FADD (Fas associated via death domain) - Rat Genome Database

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Pathways
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Gene: FADD (Fas associated via death domain) Canis lupus familiaris
Analyze
Symbol: FADD
Name: Fas associated via death domain
RGD ID: 12111199
Description: ENCODES a protein that exhibits death receptor binding (ortholog); protease binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN behavioral response to cocaine (ortholog); extrinsic apoptotic signaling pathway (ortholog); extrinsic apoptotic signaling pathway in absence of ligand (ortholog); PARTICIPATES IN ceramide signaling pathway; FasL mediated signaling pathway; Trail mediated signaling pathway; ASSOCIATED WITH abdominal obesity-metabolic syndrome 1 (ortholog); Acute Lung Injury (ortholog); acute myeloid leukemia (ortholog); FOUND IN CD95 death-inducing signaling complex (ortholog); cell body (ortholog); death-inducing signaling complex (ortholog); INTERACTS WITH marbofloxacin
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Fas (TNFRSF6)-associated via death domain
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11848,087,447 - 48,094,497 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1846,692,062 - 46,704,606 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01848,765,020 - 48,771,948 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1848,765,607 - 48,771,913 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11848,212,163 - 48,219,087 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01847,792,264 - 47,804,830 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01848,543,968 - 48,550,895 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA)
apoptotic signaling pathway  (IEA)
behavioral response to cocaine  (ISO)
cellular response to mechanical stimulus  (IEA)
death-inducing signaling complex assembly  (IEA)
defense response to virus  (IEA)
extrinsic apoptotic signaling pathway  (IEA,ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (IEA,ISO)
extrinsic apoptotic signaling pathway via death domain receptors  (IEA)
innate immune response  (IEA)
kidney development  (ISO)
lymph node development  (IEA)
motor neuron apoptotic process  (IEA,ISO)
necroptotic signaling pathway  (IEA)
negative regulation of activation-induced cell death of T cells  (IEA)
negative regulation of necroptotic process  (IEA,ISO)
positive regulation of activated T cell proliferation  (IEA)
positive regulation of adaptive immune response  (IEA)
positive regulation of apoptotic process  (IEA)
positive regulation of canonical NF-kappaB signal transduction  (IEA)
positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation  (IEA)
positive regulation of execution phase of apoptosis  (IEA)
positive regulation of extrinsic apoptotic signaling pathway  (IEA,ISO)
positive regulation of interleukin-8 production  (IEA)
positive regulation of macrophage differentiation  (IEA)
positive regulation of proteolysis  (IEA)
positive regulation of T cell mediated cytotoxicity  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA)
positive regulation of tumor necrosis factor production  (IEA)
positive regulation of type I interferon-mediated signaling pathway  (IEA)
positive regulation of type II interferon production  (IEA)
regulation of apoptotic process  (IEA)
regulation of necroptotic process  (ISO)
response to cocaine  (ISO)
signal transduction  (IEA)
spleen development  (IEA)
T cell differentiation in thymus  (IEA)
T cell homeostasis  (IEA)
thymus development  (IEA)
TRAIL-activated apoptotic signaling pathway  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21183682   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
FADD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11848,087,447 - 48,094,497 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1846,692,062 - 46,704,606 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01848,765,020 - 48,771,948 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1848,765,607 - 48,771,913 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11848,212,163 - 48,219,087 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01847,792,264 - 47,804,830 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01848,543,968 - 48,550,895 (-)NCBIUU_Cfam_GSD_1.0
FADD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381170,203,296 - 70,207,390 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1170,203,296 - 70,207,390 (+)EnsemblGRCh38hg38GRCh38
GRCh371170,049,402 - 70,053,496 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361169,726,917 - 69,731,144 (+)NCBINCBI36Build 36hg18NCBI36
Build 341169,726,916 - 69,731,134NCBI
Celera1167,315,851 - 67,320,090 (+)NCBICelera
Cytogenetic Map11q13.3NCBI
HuRef1166,308,990 - 66,313,229 (+)NCBIHuRef
CHM1_11169,932,172 - 69,936,414 (+)NCBICHM1_1
T2T-CHM13v2.01170,218,250 - 70,222,344 (+)NCBIT2T-CHM13v2.0
Fadd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397144,132,060 - 144,136,178 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7144,131,055 - 144,136,200 (-)EnsemblGRCm39 Ensembl
GRCm387144,578,323 - 144,582,441 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7144,577,318 - 144,582,463 (-)EnsemblGRCm38mm10GRCm38
MGSCv377151,764,228 - 151,768,341 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367144,387,713 - 144,391,826 (-)NCBIMGSCv36mm8
Celera7144,342,191 - 144,346,305 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.85NCBI
Fadd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81209,169,245 - 209,175,423 (-)NCBIGRCr8
mRatBN7.21199,743,200 - 199,745,746 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1199,739,994 - 199,745,653 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1208,126,497 - 208,128,902 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01215,210,505 - 215,212,909 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01207,884,688 - 207,887,092 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01217,746,176 - 217,748,581 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1217,742,929 - 217,748,628 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01224,603,556 - 224,605,961 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41205,010,363 - 205,012,768 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11205,163,017 - 205,166,234 (-)NCBI
Celera1197,302,715 - 197,305,120 (-)NCBICelera
Cytogenetic Map1q42NCBI
Fadd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542216,031,280 - 16,036,281 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542216,026,323 - 16,035,808 (-)NCBIChiLan1.0ChiLan1.0
FADD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2971,170,462 - 71,177,552 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11172,214,724 - 72,218,869 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01165,300,889 - 65,305,020 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11168,590,184 - 68,593,905 (+)NCBIpanpan1.1PanPan1.1panPan2
Fadd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049474,192,521 - 4,197,087 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936599633,330 - 639,456 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936599633,501 - 639,412 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FADD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl23,185,675 - 3,194,818 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.123,191,718 - 3,194,820 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.221,388,619 - 1,389,394 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FADD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.114,358,314 - 4,361,863 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038101,642,664 - 101,647,269 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fadd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476717,055,509 - 17,059,705 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476717,050,929 - 17,059,648 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in FADD
116 total Variants

Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022405124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038424720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038424721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038454051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038454052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038454053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038500971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038500972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038563648 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038563649 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038627767 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038627768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038627769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00845026086   ⟹   ENSCAFP00845020568
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1848,765,607 - 48,771,913 (-)Ensembl
RefSeq Acc Id: XM_038424720   ⟹   XP_038280648
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01848,765,020 - 48,771,942 (-)NCBI
RefSeq Acc Id: XM_038424721   ⟹   XP_038280649
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01848,765,020 - 48,771,948 (-)NCBI
RefSeq Acc Id: XM_038454051   ⟹   XP_038309979
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1846,697,680 - 46,704,597 (-)NCBI
RefSeq Acc Id: XM_038454052   ⟹   XP_038309980
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1846,697,680 - 46,704,603 (-)NCBI
RefSeq Acc Id: XM_038454053   ⟹   XP_038309981
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1846,692,062 - 46,704,606 (-)NCBI
RefSeq Acc Id: XM_038500971   ⟹   XP_038356899
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11848,212,163 - 48,219,081 (-)NCBI
RefSeq Acc Id: XM_038500972   ⟹   XP_038356900
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11848,212,163 - 48,219,087 (-)NCBI
RefSeq Acc Id: XM_038563648   ⟹   XP_038419576
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01848,543,968 - 48,550,889 (-)NCBI
RefSeq Acc Id: XM_038563649   ⟹   XP_038419577
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01848,543,968 - 48,550,895 (-)NCBI
RefSeq Acc Id: XM_038627767   ⟹   XP_038483695
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01847,797,900 - 47,804,830 (-)NCBI
RefSeq Acc Id: XM_038627768   ⟹   XP_038483696
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01847,797,900 - 47,804,830 (-)NCBI
RefSeq Acc Id: XM_038627769   ⟹   XP_038483697
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01847,792,264 - 47,804,830 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_038356900   ⟸   XM_038500972
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038356899   ⟸   XM_038500971
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038483697   ⟸   XM_038627769
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038483696   ⟸   XM_038627768
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038483695   ⟸   XM_038627767
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038280649   ⟸   XM_038424721
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038280648   ⟸   XM_038424720
- Peptide Label: isoform X1
- UniProtKB: A0A8C0KSA2 (UniProtKB/TrEMBL),   A0A8I3NIL2 (UniProtKB/TrEMBL),   A0A8C0PGD2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038309981   ⟸   XM_038454053
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038309980   ⟸   XM_038454052
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038309979   ⟸   XM_038454051
- Peptide Label: isoform X1
- UniProtKB: A0A8C0KSA2 (UniProtKB/TrEMBL),   A0A8I3NIL2 (UniProtKB/TrEMBL),   A0A8C0PGD2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038419577   ⟸   XM_038563649
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038419576   ⟸   XM_038563648
- Peptide Label: isoform X1
- UniProtKB: A0A8C0KSA2 (UniProtKB/TrEMBL),   A0A8C0PGD2 (UniProtKB/TrEMBL),   A0A8I3NIL2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845020568   ⟸   ENSCAFT00845026086
Protein Domains
Death   DED


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000057266 UniProtKB/TrEMBL
  ENSCAFG00030024759 UniProtKB/TrEMBL
  ENSCAFG00040006770 UniProtKB/TrEMBL
  ENSCAFG00845014582 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000100573.1 UniProtKB/TrEMBL
  ENSCAFT00030045598.1 UniProtKB/TrEMBL
  ENSCAFT00040012585.1 UniProtKB/TrEMBL
  ENSCAFT00845026086 ENTREZGENE
  ENSCAFT00845026086.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
InterPro DEATH-like_dom_sf UniProtKB/TrEMBL
  Death_domain UniProtKB/TrEMBL
  DED_dom UniProtKB/TrEMBL
  FADD UniProtKB/TrEMBL
  FADD_vert UniProtKB/TrEMBL
NCBI Gene FADD ENTREZGENE
PANTHER FAS-ASSOCIATED DEATH DOMAIN PROTEIN UniProtKB/TrEMBL
  PTHR15077 UniProtKB/TrEMBL
Pfam Death UniProtKB/TrEMBL
  DED UniProtKB/TrEMBL
PIRSF FADD UniProtKB/TrEMBL
PROSITE DEATH_DOMAIN UniProtKB/TrEMBL
  DED UniProtKB/TrEMBL
SMART DEATH UniProtKB/TrEMBL
  DED UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/TrEMBL
UniProt A0A8C0KSA2 ENTREZGENE
  A0A8C0PGD2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NIL2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PQC7_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:51869 ENTREZGENE