Ccnd3 (cyclin D3) - Rat Genome Database

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Gene: Ccnd3 (cyclin D3) Rattus norvegicus
Symbol: Ccnd3
Name: cyclin D3
RGD ID: 2293
Description: Enables protein kinase binding activity. Involved in several processes, including G1/S transition of mitotic cell cycle; hyaluronan biosynthetic process; and response to glucose. Predicted to be located in nucleoplasm. Predicted to be part of cyclin D3-CDK4 complex. Predicted to be active in centrosome; cytoplasm; and nucleus. Orthologous to human CCND3 (cyclin D3); PARTICIPATES IN G1/S transition pathway; cell cycle pathway, mitotic; Jak-Stat signaling pathway; INTERACTS WITH 17beta-estradiol; 2-methoxyethanol; 3,3',5,5'-tetrabromobisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: G1/S-specific cyclin-D3; MGC108760; MGC93643
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2913,394,161 - 13,400,341 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl913,394,169 - 13,489,371 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx921,973,914 - 21,980,097 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0927,038,080 - 27,044,259 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0925,337,315 - 25,343,498 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0915,404,816 - 15,410,905 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl915,404,822 - 15,410,943 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0914,326,227 - 14,332,267 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera911,145,441 - 11,151,481 (-)NCBICelera
Cytogenetic Map9q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(aminomethyl)phosphonic acid  (ISO)
(S)-amphetamine  (ISO)
1,2-dimethylhydrazine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-methoxy-17beta-estradiol  (ISO)
2-methoxyethanol  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3'-diindolylmethane  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
9-cis-retinoic acid  (ISO)
acetylleucyl-leucyl-norleucinal  (ISO)
acetylsalicylic acid  (ISO)
acteoside  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
Allylamine  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
aniline  (EXP)
aristolochic acid A  (ISO)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
atropine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzoates  (ISO)
biotin  (ISO)
biphenyl-4-amine  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bosutinib  (ISO)
bucladesine  (EXP)
butan-1-ol  (ISO)
Butylparaben  (ISO)
butyric acid  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calycosin  (ISO)
camostat  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorohydrocarbon  (ISO)
chloroprene  (ISO)
chlorpromazine  (ISO)
chromium(6+)  (EXP)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
clozapine  (EXP)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
cytarabine  (ISO)
daunorubicin  (ISO)
deguelin  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
dronedarone  (ISO)
ethyl methanesulfonate  (ISO)
everolimus  (ISO)
fenamidone  (ISO)
fluoxetine  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (EXP,ISO)
furazolidone  (ISO)
gamma-tocopherol  (ISO)
gefitinib  (ISO)
haloperidol  (EXP)
hydroxyurea  (ISO)
hypochlorous acid  (ISO)
isoprenaline  (ISO)
isosilybin A  (ISO)
juglone  (ISO)
kinamycin F  (ISO)
L-ascorbic acid  (EXP,ISO)
lithium chloride  (ISO)
lovastatin  (ISO)
LY294002  (ISO)
lycorine  (ISO)
methimazole  (EXP)
methoxyacetic acid  (ISO)
methyl methanesulfonate  (ISO)
methylazoxymethanol  (ISO)
methylmercury chloride  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
monoethyl phthalate  (ISO)
monosodium L-glutamate  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-N-nitrosourea  (EXP)
nelfinavir  (ISO)
nickel atom  (ISO)
niclosamide  (ISO)
ozone  (EXP)
palbociclib  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
parathion  (ISO)
PD 0325901  (ISO)
pentobarbital  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picrotoxin  (EXP)
pioglitazone  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium dichromate  (EXP)
progesterone  (EXP)
quercetin  (ISO)
resveratrol  (EXP,ISO)
Ro 41-5253  (ISO)
rotenone  (ISO)
rottlerin  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sorafenib  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
tamoxifen  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP)
thymoquinone  (ISO)
titanium dioxide  (ISO)
tocopherol  (ISO)
tolbutamide  (EXP)
Tributyltin oxide  (EXP,ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
Tryptanthrine  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
ursolic acid  (ISO)
usnic acid  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (EXP)
wortmannin  (ISO)
XAV939  (ISO)
Y-27632  (ISO)
ziram  (EXP)
zoledronic acid  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma. Bergsagel PL, etal., Blood. 2005 Jul 1;106(1):296-303. Epub 2005 Mar 8.
2. D-type cyclins and G1 progression during liver development in the rat. Boylan JM and Gruppuso PA, Biochem Biophys Res Commun. 2005 May 13;330(3):722-30.
3. [Retrospective study of one year of family therapy in a neurological practice (author's transl)] Gattringer B Nervenarzt 1977 Jun;48(6):326-30.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Circadian regulation of diverse gene products revealed by mRNA expression profiling of synchronized fibroblasts. Grundschober C, etal., J Biol Chem 2001 Dec 14;276(50):46751-8.
7. Induction of D2 and D3 cyclin-encoding genes during promotion of the G1/S transition by prolactin in rat Nb2 cells. Hosokawa Y, etal., Gene 1994 Sep 30;147(2):249-52.
8. Increased expression of CDK11p58 and cyclin D3 following spinal cord injury in rats. Ji Y, etal., Mol Cell Biochem. 2008 Feb;309(1-2):49-60. Epub 2007 Nov 16.
9. Polymorphic loci of E2F2, CCND1 and CCND3 are associated with HER2 status of breast tumors. Justenhoven C, etal., Int J Cancer. 2009 May 1;124(9):2077-81.
10. Expression and prognostic significance of cyclin D3 in ovarian adenocarcinomas. Levidou G, etal., Int J Gynecol Pathol. 2007 Oct;26(4):410-7.
11. Cyclin D3 expression in primary Ta/T1 bladder cancer. Lopez-Beltran A, etal., J Pathol. 2006 May;209(1):106-13.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Critical role of cyclin D3 in TSH-dependent growth of thyrocytes and in hyperproliferative diseases of the thyroid gland. Motti ML, etal., Oncogene. 2003 Oct 23;22(48):7576-86.
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Expression of p27((Kip1)), cyclin D3 and Ki67 in BPH, prostate cancer and hormone-treated prostate cancer cells. Nikoleishvili D, etal., Int Urol Nephrol. 2008;40(4):953-9. Epub 2008 Mar 4.
16. Differential enantioselective effects of pentyl-4-yn-valproate on spatial learning in the rat, and neurite outgrowth and cyclin D3 expression in vitro. O'Loinsigh ED, etal., J Neurochem. 2004 Jan;88(2):370-9.
17. Immunoreactivity of p27(Kip1), cyclin D3, and Ki67 in conventional renal cell carcinoma. Pertia A, etal., Int Urol Nephrol. 2009;41(2):243-9. Epub 2008 Aug 5.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. Alternative mammary oncogenic pathways are induced by D-type cyclins; MMTV-cyclin D3 transgenic mice develop squamous cell carcinoma. Pirkmaier A, etal., Oncogene. 2003 Jul 10;22(28):4425-33.
20. Cyclin D3 mediates synthesis of a hyaluronan matrix that is adhesive for monocytes in mesangial cells stimulated to divide in hyperglycemic medium. Ren J, etal., J Biol Chem. 2009 Jun 12;284(24):16621-32. Epub 2009 Mar 9.
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Differential regulation of cyclins D1 and D3 in hepatocyte proliferation. Rickheim DG, etal., Hepatology 2002 Jul;36(1):30-8.
25. The Pezcoller lecture: cancer cell cycles revisited. Sherr CJ Cancer Res. 2000 Jul 15;60(14):3689-95.
26. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
27. Cyclins and proliferation markers in early squamous cervical carcinoma. Van de Putte G, etal., Gynecol Oncol. 2004 Jan;92(1):40-6.
28. Overexpression of cyclins D1 and D3 during estrogen-induced breast oncogenesis in female ACI rats. Weroha SJ, etal., Carcinogenesis. 2006 Mar;27(3):491-8. Epub 2005 Nov 25.
29. Differential expression of p16/p21/p27 and cyclin D1/D3, and their relationships to cell proliferation, apoptosis, and tumour progression in invasive ductal carcinoma of the breast. Wong SC, etal., J Pathol. 2001 May;194(1):35-42.
30. Structure and characterization of rat cyclin D3 promoter. Yang M, etal., Gene 1996 Nov 28;181(1-2):153-9.
Additional References at PubMed
PMID:8114739   PMID:8822197   PMID:11809706   PMID:12130539   PMID:12477932   PMID:14706337   PMID:16412096   PMID:19550149   PMID:19672123   PMID:20066559   PMID:21539824   PMID:23109711  
PMID:25596037   PMID:26657864  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2913,394,161 - 13,400,341 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl913,394,169 - 13,489,371 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx921,973,914 - 21,980,097 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0927,038,080 - 27,044,259 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0925,337,315 - 25,343,498 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0915,404,816 - 15,410,905 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl915,404,822 - 15,410,943 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0914,326,227 - 14,332,267 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera911,145,441 - 11,151,481 (-)NCBICelera
Cytogenetic Map9q12NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38641,934,933 - 42,050,035 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl641,934,934 - 42,050,357 (-)EnsemblGRCh38hg38GRCh38
GRCh37641,902,671 - 42,016,632 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36642,010,649 - 42,017,530 (-)NCBINCBI36Build 36hg18NCBI36
Build 34642,010,649 - 42,017,530NCBI
Celera643,455,463 - 43,569,077 (-)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef641,621,515 - 41,734,566 (-)NCBIHuRef
CHM1_1641,905,431 - 42,019,143 (-)NCBICHM1_1
T2T-CHM13v2.0641,763,493 - 41,878,294 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391747,815,976 - 47,910,614 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1747,815,976 - 47,910,616 (+)EnsemblGRCm39 Ensembl
GRCm381747,505,051 - 47,599,689 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1747,505,051 - 47,599,691 (+)EnsemblGRCm38mm10GRCm38
MGSCv371747,642,000 - 47,736,638 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361747,056,739 - 47,062,880 (+)NCBIMGSCv36mm8
Celera1750,938,969 - 51,036,715 (+)NCBICelera
Cytogenetic Map17CNCBI
cM Map1723.37NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554378,268,118 - 8,273,855 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554378,266,523 - 8,273,855 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1652,296,193 - 52,407,867 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0641,518,421 - 41,630,103 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1642,820,569 - 42,932,944 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl642,820,569 - 42,827,498 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11210,593,786 - 10,688,304 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1210,594,712 - 10,600,891 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1210,623,109 - 10,717,215 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01211,074,540 - 11,169,519 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1211,074,547 - 11,169,151 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11210,604,536 - 10,698,641 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01210,688,499 - 10,783,041 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01210,782,466 - 10,877,073 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494646,073,366 - 46,160,552 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647617,879,869 - 17,886,827 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647617,799,754 - 17,886,835 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl737,082,097 - 37,181,366 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1737,087,336 - 37,182,462 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2742,489,107 - 42,493,235 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11730,107,236 - 30,228,449 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1730,221,598 - 30,227,452 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604441,934,657 - 42,061,231 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462475417,148,076 - 17,194,000 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475417,148,108 - 17,194,626 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Ccnd3
20 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:73
Count of miRNA genes:64
Interacting mature miRNAs:65
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9114209783Rat
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
1578675Bss17Bone structure and strength QTL 173.8femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)9336865213533896Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)9795472022071169Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8q24UniSTS
D2Mit27   No map positions available.
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2913,401,258 - 13,401,435 (+)MAPPERmRatBN7.2
Rnor_6.0915,411,905 - 15,412,081NCBIRnor6.0
Rnor_5.0914,333,257 - 14,333,433UniSTSRnor5.0
Celera911,152,425 - 11,152,591UniSTS
Cytogenetic Map8q24UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2913,400,793 - 13,400,943 (+)MAPPERmRatBN7.2
Rnor_6.0915,411,440 - 15,411,589NCBIRnor6.0
Rnor_5.0914,332,792 - 14,332,941UniSTSRnor5.0
Celera911,151,957 - 11,152,109UniSTS
Cytogenetic Map8q24UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2913,394,166 - 13,394,439 (+)MAPPERmRatBN7.2
Rnor_6.0915,404,822 - 15,405,094NCBIRnor6.0
Rnor_5.0914,326,184 - 14,326,456UniSTSRnor5.0
Celera911,145,398 - 11,145,670UniSTS
Cytogenetic Map8q24UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 43 51 35 19 35 4 7 71 35 36 11 4
Low 6 6 6 4 4 3 5 4
Below cutoff


RefSeq Acc Id: ENSRNOT00000074217   ⟹   ENSRNOP00000064704
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl913,394,169 - 13,489,371 (-)Ensembl
Rnor_6.0 Ensembl915,404,822 - 15,410,943 (-)Ensembl
RefSeq Acc Id: NM_012766   ⟹   NP_036898
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.2913,394,161 - 13,400,341 (-)NCBI
Rnor_6.0915,404,865 - 15,410,905 (-)NCBI
Rnor_5.0914,326,227 - 14,332,267 (-)NCBI
Celera911,145,441 - 11,151,481 (-)NCBI
RefSeq Acc Id: XM_039083034   ⟹   XP_038938962
Rat AssemblyChrPosition (strand)Source
mRatBN7.2913,394,161 - 13,399,448 (-)NCBI
Protein Sequences
Protein RefSeqs NP_036898 (Get FASTA)   NCBI Sequence Viewer  
  XP_038938962 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB40713 (Get FASTA)   NCBI Sequence Viewer  
  AAH85763 (Get FASTA)   NCBI Sequence Viewer  
  AAH89819 (Get FASTA)   NCBI Sequence Viewer  
  BAA03816 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000064704
GenBank Protein P48961 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036898   ⟸   NM_012766
- UniProtKB: Q63628 (UniProtKB/Swiss-Prot),   P48961 (UniProtKB/Swiss-Prot),   Q5U321 (UniProtKB/TrEMBL),   M0R5N2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000064704   ⟸   ENSRNOT00000074217
RefSeq Acc Id: XP_038938962   ⟸   XM_039083034
- Peptide Label: isoform X1
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P48961-F1-model_v2 AlphaFold P48961 1-293 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13696499
Promoter ID:EPDNEW_R7022
Type:initiation region
Description:cyclin D3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.0915,410,992 - 15,411,052EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2293 AgrOrtholog
BioCyc Gene G2FUF-28269 BioCyc
Ensembl Genes ENSRNOG00000050258 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000074217 ENTREZGENE
  ENSRNOT00000074217.2 UniProtKB/TrEMBL
Gene3D-CATH Cyclin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cyclin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin_C-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclins_cyclin-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25193 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PANTHER PTHR10177 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10177:SF65 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cyclin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ccnd3 PhenoGen
RatGTEx ENSRNOG00000050258 RatGTEx
  Cyclin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47954 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC228844
UniProt CCND3_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q63628 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Ccnd3  Cyclin D3      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function binds both cdk4 and cdk6 in hepatocytes 1298736
gene_physical_interaction interacts with Cdk4 70761
gene_process plays a key role in the G1/S transition in cell cycle 70761
gene_regulation protein amount is regulated at the transcription level and protein half-life is 25 minutes 70761