RGD Reference Report - Cyclin D1, p16(INK) (4A) and p27(Kip1) in pancreatic adenocarcinoma: assessing prognostic implications through quantitative image analysis. - Rat Genome Database

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Cyclin D1, p16(INK) (4A) and p27(Kip1) in pancreatic adenocarcinoma: assessing prognostic implications through quantitative image analysis.

Authors: Georgiadou, Despoina  Sergentanis, Theodoros N  Sakellariou, Stratigoula  Filippakis, George M  Zagouri, Flora  Vlachodimitropoulos, Dimitris  Psaltopoulou, Theodora  Lazaris, Andreas C  Patsouris, Efstratios  Zografos, George C 
Citation: Georgiadou D, etal., APMIS. 2014 Dec;122(12):1230-9. doi: 10.1111/apm.12289. Epub 2014 Jul 22.
RGD ID: 13462053
Pubmed: PMID:25053516   (View Abstract at PubMed)
DOI: DOI:10.1111/apm.12289   (Journal Full-text)

The prognostic significance of cyclin D1, p16(INK) (4A) and p27(Kip1) expression has been documented in several human malignancies; however, their prognostic potential in pancreatic adenocarcinoma is still unclear. This study aimed to assess the correlation of the aforementioned molecules with clinicopathological parameters and prognosis. Sixty patients with pancreatic ductal adenocarcinoma underwent surgical resection at a single institution; immunohistochemical staining of the studied markers was quantified by ¿mage analysis system. Cyclin D1 overexpression was positively associated with grade, neural infiltration and vascular invasion, whereas p27 positively correlated with age. Higher cyclin D1 expression indicated poorer survival (adjusted HR = 9.75, 95%CI: 1.48-64.31, p = 0.018, increment: one unit in H-score), whereas a marginal trend toward an association between p16 positivity and improved survival was observed (adjusted HR = 0.58, 95%CI: 0.32-1.05, p = 0.072 regarding positive vs negative cases). No significant association with overall survival was noted regarding p27. In conclusion, cyclin D1 overexpression and possibly p16 loss of expression in pancreatic adenocarcinoma seem to be adverse prognostic factors, whereas p27 expression did not seem to possess such prognostic properties. Further validation of the present findings in studies encompassing larger samples seems to be needed.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CCND1Humanpancreatic adenocarcinoma severityIEP protein:increased expression:pancreas (human)RGD 
Ccnd1Ratpancreatic adenocarcinoma severityISOCCND1 (Homo sapiens)protein:increased expression:pancreas (human)RGD 
Ccnd1Mousepancreatic adenocarcinoma severityISOCCND1 (Homo sapiens)protein:increased expression:pancreas (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccnd1  (cyclin D1)

Genes (Mus musculus)
Ccnd1  (cyclin D1)

Genes (Homo sapiens)
CCND1  (cyclin D1)


Additional Information