Ddit3 (DNA-damage inducible transcript 3) - Rat Genome Database

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Gene: Ddit3 (DNA-damage inducible transcript 3) Rattus norvegicus
Symbol: Ddit3
Name: DNA-damage inducible transcript 3
RGD ID: 62391
Description: Exhibits DNA-binding transcription factor activity and protein heterodimerization activity. Contributes to sequence-specific DNA binding activity. Involved in several processes, including cellular response to manganese ion; positive regulation of autophagy in response to ER overload; and regulation of transcription, DNA-templated. Localizes to CHOP-C/EBP complex and cytoplasm. Biomarker of several diseases, including borna disease; brain ischemia; chronic obstructive pulmonary disease; pulmonary venoocclusive disease; and ureteral obstruction. Human ortholog(s) of this gene implicated in myxoid liposarcoma. Orthologous to human DDIT3 (DNA damage inducible transcript 3); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH (+)-alpha-tocopherol; (+)-pilocarpine; (+)-schisandrin B.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: C/EBP homologous protein; C/EBP zeta; c/EBP-homologous protein; c/EBP-homologous protein 10; CCAAT/enhancer-binding protein homologous protein; CHOP; CHOP-10; Chop10; DDIT-3; DNA damage-inducible transcript 3; Gadd153; growth arrest and DNA-damage-inducible protein GADD153; MGC124604; RM4
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2763,115,645 - 63,121,203 (+)NCBI
Rnor_6.0 Ensembl770,580,198 - 70,585,084 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0770,578,564 - 70,585,074 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0770,753,800 - 70,759,220 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4767,247,749 - 67,252,571 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1767,268,487 - 67,273,294 (+)NCBI
Celera760,256,651 - 60,261,474 (+)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-tocopherol  (EXP,ISO)
(+)-pilocarpine  (EXP)
(+)-schisandrin B  (EXP)
(+)-Tetrandrine  (ISO)
(-)-anisomycin  (ISO)
(-)-citrinin  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-gambogic acid  (ISO)
(-)-quinic acid  (ISO)
(R)-lipoic acid  (EXP,ISO)
(R)-noradrenaline  (EXP)
(R,S)-Scoulerine  (ISO)
(S)-amphetamine  (ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (EXP,ISO)
(Z)-3-butylidenephthalide  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dithiothreitol  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP,ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
15-acetyldeoxynivalenol  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4,6-trinitrotoluene  (ISO)
2,4-diaminotoluene  (ISO)
2,4-dichlorophenol  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-arachidonoylglycerol  (ISO)
2-butoxyethanol  (ISO)
2-deoxy-D-glucose  (ISO)
2-hydroxypropanoic acid  (ISO)
2-tert-butylhydroquinone  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3'-diindolylmethane  (ISO)
3,4-dihydrocoumarin  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutylamine  (ISO)
4-phenylbutyric acid  (EXP,ISO)
4-phenylcoumarin  (ISO)
5-(N,N-hexamethylene)amiloride  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP)
7,12-dimethyltetraphene  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
[6]-Shogaol  (ISO)
acetaldehyde  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (EXP,ISO)
acrolein  (EXP,ISO)
acrylamide  (EXP,ISO)
acrylonitrile  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinal  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alloxan  (ISO)
Aloe emodin  (ISO)
alpha-(methylamino)isobutyric acid  (ISO)
alpha-D-galactose  (ISO)
alpha-naphthoflavone  (ISO)
AM-251  (ISO)
amiloride  (ISO)
amino acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
amosite asbestos  (ISO)
amphibole asbestos  (ISO)
anandamide  (ISO)
aniline  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimycin A  (EXP,ISO)
antirheumatic drug  (ISO)
apigenin  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
atazanavir sulfate  (ISO)
atrazine  (ISO)
auraptene  (ISO)
Aurin  (ISO)
azathioprine  (ISO)
benomyl  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bepridil  (ISO)
beta-D-glucosamine  (ISO)
betulinic acid  (ISO)
bexarotene  (EXP)
bilirubin IXalpha  (ISO)
biphenyl-4-amine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bongkrekic acid  (ISO)
boric acid  (ISO)
borrelidin  (ISO)
bortezomib  (EXP,ISO)
brefeldin A  (ISO)
Brevetoxin B  (ISO)
bromobenzene  (EXP)
bufalin  (ISO)
butanal  (ISO)
butylated hydroxyanisole  (ISO)
Butylparaben  (ISO)
butyric acid  (EXP,ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
Calcimycin  (ISO)
calcitriol  (ISO)
calcium carbonate  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
capsaicin  (EXP,ISO)
captan  (ISO)
carbamazepine  (ISO)
carbaryl  (ISO)
carbon atom  (ISO)
carbon nanotube  (ISO)
carboplatin  (EXP)
carboxy-PTIO  (ISO)
casticin  (ISO)
celastrol  (ISO)
celecoxib  (ISO)
chenodeoxycholic acid  (ISO)
chloroacetaldehyde  (ISO)
chloroacetic acid  (ISO)
chloroform  (EXP)
chloropicrin  (ISO)
chloroquine  (EXP,ISO)
chlorpromazine  (EXP)
choline  (EXP,ISO)
chromium atom  (ISO)
chromium(6+)  (EXP)
chrysazin  (ISO)
chrysophanol  (ISO)
cibenzoline  (ISO)
cidofovir anhydrous  (ISO)
ciglitazone  (ISO)
cimetidine  (ISO)
cisplatin  (EXP,ISO)
clodronic acid  (ISO)
clofibrate  (ISO)
cobalt atom  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (EXP,ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (ISO)
D-cycloserine  (ISO)
D-glucose  (EXP,ISO)
D-penicillamine  (ISO)
dantrolene  (EXP,ISO)
demethoxycurcumin  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
desipramine  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
diclofenac  (EXP,ISO)
dicrotophos  (ISO)
dieldrin  (EXP,ISO)
diethylstilbestrol  (ISO)
dihydroartemisinin  (ISO)
dihydrocapsaicin  (ISO)
dihydroxyacetone  (ISO)
dimethyl sulfoxide  (EXP)
dimethylarsinic acid  (ISO)
dimethylarsinous acid  (EXP,ISO)
dinophysistoxin 1  (ISO)
dioxygen  (EXP,ISO)
diquat  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
dorsomorphin  (EXP,ISO)
doxazosin  (ISO)
doxorubicin  (EXP,ISO)
duvoglustat  (EXP)
echinacoside  (ISO)
efavirenz  (ISO)
elemental carbon  (ISO)
emodin  (EXP)
endosulfan  (EXP)
entinostat  (ISO)
erlotinib hydrochloride  (EXP,ISO)
erythromycin estolate  (EXP)
etacrynic acid  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
excitatory amino acid agonist  (ISO)
fangchinoline  (ISO)
fenofibrate  (ISO)
ferric oxide  (ISO)
fisetin  (ISO)
flavokawain B  (ISO)
flavonoids  (EXP)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (EXP,ISO)
folpet  (ISO)
formaldehyde  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
furosemide  (ISO)
gadolinium atom  (ISO)
gadolinium trichloride  (EXP)
galactose  (ISO)
gedunin  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP,ISO)
geraniol  (ISO)
ginsenoside Rg1  (ISO)
glafenine  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glycine  (ISO)
glycochenodeoxycholic acid  (EXP,ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
graphite  (EXP)
Guanabenz  (EXP,ISO)
GW 4064  (ISO)
helenalin  (ISO)
hemin  (EXP,ISO)
hexachlorophene  (ISO)
hexadecanoic acid  (ISO)
homocysteine  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hydroxytyrosol  (EXP)
hypochlorous acid  (ISO)
ifosfamide  (ISO)
Ilimaquinone  (ISO)
indometacin  (EXP,ISO)
ionomycin  (ISO)
iprodione  (ISO)
irinotecan  (EXP)
iron atom  (EXP,ISO)
iron(0)  (EXP,ISO)
iron(III) citrate  (ISO)
isoniazide  (EXP,ISO)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
ketoconazole  (ISO)
KN-93  (EXP)
kojic acid  (EXP)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (EXP)
L-methionine  (EXP)
lactacystin  (ISO)
lamivudine  (ISO)
lead diacetate  (EXP,ISO)
lead nitrate  (ISO)
leflunomide  (ISO)
linagliptin  (ISO)
linoleic acid  (ISO)
linsidomine  (ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (EXP)
lomustine  (ISO)
lucanthone  (ISO)
luteolin  (EXP,ISO)
LY294002  (EXP,ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
mannose  (ISO)
melatonin  (EXP)
menadione  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP,ISO)
metacetamol  (ISO)
metformin  (EXP)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP,ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methyl beta-cyclodextrin  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
methyltestosterone  (ISO)
metyrapone  (ISO)
mevastatin  (ISO)
microcystin-LR  (ISO)
minocycline  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (ISO)
morusin  (ISO)
motexafin gadolinium  (ISO)
myriocin  (ISO)
N,N-dimethylformamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-hexadecanoylsphingosine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methylnicotinate  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
naltrexone  (ISO)
nefazodone  (ISO)
nelfinavir  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (EXP)
niclosamide  (ISO)
nicotine  (EXP,ISO)
nifedipine  (EXP)
Niflumic acid  (ISO)
nilotinib  (ISO)
nimesulide  (EXP,ISO)
nitrofen  (EXP)
nitroprusside  (ISO)
nobiletin  (EXP,ISO)
Nodularin  (ISO)
Nonidet P-40  (ISO)
nonivamide  (ISO)
Nonylphenol  (EXP)
Norbinaltorphimine  (ISO)
NS-398  (ISO)
NSC 23766  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
olaparib  (ISO)
oleanolic acid  (ISO)
oleic acid  (ISO)
oleuropein  (EXP)
omeprazole  (ISO)
orlistat  (ISO)
ouabain  (ISO)
oxaliplatin  (EXP)
oxidopamine  (EXP,ISO)
ozone  (EXP)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parthenolide  (ISO)
patulin  (ISO)
pemetrexed  (ISO)
pentachlorophenol  (ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (ISO)
permethrin  (ISO)
phalloidin  (ISO)
phenethyl caffeate  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
platycodin D  (ISO)
plumbagin  (ISO)
poly(guanylic acid)  (EXP)
potassium bromate  (ISO)
potassium chromate  (ISO)
potassium dichromate  (EXP,ISO)
potassium iodide  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
prostaglandin E2  (ISO)
Ptaquiloside  (ISO)
pterostilbene  (ISO)
pyrazinecarboxamide  (EXP,ISO)
pyrrolidine dithiocarbamate  (EXP,ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
raspberry ketone  (ISO)
reactive oxygen species  (ISO)
resorcinol  (ISO)
resveratrol  (EXP,ISO)
riboflavin  (ISO)
rifampicin  (ISO)
rimonabant  (ISO)
rotenone  (EXP,ISO)
rottlerin  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
Salinomycin  (ISO)
salubrinal  (EXP,ISO)
Salvianolic acid A  (ISO)
salvianolic acid B  (EXP)
SB 203580  (ISO)
SB 431542  (ISO)
SB-239063  (ISO)
SCH 23390  (EXP)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenomethionine  (EXP)
serpentine asbestos  (ISO)
sertraline  (ISO)
sibutramine  (ISO)
silibinin  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (EXP,ISO)
SKF-96365 hydrochloride  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (EXP,ISO)
Soman  (EXP)
sorafenib  (ISO)
SR 144528  (ISO)
staurosporine  (ISO)
streptozocin  (EXP,ISO)
SU6656  (ISO)
succimer  (ISO)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sulfur dioxide  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
superoxide  (ISO)
T-2 toxin  (EXP)
tacrine  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
tauroursodeoxycholic acid  (EXP,ISO)
telmisartan  (EXP)
Terfenadine  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thalidomide  (ISO)
thapsigargin  (EXP,ISO)
thioacetamide  (ISO)
thiostrepton  (ISO)
thymoquinone  (ISO)
Tiron  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
torin 1  (ISO)
triacetin  (ISO)
tributyl phosphate  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (EXP,ISO)
trichloroethene  (ISO)
trimethylamine N-oxide  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (ISO)
tungsten  (EXP)
tunicamycin  (EXP,ISO)
undecane  (EXP)
uranium atom  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
ursolic acid  (ISO)
usnic acid  (ISO)
valproic acid  (ISO)
valsartan  (EXP)
vemurafenib  (ISO)
verapamil  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin E  (EXP,ISO)
vitexin  (ISO)
WIN 55212-2  (ISO)
withaferin A  (ISO)
wortmannin  (ISO)
zearalenone  (ISO)
zidovudine  (ISO)
zileuton  (EXP)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc oxide  (ISO)
zinc protoporphyrin  (EXP)
zinc pyrithione  (ISO)
zinc(0)  (ISO)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (IEP)
anterior/posterior axis specification  (IEA,ISO)
apoptotic process  (ISO,ISS)
blood vessel maturation  (IEA,ISO,ISS)
cell redox homeostasis  (IEA)
cellular response to manganese ion  (IEP)
embryonic organ development  (IEP)
endoplasmic reticulum unfolded protein response  (IEA,ISO,ISS)
ER overload response  (IBA,IEA,IMP,ISO)
establishment of protein localization to mitochondrion  (IEA,ISO)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (IBA,IEA,ISO,ISS)
intrinsic apoptotic signaling pathway in response to nitrosative stress  (IEA,ISO)
luteolysis  (IEP)
negative regulation of canonical Wnt signaling pathway  (IEA,ISO)
negative regulation of cold-induced thermogenesis  (ISO,ISS)
negative regulation of CREB transcription factor activity  (IBA,IDA,IEA,ISO)
negative regulation of determination of dorsal identity  (IEA,ISO)
negative regulation of DNA binding  (IDA,ISO)
negative regulation of DNA-binding transcription factor activity  (ISO)
negative regulation of fat cell differentiation  (IEA,ISO)
negative regulation of interferon-gamma production  (IEA,ISO)
negative regulation of interleukin-17 production  (IEA,ISO)
negative regulation of interleukin-4 production  (IEA,ISO)
negative regulation of myoblast differentiation  (IEA,ISO,ISS)
negative regulation of NF-kappaB transcription factor activity  (IEA,ISO)
negative regulation of protein kinase B signaling  (IEA,ISO)
negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IBA,IDA,IEA,ISO)
negative regulation of transcription, DNA-templated  (ISO,ISS)
positive regulation of apoptotic process  (IMP)
positive regulation of autophagy in response to ER overload  (IMP)
positive regulation of DNA-binding transcription factor activity  (IEA,ISO)
positive regulation of interleukin-8 production  (IEA,ISO,ISS)
positive regulation of intrinsic apoptotic signaling pathway  (IBA,IEA,ISO,ISS)
positive regulation of neuron apoptotic process  (IEA,IMP,ISO,ISS)
positive regulation of neuron death  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  (IBA,IDA,IEA,ISO)
positive regulation of transcription, DNA-templated  (IDA,ISO)
proteasome-mediated ubiquitin-dependent protein catabolic process  (IEA,ISO,ISS)
regulation of autophagy  (IMP)
regulation of cell cycle  (IEA)
regulation of transcription, DNA-templated  (IDA,ISO)
release of sequestered calcium ion into cytosol  (IEA,ISO,ISS)
response to amphetamine  (IEP)
response to drug  (IEP)
response to endoplasmic reticulum stress  (ISO,ISS)
response to hydrogen peroxide  (IEP)
response to nutrient  (IEP)
response to oxidative stress  (IEP)
response to starvation  (IEA,ISO,ISS)
response to toxic substance  (IEP)
response to unfolded protein  (ISO,ISS)
sensory perception of sound  (IEA,ISO)
Wnt signaling pathway  (IEA)

Cellular Component
CHOP-ATF3 complex  (IBA,IEA,ISO)
CHOP-ATF4 complex  (IBA,IEA,ISO)
cytoplasm  (IBA,IDA,ISO)
late endosome  (IEA,ISO)
nucleoplasm  (TAS)
nucleus  (IDA,ISO,TAS)
protein-DNA complex  (IEA,ISO)
RNA polymerase II transcription regulator complex  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
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19. MGD data from the GO Consortium
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24. Pipeline to import KEGG annotations from KEGG into RGD
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27. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
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36. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
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40. Xu X, etal., Front Mol Neurosci. 2017 Jun 26;10:203. doi: 10.3389/fnmol.2017.00203. eCollection 2017.
41. Yang H, etal., Autophagy. 2020 Feb;16(2):271-288. doi: 10.1080/15548627.2019.1606647. Epub 2019 Apr 21.
42. Yang Y, etal., Reprod Sci. 2015 May;22(5):572-84. doi: 10.1177/1933719114553445. Epub 2014 Oct 20.
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Additional References at PubMed
PMID:1547942   PMID:8622660   PMID:9531536   PMID:9930704   PMID:10523647   PMID:10820183   PMID:11478948   PMID:11691921   PMID:11854325   PMID:12477932   PMID:12907753   PMID:14667815  
PMID:14729979   PMID:14752510   PMID:15277470   PMID:15322075   PMID:15601821   PMID:15694370   PMID:15775988   PMID:16434966   PMID:17113167   PMID:17395747   PMID:17715997   PMID:17872950  
PMID:17911345   PMID:18006442   PMID:18534616   PMID:18940792   PMID:19061639   PMID:19175159   PMID:19215662   PMID:19218986   PMID:19299913   PMID:19424493   PMID:19614958   PMID:19752026  
PMID:19769458   PMID:19890920   PMID:20109102   PMID:20829347   PMID:21068199   PMID:21159964   PMID:21225541   PMID:21479580   PMID:21767604   PMID:22065586   PMID:22083547   PMID:22180248  
PMID:22242125   PMID:22265908   PMID:22441668   PMID:22496745   PMID:22653339   PMID:22705154   PMID:22761832   PMID:22815481   PMID:23028046   PMID:23074209   PMID:23239445   PMID:23555658  
PMID:24133119   PMID:24668805   PMID:24939851   PMID:25012492   PMID:25412307   PMID:25902191   PMID:26027784   PMID:26099737   PMID:27278525   PMID:27322831   PMID:27484784   PMID:27957794  
PMID:28667101   PMID:28893685   PMID:29414031   PMID:29653943   PMID:29901175   PMID:29958740   PMID:30188326   PMID:30456794   PMID:30486828   PMID:30561076   PMID:31084986   PMID:31914690  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2763,115,645 - 63,121,203 (+)NCBI
Rnor_6.0 Ensembl770,580,198 - 70,585,084 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0770,578,564 - 70,585,074 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0770,753,800 - 70,759,220 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4767,247,749 - 67,252,571 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1767,268,487 - 67,273,294 (+)NCBI
Celera760,256,651 - 60,261,474 (+)NCBICelera
Cytogenetic Map7q22NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1257,516,588 - 57,521,737 (-)EnsemblGRCh38hg38GRCh38
GRCh381257,516,588 - 57,520,517 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371257,910,371 - 57,914,300 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361256,196,638 - 56,200,567 (-)NCBINCBI36hg18NCBI36
Build 341256,196,639 - 56,200,567NCBI
Celera1257,566,204 - 57,570,133 (-)NCBI
Cytogenetic Map12q13.3NCBI
HuRef1254,948,369 - 54,952,298 (-)NCBIHuRef
CHM1_11257,878,226 - 57,882,156 (-)NCBICHM1_1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3910127,126,662 - 127,132,160 (+)NCBIGRCm39mm39
GRCm39 Ensembl10127,126,643 - 127,132,157 (+)Ensembl
GRCm39 Ensembl10127,126,698 - 127,129,622 (+)Ensembl
GRCm3810127,290,793 - 127,296,291 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10127,290,774 - 127,296,288 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl10127,290,829 - 127,293,753 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710126,727,849 - 126,733,344 (+)NCBIGRCm37mm9NCBIm37
MGSCv3610126,693,759 - 126,699,235 (+)NCBImm8
Celera10129,683,104 - 129,688,599 (+)NCBICelera
Cytogenetic Map10D3NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554585,232,979 - 5,238,513 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554585,232,979 - 5,238,513 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.11231,664,766 - 31,668,699 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1231,664,743 - 31,668,701 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01231,406,332 - 31,410,293 (+)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1101,606,693 - 1,612,410 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl101,606,693 - 1,611,303 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha101,669,927 - 1,675,567 (-)NCBI
ROS_Cfam_1.0101,615,759 - 1,621,400 (-)NCBI
UMICH_Zoey_3.1101,593,774 - 1,599,407 (-)NCBI
UNSW_CanFamBas_1.0101,835,463 - 1,841,297 (-)NCBI
UU_Cfam_GSD_1.0101,960,652 - 1,966,292 (-)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494557,201,026 - 57,205,216 (+)NCBI
SpeTri2.0NW_0049366461,665,019 - 1,669,212 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl522,785,441 - 22,791,134 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1522,785,441 - 22,789,867 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11153,424,693 - 53,429,094 (-)NCBI
ChlSab1.1 Ensembl1153,424,868 - 53,425,576 (-)Ensembl
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_00462480210,437,998 - 10,443,278 (+)NCBI

Position Markers
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0770,585,083 - 70,585,384NCBIRnor6.0
Rnor_5.0770,759,229 - 70,759,530UniSTSRnor5.0
RGSC_v3.4767,252,580 - 67,252,881UniSTSRGSC3.4
Celera760,261,483 - 60,261,784UniSTS
Cytogenetic Map7q22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0770,584,129 - 70,584,846NCBIRnor6.0
Rnor_5.0770,758,275 - 70,758,992UniSTSRnor5.0
RGSC_v3.4767,251,626 - 67,252,343UniSTSRGSC3.4
Celera760,260,528 - 60,261,246UniSTS
Cytogenetic Map7q22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0770,583,737 - 70,583,941NCBIRnor6.0
Rnor_5.0770,757,883 - 70,758,087UniSTSRnor5.0
RGSC_v3.4767,251,234 - 67,251,438UniSTSRGSC3.4
Celera760,260,136 - 60,260,340UniSTS
Cytogenetic Map7q22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0770,584,745 - 70,584,963NCBIRnor6.0
Rnor_5.0770,758,891 - 70,759,109UniSTSRnor5.0
RGSC_v3.4767,252,242 - 67,252,460UniSTSRGSC3.4
Celera760,261,145 - 60,261,363UniSTS
Cytogenetic Map7q22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0770,584,635 - 70,584,938NCBIRnor6.0
Rnor_5.0770,758,781 - 70,759,084UniSTSRnor5.0
RGSC_v3.4767,252,132 - 67,252,435UniSTSRGSC3.4
Celera760,261,035 - 60,261,338UniSTS
Cytogenetic Map7q22UniSTS

QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)72920071124838025Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)712328467106995532Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)72536563393155402Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72820465373204653Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)73138152976381529Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)73203505377035053Rat
61439Cia8Collagen induced arthritis QTL 85.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)73257294277572942Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)73304444971352127Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)73586772980867729Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)73586772993155402Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73854770683547706Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)74087268285872682Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)74087268285872682Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74530157390301573Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)748118835128611831Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)75025210395252103Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)750704769128085642Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)75079381895793818Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)751251919118477612Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)751251919145729302Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)751252005111589099Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)75320034498200344Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)75425951299259512Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)75453499673293934Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)755072862123602998Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)755072862123602998Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)755072862123602998Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)755495689100495689Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)755495689100495689Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)755495689100495689Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)755495689100495689Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)755495689100495689Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)755495689100495689Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)755495689100495689Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)761047589113228378Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)768518460113518460Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)769399586111043530Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)769399586111043530Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)770421228115421228Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:177
Count of miRNA genes:145
Interacting mature miRNAs:161
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 43 34 18 19 18 4 7 72 35 41 11 4
Low 23 23 23 4 4 2 4
Below cutoff