Ddit3 (DNA-damage inducible transcript 3) - Rat Genome Database

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Gene: Ddit3 (DNA-damage inducible transcript 3) Rattus norvegicus
Symbol: Ddit3
Name: DNA-damage inducible transcript 3
RGD ID: 62391
Description: Enables DNA-binding transcription factor activity and protein heterodimerization activity. Contributes to sequence-specific DNA binding activity. Involved in several processes, including cellular response to manganese ion; positive regulation of autophagy in response to ER overload; and regulation of DNA-templated transcription. Located in cytoplasm and nucleus. Part of CHOP-C/EBP complex. Biomarker of several diseases, including borna disease; brain ischemia; chronic obstructive pulmonary disease; pulmonary venoocclusive disease; and ureteral obstruction. Human ortholog(s) of this gene implicated in myxoid liposarcoma. Orthologous to human DDIT3 (DNA damage inducible transcript 3); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; (R)-lipoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C/EBP homologous protein; C/EBP zeta; c/EBP-homologous protein; c/EBP-homologous protein 10; CCAAT/enhancer-binding protein homologous protein; CHOP; CHOP-10; Chop10; DDIT-3; DNA damage-inducible transcript 3; Gadd153; growth arrest and DNA-damage-inducible protein GADD153; MGC124604; RM4
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2763,115,645 - 63,121,203 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl763,116,380 - 63,121,201 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx765,005,654 - 65,010,476 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0767,208,074 - 67,212,896 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0767,009,429 - 67,014,244 (+)NCBIRnor_WKY
Rnor_6.0770,578,564 - 70,585,074 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl770,580,198 - 70,585,084 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0770,753,800 - 70,759,220 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4767,247,749 - 67,252,571 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1767,268,487 - 67,273,294 (+)NCBI
Celera760,256,651 - 60,261,474 (+)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+)-schisandrin B  (EXP)
(+)-Tetrandrine  (ISO)
(-)-anisomycin  (ISO)
(-)-citrinin  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-gambogic acid  (ISO)
(-)-quinic acid  (ISO)
(E)-thiamethoxam  (ISO)
(R)-lipoic acid  (EXP,ISO)
(R)-noradrenaline  (EXP)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(R,S)-Scoulerine  (ISO)
(S)-amphetamine  (ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (EXP,ISO)
(Z)-3-butylidenephthalide  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dithiothreitol  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP,ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
15-acetyldeoxynivalenol  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4,6-trinitrotoluene  (ISO)
2,4-D  (ISO)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dichlorophenol  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-arachidonoylglycerol  (ISO)
2-butoxyethanol  (ISO)
2-deoxy-D-glucose  (ISO)
2-hydroxypropanoic acid  (ISO)
2-tert-butylhydroquinone  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3'-diindolylmethane  (ISO)
3,4-dihydrocoumarin  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-acetyldeoxynivalenol  (ISO)
3-chloropropane-1,2-diol  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
4-phenylbutylamine  (ISO)
4-phenylbutyric acid  (EXP,ISO)
4-phenylcoumarin  (ISO)
5-(N,N-hexamethylene)amiloride  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP)
7,12-dimethyltetraphene  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
[6]-Shogaol  (ISO)
acetaldehyde  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (EXP,ISO)
acrolein  (EXP,ISO)
acrylamide  (EXP,ISO)
acrylonitrile  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
agomelatine  (EXP)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinal  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allopurinol  (ISO)
alloxan  (ISO)
Aloe emodin  (ISO)
alpha-(methylamino)isobutyric acid  (ISO)
alpha-D-galactose  (EXP,ISO)
alpha-naphthoflavone  (ISO)
AM-251  (ISO)
amiloride  (ISO)
amino acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
Ammothamnine  (ISO)
amosite asbestos  (ISO)
amphibole asbestos  (ISO)
anandamide  (ISO)
andrographolide  (ISO)
aniline  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimycin A  (EXP,ISO)
antirheumatic drug  (ISO)
apigenin  (ISO)
arachidonyl-2'-chloroethylamide  (ISO)
Archazolid B  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
atazanavir sulfate  (ISO)
atrazine  (ISO)
auraptene  (ISO)
Auriculasin  (ISO)
Aurin  (ISO)
avermectin  (ISO)
azathioprine  (ISO)
azoxystrobin  (ISO)
Bardoxolone methyl  (ISO)
benomyl  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[ghi]perylene  (ISO)
bepridil  (ISO)
beta-cyclodextrin  (ISO)
beta-D-glucosamine  (ISO)
bexarotene  (EXP)
bilirubin IXalpha  (ISO)
biphenyl-4-amine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bongkrekic acid  (ISO)
boric acid  (ISO)
borrelidin  (ISO)
bortezomib  (EXP,ISO)
brefeldin A  (ISO)
Brevetoxin B  (ISO)
bromoacetate  (ISO)
bromobenzene  (EXP)
bufalin  (ISO)
busulfan  (ISO)
butanal  (ISO)
butylated hydroxyanisole  (ISO)
Butylparaben  (ISO)
butyric acid  (EXP,ISO)
C.I. Natural Red 20  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
Calcimycin  (ISO)
calcitriol  (ISO)
calcium carbonate  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
cantharidin  (EXP,ISO)
capsaicin  (EXP,ISO)
captan  (ISO)
carbamazepine  (ISO)
carbaryl  (ISO)
carbon atom  (ISO)
carbon nanotube  (ISO)
carboplatin  (EXP)
carboxy-PTIO  (ISO)
casticin  (ISO)
celastrol  (ISO)
celecoxib  (ISO)
chenodeoxycholic acid  (ISO)
chlormequat chloride  (EXP)
chloroacetaldehyde  (ISO)
chloroacetic acid  (ISO)
chloroform  (EXP)
chlorogenic acid  (EXP)
chloropicrin  (ISO)
chloroquine  (EXP,ISO)
chlorpromazine  (EXP)
chlorpyrifos  (ISO)
choline  (EXP,ISO)
chromium atom  (ISO)
chromium(6+)  (EXP)
chrysazin  (ISO)
chrysophanol  (ISO)
cibenzoline  (ISO)
cidofovir anhydrous  (ISO)
ciglitazone  (ISO)
cimetidine  (ISO)
cisplatin  (EXP,ISO)
clodronic acid  (ISO)
clofibrate  (ISO)
cobalt atom  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
cobicistat  (ISO)
cocaine  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (EXP,ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (ISO)
D-cycloserine  (ISO)
D-glucose  (EXP,ISO)
D-mannopyranose  (ISO)
D-penicillamine  (ISO)
dantrolene  (EXP,ISO)
deguelin  (ISO)
demethoxycurcumin  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
desipramine  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
diclofenac  (EXP,ISO)
dicrotophos  (ISO)
Didecyldimethylammonium  (ISO)
dieldrin  (EXP,ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (ISO)
dihydroartemisinin  (ISO)
dihydrocapsaicin  (ISO)
dihydroxyacetone  (ISO)
dimethyl sulfoxide  (EXP)
dimethylarsinic acid  (ISO)
dimethylarsinous acid  (EXP,ISO)
Dinitramine  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (EXP,ISO)
diquat  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
dorsomorphin  (EXP,ISO)
doxazosin  (ISO)
doxorubicin  (EXP,ISO)
duvoglustat  (EXP)
echinacoside  (ISO)
efavirenz  (ISO)
elemental carbon  (ISO)
emodin  (EXP)
empagliflozin  (EXP)
endosulfan  (EXP)
entinostat  (ISO)
erastin  (ISO)
erlotinib hydrochloride  (EXP,ISO)
erythromycin estolate  (EXP)
etacrynic acid  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
ethylene glycol  (EXP)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
EUK-134  (ISO)
Evodiamine  (ISO)
excitatory amino acid agonist  (ISO)
fangchinoline  (ISO)
fenofibrate  (ISO)
fenpyroximate  (ISO)
ferric oxide  (ISO)
ferrostatin-1  (EXP)
fisetin  (ISO)
flavokawain B  (ISO)
flavonoids  (EXP)
flufenoxuron  (ISO)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (EXP,ISO)
folpet  (ISO)
formaldehyde  (ISO)
fructose  (EXP)
fumonisin B1  (ISO)
furan  (EXP,ISO)
furosemide  (ISO)
gadolinium atom  (ISO)
gadolinium trichloride  (EXP)
galactose  (EXP,ISO)
gedunin  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP,ISO)
geraniol  (ISO)
ginsenoside Rg1  (ISO)
glafenine  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glycine  (ISO)
glycochenodeoxycholic acid  (EXP,ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
graphite  (EXP)
Guanabenz  (EXP,ISO)
GW 4064  (ISO)
halothane  (ISO)
helenalin  (ISO)
hemin  (EXP,ISO)
hexachlorophene  (ISO)
hexadecanoic acid  (EXP,ISO)
homocysteine  (ISO)
Honokiol  (EXP,ISO)
hydralazine  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hydroxytyrosol  (EXP)
hypochlorous acid  (ISO)
Ibutilide  (EXP)
ifosfamide  (ISO)
Ilimaquinone  (ISO)
imidazopyrazole  (ISO)
indinavir  (ISO)
indometacin  (EXP,ISO)
ionomycin  (ISO)
iprodione  (ISO)
irinotecan  (EXP)
iron atom  (EXP,ISO)
iron(0)  (EXP,ISO)
iron(III) citrate  (ISO)
isoniazide  (EXP,ISO)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
ketamine  (ISO)
ketoconazole  (ISO)
KN-93  (EXP)
kojic acid  (EXP)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (EXP)
L-glutamic acid  (EXP)
L-methionine  (EXP,ISO)
lactacystin  (ISO)
lamivudine  (ISO)
lead diacetate  (EXP,ISO)
lead nitrate  (ISO)
leflunomide  (ISO)
letrozole  (EXP)
Licochalcone B  (ISO)
linagliptin  (ISO)
linoleic acid  (ISO)
linsidomine  (ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (EXP)
lomustine  (ISO)
lucanthone  (ISO)
luteolin  (EXP,ISO)
LY294002  (EXP,ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
melatonin  (EXP)
menadione  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP,ISO)
metacetamol  (ISO)
metformin  (EXP,ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP,ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methyl beta-cyclodextrin  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
methyltestosterone  (ISO)
metyrapone  (ISO)
mevastatin  (ISO)
microcystin-LR  (ISO)
minocycline  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (ISO)
morusin  (ISO)
motexafin gadolinium  (ISO)
myriocin  (ISO)
N,N-dimethylformamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-hexadecanoylsphingosine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methylnicotinate  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
naltrexone  (ISO)
nefazodone  (ISO)
nelfinavir  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (EXP)
niclosamide  (ISO)
nicotine  (EXP,ISO)
nifedipine  (EXP)
Niflumic acid  (ISO)
nilotinib  (ISO)
nimesulide  (EXP,ISO)
nitrofen  (EXP)
nitroprusside  (ISO)
nobiletin  (EXP,ISO)
Nodularin  (ISO)
Nonidet P-40  (ISO)
nonivamide  (ISO)
Nonylphenol  (EXP)
Norbinaltorphimine  (ISO)
NS-398  (ISO)
NSC 23766  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
Octicizer  (ISO)
okadaic acid  (ISO)
olaparib  (ISO)
oleanolic acid  (ISO)
oleic acid  (ISO)
oleuropein  (EXP)
omeprazole  (ISO)
orlistat  (ISO)
ouabain  (ISO)
oxaliplatin  (EXP)
oxidopamine  (EXP,ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parthenolide  (ISO)
patulin  (ISO)
pemetrexed  (ISO)
Pendulone  (ISO)
pentachlorophenol  (ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (ISO)
permethrin  (ISO)
phalloidin  (ISO)
phenethyl caffeate  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
platycodin D  (ISO)
plumbagin  (ISO)
poly(guanylic acid)  (EXP)
potassium bromate  (ISO)
potassium chromate  (ISO)
potassium dichromate  (EXP,ISO)
potassium iodide  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
prostaglandin E2  (ISO)
prothioconazole  (ISO)
Ptaquiloside  (ISO)
pterostilbene  (ISO)
pyrazinecarboxamide  (EXP,ISO)
pyrimidifen  (ISO)
pyrrolidine dithiocarbamate  (EXP,ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
raspberry ketone  (ISO)
reactive oxygen species  (ISO)
resorcinol  (ISO)
resveratrol  (EXP,ISO)
riboflavin  (ISO)
rifampicin  (ISO)
rimonabant  (ISO)
rotenone  (EXP,ISO)
rottlerin  (EXP,ISO)
ryanodine  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
Salidroside  (ISO)
Salinomycin  (ISO)
salubrinal  (EXP,ISO)
Salvianolic acid A  (ISO)
salvianolic acid B  (EXP)
SB 203580  (ISO)
SB 431542  (ISO)
SB-239063  (ISO)
SCH 23390  (EXP)
scopoletin  (EXP)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenomethionine  (EXP)
serpentine asbestos  (ISO)
sertraline  (ISO)
Shikonin  (EXP)
sibutramine  (ISO)
silibinin  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (EXP,ISO)
SKF-96365 hydrochloride  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium disulfite  (EXP)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (EXP,ISO)
Sodium iodate  (ISO)
Soman  (EXP)
sorafenib  (ISO)
SR 144528  (ISO)
staurosporine  (ISO)
streptozocin  (EXP,ISO)
SU6656  (ISO)
succimer  (ISO)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sulfur dioxide  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
superoxide  (ISO)
T-2 toxin  (EXP,ISO)
tacrine  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
taurine  (ISO)
tauroursodeoxycholic acid  (EXP,ISO)
tebufenpyrad  (ISO)
telmisartan  (EXP)
Terfenadine  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thalidomide  (ISO)
thapsigargin  (EXP,ISO)
thiamethoxam  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP,ISO)
thiostrepton  (ISO)
thymoquinone  (EXP,ISO)
Tiron  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
torin 1  (ISO)
triacetin  (ISO)
tributyl phosphate  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (EXP,ISO)
trichloroethene  (EXP,ISO)
trimethylamine N-oxide  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (ISO)
tungsten  (EXP)
tunicamycin  (EXP,ISO)
umbelliferone  (EXP)
undecane  (EXP)
uranium atom  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
ursolic acid  (ISO)
usnic acid  (ISO)
valproic acid  (ISO)
valsartan  (EXP)
vemurafenib  (ISO)
verapamil  (ISO)
vildagliptin  (EXP)
vinclozolin  (EXP)
vincristine  (ISO)
vitexin  (ISO)
WIN 55212-2  (ISO)
withaferin A  (ISO)
wortmannin  (ISO)
zearalenone  (ISO)
zidovudine  (ISO)
zileuton  (EXP)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc oxide  (ISO)
zinc protoporphyrin  (EXP)
zinc pyrithione  (ISO)
zinc(0)  (ISO)
ziram  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (IEP)
anterior/posterior axis specification  (ISO)
apoptotic process  (IEA,ISO,ISS)
artery development  (ISO)
blood vessel maturation  (ISO,ISS)
cell redox homeostasis  (ISO)
cellular response to manganese ion  (IEP)
DNA-templated transcription  (ISO)
DNA-templated transcription elongation  (ISO)
embryonic organ development  (IEP)
endoplasmic reticulum unfolded protein response  (ISO,ISS)
ER overload response  (IBA,IMP,ISO)
establishment of protein localization to mitochondrion  (ISO)
gene expression  (ISO)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (IBA,ISO,ISS)
intrinsic apoptotic signaling pathway in response to nitrosative stress  (ISO)
luteolysis  (IEP)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cold-induced thermogenesis  (ISO,ISS)
negative regulation of CREB transcription factor activity  (IBA,IDA,ISO)
negative regulation of determination of dorsal identity  (ISO)
negative regulation of DNA binding  (IDA,ISO)
negative regulation of DNA-binding transcription factor activity  (ISO)
negative regulation of DNA-templated transcription  (ISO,ISS)
negative regulation of fat cell differentiation  (ISO)
negative regulation of interleukin-17 production  (ISO)
negative regulation of interleukin-4 production  (ISO)
negative regulation of myoblast differentiation  (ISO,ISS)
negative regulation of NF-kappaB transcription factor activity  (ISO)
negative regulation of protein kinase B signaling  (ISO)
negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding  (ISO)
negative regulation of transcription by RNA polymerase II  (IBA,IDA,ISO,ISS)
negative regulation of type II interferon production  (ISO)
positive regulation of apoptotic process  (IMP)
positive regulation of autophagy in response to ER overload  (IMP)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of DNA-templated transcription  (IDA,ISO)
positive regulation of interleukin-8 production  (ISO,ISS)
positive regulation of intrinsic apoptotic signaling pathway  (IBA,ISO,ISS)
positive regulation of neuron apoptotic process  (IMP,ISO,ISS)
positive regulation of neuron death  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  (IBA,IDA,ISO)
proteasome-mediated ubiquitin-dependent protein catabolic process  (ISO,ISS)
regulation of autophagy  (IMP)
regulation of cell cycle  (IEA)
regulation of DNA-templated transcription  (IDA,IEA,ISO)
regulation of transcription by RNA polymerase II  (ISO)
release of sequestered calcium ion into cytosol  (ISO,ISS)
response to amphetamine  (IEP)
response to endoplasmic reticulum stress  (ISO,ISS)
response to hydrogen peroxide  (IEP)
response to nutrient  (IEP)
response to oxidative stress  (IEP)
response to platelet-derived growth factor  (ISO)
response to starvation  (ISO,ISS)
response to toxic substance  (IEP)
response to unfolded protein  (IEA,ISO,ISS)
response to wounding  (ISO)
response to xenobiotic stimulus  (IEP)
sensory perception of sound  (ISO)
vascular associated smooth muscle cell migration  (ISO)
vascular associated smooth muscle cell proliferation  (ISO)
Wnt signaling pathway  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
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3. Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine. Cai D, etal., Cell Death Dis. 2016 Mar 31;7:e2161. doi: 10.1038/cddis.2016.67.
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7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
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9. Expression of the pro-apoptotic gene gadd153/chop is elevated in liver with aging and sensitizes cells to oxidant injury. Ikeyama S, etal., J Biol Chem 2003 May 9;278(19):16726-31. Epub 2003 Feb 27.
10. A projectionist speaks. Kesterton DB, Med Biol Illus. 1977 Feb;27(1):15-9.
11. Bidirectional regulation of monocyte chemoattractant protein-1 gene at distinct sites of its promoter by nitric oxide in vascular smooth muscle cells. Kodama K, etal., Am J Physiol Cell Physiol. 2005 Sep;289(3):C582-90. Epub 2005 Apr 13.
12. The protective effect of dantrolene on ischemic neuronal cell death is associated with reduced expression of endoplasmic reticulum stress markers. Li F, etal., Brain Res. 2005 Jun 28;1048(1-2):59-68.
13. Ginsenoside-Rg1 inhibits endoplasmic reticulum stress-induced apoptosis after unilateral ureteral obstruction in rats. Li SS, etal., Ren Fail. 2015 Jun;37(5):890-5. doi: 10.3109/0886022X.2015.1015427. Epub 2015 Feb 24.
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18. Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. McCullough KD, etal., Mol Cell Biol 2001 Feb;21(4):1249-59.
19. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
20. The unfolded protein response in lens epithelial cells from galactosemic rat lenses. Mulhern ML, etal., Invest Ophthalmol Vis Sci. 2006 Sep;47(9):3951-9.
21. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
22. Activation of Toll-like receptor 4 (TLR4) attenuates adaptive thermogenesis via endoplasmic reticulum stress. Okla M, etal., J Biol Chem. 2015 Oct 30;290(44):26476-90. doi: 10.1074/jbc.M115.677724. Epub 2015 Sep 14.
23. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
24. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
25. Expression of the growth arrest genes (GAS and GADD) changes during organogenesis in the rat fetus. Rees WD, etal., J Nutr 1999 Aug;129(8):1532-6.
26. GOA pipeline RGD automated data pipeline
27. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
28. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
29. Induction of ER stress in macrophages of tuberculosis granulomas. Seimon TA, etal., PLoS One. 2010 Sep 15;5(9):e12772. doi: 10.1371/journal.pone.0012772.
30. CHOP/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism. Silva RM, etal., J Neurochem. 2005 Nov;95(4):974-86. Epub 2005 Aug 31.
31. Valsartan Protects Against Contrast-Induced Acute Kidney Injury in Rats by Inhibiting Endoplasmic Reticulum Stress-Induced Apoptosis. Sun Y, etal., Curr Vasc Pharmacol. 2017;15(2):174-183. doi: 10.2174/1570161114666161025100656.
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34. ZIKV infection activates the IRE1-XBP1 and ATF6 pathways of unfolded protein response in neural cells. Tan Z, etal., J Neuroinflammation. 2018 Sep 21;15(1):275. doi: 10.1186/s12974-018-1311-5.
35. Mechanism of oxidative stress-induced GADD153 gene expression in vascular smooth muscle cells. Tang JR, etal., Biochem Biophys Res Commun. 2002 Feb 1;290(4):1255-9.
36. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
37. Stress-induced binding of the transcriptional factor CHOP to a novel DNA control element. Ubeda M, etal., Mol Cell Biol. 1996 Apr;16(4):1479-89.
38. Endoplasmic reticulum stress and neurodegeneration in rats neonatally infected with borna disease virus. Williams BL and Lipkin WI, J Virol. 2006 Sep;80(17):8613-26. doi: 10.1128/JVI.00836-06.
39. alpha-Synuclein is involved in manganese-induced ER stress via PERK signal pathway in organotypic brain slice cultures. Xu B, etal., Mol Neurobiol. 2014 Feb;49(1):399-412. doi: 10.1007/s12035-013-8527-2. Epub 2013 Aug 10.
40. Nupr1 Modulates Methamphetamine-Induced Dopaminergic Neuronal Apoptosis and Autophagy through CHOP-Trib3-Mediated Endoplasmic Reticulum Stress Signaling Pathway. Xu X, etal., Front Mol Neurosci. 2017 Jun 26;10:203. doi: 10.3389/fnmol.2017.00203. eCollection 2017.
41. MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint. Yang H, etal., Autophagy. 2020 Feb;16(2):271-288. doi: 10.1080/15548627.2019.1606647. Epub 2019 Apr 21.
42. Endoplasmic reticulum stress-mediated apoptotic pathway is involved in corpus luteum regression in rats. Yang Y, etal., Reprod Sci. 2015 May;22(5):572-84. doi: 10.1177/1933719114553445. Epub 2014 Oct 20.
43. Hepatocyte autophagy is linked to C/EBP-homologous protein, Bcl2-interacting mediator of cell death, and BH3-interacting domain death agonist gene expression. Zhang J, etal., J Surg Res. 2015 May 15;195(2):588-95. doi: 10.1016/j.jss.2015.01.039. Epub 2015 Jan 28.
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Additional References at PubMed
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