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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621511
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ctsd
Name: cathepsin D
Acc ID: CHEBI:83629
Term: tea tree oil
Definition: An essential oil consisting of approximately one hundred hydrocarbon and terpenoid components obtained by steam distillation from the leaves and terminal branchlets of the tea tree, Melaleuca alternifolia; the yield of oil is typically 1-2% of wet plant material weight. The main components are 4-terpineol (40%), gamma-terpinene (23%), alpha-terpinene (10%), 1,8-cineole (5%), terpinolene (3%), and p-cymene (3%).
Chemical ID: MESH:D020947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ctsdincreases expressionISORGD:13510146480464CTDTea Tree Oil results in increased expression of CTSD mRNA

PMID:31393563
Ctsdmultiple interactionsISORGD:13510146480464CTDFulvestrant inhibits the reaction [Tea Tree Oil results in increased expression of CTSD mRNA]

PMID:31393563
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.