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Gene: FADD (Fas associated via death domain) Homo sapiens
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Symbol: FADD
Name: Fas associated via death domain
Description: Exhibits several functions, including caspase binding activity; death effector domain binding activity; and identical protein binding activity. Involved in several processes, including positive regulation of cytokine production; positive regulation of macromolecule metabolic process; and positive regulation of signal transduction. Localizes to the CD95 death-inducing signaling complex and ripoptosome. Implicated in leukemia. Biomarker of Alzheimer's disease and acute myeloid leukemia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Fas (TNFRSF6)-associated via death domain; FAS-associated death domain protein; Fas-associating death domain-containing protein; Fas-associating protein with death domain; GIG3; growth-inhibiting gene 3 protein; mediator of receptor induced toxicity; mediator of receptor-induced toxicity; MGC8528; MORT1
Orthologs:
Mus musculus (house mouse) : Fadd (Fas (TNFRSF6)-associated via death domain)  MGI  Alliance
Rattus norvegicus (Norway rat) : Fadd (Fas associated via death domain)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fadd (Fas associated via death domain)
Pan paniscus (bonobo/pygmy chimpanzee) : FADD (Fas associated via death domain)
Canis lupus familiaris (dog) : FADD (Fas associated via death domain)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fadd (Fas associated via death domain)
Sus scrofa (pig) : FADD (Fas associated via death domain)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381170,203,163 - 70,207,402 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371170,049,269 - 70,053,508 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361169,726,917 - 69,731,144 (+)NCBINCBI36hg18NCBI36
Build 341169,726,916 - 69,731,134NCBI
Celera1167,315,851 - 67,320,090 (+)NCBI
Cytogenetic Map11q13.3NCBI
HuRef1166,308,990 - 66,313,229 (+)NCBIHuRef
CHM1_11169,932,172 - 69,936,414 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on FADD
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1345195
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.