Ctsd (cathepsin D) - Rat Genome Database

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Gene: Ctsd (cathepsin D) Rattus norvegicus
Analyze
Symbol: Ctsd
Name: cathepsin D
RGD ID: 621511
Description: Enables endopeptidase activity and peptide binding activity. Involved in several processes, including protein catabolic process; synaptic vesicle endosomal processing; and vesicle-mediated transport in synapse. Is active in GABA-ergic synapse and presynaptic endosome. Human ortholog(s) of this gene implicated in Alzheimer's disease; breast cancer; and neuronal ceroid lipofuscinosis 10. Orthologous to human CTSD (cathepsin D); PARTICIPATES IN ceramide signaling pathway; chaperone mediated autophagy pathway; tuberculosis pathway; INTERACTS WITH (+)-pilocarpine; (-)-epigallocatechin 3-gallate; (R)-lipoic acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81206,956,945 - 206,968,821 (-)NCBIGRCr8
mRatBN7.21197,527,467 - 197,539,343 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1197,527,467 - 197,539,488 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1205,900,151 - 205,912,026 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01212,986,334 - 212,998,210 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01205,660,486 - 205,672,362 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01215,541,570 - 215,553,446 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1215,541,542 - 215,553,451 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01222,436,922 - 222,448,798 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41202,619,669 - 202,631,545 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11202,779,384 - 202,791,261 (-)NCBI
Celera1195,146,345 - 195,158,236 (-)NCBICelera
Cytogenetic Map1q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(1->4)-beta-D-glucan  (ISO)
(R)-linalyl acetate  (ISO)
(R)-lipoic acid  (EXP)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-amphetamine  (ISO)
(S)-naringenin  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3-dichloropropan-2-ol  (ISO)
1,8-cineole  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butoxyethanol  (ISO)
2-deoxy-D-glucose  (EXP)
2-nitrofluorene  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3'-diindolylmethane  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3-chloropropane-1,2-diol  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxynon-2-enal  (ISO)
4-nitroquinoline N-oxide  (EXP)
4-nonylphenol  (ISO)
4-phenylbutyric acid  (ISO)
4-terpineol  (ISO)
4-tert-Octylphenol  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6alpha-methylprednisolone  (EXP)
7,12-dimethyltetraphene  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (ISO)
alliin  (EXP)
aloxistatin  (ISO)
alpha,alpha-trehalose  (EXP)
alpha-naphthoflavone  (ISO)
alpha-pinene  (ISO)
alpha-terpineol  (ISO)
alpha-Zearalanol  (EXP)
amiodarone  (ISO)
amlodipine  (EXP)
ammonium chloride  (EXP)
amodiaquine  (ISO)
anthocyanin  (EXP)
aristolochic acid A  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
Azaspiracid  (ISO)
bafilomycin A1  (ISO)
beauvericin  (ISO)
benzamide  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
berberine  (ISO)
beta-D-glucosamine  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bortezomib  (ISO)
brucine  (ISO)
Brusatol  (EXP)
buspirone  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
celecoxib  (ISO)
chloroquine  (EXP,ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (EXP)
cimetidine  (EXP)
cis-caffeic acid  (EXP)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP,ISO)
coenzyme Q10  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
curcumin  (EXP,ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
cyprodinil  (ISO)
cysteamine  (EXP)
DDE  (ISO)
DDT  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
Diallyl sulfide  (ISO)
diarsenic trioxide  (ISO)
diarylheptanoid  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (EXP)
disodium cromoglycate  (ISO)
diuron  (EXP)
dopamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
ellagic acid  (EXP)
emodin  (ISO)
enniatin  (ISO)
epoxiconazole  (ISO)
ethambutol  (EXP)
fangchinoline  (ISO)
fenamidone  (ISO)
fenhexamid  (ISO)
ferulic acid  (EXP)
flavonoids  (EXP)
fludioxonil  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
gamma-terpinene  (ISO)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (EXP)
ginsenoside Rb1  (ISO)
glycidyl methacrylate  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indole-3-methanol  (ISO)
indometacin  (EXP)
inulin  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
kainic acid  (EXP)
L-ascorbic acid  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
leflunomide  (EXP)
Liensinine  (ISO)
limonene  (ISO)
linalool  (ISO)
linalyl acetate  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
lucanthone  (ISO)
malathion  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (EXP)
Mecamylamine  (ISO)
medroxyprogesterone acetate  (ISO)
melatonin  (ISO)
methamphetamine  (EXP)
methapyrilene  (EXP)
miconazole  (ISO)
morin  (EXP)
morusin  (ISO)
myo-inositol hexakisphosphate  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (EXP)
N-acetyl-L-cysteine  (ISO)
N-acetylsphingosine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodimethylamine  (EXP)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
NADP zwitterion  (EXP)
NADP(+)  (EXP)
naphthalenes  (EXP)
naringin  (EXP)
nefazodone  (EXP)
niclosamide  (ISO)
nicorandil  (EXP)
nitric oxide  (EXP)
nitroglycerin  (EXP)
Nonylphenol  (ISO)
omeprazole  (EXP)
oxidopamine  (ISO)
ozone  (ISO)
p-tert-Amylphenol  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pepstatin A  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenacetin  (EXP)
phenobarbital  (EXP)
phenylhydrazine  (EXP)
phenylmercury acetate  (ISO)
PhIP  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
phytoestrogen  (ISO)
picene  (ISO)
piperonyl butoxide  (EXP)
pirimiphos-methyl  (EXP)
pirinixic acid  (EXP,ISO)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
pristane  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
quizartinib  (ISO)
resveratrol  (ISO)
retinyl acetate  (ISO)
rotenone  (EXP,ISO)
S-allylcysteine  (EXP)
sarin  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
stilben-4-ol  (ISO)
stilbene-4,4'-diol  (ISO)
streptozocin  (ISO)
swainsonine  (EXP)
tamibarotene  (ISO)
tamoxifen  (ISO)
tea tree oil  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trans-caffeic acid  (EXP)
trans-stilbene-4,4'-diol  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
WIN 55212-2  (ISO)
Yessotoxin  (ISO)
zearalenone  (ISO)
zinc pyrithione  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Detection of procathepsin D in rat milk. Benes P, etal., Comp Biochem Physiol B Biochem Mol Biol 2002 Sep;133(1):113-8.
2. Cloning, sequence and expression of rat cathepsin D. Birch NP and Loh YP, Nucleic Acids Res 1990 Nov 11;18(21):6445-6.
3. Biochemical and immunohistochemical study on physiological activity and distribution of hepatic cathepsin D. Burdan F, etal., Acta Physiol Hung 2003;90(1):47-56.
4. Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies. Ciechanover A and Kwon YT, Exp Mol Med. 2015 Mar 13;47:e147. doi: 10.1038/emm.2014.117.
5. Predictive value of cathepsin-D for cervical lymph node metastasis in head and neck squamous cell carcinoma. Gandour-Edwards R, etal., Head Neck 1999 Dec;21(8):718-22.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Down-regulation of cathepsin-D expression by antisense gene transfer inhibits tumor growth and experimental lung metastasis of human breast cancer cells. Glondu M, etal., Oncogene 2002 Aug 1;21(33):5127-34.
8. Differential expression of cysteine and aspartic proteases during progression of atherosclerosis in apolipoprotein E-deficient mice. Jormsjo S, etal., Am J Pathol. 2002 Sep;161(3):939-45.
9. Changes in the activity of lysosomal enzymes in rat kidneys in the course of acute pancreatitis. Lakowska H, etal., Med Sci Monit. 2001 Nov-Dec;7(6):1193-7.
10. Presynaptic Endosomal Cathepsin D Regulates the Biogenesis of GABAergic Synaptic Vesicles. Li X, etal., Cell Rep. 2019 Jul 23;28(4):1015-1028.e5. doi: 10.1016/j.celrep.2019.06.006.
11. Non-replication of association between cathepsin D genotype and late onset Alzheimer disease. Menzer G, etal., Am J Med Genet 2001 Mar 8;105(2):179-82.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. Role of chaperone-mediated autophagy in degrading Huntington's disease-associated huntingtin protein. Qi L and Zhang XD, Acta Biochim Biophys Sin (Shanghai). 2014 Feb;46(2):83-91. doi: 10.1093/abbs/gmt133. Epub 2013 Dec 8.
18. Alterations in certain lysosomal glycohydrolases and cathepsins in rats on dexamethasone administration. Rajashree S and Puvanakrishnan R, Mol Cell Biochem. 1996 Jan 26;154(2):165-70.
19. GOA pipeline RGD automated data pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Rat brain contains high levels of mannose-6-phosphorylated glycoproteins including lysosomal enzymes and palmitoyl-protein thioesterase, an enzyme implicated in infantile neuronal lipofuscinosis. Sleat DE, etal., J Biol Chem. 1996 Aug 9;271(32):19191-8.
23. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
24. Autophagy in the heart and liver during normal aging and calorie restriction. Wohlgemuth SE, etal., Rejuvenation Res. 2007 Sep;10(3):281-92.
Additional References at PubMed
PMID:1692625   PMID:1837142   PMID:1883350   PMID:2350688   PMID:3182800   PMID:9034150   PMID:9645704   PMID:10591619   PMID:12107093   PMID:12676993   PMID:12775715   PMID:14631510  
PMID:14651853   PMID:14977632   PMID:15452145   PMID:15456852   PMID:15588329   PMID:16242638   PMID:16423528   PMID:16502470   PMID:16914181   PMID:16997486   PMID:17105920   PMID:17188016  
PMID:17285857   PMID:17500053   PMID:18419753   PMID:18420735   PMID:18840968   PMID:19056867   PMID:19293336   PMID:19710420   PMID:19723497   PMID:19819948   PMID:20551380   PMID:21374014  
PMID:23132538   PMID:23295649   PMID:23376485   PMID:23533145   PMID:25204797   PMID:25673507   PMID:26370502   PMID:26467158   PMID:27068509   PMID:27894668   PMID:29263022   PMID:31862139  
PMID:33914781  


Genomics

Comparative Map Data
Ctsd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81206,956,945 - 206,968,821 (-)NCBIGRCr8
mRatBN7.21197,527,467 - 197,539,343 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1197,527,467 - 197,539,488 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1205,900,151 - 205,912,026 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01212,986,334 - 212,998,210 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01205,660,486 - 205,672,362 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01215,541,570 - 215,553,446 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1215,541,542 - 215,553,451 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01222,436,922 - 222,448,798 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41202,619,669 - 202,631,545 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11202,779,384 - 202,791,261 (-)NCBI
Celera1195,146,345 - 195,158,236 (-)NCBICelera
Cytogenetic Map1q41NCBI
CTSD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38111,752,755 - 1,763,927 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl111,752,752 - 1,764,573 (-)EnsemblGRCh38hg38GRCh38
GRCh37111,773,985 - 1,785,157 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,730,561 - 1,741,798 (-)NCBINCBI36Build 36hg18NCBI36
Build 34111,730,560 - 1,741,798NCBI
Celera111,812,103 - 1,823,339 (-)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef111,564,872 - 1,576,226 (-)NCBIHuRef
CHM1_1111,772,933 - 1,784,154 (-)NCBICHM1_1
T2T-CHM13v2.0111,838,305 - 1,849,587 (-)NCBIT2T-CHM13v2.0
Ctsd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397141,929,647 - 141,941,564 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7141,929,648 - 141,941,775 (-)EnsemblGRCm39 Ensembl
GRCm387142,375,910 - 142,387,827 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7142,375,911 - 142,388,038 (-)EnsemblGRCm38mm10GRCm38
MGSCv377149,561,821 - 149,573,775 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367142,185,306 - 142,197,260 (-)NCBIMGSCv36mm8
Celera7142,131,673 - 142,143,627 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map787.93NCBI
Ctsd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542213,576,202 - 13,584,298 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542213,576,315 - 13,584,267 (-)NCBIChiLan1.0ChiLan1.0
CTSD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v294,174,444 - 4,185,715 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1113,385,404 - 3,396,669 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0111,789,326 - 1,800,524 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1111,821,442 - 1,832,970 (-)NCBIpanpan1.1PanPan1.1panPan2
CTSD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11846,010,440 - 46,019,457 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1846,010,440 - 46,019,457 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1844,620,711 - 44,629,727 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01846,691,854 - 46,700,871 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1846,676,835 - 46,700,888 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11846,139,444 - 46,148,460 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01845,719,812 - 45,728,828 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01846,465,360 - 46,474,395 (-)NCBIUU_Cfam_GSD_1.0
Ctsd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049471,426,783 - 1,436,952 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936816680,798 - 691,039 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936816680,798 - 690,959 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CTSD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl21,188,549 - 1,197,643 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.121,188,548 - 1,197,642 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CTSD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111,570,163 - 1,581,857 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11,570,069 - 1,581,833 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603898,757,257 - 98,768,016 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ctsd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476714,660,936 - 14,671,671 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476714,661,058 - 14,671,116 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ctsd
43 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:86
Count of miRNA genes:76
Interacting mature miRNAs:76
Transcripts:ENSRNOT00000027407
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1184550676229550676Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1185145134221264292Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1193113876238113876Rat
1359018Hrtrt20Heart rate QTL 203.08heart pumping trait (VT:2000009)heart rate (CMO:0000002)1185356336202902618Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1196248093241248093Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1182623426219932796Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1181759564214537555Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
631260Tcas2Tongue tumor susceptibility QTL 24.93tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1192485903199050587Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1185356336231689108Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
10059590Kidm44Kidney mass QTL 443.420.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1191033875236033875Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1196248093241248093Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1188377360224054420Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1193422268214537671Rat
6480777Insul17Insulin level QTL 173.86blood insulin amount (VT:0001560)blood insulin level area under curve (AUC) (CMO:0000351)1197260913198211706Rat
6480783Insul19Insulin level QTL 194.33blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1197489281200611765Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
6480780Insul18Insulin level QTL 184.11blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1189607473200611765Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1181829673224569684Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat

Markers in Region
D1Bda43  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,527,713 - 197,528,026 (+)MAPPERmRatBN7.2
Rnor_6.01215,541,817 - 215,542,129NCBIRnor6.0
Rnor_5.01222,437,169 - 222,437,481UniSTSRnor5.0
RGSC_v3.41202,619,916 - 202,620,228UniSTSRGSC3.4
Celera1195,146,592 - 195,146,904UniSTS
Cytogenetic Map1q41UniSTS
UniSTS:498756  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,527,747 - 197,529,055 (+)MAPPERmRatBN7.2
Rnor_6.01215,541,851 - 215,543,158NCBIRnor6.0
Rnor_5.01222,437,203 - 222,438,510UniSTSRnor5.0
RGSC_v3.41202,619,950 - 202,621,257UniSTSRGSC3.4
Celera1195,146,626 - 195,147,948UniSTS
Cytogenetic Map1q41UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 1
Medium 3 43 57 41 19 41 8 11 74 35 41 10 8
Low
Below cutoff

Sequence


Ensembl Acc Id: ENSRNOT00000027407   ⟹   ENSRNOP00000027407
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1197,527,467 - 197,539,488 (-)Ensembl
Rnor_6.0 Ensembl1215,541,542 - 215,553,451 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107378   ⟹   ENSRNOP00000093455
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1197,527,467 - 197,539,307 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117470   ⟹   ENSRNOP00000092879
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1197,527,467 - 197,539,341 (-)Ensembl
RefSeq Acc Id: NM_134334   ⟹   NP_599161
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81206,956,945 - 206,968,821 (-)NCBI
mRatBN7.21197,527,467 - 197,539,343 (-)NCBI
Rnor_6.01215,541,570 - 215,553,446 (-)NCBI
Rnor_5.01222,436,922 - 222,448,798 (-)NCBI
RGSC_v3.41202,619,669 - 202,631,545 (-)RGD
Celera1195,146,345 - 195,158,236 (-)RGD
Sequence:
RefSeq Acc Id: NP_599161   ⟸   NM_134334
- Peptide Label: precursor
- UniProtKB: P24268 (UniProtKB/Swiss-Prot),   Q6P6T6 (UniProtKB/TrEMBL),   A6HY44 (UniProtKB/TrEMBL),   F7F3R8 (UniProtKB/TrEMBL),   A0A8I6AIK0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000027407   ⟸   ENSRNOT00000027407
Ensembl Acc Id: ENSRNOP00000092879   ⟸   ENSRNOT00000117470
Ensembl Acc Id: ENSRNOP00000093455   ⟸   ENSRNOT00000107378
Protein Domains
Peptidase A1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P24268-F1-model_v2 AlphaFold P24268 1-407 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690560
Promoter ID:EPDNEW_R1085
Type:initiation region
Name:Ctsd_1
Description:cathepsin D
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01215,553,410 - 215,553,470EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621511 AgrOrtholog
BioCyc Gene G2FUF-56919 BioCyc
Ensembl Genes ENSRNOG00000020206 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000027407.5 UniProtKB/TrEMBL
  ENSRNOT00000107378.1 UniProtKB/TrEMBL
  ENSRNOT00000117470.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.70.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.1960 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5623627 IMAGE-MGC_LOAD
InterPro Aspartic_peptidase_A1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aspartic_peptidase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aspartic_peptidase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cathepsin_D UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PEPTIDASE_A1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_aspartic_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:171293 UniProtKB/TrEMBL
MGC_CLONE MGC:72315 IMAGE-MGC_LOAD
NCBI Gene 171293 ENTREZGENE
PANTHER CATHEPSIN D UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR47966 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam A1_Propeptide UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Asp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ctsd PhenoGen
PRINTS PEPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ASP_PROTEASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PEPTIDASE_A1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020206 RatGTEx
Superfamily-SCOP SSF50630 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AIK0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AKF2_RAT UniProtKB/TrEMBL
  A6HY43_RAT UniProtKB/TrEMBL
  A6HY44 ENTREZGENE, UniProtKB/TrEMBL
  A6HY45_RAT UniProtKB/TrEMBL
  CATD_RAT UniProtKB/Swiss-Prot
  F7F3R8 ENTREZGENE, UniProtKB/TrEMBL
  P24268 ENTREZGENE
  Q6P6T6 ENTREZGENE
UniProt Secondary Q6P6T6 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Ctsd  cathepsin D      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Ctsd        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization found secreted in mammal breast milk 1299318