Ddit3 (DNA-damage inducible transcript 3) - Rat Genome Database

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Gene: Ddit3 (DNA-damage inducible transcript 3) Rattus norvegicus
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Symbol: Ddit3
Name: DNA-damage inducible transcript 3
RGD ID: 62391
Description: Enables DNA-binding transcription factor activity and protein heterodimerization activity. Contributes to sequence-specific DNA binding activity. Involved in several processes, including cellular response to manganese ion; positive regulation of autophagy in response to ER overload; and regulation of transcription, DNA-templated. Located in cytoplasm and nucleus. Part of CHOP-C/EBP complex. Biomarker of several diseases, including borna disease; brain ischemia; chronic obstructive pulmonary disease; pulmonary venoocclusive disease; and ureteral obstruction. Human ortholog(s) of this gene implicated in myxoid liposarcoma. Orthologous to human DDIT3 (DNA damage inducible transcript 3); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; (R)-lipoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: C/EBP homologous protein; C/EBP zeta; c/EBP-homologous protein; c/EBP-homologous protein 10; CCAAT/enhancer-binding protein homologous protein; CHOP; CHOP-10; Chop10; DDIT-3; DNA damage-inducible transcript 3; Gadd153; growth arrest and DNA-damage-inducible protein GADD153; MGC124604; RM4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2763,115,645 - 63,121,203 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl763,116,380 - 63,121,201 (+)Ensembl
Rnor_6.0770,578,564 - 70,585,074 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl770,580,198 - 70,585,084 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0770,753,800 - 70,759,220 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4767,247,749 - 67,252,571 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1767,268,487 - 67,273,294 (+)NCBI
Celera760,256,651 - 60,261,474 (+)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+)-schisandrin B  (EXP)
(+)-Tetrandrine  (ISO)
(-)-anisomycin  (ISO)
(-)-citrinin  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-gambogic acid  (ISO)
(-)-quinic acid  (ISO)
(E)-thiamethoxam  (ISO)
(R)-lipoic acid  (EXP,ISO)
(R)-noradrenaline  (EXP)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(R,S)-Scoulerine  (ISO)
(S)-amphetamine  (ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (EXP,ISO)
(Z)-3-butylidenephthalide  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dithiothreitol  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP,ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
15-acetyldeoxynivalenol  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4,6-trinitrotoluene  (ISO)
2,4-diaminotoluene  (ISO)
2,4-dichlorophenol  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-arachidonoylglycerol  (ISO)
2-butoxyethanol  (ISO)
2-deoxy-D-glucose  (ISO)
2-hydroxypropanoic acid  (ISO)
2-tert-butylhydroquinone  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3'-diindolylmethane  (ISO)
3,4-dihydrocoumarin  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutylamine  (ISO)
4-phenylbutyric acid  (EXP,ISO)
4-phenylcoumarin  (ISO)
5-(N,N-hexamethylene)amiloride  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP)
7,12-dimethyltetraphene  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
[6]-Shogaol  (ISO)
acetaldehyde  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (EXP,ISO)
acrolein  (EXP,ISO)
acrylamide  (EXP,ISO)
acrylonitrile  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinal  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allopurinol  (ISO)
alloxan  (ISO)
Aloe emodin  (ISO)
alpha-(methylamino)isobutyric acid  (ISO)
alpha-D-galactose  (ISO)
alpha-naphthoflavone  (ISO)
AM-251  (ISO)
amiloride  (ISO)
amino acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
amosite asbestos  (ISO)
amphibole asbestos  (ISO)
anandamide  (ISO)
aniline  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimycin A  (EXP,ISO)
antirheumatic drug  (ISO)
apigenin  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
atazanavir sulfate  (ISO)
atrazine  (ISO)
auraptene  (ISO)
Auriculasin  (ISO)
Aurin  (ISO)
avermectin  (ISO)
azathioprine  (ISO)
azoxystrobin  (ISO)
BAPTA  (ISO)
benomyl  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bepridil  (ISO)
beta-cyclodextrin  (ISO)
beta-D-glucosamine  (ISO)
betulinic acid  (ISO)
bexarotene  (EXP)
bilirubin IXalpha  (ISO)
biphenyl-4-amine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bongkrekic acid  (ISO)
boric acid  (ISO)
borrelidin  (ISO)
bortezomib  (EXP,ISO)
brefeldin A  (ISO)
Brevetoxin B  (ISO)
bromobenzene  (EXP)
bufalin  (ISO)
butanal  (ISO)
butylated hydroxyanisole  (ISO)
Butylparaben  (ISO)
butyric acid  (EXP,ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
Calcimycin  (ISO)
calcitriol  (ISO)
calcium carbonate  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
capsaicin  (EXP,ISO)
captan  (ISO)
carbamazepine  (ISO)
carbaryl  (ISO)
carbon atom  (ISO)
carbon nanotube  (ISO)
carboplatin  (EXP)
carboxy-PTIO  (ISO)
casticin  (ISO)
celastrol  (ISO)
celecoxib  (ISO)
chenodeoxycholic acid  (ISO)
chloroacetaldehyde  (ISO)
chloroacetic acid  (ISO)
chloroform  (EXP)
chloropicrin  (ISO)
chloroquine  (EXP,ISO)
chlorpromazine  (EXP)
chlorpyrifos  (ISO)
choline  (EXP,ISO)
chromium atom  (ISO)
chromium(6+)  (EXP)
chrysazin  (ISO)
chrysophanol  (ISO)
cibenzoline  (ISO)
cidofovir anhydrous  (ISO)
ciglitazone  (ISO)
cimetidine  (ISO)
cisplatin  (EXP,ISO)
clodronic acid  (ISO)
clofibrate  (ISO)
cobalt atom  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
cobicistat  (ISO)
cocaine  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (EXP,ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (ISO)
D-cycloserine  (ISO)
D-glucose  (EXP,ISO)
D-mannopyranose  (ISO)
D-penicillamine  (ISO)
dantrolene  (EXP,ISO)
DDE  (ISO)
deguelin  (ISO)
demethoxycurcumin  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
desipramine  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
diclofenac  (EXP,ISO)
dicrotophos  (ISO)
dieldrin  (EXP,ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (ISO)
dihydroartemisinin  (ISO)
dihydrocapsaicin  (ISO)
dihydroxyacetone  (ISO)
dimethyl sulfoxide  (EXP)
dimethylarsinic acid  (ISO)
dimethylarsinous acid  (EXP,ISO)
Dinitramine  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (EXP,ISO)
diquat  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
dorsomorphin  (EXP,ISO)
doxazosin  (ISO)
doxorubicin  (EXP,ISO)
duvoglustat  (EXP)
echinacoside  (ISO)
efavirenz  (ISO)
elemental carbon  (ISO)
emodin  (EXP)
endosulfan  (EXP)
entinostat  (ISO)
erastin  (ISO)
erlotinib hydrochloride  (EXP,ISO)
erythromycin estolate  (EXP)
etacrynic acid  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
excitatory amino acid agonist  (ISO)
fangchinoline  (ISO)
fenofibrate  (ISO)
fenpyroximate  (ISO)
ferric oxide  (ISO)
fisetin  (ISO)
flavokawain B  (ISO)
flavonoids  (EXP)
flufenoxuron  (ISO)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (EXP,ISO)
folpet  (ISO)
formaldehyde  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
furosemide  (ISO)
gadolinium atom  (ISO)
gadolinium trichloride  (EXP)
galactose  (ISO)
gedunin  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP,ISO)
geraniol  (ISO)
ginsenoside Rg1  (ISO)
glafenine  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glycine  (ISO)
glycochenodeoxycholic acid  (EXP,ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
graphite  (EXP)
Guanabenz  (EXP,ISO)
GW 4064  (ISO)
halothane  (ISO)
helenalin  (ISO)
hemin  (EXP,ISO)
hexachlorophene  (ISO)
hexadecanoic acid  (ISO)
homocysteine  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hydroxytyrosol  (EXP)
hypochlorous acid  (ISO)
Ibutilide  (EXP)
ifosfamide  (ISO)
Ilimaquinone  (ISO)
indinavir  (ISO)
indometacin  (EXP,ISO)
ionomycin  (ISO)
iprodione  (ISO)
irinotecan  (EXP)
iron atom  (EXP,ISO)
iron(0)  (EXP,ISO)
iron(III) citrate  (ISO)
isoniazide  (EXP,ISO)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
ketoconazole  (ISO)
KN-93  (EXP)
kojic acid  (EXP)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (EXP)
L-methionine  (EXP,ISO)
lactacystin  (ISO)
lamivudine  (ISO)
lead diacetate  (EXP,ISO)
lead nitrate  (ISO)
leflunomide  (ISO)
letrozole  (EXP)
Licochalcone B  (ISO)
linagliptin  (ISO)
linoleic acid  (ISO)
linsidomine  (ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (EXP)
lomustine  (ISO)
lucanthone  (ISO)
luteolin  (EXP,ISO)
LY294002  (EXP,ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
melatonin  (EXP)
menadione  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP,ISO)
metacetamol  (ISO)
metformin  (EXP,ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP,ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methyl beta-cyclodextrin  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
methyltestosterone  (ISO)
metyrapone  (ISO)
mevastatin  (ISO)
microcystin-LR  (ISO)
minocycline  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (ISO)
morusin  (ISO)
motexafin gadolinium  (ISO)
myriocin  (ISO)
N,N-dimethylformamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-hexadecanoylsphingosine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methylnicotinate  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
naltrexone  (ISO)
nefazodone  (ISO)
nelfinavir  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (EXP)
niclosamide  (ISO)
nicotine  (EXP,ISO)
nifedipine  (EXP)
Niflumic acid  (ISO)
nilotinib  (ISO)
nimesulide  (EXP,ISO)
nitrofen  (EXP)
nitroprusside  (ISO)
nobiletin  (EXP,ISO)
Nodularin  (ISO)
Nonidet P-40  (ISO)
nonivamide  (ISO)
Nonylphenol  (EXP)
Norbinaltorphimine  (ISO)
NS-398  (ISO)
NSC 23766  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
olaparib  (ISO)
oleanolic acid  (ISO)
oleic acid  (ISO)
oleuropein  (EXP)
omeprazole  (ISO)
orlistat  (ISO)
ouabain  (ISO)
oxaliplatin  (EXP)
oxidopamine  (EXP,ISO)
ozone  (EXP)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parthenolide  (ISO)
patulin  (ISO)
pemetrexed  (ISO)
pentachlorophenol  (ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
phalloidin  (ISO)
phenethyl caffeate  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
platycodin D  (ISO)
plumbagin  (ISO)
poly(guanylic acid)  (EXP)
potassium bromate  (ISO)
potassium chromate  (ISO)
potassium dichromate  (EXP,ISO)
potassium iodide  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
prostaglandin E2  (ISO)
Ptaquiloside  (ISO)
pterostilbene  (ISO)
pyrazinecarboxamide  (EXP,ISO)
pyrimidifen  (ISO)
pyrrolidine dithiocarbamate  (EXP,ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
raspberry ketone  (ISO)
reactive oxygen species  (ISO)
resorcinol  (ISO)
resveratrol  (EXP,ISO)
riboflavin  (ISO)
rifampicin  (ISO)
rimonabant  (ISO)
rotenone  (EXP,ISO)
rottlerin  (EXP,ISO)
ryanodine  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
Salinomycin  (ISO)
salubrinal  (EXP,ISO)
Salvianolic acid A  (ISO)
salvianolic acid B  (EXP)
SB 203580  (ISO)
SB 431542  (ISO)
SB-239063  (ISO)
SCH 23390  (EXP)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenomethionine  (EXP)
serpentine asbestos  (ISO)
sertraline  (ISO)
sibutramine  (ISO)
silibinin  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (EXP,ISO)
SKF-96365 hydrochloride  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (EXP,ISO)
Soman  (EXP)
sorafenib  (ISO)
SR 144528  (ISO)
staurosporine  (ISO)
streptozocin  (EXP,ISO)
SU6656  (ISO)
succimer  (ISO)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sulfur dioxide  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
superoxide  (ISO)
T-2 toxin  (EXP)
tacrine  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
tauroursodeoxycholic acid  (EXP,ISO)
tebufenpyrad  (ISO)
telmisartan  (EXP)
TEMPO  (EXP)
Terfenadine  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thalidomide  (ISO)
thapsigargin  (EXP,ISO)
thiamethoxam  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP,ISO)
thiostrepton  (ISO)
thymoquinone  (ISO)
Tiron  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
torin 1  (ISO)
triacetin  (ISO)
tributyl phosphate  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (EXP,ISO)
trichloroethene  (ISO)
trimethylamine N-oxide  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (ISO)
tungsten  (EXP)
tunicamycin  (EXP,ISO)
undecane  (EXP)
uranium atom  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
ursolic acid  (ISO)
usnic acid  (ISO)
valproic acid  (ISO)
valsartan  (EXP)
vemurafenib  (ISO)
verapamil  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitexin  (ISO)
WIN 55212-2  (ISO)
withaferin A  (ISO)
wortmannin  (ISO)
zearalenone  (ISO)
zidovudine  (ISO)
zileuton  (EXP)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc oxide  (ISO)
zinc protoporphyrin  (EXP)
zinc pyrithione  (ISO)
zinc(0)  (ISO)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (IEP)
anterior/posterior axis specification  (IEA,ISO)
apoptotic process  (ISO,ISS)
artery development  (ISO)
blood vessel maturation  (IEA,ISO,ISS)
cell redox homeostasis  (IEA,ISO)
cellular response to manganese ion  (IEP)
embryonic organ development  (IEP)
endoplasmic reticulum unfolded protein response  (IEA,ISO,ISS)
ER overload response  (IBA,IEA,IMP,ISO)
establishment of protein localization to mitochondrion  (IEA,ISO)
gene expression  (ISO)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (IBA,IEA,ISO,ISS)
intrinsic apoptotic signaling pathway in response to nitrosative stress  (IEA,ISO)
luteolysis  (IEP)
negative regulation of canonical Wnt signaling pathway  (IEA,ISO)
negative regulation of cold-induced thermogenesis  (ISO,ISS)
negative regulation of CREB transcription factor activity  (IBA,IDA,IEA,ISO)
negative regulation of determination of dorsal identity  (IEA,ISO)
negative regulation of DNA binding  (IDA,ISO)
negative regulation of DNA-binding transcription factor activity  (ISO)
negative regulation of fat cell differentiation  (IEA,ISO)
negative regulation of interferon-gamma production  (IEA,ISO)
negative regulation of interleukin-17 production  (IEA,ISO)
negative regulation of interleukin-4 production  (IEA,ISO)
negative regulation of myoblast differentiation  (IEA,ISO,ISS)
negative regulation of NF-kappaB transcription factor activity  (IEA,ISO)
negative regulation of protein kinase B signaling  (IEA,ISO)
negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IBA,IDA,IEA,ISO)
negative regulation of transcription, DNA-templated  (ISO,ISS)
positive regulation of apoptotic process  (IMP)
positive regulation of autophagy in response to ER overload  (IMP)
positive regulation of DNA-binding transcription factor activity  (IEA,ISO)
positive regulation of interleukin-8 production  (IEA,ISO,ISS)
positive regulation of intrinsic apoptotic signaling pathway  (IBA,IEA,ISO,ISS)
positive regulation of neuron apoptotic process  (IEA,IMP,ISO,ISS)
positive regulation of neuron death  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  (IBA,IDA,IEA,ISO)
positive regulation of transcription, DNA-templated  (IDA,ISO)
proteasome-mediated ubiquitin-dependent protein catabolic process  (IEA,ISO,ISS)
regulation of autophagy  (IMP)
regulation of transcription by RNA polymerase II  (ISO)
regulation of transcription, DNA-templated  (IDA,ISO)
release of sequestered calcium ion into cytosol  (IEA,ISO,ISS)
response to amphetamine  (IEP)
response to endoplasmic reticulum stress  (ISO,ISS)
response to hydrogen peroxide  (IEP)
response to nutrient  (IEP)
response to oxidative stress  (IEP)
response to platelet-derived growth factor  (ISO)
response to starvation  (IEA,ISO,ISS)
response to toxic substance  (IEP)
response to unfolded protein  (IEA,ISO,ISS)
response to wounding  (ISO)
response to xenobiotic stimulus  (IEP)
sensory perception of sound  (IEA,ISO)
vascular associated smooth muscle cell migration  (ISO)
vascular associated smooth muscle cell proliferation  (ISO)
Wnt signaling pathway  (IEA)

Cellular Component
CHOP-ATF3 complex  (IBA,IEA,ISO)
CHOP-ATF4 complex  (IBA,IEA,ISO)
CHOP-C/EBP complex  (IBA,IEA,IPI,ISO)
cytoplasm  (IBA,IDA,IEA,ISO)
late endosome  (IEA,ISO)
nucleoplasm  (TAS)
nucleus  (IDA,ISO,TAS)
protein-DNA complex  (IEA,ISO)
RNA polymerase II transcription regulator complex  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
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19. MGD data from the GO Consortium
20. Mulhern ML, etal., Invest Ophthalmol Vis Sci. 2006 Sep;47(9):3951-9.
21. NCBI rat LocusLink and RefSeq merged data July 26, 2002
22. Okla M, etal., J Biol Chem. 2015 Oct 30;290(44):26476-90. doi: 10.1074/jbc.M115.677724. Epub 2015 Sep 14.
23. OMIM Disease Annotation Pipeline
24. Pipeline to import KEGG annotations from KEGG into RGD
25. Rees WD, etal., J Nutr 1999 Aug;129(8):1532-6.
26. RGD automated data pipeline
27. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
28. RGD automated import pipeline for gene-chemical interactions
29. Seimon TA, etal., PLoS One. 2010 Sep 15;5(9):e12772. doi: 10.1371/journal.pone.0012772.
30. Silva RM, etal., J Neurochem. 2005 Nov;95(4):974-86. Epub 2005 Aug 31.
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32. Sylvester SL, etal., J Biol Chem. 1994 Aug 5;269(31):20119-25.
33. Szpirer C, etal., Mamm Genome 2000 Sep;11(9):729-35
34. Tan Z, etal., J Neuroinflammation. 2018 Sep 21;15(1):275. doi: 10.1186/s12974-018-1311-5.
35. Tang JR, etal., Biochem Biophys Res Commun. 2002 Feb 1;290(4):1255-9.
36. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
37. Ubeda M, etal., Mol Cell Biol. 1996 Apr;16(4):1479-89.
38. Williams BL and Lipkin WI, J Virol. 2006 Sep;80(17):8613-26. doi: 10.1128/JVI.00836-06.
39. Xu B, etal., Mol Neurobiol. 2014 Feb;49(1):399-412. doi: 10.1007/s12035-013-8527-2. Epub 2013 Aug 10.
40. Xu X, etal., Front Mol Neurosci. 2017 Jun 26;10:203. doi: 10.3389/fnmol.2017.00203. eCollection 2017.
41. Yang H, etal., Autophagy. 2020 Feb;16(2):271-288. doi: 10.1080/15548627.2019.1606647. Epub 2019 Apr 21.
42. Yang Y, etal., Reprod Sci. 2015 May;22(5):572-84. doi: 10.1177/1933719114553445. Epub 2014 Oct 20.
43. Zhang J, etal., J Surg Res. 2015 May 15;195(2):588-95. doi: 10.1016/j.jss.2015.01.039. Epub 2015 Jan 28.
44. Zhou H, etal., Toxicol Appl Pharmacol. 2004 Oct 15;200(2):111-20.
Additional References at PubMed
PMID:1547942   PMID:8622660   PMID:9531536   PMID:9930704   PMID:10523647   PMID:10820183   PMID:11478948   PMID:11691921   PMID:11854325   PMID:12477932   PMID:12907753   PMID:14667815  
PMID:14729979   PMID:14752510   PMID:15277470   PMID:15322075   PMID:15601821   PMID:15694370   PMID:15775988   PMID:16434966   PMID:17113167   PMID:17395747   PMID:17715997   PMID:17872950  
PMID:17911345   PMID:18006442   PMID:18534616   PMID:18940792   PMID:19061639   PMID:19175159   PMID:19215662   PMID:19218986   PMID:19299913   PMID:19424493   PMID:19614958   PMID:19752026  
PMID:19769458   PMID:19890920   PMID:20109102   PMID:20829347   PMID:21068199   PMID:21159964   PMID:21225541   PMID:21479580   PMID:21767604   PMID:22065586   PMID:22083547   PMID:22180248  
PMID:22242125   PMID:22265908   PMID:22441668   PMID:22496745   PMID:22653339   PMID:22705154   PMID:22761832   PMID:22815481   PMID:23028046   PMID:23074209   PMID:23239445   PMID:23555658  
PMID:24133119   PMID:24668805   PMID:24939851   PMID:25012492   PMID:25412307   PMID:25902191   PMID:26027784   PMID:26099737   PMID:27278525   PMID:27322831   PMID:27484784   PMID:27957794  
PMID:28667101   PMID:28893685   PMID:29414031   PMID:29653943   PMID:29901175   PMID:29958740   PMID:30188326   PMID:30456794   PMID:30486828   PMID:30561076   PMID:31084986   PMID:31914690  
PMID:32304741   PMID:33725228  


Genomics

Comparative Map Data
Ddit3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2763,115,645 - 63,121,203 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl763,116,380 - 63,121,201 (+)Ensembl
Rnor_6.0770,578,564 - 70,585,074 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl770,580,198 - 70,585,084 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0770,753,800 - 70,759,220 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4767,247,749 - 67,252,571 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1767,268,487 - 67,273,294 (+)NCBI
Celera760,256,651 - 60,261,474 (+)NCBICelera
Cytogenetic Map7q22NCBI
DDIT3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1257,516,588 - 57,521,737 (-)EnsemblGRCh38hg38GRCh38
GRCh381257,516,588 - 57,520,517 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371257,910,371 - 57,914,300 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361256,196,638 - 56,200,567 (-)NCBINCBI36hg18NCBI36
Build 341256,196,639 - 56,200,567NCBI
Celera1257,566,204 - 57,570,133 (-)NCBI
Cytogenetic Map12q13.3NCBI
HuRef1254,948,369 - 54,952,298 (-)NCBIHuRef
CHM1_11257,878,226 - 57,882,156 (-)NCBICHM1_1
Ddit3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910127,126,662 - 127,132,160 (+)NCBIGRCm39mm39
GRCm39 Ensembl10127,126,643 - 127,132,157 (+)Ensembl
GRCm39 Ensembl10127,126,698 - 127,129,622 (+)Ensembl
GRCm3810127,290,793 - 127,296,291 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10127,290,774 - 127,296,288 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl10127,290,829 - 127,293,753 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710126,727,849 - 126,733,344 (+)NCBIGRCm37mm9NCBIm37
MGSCv3610126,693,759 - 126,699,235 (+)NCBImm8
Celera10129,683,104 - 129,688,599 (+)NCBICelera
Cytogenetic Map10D3NCBI
Ddit3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554585,232,979 - 5,238,513 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554585,232,979 - 5,238,513 (-)NCBIChiLan1.0ChiLan1.0
DDIT3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11231,664,766 - 31,668,699 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1231,664,743 - 31,668,701 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01231,406,332 - 31,410,293 (+)NCBIMhudiblu_PPA_v0panPan3
DDIT3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1101,606,693 - 1,612,410 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl101,606,693 - 1,611,303 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha101,669,927 - 1,675,567 (-)NCBI
ROS_Cfam_1.0101,615,759 - 1,621,400 (-)NCBI
UMICH_Zoey_3.1101,593,774 - 1,599,407 (-)NCBI
UNSW_CanFamBas_1.0101,835,463 - 1,841,297 (-)NCBI
UU_Cfam_GSD_1.0101,960,652 - 1,966,292 (-)NCBI
Ddit3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494557,201,026 - 57,205,216 (+)NCBI
SpeTri2.0NW_0049366461,665,019 - 1,669,212 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DDIT3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl522,785,441 - 22,791,134 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1522,785,441 - 22,789,867 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
DDIT3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11153,424,693 - 53,429,094 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1153,424,868 - 53,425,576 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037192,535,088 - 192,539,471 (+)NCBIVero_WHO_p1.0
Ddit3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462480210,437,998 - 10,443,278 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
RH128750  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2763,121,211 - 63,121,513 (+)MAPPERmRatBN7.2
Rnor_6.0770,585,083 - 70,585,384NCBIRnor6.0
Rnor_5.0770,759,229 - 70,759,530UniSTSRnor5.0
RGSC_v3.4767,252,580 - 67,252,881UniSTSRGSC3.4
Celera760,261,483 - 60,261,784UniSTS
Cytogenetic Map7q22UniSTS
PMC152658P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2763,120,257 - 63,120,975 (+)MAPPERmRatBN7.2
Rnor_6.0770,584,129 - 70,584,846NCBIRnor6.0
Rnor_5.0770,758,275 - 70,758,992UniSTSRnor5.0
RGSC_v3.4767,251,626 - 67,252,343UniSTSRGSC3.4
Celera760,260,528 - 60,261,246UniSTS
Cytogenetic Map7q22UniSTS
RH140361  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2763,119,865 - 63,120,070 (+)MAPPERmRatBN7.2
Rnor_6.0770,583,737 - 70,583,941NCBIRnor6.0
Rnor_5.0770,757,883 - 70,758,087UniSTSRnor5.0
RGSC_v3.4767,251,234 - 67,251,438UniSTSRGSC3.4
Celera760,260,136 - 60,260,340UniSTS
Cytogenetic Map7q22UniSTS
RH141558  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2763,120,873 - 63,121,092 (+)MAPPERmRatBN7.2
Rnor_6.0770,584,745 - 70,584,963NCBIRnor6.0
Rnor_5.0770,758,891 - 70,759,109UniSTSRnor5.0
RGSC_v3.4767,252,242 - 67,252,460UniSTSRGSC3.4
Celera760,261,145 - 60,261,363UniSTS
Cytogenetic Map7q22UniSTS
PMC150726P4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2763,120,763 - 63,121,067 (+)MAPPERmRatBN7.2
Rnor_6.0770,584,635 - 70,584,938NCBIRnor6.0
Rnor_5.0770,758,781 - 70,759,084UniSTSRnor5.0
RGSC_v3.4767,252,132 - 67,252,435UniSTSRGSC3.4
Celera760,261,035 - 60,261,338UniSTS
Cytogenetic Map7q22UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer