RGD Reference Report - [Regulatory mechanisms of PI3K/AKT signaling pathway in acute leukemia]. - Rat Genome Database

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[Regulatory mechanisms of PI3K/AKT signaling pathway in acute leukemia].

Authors: Wang, WL  Zhang, YC  Zeng, HM  Hua, CL  Wei, W  Xu, J  Zhu, XF  Cheng, T  Yuan, WP 
Citation: Wang WL, etal., Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2012 Feb;20(1):18-21.
RGD ID: 11352824
Pubmed: PMID:22391157   (View Abstract at PubMed)

This study was aimed to analyze the expression profiles of PI3K/AKT signaling pathway genes from bone marrow samples of AML and ALL patients and normal samples. AML, ALL and normal bone marrow samples were collected from 6 AML, 6 ALL patients and 4 normal persons. The expression of PI3K/AKT signaling pathway genes including PTEN, CCND1, mTOR, RICTOR, FOXO1 were detected by real-time fluorescent quantification RT-PCR while GAPDH gene expression was used as an internal reference. The relative gene expression level was calculated by the method of the 2(-DeltaDeltaCt). The results showed that the gene expression profiles were different between normal and leukemic groups. PTEN, mTOR and RICTOR expression levels were down-regulated, while FOXO1 and CCND1 levels were up-regulated in AML and ALL. PTEN was down-regulated in 10 out of the 12 samples; mTOR was down-regulated in 9 out of the 12 samples; RICTOR was down-regulated in 7 out of the 12 samples; FOXO1 was up-regulated in 9 out of the 12 samples and CCND1 was up-regulated in 7 out of the 12 samples. It is concluded that PI3K/AKT signal pathway is activated in both AML and ALL leukemic cells.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CCND1Humanacute lymphoblastic leukemia  IEP mRNA:increased expression:bone marrow (human)RGD 
Ccnd1Ratacute lymphoblastic leukemia  ISOCCND1 (Homo sapiens)mRNA:increased expression:bone marrow (human)RGD 
Ccnd1Mouseacute lymphoblastic leukemia  ISOCCND1 (Homo sapiens)mRNA:increased expression:bone marrow (human)RGD 
CCND1Humanacute myeloid leukemia  IEP mRNA:increased expression:bone marrow (human)RGD 
Ccnd1Ratacute myeloid leukemia  ISOCCND1 (Homo sapiens)mRNA:increased expression:bone marrow (human)RGD 
Ccnd1Mouseacute myeloid leukemia  ISOCCND1 (Homo sapiens)mRNA:increased expression:bone marrow (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccnd1  (cyclin D1)

Genes (Mus musculus)
Ccnd1  (cyclin D1)

Genes (Homo sapiens)
CCND1  (cyclin D1)


Additional Information