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Gene: Cdk4 (cyclin-dependent kinase 4) Mus musculus
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Symbol: Cdk4
Name: cyclin-dependent kinase 4
Description: Exhibits cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Involved in several processes, including cellular response to interleukin-4; cellular response to lipid; and regulation of lipid metabolic process. Localizes to several cellular components, including cyclin D2-CDK4 complex; nucleus; and transcription regulator complex. Colocalizes with bicellular tight junction. Is expressed in several structures, including alimentary system; branchial arch; genitourinary system; nervous system; and sensory organ. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); familial melanoma; glioblastoma multiforme; obesity; and type 2 diabetes mellitus. Orthologous to human CDK4 (cyclin dependent kinase 4); PARTICIPATES IN G1/S transition pathway; cell cycle pathway, mitotic; ceramide signaling pathway; INTERACTS WITH (S)-nicotine; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,2-dichloroethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cell division protein kinase 4; Crk3; cyclin dependent kinase 4; p34/cdk4; PSK-J3; serine/threonine kinase
Orthologs:
Homo sapiens (human) : CDK4 (cyclin dependent kinase 4)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cdk4 (cyclin-dependent kinase 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cdk4 (cyclin dependent kinase 4)
Pan paniscus (bonobo/pygmy chimpanzee) : CDK4 (cyclin dependent kinase 4)
Canis lupus familiaris (dog) : CDK4 (cyclin dependent kinase 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cdk4 (cyclin dependent kinase 4)
Sus scrofa (pig) : CDK4 (cyclin dependent kinase 4)
Chlorocebus sabaeus (African green monkey) : CDK4 (cyclin dependent kinase 4)
Heterocephalus glaber (naked mole-rat) : Cdk4 (cyclin dependent kinase 4)
more info ...
Related Pseudogenes: Gm13521   Gm18319   Gm18326   Gm18346   Gm18368   Gm7158   Gm7272  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl10127,063,534 - 127,067,920 (+)EnsemblGRCm38mm10GRCm38
GRCm3810127,063,535 - 127,067,288 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3710126,500,659 - 126,504,339 (+)NCBIGRCm37mm9NCBIm37
MGSCv3610126,466,564 - 126,470,344 (+)NCBImm8
Celera10129,456,113 - 129,459,793 (+)NCBICelera
Cytogenetic Map10D3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Cdk4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732062
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.