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Gene: Cdk4 (cyclin-dependent kinase 4) Mus musculus
Symbol: Cdk4
Name: cyclin-dependent kinase 4
Description: Exhibits cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Involved in several processes, including cellular response to interleukin-4; cellular response to lipid; and regulation of lipid metabolic process. Localizes to several cellular components, including cyclin D2-CDK4 complex; nucleus; and transcription regulator complex. Colocalizes with bicellular tight junction. Is expressed in several structures, including alimentary system; branchial arch; genitourinary system; nervous system; and sensory organ. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); familial melanoma; glioblastoma multiforme; obesity; and type 2 diabetes mellitus. Orthologous to human CDK4 (cyclin dependent kinase 4); PARTICIPATES IN G1/S transition pathway; cell cycle pathway, mitotic; ceramide signaling pathway; INTERACTS WITH (S)-nicotine; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,2-dichloroethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cell division protein kinase 4; Crk3; cyclin dependent kinase 4; p34/cdk4; PSK-J3; serine/threonine kinase
Homo sapiens (human) : CDK4 (cyclin dependent kinase 4)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cdk4 (cyclin-dependent kinase 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cdk4 (cyclin dependent kinase 4)
Pan paniscus (bonobo/pygmy chimpanzee) : CDK4 (cyclin dependent kinase 4)
Canis lupus familiaris (dog) : CDK4 (cyclin dependent kinase 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cdk4 (cyclin dependent kinase 4)
Sus scrofa (pig) : CDK4 (cyclin dependent kinase 4)
Chlorocebus sabaeus (African green monkey) : CDK4 (cyclin dependent kinase 4)
Heterocephalus glaber (naked mole-rat) : Cdk4 (cyclin dependent kinase 4)
more info ...
Related Pseudogenes: Gm13521   Gm18319   Gm18326   Gm18346   Gm18368   Gm7158   Gm7272  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl10127,063,534 - 127,067,920 (+)EnsemblGRCm38mm10GRCm38
GRCm3810127,063,535 - 127,067,288 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3710126,500,659 - 126,504,339 (+)NCBIGRCm37mm9NCBIm37
MGSCv3610126,466,564 - 126,470,344 (+)NCBImm8
Celera10129,456,113 - 129,459,793 (+)NCBICelera
Cytogenetic Map10D3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Cdk4
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732062
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.