 (ortholog); Acute Lung Injury (ortholog); acute myeloid leukemia (ortholog); FOUND IN CD95 death-inducing signaling complex (ortholog); cell body (ortholog); death-inducing signaling complex (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Fas (TNF receptor superfamily, member 6); Fas (TNFRSF6)-associated via death domain; FAS-associated death domain protein; Fas-associating death domain-containing protein; TNFRSF6
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl23,185,675 - 3,194,818 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.123,191,718 - 3,194,820 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.221,388,619 - 1,389,394 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity  (ISO)
apoptotic process  (IEA,ISS)
apoptotic signaling pathway  (IEA)
behavioral response to cocaine  (ISO)
cellular response to mechanical stimulus  (IEA)
death-inducing signaling complex assembly  (IEA)
defense response to virus  (IEA)
extrinsic apoptotic signaling pathway  (IBA,IEA,ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (IEA,ISO)
extrinsic apoptotic signaling pathway via death domain receptors  (IEA)
innate immune response  (IEA)
kidney development  (ISO)
lymph node development  (IEA,ISS)
motor neuron apoptotic process  (IEA,ISO)
necroptotic signaling pathway  (IEA)
negative regulation of activation-induced cell death of T cells  (IEA,ISS)
negative regulation of necroptotic process  (IEA,ISO)
positive regulation of activated T cell proliferation  (IEA,ISS)
positive regulation of adaptive immune response  (IEA,ISS)
positive regulation of apoptotic process  (IEA)
positive regulation of canonical NF-kappaB signal transduction  (IEA)
positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation  (IEA,ISS)
positive regulation of execution phase of apoptosis  (IEA)
positive regulation of extrinsic apoptotic signaling pathway  (IEA,ISO)
positive regulation of innate immune response  (IBA)
positive regulation of interleukin-8 production  (IEA)
positive regulation of macrophage differentiation  (IEA)
positive regulation of proteolysis  (IEA)
positive regulation of T cell mediated cytotoxicity  (IEA,ISS)
positive regulation of transcription by RNA polymerase II  (IEA)
positive regulation of tumor necrosis factor production  (IEA)
positive regulation of type I interferon-mediated signaling pathway  (IEA)
positive regulation of type II interferon production  (IEA,ISS)
regulation of apoptotic process  (IEA)
regulation of necroptotic process  (ISO)
response to cocaine  (ISO)
signal transduction  (IEA)
spleen development  (IEA,ISS)
T cell differentiation in thymus  (IEA,ISS)
T cell homeostasis  (IEA,ISS)
thymus development  (IEA,ISS)
TRAIL-activated apoptotic signaling pathway  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:17179649   PMID:22301074  


Genomics

Comparative Map Data
FADD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl23,185,675 - 3,194,818 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.123,191,718 - 3,194,820 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.221,388,619 - 1,389,394 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FADD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381170,203,296 - 70,207,390 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1170,203,296 - 70,207,390 (+)EnsemblGRCh38hg38GRCh38
GRCh371170,049,402 - 70,053,496 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361169,726,917 - 69,731,144 (+)NCBINCBI36Build 36hg18NCBI36
Build 341169,726,916 - 69,731,134NCBI
Celera1167,315,851 - 67,320,090 (+)NCBICelera
Cytogenetic Map11q13.3NCBI
HuRef1166,308,990 - 66,313,229 (+)NCBIHuRef
CHM1_11169,932,172 - 69,936,414 (+)NCBICHM1_1
T2T-CHM13v2.01170,218,250 - 70,222,344 (+)NCBIT2T-CHM13v2.0
Fadd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397144,132,060 - 144,136,178 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7144,131,055 - 144,136,200 (-)EnsemblGRCm39 Ensembl
GRCm387144,578,323 - 144,582,441 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7144,577,318 - 144,582,463 (-)EnsemblGRCm38mm10GRCm38
MGSCv377151,764,228 - 151,768,341 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367144,387,713 - 144,391,826 (-)NCBIMGSCv36mm8
Celera7144,342,191 - 144,346,305 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.85NCBI
Fadd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81209,169,245 - 209,175,423 (-)NCBIGRCr8
mRatBN7.21199,743,200 - 199,745,746 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1199,739,994 - 199,745,653 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1208,126,497 - 208,128,902 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01215,210,505 - 215,212,909 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01207,884,688 - 207,887,092 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01217,746,176 - 217,748,581 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1217,742,929 - 217,748,628 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01224,603,556 - 224,605,961 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41205,010,363 - 205,012,768 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11205,163,017 - 205,166,234 (-)NCBI
Celera1197,302,715 - 197,305,120 (-)NCBICelera
Cytogenetic Map1q42NCBI
Fadd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542216,031,280 - 16,036,281 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542216,026,323 - 16,035,808 (-)NCBIChiLan1.0ChiLan1.0
FADD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2971,170,462 - 71,177,552 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11172,214,724 - 72,218,869 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01165,300,889 - 65,305,020 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11168,590,184 - 68,593,905 (+)NCBIpanpan1.1PanPan1.1panPan2
FADD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11848,087,447 - 48,094,497 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1846,692,062 - 46,704,606 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01848,765,020 - 48,771,948 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1848,765,607 - 48,771,913 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11848,212,163 - 48,219,087 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01847,792,264 - 47,804,830 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01848,543,968 - 48,550,895 (-)NCBIUU_Cfam_GSD_1.0
Fadd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049474,192,521 - 4,197,087 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936599633,330 - 639,456 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936599633,501 - 639,412 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FADD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.114,358,314 - 4,361,863 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038101,642,664 - 101,647,269 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fadd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476717,055,509 - 17,059,705 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476717,050,929 - 17,059,648 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in FADD
98 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000035749   ⟹   ENSSSCP00000030483
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl23,186,744 - 3,194,792 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000105894   ⟹   ENSSSCP00000075653
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl23,185,675 - 3,194,818 (-)Ensembl
RefSeq Acc Id: NM_001031797   ⟹   NP_001026967
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.123,191,718 - 3,194,820 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001026967   ⟸   NM_001031797
- UniProtKB: Q56VC2 (UniProtKB/TrEMBL),   A0A4X1SI57 (UniProtKB/TrEMBL),   K7GRF6 (UniProtKB/TrEMBL),   A0A8D0UW64 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000030483   ⟸   ENSSSCT00000035749
Ensembl Acc Id: ENSSSCP00000075653   ⟸   ENSSSCT00000105894
Protein Domains
Death   DED


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000030888 Ensembl
  ENSSSCG00000054981 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025057309 UniProtKB/TrEMBL
  ENSSSCG00030062323 UniProtKB/TrEMBL
  ENSSSCG00040062141 UniProtKB/TrEMBL
  ENSSSCG00045004124 UniProtKB/TrEMBL
  ENSSSCG00050033644 UniProtKB/TrEMBL
  ENSSSCG00055008644 UniProtKB/TrEMBL
  ENSSSCG00060046296 UniProtKB/TrEMBL
  ENSSSCG00065031566 UniProtKB/TrEMBL
  ENSSSCG00070001233 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000105894 ENTREZGENE
  ENSSSCT00000105894.1 UniProtKB/TrEMBL
  ENSSSCT00025078414.1 UniProtKB/TrEMBL
  ENSSSCT00030087185.1 UniProtKB/TrEMBL
  ENSSSCT00040084639.1 UniProtKB/TrEMBL
  ENSSSCT00045006864.1 UniProtKB/TrEMBL
  ENSSSCT00050045087.1 UniProtKB/TrEMBL
  ENSSSCT00055016899.1 UniProtKB/TrEMBL
  ENSSSCT00060062863.1 UniProtKB/TrEMBL
  ENSSSCT00065042724.1 UniProtKB/TrEMBL
  ENSSSCT00070002327.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
InterPro DEATH-like_dom_sf UniProtKB/TrEMBL
  Death_domain UniProtKB/TrEMBL
  DED_dom UniProtKB/TrEMBL
  FADD UniProtKB/TrEMBL
  FADD_vert UniProtKB/TrEMBL
KEGG Report ssc:595129 UniProtKB/TrEMBL
NCBI Gene FADD ENTREZGENE
PANTHER FAS-ASSOCIATED DEATH DOMAIN PROTEIN UniProtKB/TrEMBL
  PTHR15077 UniProtKB/TrEMBL
Pfam Death UniProtKB/TrEMBL
  DED UniProtKB/TrEMBL
PIRSF FADD UniProtKB/TrEMBL
PROSITE DEATH_DOMAIN UniProtKB/TrEMBL
  DED UniProtKB/TrEMBL
SMART DEATH UniProtKB/TrEMBL
  DED UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/TrEMBL
UniProt A0A4X1SI57 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0UW64 ENTREZGENE, UniProtKB/TrEMBL
  K7GRF6 ENTREZGENE
  Q56VC2 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary K7GRF6 UniProtKB/TrEMBL
VGNC ID VGNC:87874 ENTREZGENE