Dctn2 (dynactin subunit 2) - Rat Genome Database

Name: Dctn2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Dctn2 (dynactin subunit 2) Rattus norvegicus

Analyze

Symbol:

Dctn2

Name:

dynactin subunit 2

RGD ID:

1303182

Description:

Predicted to have identical protein binding activity; protein kinase binding activity; and spectrin binding activity. Involved in mitotic spindle organization. Localizes to centrosome; dynactin complex; and kinetochore. Biomarker of synucleinopathy. Orthologous to human DCTN2 (dynactin subunit 2); PARTICIPATES IN mitochondria transport pathway; Huntington's disease pathway; vasopressin signaling pathway via receptor type 2; INTERACTS WITH 3-chloropropane-1,2-diol; bisphenol A; methoxychlor.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

dynactin 2; dynactin 2 (p50); MGC93976

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DCTN2 (dynactin subunit 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Dctn2 (dynactin 2)	HGNC	Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Dctn2 (dynactin subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DCTN2 (dynactin subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DCTN2 (dynactin subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Dctn2 (dynactin subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DCTN2 (dynactin subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	DCTN2 (dynactin subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Dctn2 (dynactin subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	DCTN2 (dynactin subunit 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Mus musculus (house mouse):	Dctn2 (dynactin 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Danio rerio (zebrafish):	dctn2 (dynactin 2 (p50))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Saccharomyces cerevisiae (baker's yeast):	JNM1	Alliance	DIOPT (Hieranoid\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	DCTN2-p50	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Caenorhabditis elegans (roundworm):	dnc-2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	7	63,092,061 - 63,107,560 (+)	NCBI
Rnor_6.0 Ensembl	7	70,556,019 - 70,572,614 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	7	70,555,953 - 70,571,433 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	7	70,730,089 - 70,745,583 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	67,223,893 - 67,239,157 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	7	67,244,622 - 67,259,886 (+)	NCBI
Celera	7	60,232,682 - 60,247,954 (+)	NCBI		Celera
Cytogenetic Map	7	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Charcot-Marie-Tooth disease (ISO)

synucleinopathy (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3-chloropropane-1,2-diol (EXP)

acrolein (ISO)

alpha-pinene (ISO)

Aroclor 1254 (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

cyclosporin A (ISO)

D-mannitol (ISO)

doxorubicin (ISO)

enzyme inhibitor (ISO)

ethanol (ISO)

folic acid (ISO)

irinotecan (ISO)

lead(0) (ISO)

lead(2+) (ISO)

lovastatin (ISO)

methoxychlor (EXP)

methyl methanesulfonate (ISO)

ozone (ISO)

paracetamol (ISO)

pentachlorophenol (ISO)

sarin (EXP)

tamoxifen (ISO)

tetrahydropalmatine (ISO)

warfarin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

melanosome transport (IEA,ISO)

mitotic cell cycle (IDA)

mitotic metaphase plate congression (IEA,ISO)

mitotic spindle organization (IBA,IDA,IEA,ISO)

protein localization to centrosome (IEA,ISO)

Cellular Component

centrosome (IBA,IDA,IEA,ISO)

cytoplasm (IBA)

cytoskeleton (TAS)

cytosol (IEA,ISO)

dynactin complex (IBA,IDA,IEA,ISO)

dynein complex (IEA)

growth cone (IEA,ISO)

kinetochore (IDA,IEA,ISO)

membrane (IEA)

microtubule (IEA)

vesicle (IEA,ISO,ISS)

Molecular Function

identical protein binding (IEA,ISO)

molecular_function (ND)

motor activity (IEA)

protein binding (ISO)

protein kinase binding (IEA,ISO)

spectrin binding (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

Huntington's disease pathway (IEA)

mitochondria transport pathway (ISO)

vasopressin signaling pathway via receptor type 2 (IEA)

References

References - curated


1.	Chung CY, etal., J Neurosci. 2009 Mar 18;29(11):3365-73. doi: 10.1523/JNEUROSCI.5427-08.2009.
2.	Echeverri CJ, etal., J Cell Biol 1996 Feb;132(4):617-33.
3.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	MGD data from the GO Consortium
5.	Pipeline to import KEGG annotations from KEGG into RGD
6.	RGD automated data pipeline
7.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	RGD automated import pipeline for gene-chemical interactions
9.	RGD comprehensive gene curation
10.	Schroer TA, Annu Rev Cell Dev Biol. 2004;20:759-79.
11.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:9144527	PMID:16051887	PMID:17139249	PMID:19056867	PMID:19182904	PMID:20682791	PMID:21399614	PMID:21911489	PMID:22275436	PMID:22871113	PMID:23704327	PMID:24625528
PMID:24816561	PMID:25416956	PMID:29476059

Genomics

Comparative Map Data

Dctn2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	7	63,092,061 - 63,107,560 (+)	NCBI
Rnor_6.0 Ensembl	7	70,556,019 - 70,572,614 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	7	70,555,953 - 70,571,433 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	7	70,730,089 - 70,745,583 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	67,223,893 - 67,239,157 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	7	67,244,622 - 67,259,886 (+)	NCBI
Celera	7	60,232,682 - 60,247,954 (+)	NCBI		Celera
Cytogenetic Map	7	q22	NCBI

DCTN2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	12	57,529,633 - 57,547,224 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38.p13 Ensembl	12	57,530,102 - 57,547,331 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38.p13 Ensembl	12	57,530,051 - 57,547,224 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	12	57,530,051 - 57,547,216 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	12	57,923,834 - 57,940,975 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
GRCh37	12	57,923,833 - 57,941,114 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	56,210,361 - 56,227,245 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	12	56,210,360 - 56,227,245	NCBI
Celera	12	57,579,926 - 57,596,808 (-)	NCBI
Cytogenetic Map	12	q13.3	NCBI
HuRef	12	54,961,731 - 54,979,012 (-)	NCBI		HuRef
CHM1_1	12	57,891,658 - 57,908,952 (-)	NCBI		CHM1_1

Dctn2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	127,102,131 - 127,117,828 (+)	NCBI	GRCm39		mm39
GRCm38	10	127,266,262 - 127,281,959 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	127,266,368 - 127,281,950 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	126,703,318 - 126,719,015 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	10	126,669,348 - 126,684,756 (+)	NCBI			mm8
Celera	10	129,658,775 - 129,674,400 (+)	NCBI		Celera
Cytogenetic Map	10	D3	NCBI
cM Map	10	74.5	NCBI

Dctn2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955458	5,247,871 - 5,265,242 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955458	5,247,871 - 5,264,424 (-)	NCBI	ChiLan1.0	ChiLan1.0

DCTN2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	12	31,638,272 - 31,655,458 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	31,636,884 - 31,655,458 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	12	31,379,531 - 31,396,570 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

DCTN2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	10	1,620,724 - 1,634,309 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	10	1,620,702 - 1,634,385 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Dctn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936646	1,678,678 - 1,695,142 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DCTN2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	22,799,286 - 22,814,364 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	22,799,286 - 22,814,358 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

DCTN2
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	53,438,878 - 53,456,181 (-)	NCBI
ChlSab1.1 Ensembl	11	53,439,249 - 53,456,267 (-)	Ensembl

Dctn2
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624802	10,412,466 - 10,429,354 (+)	NCBI

Position Markers

D10Wsu93e

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	7	70,571,535 - 70,571,785	NCBI	Rnor6.0
Rnor_5.0	7	70,745,685 - 70,745,935	UniSTS	Rnor5.0
RGSC_v3.4	7	67,239,405 - 67,239,655	UniSTS	RGSC3.4
Celera	7	60,248,201 - 60,248,451	UniSTS
Cytogenetic Map	7	q22	UniSTS

RH127945

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	7	70,571,007 - 70,571,189	NCBI	Rnor6.0
Rnor_5.0	7	70,745,157 - 70,745,339	UniSTS	Rnor5.0
RGSC_v3.4	7	67,238,876 - 67,239,058	UniSTS	RGSC3.4
Celera	7	60,247,673 - 60,247,855	UniSTS
Cytogenetic Map	7	q22	UniSTS

C87049

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	7	70,570,937 - 70,571,192	NCBI	Rnor6.0
Rnor_5.0	7	70,745,087 - 70,745,342	UniSTS	Rnor5.0
RGSC_v3.4	7	67,238,806 - 67,239,061	UniSTS	RGSC3.4
Celera	7	60,247,603 - 60,247,858	UniSTS
Cytogenetic Map	7	q22	UniSTS

RH136664

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	7	70,558,483 - 70,558,667	NCBI	Rnor6.0
Rnor_5.0	7	70,732,633 - 70,732,817	UniSTS	Rnor5.0
RGSC_v3.4	7	67,226,352 - 67,226,536	UniSTS	RGSC3.4
Celera	7	60,235,141 - 60,235,325	UniSTS
Cytogenetic Map	7	q22	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	2920071	124838025	Rat
1643004	Pain2	Pain QTL 2	1		mechanical nociception trait (VT:0002734)	self mutilation severity score (CMO:0002145)	7	12328467	106995532	Rat
1300132	Bp182	Blood pressure QTL 182	3.49		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	7	25365633	93155402	Rat
7411569	Bw137	Body weight QTL 137		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	7	28204653	73204653	Rat
1641885	Alcrsp9	Alcohol response QTL 9			alcohol metabolism trait (VT:0015089)	blood ethanol level (CMO:0000535)	7	31381529	76381529	Rat
1549840	Bss5	Bone structure and strength QTL 5	9.8		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	7	32035053	77035053	Rat
61439	Cia8	Collagen induced arthritis QTL 8	5.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	7	32572942	77572942	Rat
70190	Mcs6	Mammary carcinoma susceptibility QTL 6	2.29		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	7	33044449	71352127	Rat
10402855	Bp379	Blood pressure QTL 379		0.21	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	35867729	80867729	Rat
1300127	Srn1	Serum renin concentration QTL 1	3.87		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	7	35867729	93155402	Rat
10755453	Coatc12	Coat color QTL 12		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	38547706	83547706	Rat
631534	Lnnr1	Liver neoplastic nodule remodeling QTL 1	3.85	0.001	liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)	7	40872682	85872682	Rat
7411605	Foco14	Food consumption QTL 14	24.1	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	40872682	85872682	Rat
631513	Scl7	Serum cholesterol level QTL 7	4.1		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	7	45301573	90301573	Rat
61357	Bp38	Blood pressure QTL 38	1.6	0.052	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	48118835	128611831	Rat
634326	Hc3	Hypercalciuria QTL 3	2.1		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	7	50252103	95252103	Rat
631504	Cm27	Cardiac mass QTL 27	3.45		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	7	50704769	128085642	Rat
10053722	Scort27	Serum corticosterone level QTL 27	2.41	0.0083	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	7	50793818	95793818	Rat
1358361	Sradr5	Stress Responsive Adrenal Weight QTL 5	5.55		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	7	51251919	118477612	Rat
1300179	Kidm5	Kidney mass QTL 5	3.51		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	51251919	145729302	Rat
1300149	Cm6	Cardiac mass QTL 6	4.09		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	7	51252005	111589099	Rat
61428	Scl3	Serum cholesterol level QTL 3	3.2		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	7	53200344	98200344	Rat
738030	Anxrr8	Anxiety related response QTL 8	4.1		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	54259512	99259512	Rat
10059605	Kidm47	Kidney mass QTL 47	2.91	0.05	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	7	54534996	73293934	Rat
2316947	Rf58	Renal function QTL 58	7.8		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	7	55072862	123602998	Rat
2316952	Pur22	Proteinuria QTL 22	5.2		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	7	55072862	123602998	Rat
2316955	Stl24	Serum triglyceride level QTL 24	7.1		blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	7	55072862	123602998	Rat
2300178	Bmd54	Bone mineral density QTL 54	5.3	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	7	55495689	100495689	Rat
2293644	Bmd29	Bone mineral density QTL 29	5.4	0.0001	femur size trait (VT:1000369)	femoral neck cross-sectional area (CMO:0001697)	7	55495689	100495689	Rat
2293667	Bss42	Bone structure and strength QTL 42	7.25	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra cross-sectional area (CMO:0001689)	7	55495689	100495689	Rat
2293678	Bss24	Bone structure and strength QTL 24	6.71	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	7	55495689	100495689	Rat
2293685	Bmd21	Bone mineral density QTL 21	4.2	0.0003	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	7	55495689	100495689	Rat
2293696	Bmd32	Bone mineral density QTL 32	5.1	0.0001	femur strength trait (VT:0010010)	femoral neck polar moment of inertia (CMO:0001670)	7	55495689	100495689	Rat
2293707	Bss32	Bone structure and strength QTL 32	7.64	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	7	55495689	100495689	Rat
1300151	Bp181	Blood pressure QTL 181	3.36		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	7	61047589	113228378	Rat
2317035	Aia16	Adjuvant induced arthritis QTL 16	2.71		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	7	68518460	113518460	Rat
1576303	Ept7	Estrogen-induced pituitary tumorigenesis QTL 7	3.7		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	7	69399586	111043530	Rat
1559283	Emca4	Estrogen-induced mammary cancer QTL 4	3.7		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	7	69399586	111043530	Rat
1298528	Bp169	Blood pressure QTL 169		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	70421228	115421228	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	185
Count of miRNA genes:	118
Interacting mature miRNAs:	139
Transcripts:	ENSRNOT00000008120
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	11	74	35	41	11	8
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001004239	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006241448	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017594742	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017594743	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039078752	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039078753	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039078754	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC114111	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC079042	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473950	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000185	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000008120 ⟹ ENSRNOP00000008120

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	7	70,556,024 - 70,571,287 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000087495 ⟹ ENSRNOP00000069048

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	7	70,556,019 - 70,572,614 (+)	Ensembl

RefSeq Acc Id:

NM_001004239 ⟹ NP_001004239

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	63,092,151 - 63,107,415 (+)	NCBI
Rnor_6.0	7	70,556,024 - 70,571,288 (+)	NCBI
Rnor_5.0	7	70,730,089 - 70,745,583 (+)	NCBI
RGSC_v3.4	7	67,223,893 - 67,239,157 (+)	RGD
Celera	7	60,232,682 - 60,247,954 (+)	RGD

Sequence:

show sequence

CTCCCCTTATCGTCGCCTAGCCGGGGACCCGGACCCAGCCTCTCCCCCACTCGGTCACCGGCCC
GGCTCCTCCAAGGCCCCGGTTCCCCCAGCCCCGCTTCGCCGCCGCCATGGCGGACCCTAAATAC
GCCGATCTCCCCGGCATTGCCAGGAACGAGCCAGATGTTTATGAAACCAGCGACCTACCTGAGG
ATGATCAAGCAGAGTTTGATGCGGAGGAGCTGAGCAGCACAAGTGTGGAACACATCATCGTCAA
CCCCAACGCTGCCTATGACAAGTTCAAGGACAAGAGAGTAGGGACAAAGGGGCTTGATTTCTCA
GATCGCATTGGAAAGACCAAGAGGACAGGATATGAGTCTGGAGACTATGAAATGCTTGGAGAGG
GTCTGGGAGTAAAGGAGACACCACAGCAGAAGTACCAACGACTACTGCATGAAGTCCAGGAGCT
GACAACGGAGGTGGAGAAGATCAAGACAACAGTGAAGGAGTCAGCCACTGAGGAGAAGCTCACC
CCTGTGGTGCTGGCTAAACAGCTGGCCGCTCTGAAGCAGCAGCTGGTAGCTTCCCACCTGGAGA
AGCTTCTGGGACCAGATGCTGCCATCAACCTCGCTGACCCAGATGGAGCCCTAGCTAAGCGCTT
ACTGCTGCAGCTGGAAGCAACCAAGAGCAGCAAAGGCAGCTCAGGGGGAAAGAGCACAGGTGGC
ACTCCCCCAGATAGCAGCCTTGTCACTTACGAACTCCACTCACGGCCTGAGCAGGACAAGTTCT
CGCAAGCTGCCAAAGTTGCAGAACTCGAGAAGCGCCTGACAGAGCTGGAGGCCACTGTCCGCTG
TGATCAGGATGCTCAGAATCCCCTTTCTGCAGGTCTACAGGGAGCCTGCCTTATGGAAACGGTA
GAACTGTTACAGGCCAAAGTGAACGCCCTGGACCTTGCAGTTCTGGACCAAGTAGAGGCTCGAC
TGCAGAGTGTCCTGGGAAAGGTGAATGAGATTGCTAAGCACAAGGCATCTGTGGAGGACGCAGA
CACACAGAATAAGGTGCACCAGCTCTATGAGACCATCCAGCGCTGGAGCCCTGTGGCCTCCACT
CTCCCTGAGCTGGTACAGAGACTTGTCACCATCAAGCAGCTTCATGAGCAAGCTATGCAGTTTG
GTCAGCTCCTGACACACTTGGATACCACCCAGCAGATGATGGCGAGTTCTCTTAAGGACAATAC
TGCCCTCCTGACCCAGGTTCAGACAACGATGCGTGAAAACTTGGCCACAGTTGAGGGGAATTTT
GCCAGCATTGATGCTCGTATGAAGAAGCTGGGAAAGTGAGCGCCACTGGGAGTTGGGGAGCTGG
GGTAACCCTTGCCCCTGAGCTTTGTCAGACACTTCCACAGAGCTTCCCCTTGACCATACTCATA
GTCCCATCCCACCTGACAAGGGCAAGGGTTCTTCTTGCATGTGGGGTGCACACCCTCCCCTGAG
GAAGAGTGGGAGCTGGGAGCTATCACGGGATGAGGTTGTGGGCCCAGCCACATGCCAGCTCTTG
TCCAGTAAGTGCTTGCCTGCTGTGGGAGAGGACTGGATCCTGTCCTCACACAGCTCTGTGGCTG
ATTCTAATACTGTACAACCGTCTCTGACCATTAAATGATGTTGTACCGTGGAAAAAAAAAAAAA
AAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006241448 ⟹ XP_006241510

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	63,092,064 - 63,107,560 (+)	NCBI
Rnor_6.0	7	70,555,953 - 70,571,433 (+)	NCBI
Rnor_5.0	7	70,730,089 - 70,745,583 (+)	NCBI

Sequence:

show sequence

CTATCCTCGCGACTTTTGCGGTCCCCTCCTGCCGGCCTGCTCCTGTCGCGAGACTTCCTGCTCC
TCCGCCGCTCCCCTTATCGTCGCCTAGCCGGGGACCCGGACCCAGCCTCTCCCCCACTCGGTCA
CCGGCCCGGCTCCTCCAAGGCCCCGGTTCCCCCAGCCCCGCTTCGCCGCCGCCATGGCGGACCC
TAAATACGCCGATCTCCCCGGCATTGCCAGGAACGAGCCAGATGTTTATGAAACCAGCGACCTA
CCTGAGGATGATCAAGCAGAGTTTGATGCGGAGCTGGAGGAGCTGAGCAGCACAAGTGTGGAAC
ACATCATCGTCAACCCCAACGCTGCCTATGACAAGTTCAAGGACAAGAGAGTAGGGACAAAGGG
GCTTGATTTCTCAGATCGCATTGGAAAGACCAAGAGGACAGGATATGAGTCTGGAGACTATGAA
ATGCTTGGAGAGGGTCTGGGAGTAAAGGAGACACCACAGCAGAAGTACCAACGACTACTGCATG
AAGTCCAGGAGCTGACAACGGAGGTGGAGAAGATCAAGACAACAGTGAAGGAGTCAGCCACTGA
GGAGAAGCTCACCCCTGTGGTGCTGGCTAAACAGCTGGCCGCTCTGAAGCAGCAGCTGGTAGCT
TCCCACCTGGAGAAGCTTCTGGGACCAGATGCTGCCATCAACCTCGCTGACCCAGATGGAGCCC
TAGCTAAGCGCTTACTGCTGCAGCTGGAAGCAACCAAGAGCAGCAAAGGCAGCTCAGGGGGAAA
GAGCACAGGTGGCACTCCCCCAGATAGCAGCCTTGTCACTTACGAACTCCACTCACGGCCTGAG
CAGGACAAGTTCTCGCAAGCTGCCAAAGTTGCAGAACTCGAGAAGCGCCTGACAGAGCTGGAGG
CCACTGTCCGCTGTGATCAGGATGCTCAGAATCCCCTTTCTGCAGGTCTACAGGGAGCCTGCCT
TATGGAAACGGTAGAACTGTTACAGGCCAAAGTGAACGCCCTGGACCTTGCAGTTCTGGACCAA
GTAGAGGCTCGACTGCAGAGTGTCCTGGGAAAGGTGAATGAGATTGCTAAGCACAAGGCATCTG
TGGAGGACGCAGACACACAGAATAAGGTGCACCAGCTCTATGAGACCATCCAGCGCTGGAGCCC
TGTGGCCTCCACTCTCCCTGAGCTGGTACAGAGACTTGTCACCATCAAGCAGCTTCATGAGCAA
GCTATGCAGTTTGGTCAGCTCCTGACACACTTGGATACCACCCAGCAGATGATGGCGAGTTCTC
TTAAGGACAATACTGCCCTCCTGACCCAGGTTCAGACAACGATGCGTGAAAACTTGGCCACAGT
TGAGGGGAATTTTGCCAGCATTGATGCTCGTATGAAGAAGCTGGGAAAGTGAGCGCCACTGGGA
GTTGGGGAGCTGGGGTAACCCTTGCCCCTGAGCTTTGTCAGACACTTCCACAGAGCTTCCCCTT
GACCATACTCATAGTCCCATCCCACCTGACAAGGGCAAGGGTTCTTCTTGCATGTGGGGTGCAC
ACCCTCCCCTGAGGAAGAGTGGGAGCTGGGAGCTATCACGGGATGAGGTTGTGGGCCCAGCCAC
ATGCCAGCTCTTGTCCAGTAAGTGCTTGCCTGCTGTGGGAGAGGACTGGATCCTGTCCTCACAC
AGCTCTGTGGCTGATTCTAATACTGTACAACCGTCTCTGACCATTAAATGATGTTGTACCGTGG
AGACTCTGCTGTGTTTCCTGGATTTCGAAGAGGCAGCACTGTCAGACGTGCATACCTAACAATC
CAAGCCACACTATTATGAGACTATTTCAGTTGTAATCTGTTCTTACCAAAGAACCAAATAAAAA
ATGAGTACAGAGCCAGAA

hide sequence

RefSeq Acc Id:

XM_017594742 ⟹ XP_017450231

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	63,092,063 - 63,107,560 (+)	NCBI
Rnor_6.0	7	70,555,997 - 70,571,433 (+)	NCBI

Sequence:

show sequence

GTCGCGAGACTTCCTGCTCCTCCGCCGCTCCCCTTATCGTCGCCTAGCCGGGGACCCGGACCCA
GCCTCTCCCCCACTCGGTCACCGGCCCGGCTCCTCCAAGGCCCCGGTTCCCCCAGCCCCGCTTC
GCCGCCGCCATGGCGGACCCTAAATACGCCGATCTCCCCGGCATTGCCAGGAACGAGCCAGATG
TTTATGAAACCAGCGACCTACCTGAGGATGATCAAGCAGAGTTTGATGCGTTTGCACAAGAGCT
GGAGGAGCTGAGCAGCACAAGTGTGGAACACATCATCGTCAACCCCAACGCTGCCTATGACAAG
TTCAAGGACAAGAGAGTAGGGACAAAGGGGCTTGATTTCTCAGATCGCATTGGAAAGACCAAGA
GGACAGGATATGAGTCTGGAGACTATGAAATGCTTGGAGAGGGTCTGGGAGTAAAGGAGACACC
ACAGCAGAAGTACCAACGACTACTGCATGAAGTCCAGGAGCTGACAACGGAGGTGGAGAAGATC
AAGACAACAGTGAAGGAGTCAGCCACTGAGGAGAAGCTCACCCCTGTGGTGCTGGCTAAACAGC
TGGCCGCTCTGAAGCAGCAGCTGGTAGCTTCCCACCTGGAGAAGCTTCTGGGACCAGATGCTGC
CATCAACCTCGCTGACCCAGATGGAGCCCTAGCTAAGCGCTTACTGCTGCAGCTGGAAGCAACC
AAGAGCAGCAAAGGCAGCTCAGGGGGAAAGAGCACAGGTGGCACTCCCCCAGATAGCAGCCTTG
TCACTTACGAACTCCACTCACGGCCTGAGCAGGACAAGTTCTCGCAAGCTGCCAAAGTTGCAGA
ACTCGAGAAGCGCCTGACAGAGCTGGAGGCCACTGTCCGCTGTGATCAGGATGCTCAGAATCCC
CTTTCTGCAGGTCTACAGGGAGCCTGCCTTATGGAAACGGTAGAACTGTTACAGGCCAAAGTGA
ACGCCCTGGACCTTGCAGTTCTGGACCAAGTAGAGGCTCGACTGCAGAGTGTCCTGGGAAAGGT
GAATGAGATTGCTAAGCACAAGGCATCTGTGGAGGACGCAGACACACAGAATAAGGTGCACCAG
CTCTATGAGACCATCCAGCGCTGGAGCCCTGTGGCCTCCACTCTCCCTGAGCTGGTACAGAGAC
TTGTCACCATCAAGCAGCTTCATGAGCAAGCTATGCAGTTTGGTCAGCTCCTGACACACTTGGA
TACCACCCAGCAGATGATGGCGAGTTCTCTTAAGGACAATACTGCCCTCCTGACCCAGGTTCAG
ACAACGATGCGTGAAAACTTGGCCACAGTTGAGGGGAATTTTGCCAGCATTGATGCTCGTATGA
AGAAGCTGGGAAAGTGAGCGCCACTGGGAGTTGGGGAGCTGGGGTAACCCTTGCCCCTGAGCTT
TGTCAGACACTTCCACAGAGCTTCCCCTTGACCATACTCATAGTCCCATCCCACCTGACAAGGG
CAAGGGTTCTTCTTGCATGTGGGGTGCACACCCTCCCCTGAGGAAGAGTGGGAGCTGGGAGCTA
TCACGGGATGAGGTTGTGGGCCCAGCCACATGCCAGCTCTTGTCCAGTAAGTGCTTGCCTGCTG
TGGGAGAGGACTGGATCCTGTCCTCACACAGCTCTGTGGCTGATTCTAATACTGTACAACCGTC
TCTGACCATTAAATGATGTTGTACCGTGGAGACTCTGCTGTGTTTCCTGGATTTCGAAGAGGCA
GCACTGTCAGACGTGCATACCTAACAATCCAAGCCACACTATTATGAGACTATTTCAGTTGTAA
TCTGTTCTTACCAAAGAACCAAATAAAAAATGAGTACAGAGCCAGAA

hide sequence

RefSeq Acc Id:

XM_017594743 ⟹ XP_017450232

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	63,092,061 - 63,107,560 (+)	NCBI
Rnor_6.0	7	70,555,994 - 70,571,433 (+)	NCBI

Sequence:

show sequence

CCTGTCGCGAGACTTCCTGCTCCTCCGCCGCTCCCCTTATCGTCGCCTAGCCGGGGACCCGGAC
CCAGCCTCTCCCCCACTCGGTCACCGGCCCGGCTCCTCCAAGGCCCCGGTTCCCCCAGCCCCGC
TTCGCCGCCGCCATGGCGGACCCTAAATACGCCGATCTCCCCGGCATTGCCAGGAACGAGCCAG
ATGTTTATGAAACCAGCGACCTACCTGAGGATGATCAAGCAGAGTTTGATGCGTTTGCACAAGA
GCTGGAGGAGCTGAGCAGCACAAGTGTGGAACACATCATCGTCAACCCCAACGCTGCCTATGAC
AAGTTCAAGGACAAGAGAGTAGGGACAAAGGGGCTTGATTTCTCAGATCGCATTGGAAAGACCA
AGAGGACAGGATATGAGTCTGGAGACTATGAAATGCTTGGAGAGGGTCTGGGAGTAAAGGAGAC
ACCACAGCAGAAGTACCAACGACTACTGCATGAAGTCCAGGAGCTGACAACGGAGGTGGAGAAG
ATCAAGACAACAGTGAAGGAGTCAGCCACTGAGGAGAAGCTCACCCCTGTGGTGCTGGCTAAAC
AGCTGGCCGCTCTGAAGCAGCAGCTGGTAGCTTCCCACCTGGAGAAGCTTCTGGGACCAGATGC
TGCCATCAACCTCGCTGACCCAGATGGAGCCCTAGCTAAGCGCTTACTGCTGCAGCTGGAAGCA
ACCAAGAGCAGCAAAGGCAGCTCAGGGGGAAAGAGCACAGGTGGCACTCCCCCAGATAGCAGCC
TTGTCACTTACGAACTCCACTCACGGCCTGAGCAGGACAAGTTCTCGCAAGCTGCCAAAGTTGC
AGAACTCGAGAAGCGCCTGACAGAGCTGGAGGCCACTGTCCGCTGTGATCAGGATGCTCAGAAT
CCCCTTTCTGCAGGTCTACAGGGAGCCTGCCTTATGGAAACGGTAGAACTGTTACAGGCCAAAG
TGAACGCCCTGGACCTTGCAGTTCTGGACCAAGTAGAGGCTCGACTGCAGAGTGTCCTGGGAAA
GGTGAATGAGATTGCTAAGCACAAGGCATCTGTGGAGGACGCAGACACACAGAATAAGGTGCAC
CAGCTCTATGAGACCATCCAGCGCTGGAGCCCTGTGGCCTCCACTCTCCCTGAGCTGGTACAGA
GACTTGTCACCATCAAGCAGCTTCATGAGCAAGCTATGCAGTTTGGTCAGCTCCTGACACACTT
GGATACCACCCAGCAGATGATGGCGAGTTCTCTTAAGGACAATACTGCCCTCCTGACCCAGTTT
CTTATGGATGTTCCTCATCTGATAGACACCTGGGCCAAACAAACATAAGGCTTCTCTTCCCCTT
TTGTAGGTTCAGACAACGATGCGTGAAAACTTGGCCACAGTTGAGGGGAATTTTGCCAGCATTG
ATGCTCGTATGAAGAAGCTGGGAAAGTGAGCGCCACTGGGAGTTGGGGAGCTGGGGTAACCCTT
GCCCCTGAGCTTTGTCAGACACTTCCACAGAGCTTCCCCTTGACCATACTCATAGTCCCATCCC
ACCTGACAAGGGCAAGGGTTCTTCTTGCATGTGGGGTGCACACCCTCCCCTGAGGAAGAGTGGG
AGCTGGGAGCTATCACGGGATGAGGTTGTGGGCCCAGCCACATGCCAGCTCTTGTCCAGTAAGT
GCTTGCCTGCTGTGGGAGAGGACTGGATCCTGTCCTCACACAGCTCTGTGGCTGATTCTAATAC
TGTACAACCGTCTCTGACCATTAAATGATGTTGTACCGTGGAGACTCTGCTGTGTTTCCTGGAT
TTCGAAGAGGCAGCACTGTCAGACGTGCATACCTAACAATCCAAGCCACACTATTATGAGACTA
TTTCAGTTGTAATCTGTTCTTACCAAAGAACCAAATAAAAAATGAGTACAGAGCCAGAA

hide sequence

RefSeq Acc Id:

XM_039078752 ⟹ XP_038934680

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	63,092,063 - 63,107,560 (+)	NCBI

RefSeq Acc Id:

XM_039078753 ⟹ XP_038934681

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	63,092,062 - 63,107,560 (+)	NCBI

RefSeq Acc Id:

XM_039078754 ⟹ XP_038934682

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	63,092,063 - 63,107,560 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001004239	(Get FASTA)	NCBI Sequence Viewer
	XP_006241510	(Get FASTA)	NCBI Sequence Viewer
	XP_017450231	(Get FASTA)	NCBI Sequence Viewer
	XP_017450232	(Get FASTA)	NCBI Sequence Viewer
	XP_038934680	(Get FASTA)	NCBI Sequence Viewer
	XP_038934681	(Get FASTA)	NCBI Sequence Viewer
	XP_038934682	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH79042	(Get FASTA)	NCBI Sequence Viewer
	EDM16482	(Get FASTA)	NCBI Sequence Viewer
	EDM16483	(Get FASTA)	NCBI Sequence Viewer
	EDM16484	(Get FASTA)	NCBI Sequence Viewer
	EDM16485	(Get FASTA)	NCBI Sequence Viewer
	Q6AYH5	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001004239 ⟸ NM_001004239

- UniProtKB:

Q6AYH5 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MADPKYADLPGIARNEPDVYETSDLPEDDQAEFDAEELSSTSVEHIIVNPNAAYDKFKDKRVGT
KGLDFSDRIGKTKRTGYESGDYEMLGEGLGVKETPQQKYQRLLHEVQELTTEVEKIKTTVKESA
TEEKLTPVVLAKQLAALKQQLVASHLEKLLGPDAAINLADPDGALAKRLLLQLEATKSSKGSSG
GKSTGGTPPDSSLVTYELHSRPEQDKFSQAAKVAELEKRLTELEATVRCDQDAQNPLSAGLQGA
CLMETVELLQAKVNALDLAVLDQVEARLQSVLGKVNEIAKHKASVEDADTQNKVHQLYETIQRW
SPVASTLPELVQRLVTIKQLHEQAMQFGQLLTHLDTTQQMMASSLKDNTALLTQVQTTMRENLA
TVEGNFASIDARMKKLGK

hide sequence

RefSeq Acc Id:

XP_006241510 ⟸ XM_006241448

- Peptide Label:

isoform X2

- Sequence:

show sequence

MADPKYADLPGIARNEPDVYETSDLPEDDQAEFDAELEELSSTSVEHIIVNPNAAYDKFKDKRV
GTKGLDFSDRIGKTKRTGYESGDYEMLGEGLGVKETPQQKYQRLLHEVQELTTEVEKIKTTVKE
SATEEKLTPVVLAKQLAALKQQLVASHLEKLLGPDAAINLADPDGALAKRLLLQLEATKSSKGS
SGGKSTGGTPPDSSLVTYELHSRPEQDKFSQAAKVAELEKRLTELEATVRCDQDAQNPLSAGLQ
GACLMETVELLQAKVNALDLAVLDQVEARLQSVLGKVNEIAKHKASVEDADTQNKVHQLYETIQ
RWSPVASTLPELVQRLVTIKQLHEQAMQFGQLLTHLDTTQQMMASSLKDNTALLTQVQTTMREN
LATVEGNFASIDARMKKLGK

hide sequence

RefSeq Acc Id:

XP_017450232 ⟸ XM_017594743

- Peptide Label:

isoform X4

- Sequence:

show sequence

MADPKYADLPGIARNEPDVYETSDLPEDDQAEFDAFAQELEELSSTSVEHIIVNPNAAYDKFKD
KRVGTKGLDFSDRIGKTKRTGYESGDYEMLGEGLGVKETPQQKYQRLLHEVQELTTEVEKIKTT
VKESATEEKLTPVVLAKQLAALKQQLVASHLEKLLGPDAAINLADPDGALAKRLLLQLEATKSS
KGSSGGKSTGGTPPDSSLVTYELHSRPEQDKFSQAAKVAELEKRLTELEATVRCDQDAQNPLSA
GLQGACLMETVELLQAKVNALDLAVLDQVEARLQSVLGKVNEIAKHKASVEDADTQNKVHQLYE
TIQRWSPVASTLPELVQRLVTIKQLHEQAMQFGQLLTHLDTTQQMMASSLKDNTALLTQFLMDV
PHLIDTWAKQT

hide sequence

RefSeq Acc Id:

XP_017450231 ⟸ XM_017594742

- Peptide Label:

isoform X1

- Sequence:

show sequence

MADPKYADLPGIARNEPDVYETSDLPEDDQAEFDAFAQELEELSSTSVEHIIVNPNAAYDKFKD
KRVGTKGLDFSDRIGKTKRTGYESGDYEMLGEGLGVKETPQQKYQRLLHEVQELTTEVEKIKTT
VKESATEEKLTPVVLAKQLAALKQQLVASHLEKLLGPDAAINLADPDGALAKRLLLQLEATKSS
KGSSGGKSTGGTPPDSSLVTYELHSRPEQDKFSQAAKVAELEKRLTELEATVRCDQDAQNPLSA
GLQGACLMETVELLQAKVNALDLAVLDQVEARLQSVLGKVNEIAKHKASVEDADTQNKVHQLYE
TIQRWSPVASTLPELVQRLVTIKQLHEQAMQFGQLLTHLDTTQQMMASSLKDNTALLTQVQTTM
RENLATVEGNFASIDARMKKLGK

hide sequence

RefSeq Acc Id:

ENSRNOP00000008120 ⟸ ENSRNOT00000008120

RefSeq Acc Id:

ENSRNOP00000069048 ⟸ ENSRNOT00000087495

RefSeq Acc Id:	XP_038934681 ⟸ XM_039078753
- Peptide Label:	isoform X5

RefSeq Acc Id:	XP_038934680 ⟸ XM_039078752
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038934682 ⟸ XM_039078754
- Peptide Label:	isoform X6

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695278

Promoter ID:

EPDNEW_R5780

Type:

initiation region

Name:

Dctn2_1

Description:

dynactin subunit 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	70,556,020 - 70,556,080	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

Visual

CSV

TAB

Printer

Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1303182	AgrOrtholog
Ensembl Genes	ENSRNOG00000025481	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000008120	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOP00000069048	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000008120	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOT00000087495	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7114929	IMAGE-MGC_LOAD
InterPro	Dynamitin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:299850	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93976	IMAGE-MGC_LOAD
NCBI Gene	299850	ENTREZGENE
PANTHER	PTHR15346	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Dynamitin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Dctn2	PhenoGen
UniProt	A0A0G2JUC7_RAT	UniProtKB/TrEMBL
	DCTN2_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-12-02	Dctn2	dynactin subunit 2	Dctn2	dynactin 2 (p50)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-01-10	Dctn2	dynactin 2 (p50)	Dctn2	dynactin 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Dctn2	dynactin 2			Symbol and Name status set to approved	1299863	APPROVED
2005-07-14	Dctn2	dynactin 2			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)