Cdkn1a (cyclin-dependent kinase inhibitor 1A)

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Gene: Cdkn1a (cyclin-dependent kinase inhibitor 1A) Rattus norvegicus

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Symbol:

Cdkn1a

Name:

cyclin-dependent kinase inhibitor 1A

RGD ID:

69328

Description:

Predicted to enable several functions, including cyclin binding activity; enzyme binding activity; and protein kinase regulator activity. Involved in several processes, including intestinal epithelial cell maturation; response to hyperoxia; and response to mineralocorticoid. Located in perinuclear region of cytoplasm. Biomarker of several diseases, including autosomal dominant polycystic kidney disease; hypertension (multiple); lipoid nephrosis; liver benign neoplasm; and pre-malignant neoplasm. Human ortholog(s) of this gene implicated in high grade glioma; ocular hypertension; oral mucosa leukoplakia; oral squamous cell carcinoma; and primary open angle glaucoma. Orthologous to human CDKN1A (cyclin dependent kinase inhibitor 1A); PARTICIPATES IN G1/S transition pathway; Notch signaling pathway; nuclear factor, erythroid 2 like 2 signaling pathway; INTERACTS WITH (+)-schisandrin B; (R,R,R)-alpha-tocopherol; (S)-colchicine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

Cip1; cyclin-dependent kinase inhibitor 1; cyclin-dependent kinase inhibitor 1A (P21); cyclin-dependent kinase inhibitor 1A (p21, Cip1); UV96; Waf1

RGD Orthologs

Alliance Genes

More Info

more info ...

Is Marker For:

Strains: BUF.ACI-(D20Img2-Cdkn1a)/Ncc ACI.BUF-(D20Img2-Cdkn1a)/Ncc

Candidate Gene For:

Prcs2

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	20	7,149,177 - 7,159,727 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	7,149,217 - 7,159,585 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	7,860,502 - 7,870,951 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	7,222,359 - 7,232,808 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	7,697,344 - 7,707,907 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	6,348,422 - 6,358,864 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	6,351,458 - 6,358,864 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	8,592,437 - 8,602,879 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	7,376,325 - 7,386,778 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	20	7,379,612 - 7,385,803 (+)	NCBI
Celera	20	8,699,290 - 8,709,718 (+)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

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Model

Annotation Click to see Annotation Detail View

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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