FADD (Fas associated via death domain) - Rat Genome Database

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Gene: FADD (Fas associated via death domain) Chlorocebus sabaeus
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Symbol: FADD
Name: Fas associated via death domain
RGD ID: 18609559
Description: ENCODES a protein that exhibits caspase binding (ortholog); death effector domain binding (ortholog); death receptor binding (ortholog); INVOLVED IN activation of cysteine-type endopeptidase activity (ortholog); apoptotic process (ortholog); apoptotic signaling pathway (ortholog); PARTICIPATES IN ceramide signaling pathway; FasL mediated signaling pathway; Trail mediated signaling pathway; ASSOCIATED WITH abdominal obesity-metabolic syndrome 1 (ortholog); Acute Lung Injury (ortholog); acute myeloid leukemia (ortholog); FOUND IN CD95 death-inducing signaling complex (ortholog); cell body (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: FAS-associated death domain protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.114,358,314 - 4,361,863 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038101,642,664 - 101,647,269 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity  (ISO)
apoptotic process  (ISO)
apoptotic signaling pathway  (ISO)
behavioral response to cocaine  (ISO)
cellular response to mechanical stimulus  (ISO)
death-inducing signaling complex assembly  (ISO)
defense response to virus  (ISO)
extrinsic apoptotic signaling pathway  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
kidney development  (ISO)
lymph node development  (ISO)
motor neuron apoptotic process  (ISO)
necroptotic signaling pathway  (ISO)
negative regulation of activation-induced cell death of T cells  (ISO)
negative regulation of necroptotic process  (ISO)
positive regulation of activated T cell proliferation  (ISO)
positive regulation of adaptive immune response  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (ISO)
positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation  (ISO)
positive regulation of execution phase of apoptosis  (ISO)
positive regulation of extrinsic apoptotic signaling pathway  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of macrophage differentiation  (ISO)
positive regulation of proteolysis  (ISO)
positive regulation of T cell mediated cytotoxicity  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of type I interferon-mediated signaling pathway  (ISO)
positive regulation of type II interferon production  (ISO)
regulation of necroptotic process  (ISO)
response to cocaine  (ISO)
spleen development  (ISO)
T cell differentiation in thymus  (ISO)
T cell homeostasis  (ISO)
thymus development  (ISO)
TRAIL-activated apoptotic signaling pathway  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
FADD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.114,358,314 - 4,361,863 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038101,642,664 - 101,647,269 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
FADD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381170,203,296 - 70,207,390 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1170,203,296 - 70,207,390 (+)EnsemblGRCh38hg38GRCh38
GRCh371170,049,402 - 70,053,496 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361169,726,917 - 69,731,144 (+)NCBINCBI36Build 36hg18NCBI36
Build 341169,726,916 - 69,731,134NCBI
Celera1167,315,851 - 67,320,090 (+)NCBICelera
Cytogenetic Map11q13.3NCBI
HuRef1166,308,990 - 66,313,229 (+)NCBIHuRef
CHM1_11169,932,172 - 69,936,414 (+)NCBICHM1_1
T2T-CHM13v2.01170,218,250 - 70,222,344 (+)NCBIT2T-CHM13v2.0
Fadd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397144,132,060 - 144,136,178 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7144,131,055 - 144,136,200 (-)EnsemblGRCm39 Ensembl
GRCm387144,578,323 - 144,582,441 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7144,577,318 - 144,582,463 (-)EnsemblGRCm38mm10GRCm38
MGSCv377151,764,228 - 151,768,341 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367144,387,713 - 144,391,826 (-)NCBIMGSCv36mm8
Celera7144,342,191 - 144,346,305 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.85NCBI
Fadd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81209,169,245 - 209,175,423 (-)NCBIGRCr8
mRatBN7.21199,743,200 - 199,745,746 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1199,739,994 - 199,745,653 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1208,126,497 - 208,128,902 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01215,210,505 - 215,212,909 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01207,884,688 - 207,887,092 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01217,746,176 - 217,748,581 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1217,742,929 - 217,748,628 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01224,603,556 - 224,605,961 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41205,010,363 - 205,012,768 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11205,163,017 - 205,166,234 (-)NCBI
Celera1197,302,715 - 197,305,120 (-)NCBICelera
Cytogenetic Map1q42NCBI
Fadd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542216,031,280 - 16,036,281 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542216,026,323 - 16,035,808 (-)NCBIChiLan1.0ChiLan1.0
FADD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2971,170,462 - 71,177,552 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11172,214,724 - 72,218,869 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01165,300,889 - 65,305,020 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11168,590,184 - 68,593,905 (+)NCBIpanpan1.1PanPan1.1panPan2
FADD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11848,087,447 - 48,094,497 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1846,692,062 - 46,704,606 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01848,765,020 - 48,771,948 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1848,765,607 - 48,771,913 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11848,212,163 - 48,219,087 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01847,792,264 - 47,804,830 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01848,543,968 - 48,550,895 (-)NCBIUU_Cfam_GSD_1.0
Fadd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049474,192,521 - 4,197,087 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936599633,330 - 639,456 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936599633,501 - 639,412 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FADD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl23,185,675 - 3,194,818 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.123,191,718 - 3,194,820 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.221,388,619 - 1,389,394 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Fadd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476717,055,509 - 17,059,705 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476717,050,929 - 17,059,648 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


RefSeq Acc Id: XM_037998892   ⟹   XP_037854820
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666038101,642,664 - 101,647,269 (-)NCBI
Protein Sequences
Protein RefSeqs XP_037854820 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_037854820   ⟸   XM_037998892


Additional Information

Database Acc Id Source(s)
NCBI Gene FADD ENTREZGENE