Dctn2 (dynactin subunit 2) - Rat Genome Database

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Gene: Dctn2 (dynactin subunit 2) Rattus norvegicus
Analyze
Symbol: Dctn2
Name: dynactin subunit 2
RGD ID: 1303182
Description: Predicted to enable identical protein binding activity; protein kinase binding activity; and spectrin binding activity. Involved in mitotic spindle organization. Located in centrosome and kinetochore. Part of dynactin complex. Biomarker of synucleinopathy. Orthologous to human DCTN2 (dynactin subunit 2); PARTICIPATES IN mitochondria transport pathway; Huntington's disease pathway; vasopressin signaling pathway via receptor type 2; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: dynactin 2; dynactin 2 (p50); MGC93976
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2763,092,061 - 63,107,560 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl763,092,057 - 63,108,543 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx764,981,425 - 64,996,689 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0767,183,845 - 67,199,109 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0766,985,182 - 67,000,460 (+)NCBIRnor_WKY
Rnor_6.0770,555,953 - 70,571,433 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl770,556,019 - 70,572,614 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0770,730,089 - 70,745,583 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4767,223,893 - 67,239,157 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1767,244,622 - 67,259,886 (+)NCBI
Celera760,232,682 - 60,247,954 (+)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
centrosome  (IBA,IDA,IEA,ISO)
cytoplasm  (IBA,IEA)
cytoskeleton  (TAS)
cytosol  (IEA,ISO)
dynactin complex  (IBA,IDA,IEA,ISO)
dynein complex  (IEA)
growth cone  (IEA,ISO)
kinetochore  (IDA,IEA,ISO)
membrane  (IEA)
microtubule  (IEA)
vesicle  (IEA,ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV alpha-synucleinopathy. Chung CY, etal., J Neurosci. 2009 Mar 18;29(11):3365-73. doi: 10.1523/JNEUROSCI.5427-08.2009.
2. Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis. Echeverri CJ, etal., J Cell Biol 1996 Feb;132(4):617-33.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. Dynactin. Schroer TA, Annu Rev Cell Dev Biol. 2004;20:759-79.
11. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:9144527   PMID:16051887   PMID:17139249   PMID:19056867   PMID:19182904   PMID:20682791   PMID:21399614   PMID:21911489   PMID:22275436   PMID:22871113   PMID:23704327   PMID:24625528  
PMID:24816561   PMID:25416956   PMID:29476059   PMID:32357304  


Genomics

Comparative Map Data
Dctn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2763,092,061 - 63,107,560 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl763,092,057 - 63,108,543 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx764,981,425 - 64,996,689 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0767,183,845 - 67,199,109 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0766,985,182 - 67,000,460 (+)NCBIRnor_WKY
Rnor_6.0770,555,953 - 70,571,433 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl770,556,019 - 70,572,614 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0770,730,089 - 70,745,583 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4767,223,893 - 67,239,157 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1767,244,622 - 67,259,886 (+)NCBI
Celera760,232,682 - 60,247,954 (+)NCBICelera
Cytogenetic Map7q22NCBI
DCTN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381257,530,051 - 57,547,192 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1257,529,633 - 57,547,224 (-)EnsemblGRCh38hg38GRCh38
GRCh371257,923,834 - 57,940,975 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361256,210,361 - 56,227,245 (-)NCBINCBI36Build 36hg18NCBI36
Build 341256,210,360 - 56,227,245NCBI
Celera1257,579,926 - 57,596,808 (-)NCBICelera
Cytogenetic Map12q13.3NCBI
HuRef1254,961,731 - 54,979,012 (-)NCBIHuRef
CHM1_11257,891,658 - 57,908,952 (-)NCBICHM1_1
T2T-CHM13v2.01257,498,291 - 57,515,431 (-)NCBIT2T-CHM13v2.0
Dctn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910127,102,131 - 127,117,828 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10127,102,237 - 127,117,819 (+)EnsemblGRCm39 Ensembl
GRCm3810127,266,262 - 127,281,959 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10127,266,368 - 127,281,950 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710126,703,318 - 126,719,015 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610126,669,348 - 126,684,756 (+)NCBIMGSCv36mm8
Celera10129,658,775 - 129,674,400 (+)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1074.5NCBI
Dctn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554585,247,871 - 5,265,242 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554585,247,871 - 5,264,424 (-)NCBIChiLan1.0ChiLan1.0
DCTN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11231,638,272 - 31,655,458 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1231,636,884 - 31,655,458 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01231,379,531 - 31,396,570 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
DCTN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1101,620,702 - 1,634,385 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl101,620,724 - 1,634,309 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha101,683,865 - 1,697,555 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0101,629,967 - 1,643,711 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl101,630,053 - 1,643,684 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1101,607,705 - 1,621,392 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0101,849,593 - 1,863,307 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0101,974,591 - 1,988,304 (-)NCBIUU_Cfam_GSD_1.0
Dctn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494557,175,175 - 57,191,709 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366461,678,678 - 1,695,142 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049366461,678,678 - 1,695,142 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DCTN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl522,799,287 - 22,814,362 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1522,799,286 - 22,814,358 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
DCTN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11153,438,878 - 53,456,181 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1153,439,249 - 53,456,267 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037192,507,976 - 192,525,286 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dctn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462480210,412,466 - 10,429,354 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dctn2
19 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:185
Count of miRNA genes:118
Interacting mature miRNAs:139
Transcripts:ENSRNOT00000008120
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72673740163902784Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)72940968374409683Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73111283276112832Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73429328279293282Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73429328279293282Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73796056982960569Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)74278731487787314Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74486753389867533Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74659007091590070Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74725178365728867Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)74765143992651439Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)74765143992651439Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)74765143992651439Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)74765143992651439Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)74765143992651439Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)753612714103945643Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)759238038104238038Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)761074194106074194Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)762004452101773158Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)762004452101773158Rat

Markers in Region
D10Wsu93e  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2763,107,661 - 63,107,912 (+)MAPPERmRatBN7.2
Rnor_6.0770,571,535 - 70,571,785NCBIRnor6.0
Rnor_5.0770,745,685 - 70,745,935UniSTSRnor5.0
RGSC_v3.4767,239,405 - 67,239,655UniSTSRGSC3.4
Celera760,248,201 - 60,248,451UniSTS
Cytogenetic Map7q22UniSTS
RH127945  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2763,107,133 - 63,107,316 (+)MAPPERmRatBN7.2
Rnor_6.0770,571,007 - 70,571,189NCBIRnor6.0
Rnor_5.0770,745,157 - 70,745,339UniSTSRnor5.0
RGSC_v3.4767,238,876 - 67,239,058UniSTSRGSC3.4
Celera760,247,673 - 60,247,855UniSTS
Cytogenetic Map7q22UniSTS
C87049  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2763,107,063 - 63,107,319 (+)MAPPERmRatBN7.2
Rnor_6.0770,570,937 - 70,571,192NCBIRnor6.0
Rnor_5.0770,745,087 - 70,745,342UniSTSRnor5.0
RGSC_v3.4767,238,806 - 67,239,061UniSTSRGSC3.4
Celera760,247,603 - 60,247,858UniSTS
Cytogenetic Map7q22UniSTS
RH136664  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2763,094,609 - 63,094,794 (+)MAPPERmRatBN7.2
Rnor_6.0770,558,483 - 70,558,667NCBIRnor6.0
Rnor_5.0770,732,633 - 70,732,817UniSTSRnor5.0
RGSC_v3.4767,226,352 - 67,226,536UniSTSRGSC3.4
Celera760,235,141 - 60,235,325UniSTS
Cytogenetic Map7q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000008120   ⟹   ENSRNOP00000008120
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl763,092,057 - 63,107,552 (+)Ensembl
Rnor_6.0 Ensembl770,556,024 - 70,571,287 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000087495   ⟹   ENSRNOP00000069048
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl763,092,057 - 63,108,543 (+)Ensembl
Rnor_6.0 Ensembl770,556,019 - 70,572,614 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000098512   ⟹   ENSRNOP00000080467
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl763,092,057 - 63,107,552 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000099598   ⟹   ENSRNOP00000096519
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl763,092,057 - 63,107,552 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000102052   ⟹   ENSRNOP00000086082
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl763,092,406 - 63,107,413 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111694   ⟹   ENSRNOP00000081052
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl763,092,159 - 63,107,555 (+)Ensembl
RefSeq Acc Id: NM_001004239   ⟹   NP_001004239
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2763,092,151 - 63,107,415 (+)NCBI
Rnor_6.0770,556,024 - 70,571,288 (+)NCBI
Rnor_5.0770,730,089 - 70,745,583 (+)NCBI
RGSC_v3.4767,223,893 - 67,239,157 (+)RGD
Celera760,232,682 - 60,247,954 (+)RGD
Sequence:
RefSeq Acc Id: XM_006241448   ⟹   XP_006241510
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2763,092,064 - 63,107,560 (+)NCBI
Rnor_6.0770,555,953 - 70,571,433 (+)NCBI
Rnor_5.0770,730,089 - 70,745,583 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594742   ⟹   XP_017450231
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2763,092,063 - 63,107,560 (+)NCBI
Rnor_6.0770,555,997 - 70,571,433 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594743   ⟹   XP_017450232
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2763,092,061 - 63,107,560 (+)NCBI
Rnor_6.0770,555,994 - 70,571,433 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039078752   ⟹   XP_038934680
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2763,092,063 - 63,107,560 (+)NCBI
RefSeq Acc Id: XM_039078753   ⟹   XP_038934681
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2763,092,062 - 63,107,560 (+)NCBI
RefSeq Acc Id: XM_039078754   ⟹   XP_038934682
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2763,092,063 - 63,107,560 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001004239   ⟸   NM_001004239
- UniProtKB: Q6AYH5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006241510   ⟸   XM_006241448
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZQ44 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450232   ⟸   XM_017594743
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017450231   ⟸   XM_017594742
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AQX8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000008120   ⟸   ENSRNOT00000008120
RefSeq Acc Id: ENSRNOP00000069048   ⟸   ENSRNOT00000087495
RefSeq Acc Id: XP_038934681   ⟸   XM_039078753
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038934680   ⟸   XM_039078752
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038934682   ⟸   XM_039078754
- Peptide Label: isoform X6
RefSeq Acc Id: ENSRNOP00000096519   ⟸   ENSRNOT00000099598
RefSeq Acc Id: ENSRNOP00000081052   ⟸   ENSRNOT00000111694
RefSeq Acc Id: ENSRNOP00000086082   ⟸   ENSRNOT00000102052
RefSeq Acc Id: ENSRNOP00000080467   ⟸   ENSRNOT00000098512

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AYH5-F1-model_v2 AlphaFold Q6AYH5 1-402 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695278
Promoter ID:EPDNEW_R5780
Type:initiation region
Name:Dctn2_1
Description:dynactin subunit 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0770,556,020 - 70,556,080EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303182 AgrOrtholog
BioCyc Gene G2FUF-33756 BioCyc
Ensembl Genes ENSRNOG00000025481 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000008120 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000069048.1 UniProtKB/TrEMBL
  ENSRNOP00000080467 ENTREZGENE
  ENSRNOP00000080467.1 UniProtKB/TrEMBL
  ENSRNOP00000081052.1 UniProtKB/TrEMBL
  ENSRNOP00000086082.1 UniProtKB/TrEMBL
  ENSRNOP00000096519 ENTREZGENE
  ENSRNOP00000096519.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008120 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000087495.2 UniProtKB/TrEMBL
  ENSRNOT00000098512 ENTREZGENE
  ENSRNOT00000098512.1 UniProtKB/TrEMBL
  ENSRNOT00000099598 ENTREZGENE
  ENSRNOT00000099598.1 UniProtKB/TrEMBL
  ENSRNOT00000102052.1 UniProtKB/TrEMBL
  ENSRNOT00000111694.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7114929 IMAGE-MGC_LOAD
InterPro Dynamitin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:299850 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93976 IMAGE-MGC_LOAD
NCBI Gene 299850 ENTREZGENE
PANTHER PTHR15346 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Dynamitin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dctn2 PhenoGen
UniProt A0A0G2JUC7_RAT UniProtKB/TrEMBL
  A0A8I5ZQ44 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZRL5_RAT UniProtKB/TrEMBL
  A0A8I6A5C2_RAT UniProtKB/TrEMBL
  A0A8I6AQX8 ENTREZGENE, UniProtKB/TrEMBL
  DCTN2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-02 Dctn2  dynactin subunit 2  Dctn2  dynactin 2 (p50)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-01-10 Dctn2  dynactin 2 (p50)  Dctn2  dynactin 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Dctn2  dynactin 2      Symbol and Name status set to approved 1299863 APPROVED
2005-07-14 Dctn2  dynactin 2      Symbol and Name status set to provisional 70820 PROVISIONAL