Ins2 (insulin 2) - Rat Genome Database

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Gene: Ins2 (insulin 2) Rattus norvegicus
Analyze
Symbol: Ins2
Name: insulin 2
RGD ID: 2916
Description: Predicted to have several functions, including identical protein binding activity; signaling receptor binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including negative regulation of cellular metabolic process; positive regulation of cellular metabolic process; and positive regulation of signal transduction. Localizes to extracellular space. Colocalizes with secretory granule. Used to study hypertension. Biomarker of Alzheimer's disease. Human ortholog(s) of this gene implicated in diabetic retinopathy; glucose metabolism disease (multiple); insulinoma; and pancreatic cancer. Orthologous to human INS (insulin); PARTICIPATES IN altered insulin signaling pathway; forkhead class A signaling pathway; gliclazide pharmacodynamics pathway; INTERACTS WITH (S)-nicotine; 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: C-peptide; CP-II; insulin-2; LOC102549619; uncharacterized LOC102549619
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21197,843,277 - 197,992,522 (-)NCBI
Rnor_6.0 Ensembl1215,856,971 - 215,858,034 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01215,856,967 - 215,858,034 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01222,751,786 - 222,756,821 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41202,935,548 - 202,936,379 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11203,123,613 - 203,124,445 (-)NCBI
Celera1195,461,309 - 195,462,376 (-)NCBICelera
Cytogenetic Map1q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Liver Failure  (ISO)
adenoma  (ISO)
Albuminuria  (ISO)
Alzheimer's disease  (IEP,ISO)
bipolar disorder  (ISO)
bladder disease  (ISO)
cardiac arrest  (ISO)
cognitive disorder  (ISO)
congestive heart failure  (ISO)
cystic kidney disease  (ISO)
developmental and epileptic encephalopathy  (ISO)
diabetes mellitus  (ISO)
Diabetic Cardiomyopathies  (ISO)
diabetic ketoacidosis  (ISO)
Diabetic Nephropathies  (IDA,ISO)
diabetic retinopathy  (ISO)
disease of metabolism  (ISO)
dystonia  (ISO)
early infantile epileptic encephalopathy  (ISO)
Edema  (ISO)
Experimental Liver Cirrhosis  (ISO)
fatty liver disease  (ISO)
gestational diabetes  (ISO)
glucose intolerance  (ISO)
hepatitis  (ISO)
hyperglycemia  (ISO)
hyperinsulinism  (ISO)
Hyperkalemia  (ISO)
Hyperproinsulinemia  (ISO)
hypertension  (IDA,ISO)
Hypertriglyceridemia  (ISO)
hypertrophic cardiomyopathy  (ISO)
hyperuricemia  (ISO)
hypoglycemia  (ISO)
hypokalemia  (ISO)
Hypotension  (ISO)
immunodeficiency 39  (ISO)
Insulin Resistance  (ISO)
insulinoma  (ISO)
kidney failure  (ISO)
Lewy body dementia  (ISO)
liver disease  (ISO)
maturity-onset diabetes of the young  (ISO,ISS)
maturity-onset diabetes of the young type 10  (ISO)
Memory Disorders  (ISO)
Metabolic Syndrome  (ISO)
Micronuclei, Chromosome-Defective  (ISO)
MPTP Poisoning  (ISO)
muscular disease  (ISO)
neonatal diabetes  (ISO,ISS)
Neoplasm Invasiveness  (ISO)
neural tube defect  (ISO)
neuronal ceroid lipofuscinosis  (ISO)
obesity  (ISO)
osteoarthritis  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
pancreatitis  (ISO)
panic disorder  (ISO)
Paralysis  (ISO)
Paresthesia  (ISO)
Parkinson's disease  (ISO)
permanent neonatal diabetes mellitus  (ISO,ISS)
Permanent Neonatal Diabetes Mellitus 4  (ISO)
Phelan-McDermid syndrome  (ISO)
polycystic ovary syndrome  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
Rhabdomyolysis  (ISO)
Segawa Syndrome, Autosomal Recessive  (ISO)
Tachycardia  (ISO)
transient neonatal diabetes mellitus  (ISO)
type 1 diabetes mellitus  (ISO)
type 1 diabetes mellitus 2  (ISO)
type 2 diabetes mellitus  (ISO)
Ventricular Dysfunction, Left  (ISO)
Ventricular Fibrillation  (ISO)
Ventricular Outflow Obstruction  (ISO)
visual epilepsy  (ISO)
Weight Loss  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-adrenaline  (ISO)
(R)-lipoic acid  (ISO)
(S)-nicotine  (EXP)
1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-hydroxyprogesterone  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,2'-Dihydroxy-4-methoxybenzophenone  (ISO)
2,2,2-tetramine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-arachidonoylglycerol  (ISO)
2-deoxy-D-glucose  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-aminobenzamide  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-phenylbutyric acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-iodotubercidin  (ISO)
5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid  (ISO)
5-oxo-L-proline  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
9-cis-retinoic acid  (ISO)
AACOCF3  (ISO)
acetaminophen O-beta-D-glucosiduronic acid  (ISO)
acetic acid  (ISO)
acrolein  (ISO)
actinomycin D  (ISO)
albuterol  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
allethrin  (ISO)
amino acid  (ISO)
amiodarone  (ISO)
amlodipine  (ISO)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
arachidonic acid  (ISO)
arotinoid acid  (ISO)
arsenite(3-)  (ISO)
aspartame  (ISO)
atenolol  (ISO)
atorvastatin calcium  (ISO)
ATP  (ISO)
atrazine  (ISO)
avobenzone  (ISO)
bafilomycin A1  (EXP,ISO)
baicalein  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (ISO)
bexarotene  (ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisoprolol  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
boric acid  (ISO)
bromochloroacetic acid  (ISO)
bromocriptine  (ISO)
butan-1-amine  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcidiol  (ISO)
capsaicin  (EXP)
capsazepine  (EXP)
carbamic acid  (ISO)
carvedilol  (ISO)
chlorpropamide  (ISO)
chlorpyrifos  (EXP)
chlorzoxazone  (ISO)
cholesterol  (ISO)
chromium atom  (EXP)
chromium(3+) trichloride  (ISO)
ciprofibrate  (EXP)
clofibrate  (ISO)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
clozapine  (ISO)
co-trimoxazole  (ISO)
cobalt dichloride  (EXP)
cocaine  (ISO)
conjugated linoleic acid  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (ISO)
corticotropin  (ISO)
cortisol  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyproterone acetate  (ISO)
D-glucose  (EXP,ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
demethoxycurcumin  (ISO)
desmosterol  (ISO)
dexamethasone  (EXP,ISO)
dexamethasone phosphate  (ISO)
diazinon  (ISO)
dibenziodolium  (ISO)
dicamba  (ISO)
diethyl sulfate  (ISO)
diethylstilbestrol  (ISO)
digoxin  (EXP,ISO)
dimercaprol  (EXP)
diphosphoric acid  (ISO)
disodium selenite  (ISO)
dopamine  (ISO)
elemental selenium  (ISO)
enalaprilat dihydrate  (ISO)
equilin  (ISO)
ethanol  (ISO)
ethyl dihydrogen phosphate  (ISO)
ethylamine  (ISO)
farnesol  (ISO)
fentin hydroxide  (ISO)
ferric ammonium citrate  (ISO)
fipronil  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
fructose  (EXP,ISO)
fulvestrant  (ISO)
furan  (EXP)
gatifloxacin  (EXP)
gemcitabine  (ISO)
genistein  (ISO)
glimepiride  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glyburide  (EXP,ISO)
glycerol 2-phosphate  (ISO)
glycine  (ISO)
glycogen  (ISO)
glyoxylic acid  (ISO)
glyphosate  (ISO)
GW 7647  (ISO)
harmine  (ISO)
hemin  (EXP)
heptadecanoic acid  (ISO)
hexadecanoic acid  (ISO)
hispidulin  (ISO)
hydrogen peroxide  (ISO)
indometacin  (EXP,ISO)
inositol  (ISO)
isoflavones  (EXP)
isoprenaline  (EXP)
isopropyl palmitate  (ISO)
kynurenic acid  (ISO)
L-ascorbic acid  (ISO)
L-cystathionine  (ISO)
lanthanum atom  (ISO)
lercanidipine  (ISO)
levonorgestrel  (ISO)
Licarin A  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
lovastatin  (EXP)
LY294002  (ISO)
magnesium atom  (ISO)
magnesium oxide  (ISO)
Magnolol  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mannose  (ISO)
Melengestrol acetate  (ISO)
mercaptopurine  (EXP)
metformin  (ISO)
methadone  (ISO)
methotrexate  (ISO)
methyl dihydrogen phosphate  (ISO)
methylarsonite  (ISO)
methylglyoxal  (EXP)
metoclopramide  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
miquelianin  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
Moxonidine  (EXP,ISO)
N,N-diethyl-m-toluamide  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nateglinide  (ISO)
neomycin  (EXP)
nicotinamide  (ISO)
nicotine  (EXP)
nitric oxide  (ISO)
norethisterone  (ISO)
norgestrel  (ISO)
NS-398  (ISO)
ochratoxin A  (ISO)
octadecanoic acid  (ISO)
octreotide  (EXP,ISO)
olanzapine  (ISO)
oleanolic acid  (ISO)
oleic acid  (ISO)
orlistat  (ISO)
orotic acid  (ISO)
oxybenzone  (ISO)
palmitoleic acid  (ISO)
paracetamol  (ISO)
paroxetine  (EXP)
Pentagastrin  (ISO)
pentolinium tartrate  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (ISO)
phenobarbital  (EXP)
phenylarsine oxide  (EXP)
phenylarsonous acid  (ISO)
PhIP  (ISO)
phloretin  (ISO)
phosphoric acid  (ISO)
pioglitazone  (ISO)
potassium chloride  (ISO)
prallethrin  (ISO)
prednisone  (ISO)
progesterone  (EXP)
propranolol  (ISO)
Ptaquiloside  (ISO)
purine-6-thiol  (EXP)
pyridine  (EXP)
pyruvic acid  (EXP)
quercetin  (EXP,ISO)
quinoxyfen  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
rimonabant  (ISO)
risperidone  (ISO)
ritodrine  (ISO)
Ro 41-5253  (ISO)
Rutamarin  (ISO)
ruthenium red  (EXP)
saquinavir  (ISO)
SB 203580  (ISO)
sebacic acid  (ISO)
selenium atom  (ISO)
sertraline  (EXP)
sirolimus  (ISO)
SKF-96365 hydrochloride  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
Sodium salicylate  (ISO)
spironolactone  (ISO)
staurosporine  (EXP)
streptozocin  (EXP,ISO)
sucrose  (ISO)
sulforaphane  (ISO)
sulpiride  (ISO)
tacrolimus hydrate  (ISO)
tauroursodeoxycholic acid  (ISO)
telmisartan  (ISO)
terbutaline  (ISO)
testosterone  (EXP,ISO)
thapsigargin  (ISO)
Thiocarbohydrazide  (ISO)
tolbutamide  (ISO)
tolylfluanid  (ISO)
triamcinolone  (ISO)
tributylstannane  (ISO)
triciribine  (ISO)
triclosan  (EXP)
triflumizole  (ISO)
trimethyltin  (EXP)
triphenyl phosphate  (ISO)
troglitazone  (EXP,ISO)
undecane  (ISO)
valproic acid  (ISO)
vandetanib  (ISO)
wortmannin  (EXP,ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of JUN kinase activity  (ISO)
activation of MAPK activity  (IBA,ISO)
activation of protein kinase B activity  (ISO)
acute-phase response  (ISO)
alpha-beta T cell activation  (ISO)
biological_process  (ND)
canonical Wnt signaling pathway  (ISO)
ER overload response  (ISO)
fatty acid homeostasis  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
glucose homeostasis  (IBA,ISO)
glucose metabolic process  (ISO)
glycoprotein biosynthetic process  (ISO)
insulin receptor signaling pathway  (ISO)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (ISO)
lactate biosynthetic process  (ISO)
lipid biosynthetic process  (ISO)
lipid catabolic process  (ISO)
lipoprotein biosynthetic process  (ISO)
myoblast fusion  (ISO)
myotube differentiation  (ISO)
negative regulation of acute inflammatory response  (ISO)
negative regulation of fatty acid metabolic process  (ISO)
negative regulation of feeding behavior  (ISO)
negative regulation of gluconeogenesis  (ISO)
negative regulation of glycogen catabolic process  (ISO)
negative regulation of lipid catabolic process  (ISO)
negative regulation of NAD(P)H oxidase activity  (ISO)
negative regulation of protein catabolic process  (ISO)
negative regulation of protein secretion  (ISO)
negative regulation of proteolysis  (ISO)
negative regulation of reactive oxygen species biosynthetic process  (ISO)
negative regulation of respiratory burst involved in inflammatory response  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
neuron projection maintenance  (ISO)
nitric oxide-cGMP-mediated signaling pathway  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cellular protein metabolic process  (ISO)
positive regulation of cytokine production  (ISO)
positive regulation of dendritic spine maintenance  (ISO)
positive regulation of DNA replication  (ISO)
positive regulation of fatty acid biosynthetic process  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of glucose import  (ISO)
positive regulation of glucose metabolic process  (ISO)
positive regulation of glycogen biosynthetic process  (ISO)
positive regulation of glycolytic process  (ISO)
positive regulation of insulin receptor signaling pathway  (ISO)
positive regulation of lipoprotein lipase activity  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of mitotic nuclear division  (ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of nitric oxide mediated signal transduction  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (IBA,ISO)
positive regulation of phosphatidylinositol 3-kinase activity  (ISO)
positive regulation of phosphatidylinositol 3-kinase signaling  (ISO)
positive regulation of protein autophosphorylation  (ISO)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of protein localization to nucleus  (ISO)
positive regulation of respiratory burst  (ISO)
protein hexamerization  (ISO)
regulation of cellular amino acid metabolic process  (ISO)
regulation of gene expression  (IBA,ISO)
regulation of phosphorylation  (ISO)
regulation of protein binding  (ISO)
regulation of protein localization  (ISO)
regulation of protein localization to plasma membrane  (ISO)
regulation of protein secretion  (ISO)
regulation of transmembrane transporter activity  (ISO)
response to organic substance  (IBA)
vasodilation  (ISO)
wound healing  (ISO)

Cellular Component

Molecular Function

References

References - curated
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2. Brands MW, etal., Hypertension. 1997 Apr;29(4):1014-9.
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4. Collinet M, etal., Eur J Pediatr. 1998 Jun;157(6):456-60.
5. Colombo C, etal., J Clin Invest. 2008 Jun;118(6):2148-56.
6. Crabtree JS, etal., Mol Cell Biol. 2003 Sep;23(17):6075-85.
7. Currie CJ, etal., Diabetologia. 2009 Sep;52(9):1766-77. Epub 2009 Jul 2.
8. Dayyani F, etal., BMC Cancer. 2016 Sep 6;16:721. doi: 10.1186/s12885-016-2723-1.
9. Denko CW, etal., J Rheumatol. 1990 Sep;17(9):1217-21.
10. Fang D, etal., Endocr J. 2012;59(1):81-90. Epub 2011 Nov 9.
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16. Holmkvist J, etal., PLoS One. 2009 Jun 11;4(6):e5872.
17. Hompesch M, etal., Diabetes Technol Ther. 2009 May;11(5):307-13.
18. Hong EG, etal., Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1687-96. doi: 10.1152/ajpendo.00256.2007. Epub 2007 Oct 2.
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21. KEGG
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23. Kozak M Nature 1984 Mar 15-21;308(5956):241-6.
24. Krechler T, etal., Neoplasma. 2009;56(1):26-32.
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31. MGD data from the GO Consortium
32. Navaneethan SD and Beddhu S, Nephrol Dial Transplant. 2009 Apr;24(4):1260-6. Epub 2008 Nov 25.
33. NCBI rat LocusLink and RefSeq merged data July 26, 2002
34. Olansky L, etal., J Clin Invest. 1992 May;89(5):1596-602.
35. OMIM Disease Annotation Pipeline
36. Park SY, etal., Biochem Biophys Res Commun. 2010 Jan 15;391(3):1449-54. Epub 2009 Dec 23.
37. Peschke E, etal., J Pineal Res. 2006 Mar;40(2):184-91.
38. Pipeline to import KEGG annotations from KEGG into RGD
39. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
40. Pipeline to import SMPDB annotations from SMPDB into RGD
41. RGD automated data pipeline
42. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
43. RGD automated import pipeline for gene-chemical interactions
44. RGD comprehensive gene curation
45. Roth J, etal., Virchows Arch B Cell Pathol Incl Mol Pathol. 1989;56(5):287-92.
46. Skyler JS, etal., Diabetes Res Clin Pract. 2008 Nov;82(2):238-46. Epub 2008 Sep 27.
47. Soares MB, etal., Mol Cell Biol 1985 Aug;5(8):2090-103.
48. Stoy J, etal., Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):15040-4. Epub 2007 Sep 12.
49. Ward WK, etal., Diabetologia. 1987 Sep;30(9):698-702.
50. Yilmaz O, etal., J Diabetes Complications. 2009 Mar 6.
51. Youngren JF Cell Mol Life Sci. 2007 Apr;64(7-8):873-91.
52. Zyromski NJ, etal., Surgery. 2009 Aug;146(2):258-63.
Additional References at PubMed
PMID:381941   PMID:1184755   PMID:2656699   PMID:2967174   PMID:3518947   PMID:3553851   PMID:4311938   PMID:4554104   PMID:4640931   PMID:7513704   PMID:7556975   PMID:7688386  
PMID:7782332   PMID:8069456   PMID:8452530   PMID:8702995   PMID:8844841   PMID:9092559   PMID:9498508   PMID:9507006   PMID:9689059   PMID:9830016   PMID:10508408   PMID:10604997  
PMID:10644978   PMID:11375348   PMID:11443198   PMID:11500939   PMID:11854325   PMID:12038757   PMID:12059784   PMID:12138094   PMID:12488434   PMID:12805218   PMID:14615391   PMID:14677856  
PMID:14739855   PMID:15185208   PMID:15282335   PMID:15473891   PMID:15591776   PMID:15788565   PMID:15792832   PMID:15793245   PMID:17472440   PMID:17925406   PMID:17957153   PMID:17993259  
PMID:18063688   PMID:18165568   PMID:19188609   PMID:19293336   PMID:19727662   PMID:20082125   PMID:20455999   PMID:20738396   PMID:20857410   PMID:21773965   PMID:21821716   PMID:21828338  
PMID:22161251   PMID:22854022   PMID:22990990   PMID:23106816   PMID:23274896   PMID:23416304   PMID:23510797   PMID:23651473   PMID:23775122   PMID:24440707   PMID:24675707   PMID:25002582  
PMID:25403480   PMID:26986474   PMID:27336168   PMID:28410130   PMID:30790128   PMID:32631952  


Genomics

Candidate Gene Status
Ins2 is a candidate Gene for QTL Hcar4
Ins2 is a candidate Gene for QTL Iddm25
Comparative Map Data
Ins2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21197,843,277 - 197,992,522 (-)NCBI
Rnor_6.0 Ensembl1215,856,971 - 215,858,034 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01215,856,967 - 215,858,034 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01222,751,786 - 222,756,821 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41202,935,548 - 202,936,379 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11203,123,613 - 203,124,445 (-)NCBI
Celera1195,461,309 - 195,462,376 (-)NCBICelera
Cytogenetic Map1q41NCBI
INS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl112,159,779 - 2,161,341 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl112,159,779 - 2,161,221 (-)EnsemblGRCh38hg38GRCh38
GRCh38112,159,779 - 2,161,209 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37112,181,009 - 2,182,439 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36112,137,585 - 2,139,015 (-)NCBINCBI36hg18NCBI36
Build 34112,137,584 - 2,139,000NCBI
Celera112,217,516 - 2,218,946 (-)NCBI
Cytogenetic Map11p15.5NCBI
HuRef111,971,272 - 1,972,702 (-)NCBIHuRef
CHM1_1112,179,957 - 2,181,387 (-)NCBICHM1_1
Ins2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397142,232,393 - 142,233,463 (-)NCBIGRCm39mm39
GRCm39 Ensembl7142,232,393 - 142,297,118 (-)Ensembl
GRCm387142,678,656 - 142,679,726 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7142,678,656 - 142,743,381 (-)EnsemblGRCm38mm10GRCm38
MGSCv377149,864,561 - 149,865,613 (-)NCBIGRCm37mm9NCBIm37
MGSCv367142,488,051 - 142,489,098 (-)NCBImm8
Celera7142,434,985 - 142,436,037 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.0NCBI
Ins
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542213,909,407 - 13,910,419 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542213,909,408 - 13,910,419 (-)NCBIChiLan1.0ChiLan1.0
INS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1112,230,309 - 2,231,666 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl112,218,117 - 2,231,666 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0112,200,785 - 2,202,579 (-)NCBIMhudiblu_PPA_v0panPan3
INS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11846,324,047 - 46,324,933 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1846,324,041 - 46,325,122 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1844,933,843 - 44,934,720 (-)NCBI
ROS_Cfam_1.01847,003,520 - 47,004,406 (-)NCBI
UMICH_Zoey_3.11846,452,280 - 46,453,156 (-)NCBI
UNSW_CanFamBas_1.01846,032,597 - 46,033,483 (-)NCBI
UU_Cfam_GSD_1.01846,779,045 - 46,779,926 (-)NCBI
Ins
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049471,748,017 - 1,749,237 (-)NCBI
SpeTri2.0NW_0049368161,002,137 - 1,003,357 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
INS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl21,496,842 - 1,497,841 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.121,496,842 - 1,498,052 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
INS
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111,965,128 - 1,969,090 (-)NCBI
Ins
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476714,999,088 - 15,000,035 (-)NCBI

Position Markers
AA986540  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01272,800,189 - 272,800,327NCBIRnor6.0
Rnor_5.01280,214,020 - 280,214,158UniSTSRnor5.0
RGSC_v3.41258,001,526 - 258,001,664UniSTSRGSC3.4
Celera1246,946,819 - 246,946,957UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map1q54-q55UniSTS
PMC123023P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01215,857,117 - 215,857,823NCBIRnor6.0
Rnor_6.01272,799,995 - 272,800,203NCBIRnor6.0
Rnor_5.01280,213,826 - 280,214,034UniSTSRnor5.0
Rnor_5.01222,751,936 - 222,752,642UniSTSRnor5.0
RGSC_v3.41258,001,332 - 258,001,540UniSTSRGSC3.4
RGSC_v3.41202,935,638 - 202,936,344UniSTSRGSC3.4
Celera1246,946,625 - 246,946,833UniSTS
Celera1195,461,459 - 195,462,165UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map1q54-q55UniSTS
PMC21231P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01215,857,051 - 215,857,850NCBIRnor6.0
Rnor_6.01272,799,968 - 272,800,268NCBIRnor6.0
Rnor_5.01280,213,799 - 280,214,099UniSTSRnor5.0
Rnor_5.01222,751,870 - 222,752,669UniSTSRnor5.0
RGSC_v3.41258,001,305 - 258,001,605UniSTSRGSC3.4
RGSC_v3.41202,935,572 - 202,936,371UniSTSRGSC3.4
Celera1246,946,598 - 246,946,898UniSTS
Celera1195,461,393 - 195,462,192UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map1q54-q55UniSTS
PMC21334P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01215,857,069 - 215,857,796NCBIRnor6.0
Rnor_6.01272,800,022 - 272,800,250NCBIRnor6.0
Rnor_5.01280,213,853 - 280,214,081UniSTSRnor5.0
Rnor_5.01222,751,888 - 222,752,615UniSTSRnor5.0
RGSC_v3.41258,001,359 - 258,001,587UniSTSRGSC3.4
RGSC_v3.41202,935,590 - 202,936,317UniSTSRGSC3.4
Celera1246,946,652 - 246,946,880UniSTS
Celera1195,461,411 - 195,462,138UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map1q54-q55UniSTS
RH94798  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01215,857,853 - 215,858,111NCBIRnor6.0
Rnor_5.01222,752,672 - 222,752,930UniSTSRnor5.0
RGSC_v3.41202,936,374 - 202,936,632UniSTSRGSC3.4
Celera1195,462,195 - 195,462,453UniSTS
Cytogenetic Map1q41UniSTS
RH94799  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01215,857,071 - 215,857,869NCBIRnor6.0
Rnor_6.01272,799,949 - 272,800,248NCBIRnor6.0
Rnor_5.01280,213,780 - 280,214,079UniSTSRnor5.0
Rnor_5.01222,751,890 - 222,752,688UniSTSRnor5.0
RGSC_v3.41258,001,286 - 258,001,585UniSTSRGSC3.4
RGSC_v3.41202,935,592 - 202,936,390UniSTSRGSC3.4
Celera1195,461,413 - 195,462,211UniSTS
Celera1246,946,579 - 246,946,878UniSTS
RH 3.4 Map11654.9UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map1q54-q55UniSTS
D1Bda44  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01215,857,502 - 215,858,036NCBIRnor6.0
Rnor_5.01222,752,321 - 222,752,855UniSTSRnor5.0
RGSC_v3.41202,936,023 - 202,936,557UniSTSRGSC3.4
Celera1195,461,844 - 195,462,378UniSTS
Cytogenetic Map1q41UniSTS
PMC123023P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01272,799,960 - 272,800,291NCBIRnor6.0
Rnor_6.01215,857,028 - 215,857,858NCBIRnor6.0
Rnor_5.01280,213,791 - 280,214,122UniSTSRnor5.0
Rnor_5.01222,751,847 - 222,752,677UniSTSRnor5.0
RGSC_v3.41258,001,297 - 258,001,628UniSTSRGSC3.4
RGSC_v3.41202,935,549 - 202,936,379UniSTSRGSC3.4
Celera1246,946,590 - 246,946,921UniSTS
Celera1195,461,370 - 195,462,200UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map1q54-q55UniSTS
PMC153767P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01215,857,122 - 215,857,833NCBIRnor6.0
Rnor_5.01222,751,941 - 222,752,652UniSTSRnor5.0
RGSC_v3.41202,935,643 - 202,936,354UniSTSRGSC3.4
Celera1195,461,464 - 195,462,175UniSTS
Cytogenetic Map1q41UniSTS
PMC24644P6  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01215,857,034 - 215,857,720NCBIRnor6.0
Rnor_6.01272,800,098 - 272,800,285NCBIRnor6.0
Rnor_5.01280,213,929 - 280,214,116UniSTSRnor5.0
Rnor_5.01222,751,853 - 222,752,539UniSTSRnor5.0
RGSC_v3.41258,001,435 - 258,001,622UniSTSRGSC3.4
RGSC_v3.41202,935,555 - 202,936,241UniSTSRGSC3.4
Celera1246,946,728 - 246,946,915UniSTS
Celera1195,461,376 - 195,462,062UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map1q54-q55UniSTS
UniSTS:267003  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01215,857,029 - 215,857,745NCBIRnor6.0
Rnor_6.01272,800,073 - 272,800,290NCBIRnor6.0
Rnor_5.01280,213,904 - 280,214,121UniSTSRnor5.0
Rnor_5.01222,751,848 - 222,752,564UniSTSRnor5.0
RGSC_v3.41258,001,410 - 258,001,627UniSTSRGSC3.4
RGSC_v3.41202,935,550 - 202,936,266UniSTSRGSC3.4
Celera1246,946,703 - 246,946,920UniSTS
Celera1195,461,371 - 195,462,087UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map1q54-q55UniSTS
UniSTS:462687  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01215,857,030 - 215,857,782NCBIRnor6.0
Rnor_5.01222,751,849 - 222,752,601UniSTSRnor5.0
RGSC_v3.41202,935,551 - 202,936,303UniSTSRGSC3.4
Celera1195,461,372 - 195,462,124UniSTS
Cytogenetic Map1q41UniSTS
Ins1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01215,857,029 - 215,857,839NCBIRnor6.0
Rnor_6.01272,799,979 - 272,800,290NCBIRnor6.0
Rnor_5.01280,213,810 - 280,214,121UniSTSRnor5.0
Rnor_5.01222,751,848 - 222,752,658UniSTSRnor5.0
RGSC_v3.41258,001,316 - 258,001,627UniSTSRGSC3.4
RGSC_v3.41202,935,550 - 202,936,360UniSTSRGSC3.4
Celera1195,461,371 - 195,462,181UniSTS
Celera1246,946,609 - 246,946,920UniSTS
Cytogenetic Map1q54-q55UniSTS
Cytogenetic Map1q41UniSTS
Ins2  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01215,857,020 - 215,857,143NCBIRnor6.0
Rnor_5.01222,751,839 - 222,751,962UniSTSRnor5.0
RGSC_v3.41202,935,541 - 202,935,664UniSTSRGSC3.4
Celera1195,461,362 - 195,461,485UniSTS
Cytogenetic Map1q41UniSTS
Ins2  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01272,800,145 - 272,800,328NCBIRnor6.0
Rnor_5.01280,213,976 - 280,214,159UniSTSRnor5.0
RGSC_v3.41258,001,482 - 258,001,665UniSTSRGSC3.4
Celera1246,946,775 - 246,946,958UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map1q54-q55UniSTS
Ins1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01215,857,064 - 215,858,035NCBIRnor6.0
Rnor_5.01222,751,883 - 222,752,854UniSTSRnor5.0
RGSC_v3.41202,935,585 - 202,936,556UniSTSRGSC3.4
Celera1195,461,406 - 195,462,377UniSTS
Cytogenetic Map1q41UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)199983293216325819Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1175447029220447029Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1175447029220447029Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1126240667217054291Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1193220385238220385Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1215711860260711860Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1156446196274977688Rat
631260Tcas2Tongue tumor susceptibility QTL 24.93tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1210019247217054418Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1189514504234514504Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1161321152273792054Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1198585664236763415Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1137787261236763528Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)199983293216213510Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1156446196243311614Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1215828102260828102Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1197963658242963658Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1167394665278228889Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1205603081244401301Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1100131562236763528Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1191825895279986079Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130779320219238476Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1197187728230420772Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1215711860258765521Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1153834077232297227Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1189170900234170900Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1189170900234170900Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1189170900234170900Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1189170900234170900Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1189170900234170900Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1189170900234170900Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1189170900234170900Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1189170900234170900Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1205195290250195290Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1198446729240017341Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149578693217054291Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1193968438261264776Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1210960636236763528Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1215828102260828102Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1195598053265002735Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1215684498260684498Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1194554354239554354Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1213476630278978026Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1213476630278978026Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1213476630278978026Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1161321256273791893Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1196395041282763074Rat
1578778Pur4Proteinuria QTL 43.30.003total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1161321256273791893Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)182788437239853971Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1201146802241482368Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1108986301219232156Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1161784169219232156Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1108986301238830534Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1161784169278228889Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1108986301219232156Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1167394665219232156Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1161784169219232156Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1192639698278228889Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1161784169219232156Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1161784169219232156Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1161784169278228889Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1192639698278228889Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1185390068230390068Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1161784169278228889Rat
1359018Hrtrt20Heart rate QTL 203.08heart pumping trait (VT:2000009)heart rate (CMO:0000002)1201358068221983732Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1196738546241738546Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1163796316282763074Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1210360774264802828Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1174905700264802994Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1174905700233490237Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1198655722244992610Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1167394665238830534Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1201358068252480016Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1161784422246226103Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1208517798266948272Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1190282646235282646Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1188850303233850303Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1137787261236763528Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1175462885220462885Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1215828102260828102Rat
6480777Insul17Insulin level QTL 173.86blood insulin amount (VT:0001560)blood insulin level area under curve (AUC) (CMO:0000351)1215097781216213510Rat
6480780Insul18Insulin level QTL 184.11blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1206950905218614387Rat
6480783Insul19Insulin level QTL 194.33blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1215494321218614387Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1197187728238220385Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1202571665264802994Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1122614824262664716Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1144634295241482368Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1125875758262433692Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1210652654255652654Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1202571665264802994Rat
10059590Kidm44Kidney mass QTL 443.420.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1210990171255990171Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)135377692217372257Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1194872362239872362Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:29
Count of miRNA genes:29
Interacting mature miRNAs:29
Transcripts:ENSRNOT00000027656
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system exocrine system hemolymphoid system hepatobiliary system nervous system renal system reproductive system respiratory system
High
Medium 3
Low 24 22 5 22 4 8
Below cutoff 13 9 6 9 19 5 10 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_019130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005496005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005496006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005496007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005496010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005496014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005496017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005496026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005496028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005496031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005496032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005496037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005496042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005496045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005496047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005496048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005496059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005496065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005496068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005496069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005496070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005496071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005496072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005496077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005496079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005496081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005496110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005496124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005496143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005496160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005496183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC098563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP467629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP472188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP485158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J00748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J04807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  V01243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000027656   ⟹   ENSRNOP00000027656
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1215,856,971 - 215,858,034 (-)Ensembl
RefSeq Acc Id: NM_019130   ⟹   NP_062003
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21197,843,277 - 197,844,344 (-)NCBI
Rnor_6.01215,856,967 - 215,858,034 (-)NCBI
Rnor_5.01222,751,786 - 222,756,821 (-)NCBI
RGSC_v3.41202,935,548 - 202,936,379 (-)RGD
Celera1195,461,309 - 195,462,376 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039096504   ⟹   XP_038952432
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21197,843,277 - 197,985,117 (-)NCBI
RefSeq Acc Id: XM_039096515   ⟹   XP_038952443
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21197,843,277 - 197,992,522 (-)NCBI
RefSeq Acc Id: XM_039096516   ⟹   XP_038952444
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21197,843,277 - 197,985,114 (-)NCBI
RefSeq Acc Id: XM_039096539   ⟹   XP_038952467
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21197,843,277 - 197,904,165 (-)NCBI
RefSeq Acc Id: XM_039096565   ⟹   XP_038952493
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21197,843,277 - 197,904,165 (-)NCBI
RefSeq Acc Id: XM_039096594   ⟹   XP_038952522
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21197,843,277 - 197,918,092 (-)NCBI
RefSeq Acc Id: XM_039096635   ⟹   XP_038952563
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21197,843,277 - 197,905,943 (-)NCBI
RefSeq Acc Id: XR_005496005
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21197,848,340 - 197,985,117 (-)NCBI
RefSeq Acc Id: XR_005496006
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21197,848,340 - 197,985,114 (-)NCBI
RefSeq Acc Id: XR_005496007
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21197,848,340 - 197,985,117 (-)NCBI
RefSeq Acc Id: XR_005496010
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21197,848,340 - 197,985,117 (-)NCBI
RefSeq Acc Id: XR_005496014
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21197,848,340 - 197,985,117 (-)NCBI
RefSeq Acc Id: XR_005496017
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21197,848,340 - 197,985,117 (-)NCBI
RefSeq Acc Id: XR_005496026
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21197,848,340 - 197,985,117 (-)NCBI
RefSeq Acc Id: XR_005496028
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21197,848,340 - 197,985,117 (-)NCBI
RefSeq Acc Id: XR_005496031
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21197,889,502 - 197,985,117 (-)NCBI
RefSeq Acc Id: XR_005496032
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21197,848,340 - 197,951,086 (-)NCBI
RefSeq Acc Id: XR_005496037
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21197,848,340 - 197,985,117 (-)NCBI
RefSeq Acc Id: XR_005496042
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21197,848,340 - 197,985,117 (-)NCBI
RefSeq Acc Id: XR_005496045
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21197,848,340 - 197,985,117 (-)NCBI
RefSeq Acc Id: XR_005496047
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21197,848,340 - 197,985,117 (-)NCBI
RefSeq Acc Id: XR_005496048
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21197,891,393 - 197,985,117 (-)NCBI
RefSeq Acc Id: XR_005496059
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21197,848,340 - 197,985,117 (-)NCBI
RefSeq Acc Id: XR_005496065
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21197,848,340 - 197,985,117 (-)NCBI
RefSeq Acc Id: XR_005496068
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21197,848,340 - 197,985,117 (-)NCBI
RefSeq Acc Id: XR_005496069
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21197,848,340 - 197,985,117 (-)NCBI
RefSeq Acc Id: XR_005496070
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21197,848,340 - 197,985,117 (-)NCBI
RefSeq Acc Id: XR_005496071
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21197,848,340 - 197,985,117 (-)NCBI
RefSeq Acc Id: XR_005496072
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21197,848,340 - 197,985,117 (-)NCBI
RefSeq Acc Id: XR_005496077
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21197,848,340 - 197,985,117 (-)NCBI
RefSeq Acc Id: XR_005496079
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21197,848,340 - 197,985,117 (-)NCBI
RefSeq Acc Id: XR_005496081
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21197,848,340 - 197,985,117 (-)NCBI
RefSeq Acc Id: XR_005496110
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21197,848,340 - 197,985,117 (-)NCBI
RefSeq Acc Id: XR_005496124
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21197,848,340 - 197,985,117 (-)NCBI
RefSeq Acc Id: XR_005496143
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21197,848,340 - 197,985,117 (-)NCBI
RefSeq Acc Id: XR_005496160
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21197,848,340 - 197,985,117 (-)NCBI
RefSeq Acc Id: XR_005496183
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21197,848,340 - 197,985,114 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_062003   ⟸   NM_019130
- Peptide Label: preproprotein
- UniProtKB: P01323 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000027656   ⟸   ENSRNOT00000027656
RefSeq Acc Id: XP_038952443   ⟸   XM_039096515
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038952432   ⟸   XM_039096504
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038952444   ⟸   XM_039096516
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038952522   ⟸   XM_039096594
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038952563   ⟸   XM_039096635
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038952467   ⟸   XM_039096539
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038952493   ⟸   XM_039096565
- Peptide Label: isoform X1

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:6850050
Promoter ID:EP17070
Type:single initiation site
Name:RN_INS2
Description:Insulin II, INS2 or INS-2 gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 45; Mammalian insulin.
Experiment Methods:Nuclease protection; experiments performed with closely related; gene; Primer extension; experiments performed with closely related; gene; Nuclease protection; transfected or transformed cells; experiments; performed with closely related gene; Primer extension; transfected or transformed cells; experiments; performed with closely related gene
Regulation:pancreas islet b' (repressed by or weakly expressed in) cells; (induced by or strongly expressed in) glucose
Position:
Rat AssemblyChrPosition (strand)Source
RGSC_v3.41202,936,557 - 202,936,617EPD
RGD ID:13690567
Promoter ID:EPDNEW_R1092
Type:single initiation site
Name:Ins2_1
Description:insulin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01215,858,034 - 215,858,094EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2916 AgrOrtholog
Ensembl Genes ENSRNOG00000020405 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000027656 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000027656 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Insulin UniProtKB/Swiss-Prot
  Insulin-like UniProtKB/Swiss-Prot
  Insulin-like_sf UniProtKB/Swiss-Prot
  Insulin_CS UniProtKB/Swiss-Prot
  Insulin_family UniProtKB/Swiss-Prot
KEGG Report rno:24506 UniProtKB/Swiss-Prot
NCBI Gene 24506 ENTREZGENE
PANTHER PTHR11454 UniProtKB/Swiss-Prot
Pfam Insulin UniProtKB/Swiss-Prot
PhenoGen Ins2 PhenoGen
PRINTS INSULIN UniProtKB/Swiss-Prot
  INSULINFAMLY UniProtKB/Swiss-Prot
PROSITE INSULIN UniProtKB/Swiss-Prot
SMART IlGF UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56994 UniProtKB/Swiss-Prot
UniProt INS2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Ins2  insulin 2  LOC102549619  uncharacterized LOC102549619  Data Merged 737654 PROVISIONAL
2013-12-18 LOC102549619  uncharacterized LOC102549619      Symbol and Name status set to provisional 70820 PROVISIONAL