Mars1 (methionyl-tRNA synthetase 1)

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Gene: Mars1 (methionyl-tRNA synthetase 1) Rattus norvegicus

Analyze

Symbol:

Mars1

Name:

methionyl-tRNA synthetase 1

RGD ID:

1305321

Description:

Predicted to have methionine-tRNA ligase activity. Predicted to be involved in several processes, including RNA metabolic process; cellular response to growth factor stimulus; and positive regulation of transcription of nucleolar large rRNA by RNA polymerase I. Localizes to aminoacyl-tRNA synthetase multienzyme complex. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2U. Orthologous to human MARS1 (methionyl-tRNA synthetase 1); PARTICIPATES IN glycine N-methyltransferase deficiency pathway; homocystinuria pathway; hypermethioninemia pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

LOC299851; Mars; methionine--tRNA ligase, cytoplasmic; methionine-tRNA synthetase; methionyl-tRNA synthetase

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MARS1 (methionyl-tRNA synthetase 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Mars1 (methionine-tRNA synthetase 1)	HGNC	Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Mars1 (methionyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MARS1 (methionyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MARS1 (methionyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mars1 (methionyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MARS1 (methionyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	MARS1 (methionyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mars1 (methionyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	MARS1 (methionyl-tRNA synthetase 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Mus musculus (house mouse):	Mars1 (methionine-tRNA synthetase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Danio rerio (zebrafish):	mars (methionyl-tRNA synthetase)	Alliance	DIOPT (PhylomeDB\|TreeFam)
Caenorhabditis elegans (roundworm):	mars-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Saccharomyces cerevisiae (baker's yeast):	MES1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Drosophila melanogaster (fruit fly):	MetRS	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	7	70,585,011 - 70,602,425 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	70,585,013 - 70,602,310 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	70,759,159 - 70,776,559 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	67,252,510 - 67,269,807 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	7	67,273,245 - 67,290,584 (-)	NCBI
Celera	7	60,261,413 - 60,278,690 (-)	NCBI		Celera
Cytogenetic Map	7	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Charcot-Marie-Tooth disease (ISO)

Charcot-Marie-Tooth disease axonal type 2U (ISO)

hereditary spastic paraplegia (ISO)

INTERSTITIAL LUNG AND LIVER DISEASE (ISO)

pulmonary alveolar proteinosis (ISO)

sensory peripheral neuropathy (ISO)

spinal muscular atrophy (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1-naphthyl isothiocyanate (EXP)

1-nitropyrene (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

5-fluorouracil (ISO)

aflatoxin B2 (ISO)

antirheumatic drug (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

butan-1-ol (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

chloropicrin (ISO)

choline (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

decabromodiphenyl ether (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

ethanol (ISO)

folic acid (ISO)

gemcitabine (ISO)

L-methionine (ISO)

lamivudine (ISO)

lead diacetate (EXP)

methapyrilene (EXP)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

mono(2-ethylhexyl) phthalate (ISO)

nickel atom (ISO)

nickel dichloride (ISO)

ochratoxin A (ISO)

p-chloromercuribenzoic acid (ISO)

paracetamol (ISO)

piroxicam (ISO)

progesterone (ISO)

S-butyl-DL-homocysteine (S,R)-sulfoximine (EXP)

Salinomycin (ISO)

SB 431542 (ISO)

silver atom (ISO)

silver(0) (ISO)

tetrachloromethane (EXP)

thapsigargin (ISO)

titanium dioxide (ISO)

trimellitic anhydride (ISO)

tunicamycin (ISO)

valproic acid (ISO)

vincristine (ISO)

vorinostat (ISO)

zidovudine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to epidermal growth factor stimulus (ISO)

cellular response to insulin stimulus (ISO)

cellular response to platelet-derived growth factor stimulus (ISO)

cellular response to starvation (ISO)

methionyl-tRNA aminoacylation (ISO)

positive regulation of transcription of nucleolar large rRNA by RNA polymerase I (ISO)

rRNA transcription (ISO)

tRNA aminoacylation for protein translation (IBA)

Cellular Component

aminoacyl-tRNA synthetase multienzyme complex (IDA,ISO)

cytoplasm (ISO)

cytosol (IBA,ISO)

nucleolus (ISO)

Molecular Function

ATP binding (IEA)

methionine-tRNA ligase activity (ISO)

protein binding (IPI)

Molecular Pathway Annotations Click to see Annotation Detail View

aminoacyl-tRNA biosynthetic pathway (IEA)

glycine N-methyltransferase deficiency pathway (ISO)

homocystinuria pathway (ISO)

hypermethioninemia pathway (ISO)

methionine cycle/metabolic pathway (ISO)

methylenetetrahydrofolate reductase deficiency pathway (ISO)

selenoamino acid metabolic pathway (IEA,ISO)

References

References - curated


1.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA data from the GO Consortium
3.	OMIM Disease Annotation Pipeline
4.	Pipeline to import KEGG annotations from KEGG into RGD
5.	Pipeline to import SMPDB annotations from SMPDB into RGD
6.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	RGD automated import pipeline for gene-chemical interactions
8.	Topalidou I, etal., PLoS Genet. 2016 May 18;12(5):e1006074. doi: 10.1371/journal.pgen.1006074. eCollection 2016 May.
9.	Yannay-Cohen N, etal., Mol Cell. 2009 Jun 12;34(5):603-11. doi: 10.1016/j.molcel.2009.05.019.

Additional References at PubMed

PMID:10791971	PMID:11714285	PMID:12060739	PMID:18614015	PMID:19131329	PMID:19289464	PMID:19946888	PMID:20458337	PMID:22424946

Genomics

Comparative Map Data

Mars1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	7	70,585,011 - 70,602,425 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	70,585,013 - 70,602,310 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	70,759,159 - 70,776,559 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	67,252,510 - 67,269,807 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	7	67,273,245 - 67,290,584 (-)	NCBI
Celera	7	60,261,413 - 60,278,690 (-)	NCBI		Celera
Cytogenetic Map	7	q22	NCBI

MARS1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	12	57,475,445 - 57,517,569 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	12	57,488,068 - 57,516,655 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	12	57,881,736 - 57,910,438 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	56,168,118 - 56,196,700 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	12	56,168,117 - 56,196,700	NCBI
Celera	12	57,535,658 - 57,566,266 (+)	NCBI
Cytogenetic Map	12	q13.3	NCBI
HuRef	12	54,919,857 - 54,948,436 (+)	NCBI		HuRef
CHM1_1	12	57,849,852 - 57,878,293 (+)	NCBI		CHM1_1

Mars1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	127,132,090 - 127,147,655 (-)	NCBI	GRCm39		mm39
GRCm38	10	127,296,221 - 127,311,786 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	127,296,221 - 127,311,786 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	126,733,277 - 126,748,842 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	10	126,699,175 - 126,714,588 (-)	NCBI			mm8
Celera	10	129,688,532 - 129,704,394 (-)	NCBI		Celera
Cytogenetic Map	10	D3	NCBI

Mars1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955458	5,215,853 - 5,233,037 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955458	5,215,853 - 5,233,037 (+)	NCBI	ChiLan1.0	ChiLan1.0

MARS1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	12	31,668,634 - 31,693,988 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	31,668,708 - 31,693,839 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	12	31,410,231 - 31,438,015 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

MARS1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	10	1,588,875 - 1,606,750 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	10	1,588,503 - 1,606,752 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Mars1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936646	1,644,457 - 1,665,081 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MARS1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	22,751,921 - 22,785,928 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	22,752,405 - 22,785,509 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

MARS1
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	53,397,380 - 53,410,596 (+)	NCBI

Mars1
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624802	10,443,216 - 10,460,971 (-)	NCBI

Position Markers

RH128750

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	7	70,585,083 - 70,585,384	NCBI	Rnor6.0
Rnor_5.0	7	70,759,229 - 70,759,530	UniSTS	Rnor5.0
RGSC_v3.4	7	67,252,580 - 67,252,881	UniSTS	RGSC3.4
Celera	7	60,261,483 - 60,261,784	UniSTS
Cytogenetic Map	7	q22	UniSTS

RH141558

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	7	70,584,745 - 70,584,963	NCBI	Rnor6.0
Rnor_5.0	7	70,758,891 - 70,759,109	UniSTS	Rnor5.0
RGSC_v3.4	7	67,252,242 - 67,252,460	UniSTS	RGSC3.4
Celera	7	60,261,145 - 60,261,363	UniSTS
Cytogenetic Map	7	q22	UniSTS

PMC150726P4

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	7	70,584,635 - 70,584,938	NCBI	Rnor6.0
Rnor_5.0	7	70,758,781 - 70,759,084	UniSTS	Rnor5.0
RGSC_v3.4	7	67,252,132 - 67,252,435	UniSTS	RGSC3.4
Celera	7	60,261,035 - 60,261,338	UniSTS
Cytogenetic Map	7	q22	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	2920071	124838025	Rat
1643004	Pain2	Pain QTL 2	1		mechanical nociception trait (VT:0002734)	self mutilation severity score (CMO:0002145)	7	12328467	106995532	Rat
1300132	Bp182	Blood pressure QTL 182	3.49		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	7	25365633	93155402	Rat
7411569	Bw137	Body weight QTL 137		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	7	28204653	73204653	Rat
1641885	Alcrsp9	Alcohol response QTL 9			alcohol metabolism trait (VT:0015089)	blood ethanol level (CMO:0000535)	7	31381529	76381529	Rat
1549840	Bss5	Bone structure and strength QTL 5	9.8		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	7	32035053	77035053	Rat
61439	Cia8	Collagen induced arthritis QTL 8	5.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	7	32572942	77572942	Rat
70190	Mcs6	Mammary carcinoma susceptibility QTL 6	2.29		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	7	33044449	71352127	Rat
10402855	Bp379	Blood pressure QTL 379		0.21	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	35867729	80867729	Rat
1300127	Srn1	Serum renin concentration QTL 1	3.87		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	7	35867729	93155402	Rat
10755453	Coatc12	Coat color QTL 12		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	38547706	83547706	Rat
631534	Lnnr1	Liver neoplastic nodule remodeling QTL 1	3.85	0.001	liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)	7	40872682	85872682	Rat
7411605	Foco14	Food consumption QTL 14	24.1	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	40872682	85872682	Rat
631513	Scl7	Serum cholesterol level QTL 7	4.1		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	7	45301573	90301573	Rat
61357	Bp38	Blood pressure QTL 38	1.6	0.052	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	48118835	128611831	Rat
634326	Hc3	Hypercalciuria QTL 3	2.1		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	7	50252103	95252103	Rat
631504	Cm27	Cardiac mass QTL 27	3.45		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	7	50704769	128085642	Rat
10053722	Scort27	Serum corticosterone level QTL 27	2.41	0.0083	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	7	50793818	95793818	Rat
1358361	Sradr5	Stress Responsive Adrenal Weight QTL 5	5.55		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	7	51251919	118477612	Rat
1300179	Kidm5	Kidney mass QTL 5	3.51		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	51251919	145729302	Rat
1300149	Cm6	Cardiac mass QTL 6	4.09		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	7	51252005	111589099	Rat
61428	Scl3	Serum cholesterol level QTL 3	3.2		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	7	53200344	98200344	Rat
738030	Anxrr8	Anxiety related response QTL 8	4.1		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	54259512	99259512	Rat
10059605	Kidm47	Kidney mass QTL 47	2.91	0.05	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	7	54534996	73293934	Rat
2316947	Rf58	Renal function QTL 58	7.8		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	7	55072862	123602998	Rat
2316952	Pur22	Proteinuria QTL 22	5.2		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	7	55072862	123602998	Rat
2316955	Stl24	Serum triglyceride level QTL 24	7.1		blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	7	55072862	123602998	Rat
2300178	Bmd54	Bone mineral density QTL 54	5.3	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	7	55495689	100495689	Rat
2293644	Bmd29	Bone mineral density QTL 29	5.4	0.0001	femur size trait (VT:1000369)	femoral neck cross-sectional area (CMO:0001697)	7	55495689	100495689	Rat
2293667	Bss42	Bone structure and strength QTL 42	7.25	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra cross-sectional area (CMO:0001689)	7	55495689	100495689	Rat
2293678	Bss24	Bone structure and strength QTL 24	6.71	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	7	55495689	100495689	Rat
2293685	Bmd21	Bone mineral density QTL 21	4.2	0.0003	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	7	55495689	100495689	Rat
2293696	Bmd32	Bone mineral density QTL 32	5.1	0.0001	femur strength trait (VT:0010010)	femoral neck polar moment of inertia (CMO:0001670)	7	55495689	100495689	Rat
2293707	Bss32	Bone structure and strength QTL 32	7.64	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	7	55495689	100495689	Rat
1300151	Bp181	Blood pressure QTL 181	3.36		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	7	61047589	113228378	Rat
2317035	Aia16	Adjuvant induced arthritis QTL 16	2.71		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	7	68518460	113518460	Rat
1576303	Ept7	Estrogen-induced pituitary tumorigenesis QTL 7	3.7		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	7	69399586	111043530	Rat
1559283	Emca4	Estrogen-induced mammary cancer QTL 4	3.7		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	7	69399586	111043530	Rat
1298528	Bp169	Blood pressure QTL 169		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	70421228	115421228	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	17
Count of miRNA genes:	16
Interacting mature miRNAs:	17
Transcripts:	ENSRNOT00000035486
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	11	74	35	41	11	8
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001127659	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006241451	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAHX01049883	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC114111	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473950	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000035486 ⟹ ENSRNOP00000034945

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	7	70,585,013 - 70,602,310 (-)	Ensembl

RefSeq Acc Id:

NM_001127659 ⟹ NP_001121131

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	70,585,013 - 70,602,310 (-)	NCBI
Rnor_5.0	7	70,759,159 - 70,776,559 (-)	NCBI
RGSC_v3.4	7	67,252,510 - 67,269,807 (-)	RGD
Celera	7	60,261,413 - 60,278,690 (-)	RGD

Sequence:

show sequence

CCGAGACACGATGAGGCTGTTCGTGAGCGAAGGCTCCCCGGGTAGCCTGCCGGTGCTGGCTGCG
GCCGCGAGGGCCCGGGGCCGGGCGGAGCTGCTCATCAGCACCGTAGGCCCCGAAGAGTGTGTGG
TACCATTTCTTACCCGGCCTAAGGTCCCTGTCTTGCAGCTGGATAGCGGCAACTACCTCTTCTC
TGCTAGTGCAATCTGCCGATATTTTTTTCTGTTATGCGGCTGGGAACAAGATGATCTTACCAAC
CAATGGCTGGAATGGGAAGCAACAGAACTGCAGCCGGTTCTGTCTGCTGCCCTATACTGTCTAG
TGGTTCAAGGCAAAAAAGGGGAAGATGTACTTGGCCCACTTCGGAGAGTCCTGACTCACATTGA
TCACAGCTTGAGTCGGCAAAACTGTCCTTTCTTGGCAGGGGACACAGAATCTCTAGCTGACATT
GTTTTGTGGGGAGCACTATATCCTTTACTGCAAGACCCAGCTTACCTCCCTGAGGAGTTGGGTG
CCCTACAAAGCTGGTTCCAGACACTAAGTACCCAGGAGCCATGTCAGCGAGCTGCAGAGACTGT
GCTGAAACAGCAGGGTGTCCTGGCACTGCGTCCCTACCTCCAAAAACAGCCCCAGCCCCAGCCC
CTACCTCCTGAGGGGAGAGCTGTCAGCAATGAACCTGAGGAGGAAGAGCTGGCTACCCTGTCTG
AGGAGGACATCATTGCTGCTGTTGCTGCTTGGGAGAAGGGTCTGGAAAACTTACCTCCACTACA
GCCCCAGCAGCATCCAGTGTTGCCTGTGCCTGGAGAAAGGAATGTGCTCATCACGAGTGCCCTC
CCTTATGTCAACAATGTCCCCCACCTTGGAAACATCATTGGCTGTGTGCTCAGTGCTGATGTCT
TTGCAAGGTACTCTCGCCTTCGCCAGTGGAACACCCTCTATCTGTGTGGCACAGATGAGTATGG
TACTGCGACAGAGACCAAGGCCATGGAAGAGGGTCTAACCCCACAAGAAATCTGTGACAAATAC
CACGCCATACATGTTGACATCTACCGCTGGTTCAATATATCGTTTGATACGTTCGGTCGCACAA
CCACTCCTCTGCAGACCAAAATCACACAGGACATCTTCCAGAGGTTGCTGACACGGGGTTTTGT
GCTGCAAGATACTGTAGAGCAGCTTCGCTGTGAGCAGTGTGCACGTTTCTTGGCTGACCGCTTT
GTGGAGGGAGTGTGTCCCTTTTGTGGCTATGAAGAGGCCCGGGGTGACCAGTGTGACAAGTGTG
GCAAGCTCATCAATGCCATTGAGCTCAAGAGACCTCAGTGCAAAGTCTGCCGCTCCCACCCTGT
GGTGAAGTCCTCAAAGCACCTGTTTCTAGACTTGCCTAAGTTAGAGAAGCGCCTGGAGGACTGG
CTGGGGAAGACGATGCCTGGCAGTGACTGGACACCCAATGCCAGGTTCATTATTCGATCCTGGC
TTCGAGATGGACTCAAGCCACGATGCATCACCAGAGACCTCAAATGGGGAACTCCTGTGCCCTT
GGAAGGTTTTGAGGACAAGGTATTTTATGTCTGGTTTGATGCTACTATTGGCTATCTGTCCATC
ACAGCCAACTACACAGACCAGTGGGAGAGATGGTGGAAGAATCCAGAACAAGTGGACCTTTACC
AGTTCATGGCCAAAGACAATGTTCCCTTCCATGGCTTGGTCTTTCCTTGTTCAGCCCTAGGAGC
TGAGGATAACTACACCTTAGTCAAGAACCTCATCGCTACAGAATACCTGAACTACGAGGACGGG
AAGTTCTCTAAGAGCCGGGGGATAGGAGTGTTTGGAGACATGGCCCAAGATACAGGGATCCCTG
CTGACATCTGGCGATTCTATCTGCTATACATTCGGCCTGAGGGCCAGGACAGTGCCTTCTCCTG
GACAGACTTGCTGATTAAAAACAATTCTGAGCTGCTTAACAACCTGGGCAACTTCATCAATAGA
GCTGGCATGTTCGTGTCTAAGTTTTTTGGGGGTTGTGTGCCTGAGATGGTGCTGACCCACGATG
ACAGACGCCTGGTGGCACATGTCTCCTGGGAACTCCAGCGCTATCACCAGCTGTTGGAAAAGGT
TCGGATCCGGGATGCCTTGCGCAGTATCCTTACCATATCTCGGCATGGCAACCAATATATTCAA
GTGAATGAGCCCTGGAAACGGATTAAAGGCGATGAGATGGACAGGCAGCGGGCAGGCACGGTGA
CAGGAATGGCAGTGAACATAGCTGCCTTGCTGTCTGTCATGCTCCAGCCGTACATGCCCACAGT
CAGCTCCACCATTCAGACCCAGCTCCAGCTCCCAGAGGCAGCCTGCCGCATCCTTGCCACAAGC
TTCATTTGTACCTTACCAGCAGGCCACCGAATTGGCACAGTCAGTCCTTTGTTCCAGAAATTGG
AAAATGACCAGATTGAAAATTTGAGGCAGCGCTTTGGAGGGGGCCAGGCTAAAGGGTCCCCCAA
GCCAGCAGTTGTTGAGGCAGTTACTACAGCAGGGTCGCAGGACATACAAGTGCTGGTGGATGAG
GTAACCAAACAGGGAAACATAGTTCGGGAACTGAAAGCACAGAAGGCAGACAAGAACCAGGTTG
CTGCAGAAGTGGCTAAACTCTTGGATCTAAAGAAACAGTTGGCTTTGGCTGAGGGGAAGCCCAT
TGAAACTCCGAAAGGCAAGAAGAAAAAGTGAGAGAATGTTCACACAAAGTCACTTTACTGGGTA
TGGACAGTAATAAAGAATGTACAGTGTACAA

hide sequence

RefSeq Acc Id:

XM_006241451 ⟹ XP_006241513

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	70,585,011 - 70,602,425 (-)	NCBI
Rnor_5.0	7	70,759,159 - 70,776,559 (-)	NCBI

Sequence:

show sequence

CGGCTTTCTTGGAGCTGACTGCGAGCGTGCGGCCGCCCCAGAACTCCATTTCCCTATATACCTT
GCAGCTTAACCCAGAAGCTGGAGGCCCGTTCCGGTTGCATCAGCGTGGGCTCCGAGACACGATG
AGGCTGTTCGTGAGCGAAGGCTCCCCGGGTAGCCTGCCGGTGCTGGCTGCGGCCGCGAGGGCCC
GGGGCCGGGCGGAGCTGCTCATCAGCACCGTAGGCCCCGAAGAGTGTGTGGTACCATTTCTTAC
CCGGCCTAAGGTCCCTGTCTTGCAGCTGGATAGCGGCAACTACCTCTTCTCTGCTAGTGCAATC
TGCCGATATTTTTTTCTGTTATGCGGCTGGGAACAAGATGATCTTACCAACCAATGGCTGGAAT
GGGAAGCAACAGAACTGCAGCCGGTTCTGTCTGCTGCCCTATACTGTCTAGTGGTTCAAGGCAA
AAAAGGGGAAGATGTACTTGGCCCACTTCGGAGAGTCCTGACTCACATTGATCACAGCTTGAGT
CGGCAAAACTGTCCTTTCTTGGCAGGGGACACAGAATCTCTAGCTGACATTGTTTTGTGGGGAG
CACTATATCCTTTACTGCAAGACCCAGCTTACCTCCCTGAGGAGTTGGGTGCCCTACAAAGCTG
GTTCCAGACACTAAGTACCCAGGAGCCATGTCAGCGAGCTGCAGAGACTGTGCTGAAACAGCAG
GGTGTCCTGGCACTGCGTCCCTACCTCCAAAAACAGCCCCAGCCCCAGCCCCTACCTCCTGAGG
GGAGAGCTGTCAGCAATGAACCTGAGGAGGAAGAGCTGGCTACCCTGTCTGAGGAGGACATCAT
TGCTGCTGTTGCTGCTTGGGAGAAGGGTCTGGAAAACTTACCTCCACTACAGCCCCAGCAGCAT
CCAGTGTTGCCTGTGCCTGGAGAAAGGAATGTGCTCATCACGAGTGCCCTCCCTTATGTCAACA
ATGTCCCCCACCTTGGAAACATCATTGGCTGTGTGCTCAGTGCTGATGTCTTTGCAAGGTACTC
TCGCCTTCGCCAGTGGAACACCCTCTATCTGTGTGGCACAGATGAGTATGGTACTGCGACAGAG
ACCAAGGCCATGGAAGAGGGTCTAACCCCACAAGAAATCTGTGACAAATACCACGCCATACATG
TTGACATCTACCGCTGGTTCAATATATCGTTTGATACGTTCGGTCGCACAACCACTCCTCTGCA
GACCAAAATCACACAGGACATCTTCCAGAGGTTGCTGACACGGGGTTTTGTGCTGCAAGATACT
GTAGAGCAGCTTCGCTGTGAGCAGTGTGCACGTTTCTTGGCTGACCGCTTTGTGGAGGGAGTGT
GTCCCTTTTGTGGCTATGAAGAGGCCCGGGGTGACCAGTGTGACAAGTGTGGCAAGCTCATCAA
TGCCATTGAGCTCAAGAGACCTCAGTGCAAAGTCTGCCGCTCCCACCCTGTGGTGAAGTCCTCA
AAGCACCTGTTTCTAGACTTGCCTAAGTTAGAGAAGCGCCTGGAGGACTGGCTGGGGAAGACGA
TGCCTGGCAGTGACTGGACACCCAATGCCAGGTTCATTATTCGATCCTGGCTTCGAGATGGACT
CAAGCCACGATGCATCACCAGAGACCTCAAATGGGGAACTCCTGTGCCCTTGGAAGGTTTTGAG
GACAAGGTATTTTATGTCTGGTTTGATGCTACTATTGGCTATCTGTCCATCACAGCCAACTACA
CAGACCAGTGGGAGAGATGGTGGAAGAATCCAGAACAAGTGGACCTTTACCAGTTCATGGCCAA
AGACAATGTTCCCTTCCATGGCTTGGTCTTTCCTTGTTCAGCCCTAGGAGCTGAGGATAACTAC
ACCTTAGTCAAGAACCTCATCGCTACAGAATACCTGAACTACGAGGACGGGAAGTTCTCTAAGA
GCCGGGGGATAGGAGTGTTTGGAGACATGGCCCAAGATACAGGGATCCCTGCTGACATCTGGCG
ATTCTATCTGCTATACATTCGGCCTGAGGGCCAGGACAGTGCCTTCTCCTGGACAGACTTGCTG
ATTAAAAACAATTCTGAGCTGCTTAACAACCTGGGCAACTTCATCAATAGAGCTGGCATGTTCG
TGTCTAAGTTTTTTGGGGGTTGTGTGCCTGAGATGGTGCTGACCCACGATGACAGACGCCTGGT
GGCACATGTCTCCTGGGAACTCCAGCGCTATCACCAGCTGTTGGAAAAGGTTCGGATCCGGGAT
GCCTTGCGCAGTATCCTTACCATATCTCGGCATGGCAACCAATATATTCAAGTGAATGAGCCCT
GGAAACGGATTAAAGGCGATGAGATGGACAGGCAGCGGGCAGGCACGGTGACAGGAATGGCAGT
GAACATAGCTGCCTTGCTGTCTGTCATGCTCCAGCCGTACATGCCCACAGTCAGCTCCACCATT
CAGACCCAGCTCCAGCTCCCAGAGGCAGCCTGCCGCATCCTTGCCACAAGCTTCATTTGTACCT
TACCAGCAGGCCACCGAATTGGCACAGTCAGTCCTTTGTTCCAGAAATTGGAAAATGACCAGAT
TGAAAATTTGAGGCAGCGCTTTGGAGGGGGCCAGCTAGAAGAGTCTTTGGAGTTACAGGCTAAA
GGGTCCCCCAAGCCAGCAGTTGTTGAGGCAGTTACTACAGCAGGGTCGCAGGACATACAAGTGC
TGGTGGATGAGGTAACCAAACAGGGAAACATAGTTCGGGAACTGAAAGCACAGAAGGCAGACAA
GAACCAGGTTGCTGCAGAAGTGGCTAAACTCTTGGATCTAAAGAAACAGTTGGCTTTGGCTGAG
GGGAAGCCCATTGAAACTCCGAAAGGCAAGAAGAAAAAGTGAGAGAATGTTCACACAAAGTCAC
TTTACTGGGTATGGACAGTAATAAAGAATGTACAGTGTACAAGC

hide sequence

Protein Sequences


Protein RefSeqs	NP_001121131	(Get FASTA)	NCBI Sequence Viewer
	XP_006241513	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM16472	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001121131 ⟸ NM_001127659

- UniProtKB:

D3Z941 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MRLFVSEGSPGSLPVLAAAARARGRAELLISTVGPEECVVPFLTRPKVPVLQLDSGNYLFSASA
ICRYFFLLCGWEQDDLTNQWLEWEATELQPVLSAALYCLVVQGKKGEDVLGPLRRVLTHIDHSL
SRQNCPFLAGDTESLADIVLWGALYPLLQDPAYLPEELGALQSWFQTLSTQEPCQRAAETVLKQ
QGVLALRPYLQKQPQPQPLPPEGRAVSNEPEEEELATLSEEDIIAAVAAWEKGLENLPPLQPQQ
HPVLPVPGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTAT
ETKAMEEGLTPQEICDKYHAIHVDIYRWFNISFDTFGRTTTPLQTKITQDIFQRLLTRGFVLQD
TVEQLRCEQCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAIELKRPQCKVCRSHPVVKS
SKHLFLDLPKLEKRLEDWLGKTMPGSDWTPNARFIIRSWLRDGLKPRCITRDLKWGTPVPLEGF
EDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHGLVFPCSALGAEDN
YTLVKNLIATEYLNYEDGKFSKSRGIGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDL
LIKNNSELLNNLGNFINRAGMFVSKFFGGCVPEMVLTHDDRRLVAHVSWELQRYHQLLEKVRIR
DALRSILTISRHGNQYIQVNEPWKRIKGDEMDRQRAGTVTGMAVNIAALLSVMLQPYMPTVSST
IQTQLQLPEAACRILATSFICTLPAGHRIGTVSPLFQKLENDQIENLRQRFGGGQAKGSPKPAV
VEAVTTAGSQDIQVLVDEVTKQGNIVRELKAQKADKNQVAAEVAKLLDLKKQLALAEGKPIETP
KGKKKK

hide sequence

RefSeq Acc Id:

XP_006241513 ⟸ XM_006241451

- Peptide Label:

isoform X1

- Sequence:

show sequence

MRLFVSEGSPGSLPVLAAAARARGRAELLISTVGPEECVVPFLTRPKVPVLQLDSGNYLFSASA
ICRYFFLLCGWEQDDLTNQWLEWEATELQPVLSAALYCLVVQGKKGEDVLGPLRRVLTHIDHSL
SRQNCPFLAGDTESLADIVLWGALYPLLQDPAYLPEELGALQSWFQTLSTQEPCQRAAETVLKQ
QGVLALRPYLQKQPQPQPLPPEGRAVSNEPEEEELATLSEEDIIAAVAAWEKGLENLPPLQPQQ
HPVLPVPGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTAT
ETKAMEEGLTPQEICDKYHAIHVDIYRWFNISFDTFGRTTTPLQTKITQDIFQRLLTRGFVLQD
TVEQLRCEQCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAIELKRPQCKVCRSHPVVKS
SKHLFLDLPKLEKRLEDWLGKTMPGSDWTPNARFIIRSWLRDGLKPRCITRDLKWGTPVPLEGF
EDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHGLVFPCSALGAEDN
YTLVKNLIATEYLNYEDGKFSKSRGIGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDL
LIKNNSELLNNLGNFINRAGMFVSKFFGGCVPEMVLTHDDRRLVAHVSWELQRYHQLLEKVRIR
DALRSILTISRHGNQYIQVNEPWKRIKGDEMDRQRAGTVTGMAVNIAALLSVMLQPYMPTVSST
IQTQLQLPEAACRILATSFICTLPAGHRIGTVSPLFQKLENDQIENLRQRFGGGQLEESLELQA
KGSPKPAVVEAVTTAGSQDIQVLVDEVTKQGNIVRELKAQKADKNQVAAEVAKLLDLKKQLALA
EGKPIETPKGKKKK

hide sequence

RefSeq Acc Id:

ENSRNOP00000034945 ⟸ ENSRNOT00000035486

Protein Domains

GST C-terminal WHEP-TRS

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695257

Promoter ID:

EPDNEW_R5782

Type:

initiation region

Name:

Mars_1

Description:

methionyl-tRNA synthetase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	70,602,320 - 70,602,380	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

Visual

CSV

TAB

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

Visual

CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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CSV

TAB

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

Visual

CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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CSV

TAB

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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CSV

TAB

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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CSV

TAB

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

Visual

CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

Visual

CSV

TAB

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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CSV

TAB

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

Visual

CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

Visual

CSV

TAB

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

Visual

CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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CSV

TAB

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

Visual

CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

Visual

CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

Visual

CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

Visual

CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

Visual

CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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CSV

TAB

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

Visual

CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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CSV

TAB

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305321	AgrOrtholog
Ensembl Genes	ENSRNOG00000025459	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000034945	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000035486	ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH	2.20.28.20	UniProtKB/TrEMBL
	3.40.30.10	UniProtKB/TrEMBL
	3.40.50.620	UniProtKB/TrEMBL
InterPro	aa-tRNA-synt_I	UniProtKB/TrEMBL
	aa-tRNA-synth_I_CS	UniProtKB/TrEMBL
	Anticodon_Met	UniProtKB/TrEMBL
	Glutathione-S-Trfase_C-like	UniProtKB/TrEMBL
	Glutathione-S-Trfase_C_sf	UniProtKB/TrEMBL
	GST_C	UniProtKB/TrEMBL
	MARS_N	UniProtKB/TrEMBL
	Met-tRNA_synth_1	UniProtKB/TrEMBL
	MetRS_core	UniProtKB/TrEMBL
	MetRS_Zn	UniProtKB/TrEMBL
	Rossmann-like_a/b/a_fold	UniProtKB/TrEMBL
	S15_NS1_RNA-bd	UniProtKB/TrEMBL
	Thioredoxin-like_sf	UniProtKB/TrEMBL
	tRNA-synt_met_N	UniProtKB/TrEMBL
	tRNAsynth_1a_anticodon-bd	UniProtKB/TrEMBL
	WHEP-TRS	UniProtKB/TrEMBL
KEGG Report	rno:299851	UniProtKB/TrEMBL
NCBI Gene	299851	ENTREZGENE
Pfam	GST_C	UniProtKB/TrEMBL
	GST_N_5	UniProtKB/TrEMBL
	tRNA-synt_1g	UniProtKB/TrEMBL
	WHEP-TRS	UniProtKB/TrEMBL
PhenoGen	Mars1	PhenoGen
PRINTS	TRNASYNTHMET	UniProtKB/TrEMBL
PROSITE	AA_TRNA_LIGASE_I	UniProtKB/TrEMBL
	GST_CTER	UniProtKB/TrEMBL
	WHEP_TRS_1	UniProtKB/TrEMBL
	WHEP_TRS_2	UniProtKB/TrEMBL
SMART	WHEP-TRS	UniProtKB/TrEMBL
Superfamily-SCOP	GST_C_like	UniProtKB/TrEMBL
	S15/NS1_bind	UniProtKB/TrEMBL
	SSF57770	UniProtKB/TrEMBL
	tRNAsyn_1a_bind	UniProtKB/TrEMBL
TIGRFAMs	metG	UniProtKB/TrEMBL
UniGene	Rn.140163	ENTREZGENE
UniProt	D3Z941	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-08-08	Mars1	methionyl-tRNA synthetase 1	Mars	methionyl-tRNA synthetase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-10-05	Mars	methionyl-tRNA synthetase	Mars	methionine-tRNA synthetase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Mars	methionine-tRNA synthetase	Mars_predicted	methionine-tRNA synthetase (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Mars_predicted	methionine-tRNA synthetase (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)