RGD Reference Report - Rate of oxidant stress regulates balance between rat gastric mucosa proliferation and apoptosis. - Rat Genome Database

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Rate of oxidant stress regulates balance between rat gastric mucosa proliferation and apoptosis.

Authors: Olguin-Martinez, M  Mendieta-Condado, E  Contreras-Zentella, M  Escamilla, JE  Aranda-Fraustro, A  El-Hafidi, M  Hernandez-Munoz, R 
Citation: Olguin-Martinez M, etal., Free Radic Biol Med. 2006 Oct 15;41(8):1325-37. Epub 2006 Jul 15.
RGD ID: 2289141
Pubmed: PMID:17015179   (View Abstract at PubMed)
DOI: DOI:10.1016/j.freeradbiomed.2006.07.013   (Journal Full-text)

We have characterized an experimental model of ethanol-induced chronic gastritis in which a compensatory mucosal cell proliferation is apparently regulated by lipoperoxidative events. Therefore, the present study is an attempt to further assess the participation of oxidant stress during gastric mucosa proliferation, by administering alpha-tocopherol (vitamin E) to rats with gastritis. A morphometric analysis was done, and parameters indicative of oxidant stress, cellular proliferation (including cyclin D1 levels), apoptotic events, and activities of endogenous antioxidant systems were measured in gastric mucosa from our experimental groups. After ethanol withdrawal, restitution of surface epithelium coincided with increased lipid peroxidation and cell proliferation and further active apoptosis. High alpha-tocopherol dosing (100 IU/kg bw) showed a clear antioxidant effect, abolished cell proliferation, and promoted an early and progressive apoptosis, despite vitamin E also enhancing levels of endogenous antioxidants. Indicators of cell proliferation inversely correlated with apoptotic events, and this relationship was blunted by administering vitamin E, probably by affecting translocation of active cyclin D1 into the nucleus. In conclusion, alpha-tocopherol administration inhibited cell proliferation, leading to a predominance of apoptotic events in ethanol-induced gastric damage. Therefore, the timing and magnitude of lipoperoxidative events seemed to synchronize in vivo cell proliferative and apoptotic events, probably by changing the cell redox state.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to ethanol  IEP 2289141 RGD 
response to vitamin E  IEP 2289141 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccnd1  (cyclin D1)


Additional Information