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Gene: FADD (Fas associated via death domain) Homo sapiens
Symbol: FADD
Name: Fas associated via death domain
RGD ID: 1345195
Description: Exhibits several functions, including caspase binding activity; death effector domain binding activity; and identical protein binding activity. Involved in several processes, including cellular response to mechanical stimulus; positive regulation of macromolecule metabolic process; and positive regulation of signal transduction. Localizes to CD95 death-inducing signaling complex and ripoptosome. Implicated in leukemia. Biomarker of Alzheimer's disease and acute myeloid leukemia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Fas (TNFRSF6)-associated via death domain; FAS-associated death domain protein; Fas-associating death domain-containing protein; Fas-associating protein with death domain; GIG3; growth-inhibiting gene 3 protein; mediator of receptor induced toxicity; mediator of receptor-induced toxicity; MGC8528; MORT1
Mus musculus (house mouse) : Fadd (Fas (TNFRSF6)-associated via death domain)  MGI  Alliance
Rattus norvegicus (Norway rat) : Fadd (Fas associated via death domain)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fadd (Fas associated via death domain)
Pan paniscus (bonobo/pygmy chimpanzee) : FADD (Fas associated via death domain)
Canis lupus familiaris (dog) : FADD (Fas associated via death domain)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fadd (Fas associated via death domain)
Sus scrofa (pig) : FADD (Fas associated via death domain)
Chlorocebus sabaeus (African green monkey) : FADD (Fas associated via death domain)
Heterocephalus glaber (naked mole-rat) : Fadd (Fas associated via death domain)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1170,203,163 - 70,207,390 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1170,203,296 - 70,207,390 (+)EnsemblGRCh38hg38GRCh38
GRCh381170,203,296 - 70,207,390 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371170,049,269 - 70,053,508 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361169,726,917 - 69,731,144 (+)NCBINCBI36hg18NCBI36
Build 341169,726,916 - 69,731,134NCBI
Celera1167,315,851 - 67,320,090 (+)NCBI
Cytogenetic Map11q13.3NCBI
HuRef1166,308,990 - 66,313,229 (+)NCBIHuRef
CHM1_11169,932,172 - 69,936,414 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on FADD
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1345195
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-10-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.