RGD Reference Report - Enhanced expression of lymphomagenesis-related genes in peripheral blood B cells of chronic hepatitis C patients. - Rat Genome Database

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Enhanced expression of lymphomagenesis-related genes in peripheral blood B cells of chronic hepatitis C patients.

Authors: Ito, Masahiko  Murakami, Kyoko  Suzuki, Tetsuro  Mochida, Keiko  Suzuki, Miho  Ikebuchi, Kenji  Yamaguchi, Kazunari  Mizuochi, Toshiaki 
Citation: Ito M, etal., Clin Immunol. 2010 Jun;135(3):459-65. doi: 10.1016/j.clim.2010.02.002. Epub 2010 Mar 1.
RGD ID: 32716380
Pubmed: PMID:20189883   (View Abstract at PubMed)
DOI: DOI:10.1016/j.clim.2010.02.002   (Journal Full-text)

Epidemiological data indicate a close relationship between chronic hepatitis C virus (HCV) infection and B-cell non-Hodgkin's lymphoma (B-NHL), suggesting that chronic HCV infection is, at least in part, associated with B-lymphomagenesis. However, experimental data concerning these conditions remains elusive. In this study, we confirmed that peripheral blood B cells of chronic hepatitis C (CHC) patients were infected with HCV. Expression levels of activation-induced cytidine deaminase (AID) which are thought to be associated with occurrence of B-NHL were analyzed in these CHC B cells. It was demonstrated that AID mRNA/protein levels in CHC B cells were dramatically increased compared with those of healthy subjects. Furthermore, expression levels of several previously reported prognostic B-NHL marker genes in the B cell subset of CHC patients were increased. These results suggest a possible relationship between chronic HCV infection and B-lymphomagenesis.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
AICDAHumanChronic Hepatitis C  IEP mRNA more ...RGD 
AURKAHumanChronic Hepatitis C  IEP mRNA:increased expression:CD19+Bcell:RGD 
AicdaRatChronic Hepatitis C  ISOAICDA (Homo sapiens)mRNA more ...RGD 
AicdaMouseChronic Hepatitis C  ISOAICDA (Homo sapiens)mRNA more ...RGD 
AurkaRatChronic Hepatitis C  ISOAURKA (Homo sapiens)mRNA:increased expression:CD19+Bcell:RGD 
AurkaMouseChronic Hepatitis C  ISOAURKA (Homo sapiens)mRNA:increased expression:CD19+Bcell:RGD 
CCND1HumanChronic Hepatitis C  IEP mRNA:increased expression:CD19+Bcell:RGD 
CCND2HumanChronic Hepatitis C  IEP mRNA:increased expression:CD19+Bcell:RGD 
Ccnd1RatChronic Hepatitis C  ISOCCND1 (Homo sapiens)mRNA:increased expression:CD19+Bcell:RGD 
Ccnd1MouseChronic Hepatitis C  ISOCCND1 (Homo sapiens)mRNA:increased expression:CD19+Bcell:RGD 
Ccnd2RatChronic Hepatitis C  ISOCCND2 (Homo sapiens)mRNA:increased expression:CD19+Bcell:RGD 
Ccnd2MouseChronic Hepatitis C  ISOCCND2 (Homo sapiens)mRNA:increased expression:CD19+Bcell:RGD 
LGALS3HumanChronic Hepatitis C  IEP mRNA:increased expression:CD19+Bcell:RGD 
Lgals3RatChronic Hepatitis C  ISOLGALS3 (Homo sapiens)mRNA:increased expression:CD19+Bcell:RGD 
Lgals3MouseChronic Hepatitis C  ISOLGALS3 (Homo sapiens)mRNA:increased expression:CD19+Bcell:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Aicda  (activation-induced cytidine deaminase)
Aurka  (aurora kinase A)
Ccnd1  (cyclin D1)
Ccnd2  (cyclin D2)
Lgals3  (galectin 3)

Genes (Mus musculus)
Aicda  (activation-induced cytidine deaminase)
Aurka  (aurora kinase A)
Ccnd1  (cyclin D1)
Ccnd2  (cyclin D2)
Lgals3  (lectin, galactose binding, soluble 3)

Genes (Homo sapiens)
AICDA  (activation induced cytidine deaminase)
AURKA  (aurora kinase A)
CCND1  (cyclin D1)
CCND2  (cyclin D2)
LGALS3  (galectin 3)


Additional Information