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Cyclin D1 (G870A) polymorphism and risk of cervix cancer: a case control study in north Indian population.

Authors: Satinder, K  Chander, SR  Pushpinder, K  Indu, G  Veena, J 
Citation: Satinder K, etal., Mol Cell Biochem. 2008 Jun 12;.
Pubmed: (View Article at PubMed) PMID:18548202
DOI: Full-text: DOI:10.1007/s11010-008-9799-0

Cyclin D1 (CCND1) is a key regulatory protein, playing a critical role in the transition from G1 to S phase of the cell cycle. We have evaluated the association between CCND1 A870G polymorphism and risk of cervix cancer in north Indian women by using PCR-RFLP method. This association was estimated by computing odds ratio (ORs) and a 95% Confidence Intervals (95% CI) using a Multivariate Logistic Regression Analysis. No significant association was observed between CCND1 genotypes and overall risk of cervix cancer. But when stratified histologically, statistically significant (OR: 3.7, 95% CI: 1.56-8.87, P: 0.001) increased risk of squamous cell carcinoma (SCC) was observed for individuals with AA genotype. Thus our findings suggest that CCND1 (G870A) polymorphism may be associated with increased risk of SCC of the uterine cervix in north Indian women.

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RGD Object Information
RGD ID: 2296032
Created: 2008-06-24
Species: All species
Last Modified: 2008-06-24
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.