Ptdss1 (phosphatidylserine synthase 1)

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Gene: Ptdss1 (phosphatidylserine synthase 1) Rattus norvegicus

Analyze

Symbol:

Ptdss1

Name:

phosphatidylserine synthase 1

RGD ID:

1308949

Description:

Predicted to enable L-serine-phosphatidylcholine phosphatidyltransferase activity and L-serine-phosphatidylethanolamine phosphatidyltransferase activity. Predicted to be involved in phosphatidylserine biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in Lenz-Majewski hyperostotic dwarfism. Orthologous to human PTDSS1 (phosphatidylserine synthase 1); PARTICIPATES IN glycerophospholipid metabolic pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC314553; PSS-1; ptdSer synthase 1; serine-exchange enzyme I

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PTDSS1 (phosphatidylserine synthase 1)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther
Mus musculus (house mouse):	Ptdss1 (phosphatidylserine synthase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ptdss1 (phosphatidylserine synthase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PTDSS1 (phosphatidylserine synthase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PTDSS1 (phosphatidylserine synthase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ptdss1 (phosphatidylserine synthase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PTDSS1 (phosphatidylserine synthase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PTDSS1 (phosphatidylserine synthase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ptdss1 (phosphatidylserine synthase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	PTDSS1 (phosphatidylserine synthase 1)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Ptdss1 (phosphatidylserine synthase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ptdss1a (phosphatidylserine synthase 1a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ptdss1b (phosphatidylserine synthase 1b)	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	pssy-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	pssy-2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Pss	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	7	63,845,017 - 63,906,791 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	63,844,268 - 63,906,791 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	65,734,217 - 65,795,993 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	7	67,936,400 - 67,998,188 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	7	67,729,165 - 67,791,454 (+)	NCBI	Rnor_WKY
Rnor_6.0	7	71,294,140 - 71,356,153 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	71,293,388 - 71,356,153 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	71,466,006 - 71,526,225 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	67,988,402 - 68,062,192 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	68,009,131 - 68,082,922 (+)	NCBI
Celera	7	60,977,457 - 61,038,477 (+)	NCBI		Celera
Cytogenetic Map	7	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Klippel-Feil syndrome 1 (ISO)

Lenz-Majewski hyperostotic dwarfism (ISO)

microcephaly (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3,3',4,4'-tetrachlorobiphenyl (ISO)

aflatoxin B1 (ISO)

antirheumatic drug (ISO)

bisphenol A (EXP,ISO)

caffeine (ISO)

cisplatin (ISO)

cocaine (EXP)

coumarin (ISO)

ethanol (ISO)

folic acid (ISO)

gentamycin (EXP)

ivermectin (ISO)

methyl methanesulfonate (ISO)

pirinixic acid (ISO)

sodium arsenite (ISO)

Soman (EXP)

thapsigargin (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

phosphatidylserine biosynthetic process (IEA,ISO)

Cellular Component

endoplasmic reticulum membrane (IEA,ISO)

Molecular Function

L-serine-phosphatidylcholine phosphatidyltransferase activity (IEA,ISO)

L-serine-phosphatidylethanolamine phosphatidyltransferase activity (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

glycerophospholipid metabolic pathway (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
3.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
4.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10938271	PMID:12477932	PMID:19946888

Genomics

Comparative Map Data

Ptdss1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	7	63,845,017 - 63,906,791 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	63,844,268 - 63,906,791 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	65,734,217 - 65,795,993 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	7	67,936,400 - 67,998,188 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	7	67,729,165 - 67,791,454 (+)	NCBI	Rnor_WKY
Rnor_6.0	7	71,294,140 - 71,356,153 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	71,293,388 - 71,356,153 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	71,466,006 - 71,526,225 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	67,988,402 - 68,062,192 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	68,009,131 - 68,082,922 (+)	NCBI
Celera	7	60,977,457 - 61,038,477 (+)	NCBI		Celera
Cytogenetic Map	7	q22	NCBI

PTDSS1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	96,261,902 - 96,336,995 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	8	96,261,902 - 96,336,995 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	97,274,130 - 97,349,223 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	97,343,343 - 97,415,950 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	97,343,342 - 97,415,950	NCBI
Celera	8	93,460,160 - 93,532,736 (+)	NCBI		Celera
Cytogenetic Map	8	q22.1	NCBI
HuRef	8	92,479,689 - 92,552,263 (+)	NCBI		HuRef
CHM1_1	8	97,314,407 - 97,387,024 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	8	97,387,620 - 97,462,689 (+)	NCBI		T2T-CHM13v2.0

Ptdss1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	67,080,894 - 67,146,465 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	67,080,894 - 67,146,465 (+)	Ensembl		GRCm39 Ensembl
GRCm38	13	66,932,830 - 66,998,401 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	66,932,830 - 66,998,401 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	67,033,766 - 67,099,337 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	64,423,650 - 64,489,143 (+)	NCBI		MGSCv36	mm8
MGSCv36	13	67,368,579 - 67,433,261 (+)	NCBI		MGSCv36	mm8
Celera	13	70,308,773 - 70,371,947 (-)	NCBI		Celera
Cytogenetic Map	13	B3	NCBI
cM Map	13	34.54	NCBI

Ptdss1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955417	12,268,107 - 12,327,127 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955417	12,268,908 - 12,327,127 (+)	NCBI	ChiLan1.0	ChiLan1.0

PTDSS1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	8	95,084,103 - 95,156,104 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	95,084,103 - 95,156,104 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	8	92,886,918 - 92,959,611 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

PTDSS1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	29	40,747,840 - 40,819,162 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	29	40,768,237 - 40,925,800 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
ROS_Cfam_1.0	29	40,939,569 - 41,010,540 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	29	40,959,875 - 41,010,535 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	29	40,982,408 - 41,053,433 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	29	40,951,514 - 41,022,559 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	29	41,414,291 - 41,485,327 (+)	NCBI		UU_Cfam_GSD_1.0

Ptdss1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	38,783,173 - 38,849,205 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936470	46,208,688 - 46,275,361 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936470	46,209,700 - 46,275,305 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PTDSS1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	40,297,879 - 40,376,076 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	40,297,876 - 40,376,099 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	43,478,296 - 43,524,101 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PTDSS1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	91,226,250 - 91,298,387 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	91,226,796 - 91,299,717 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666039	49,489,853 - 49,560,889 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ptdss1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624763	3,587,724 - 3,650,799 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624763	3,587,863 - 3,649,921 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Ptdss1
217 total Variants

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	924703	115097879	Rat
1643004	Pain2	Pain QTL 2	1		mechanical nociception trait (VT:0002734)	self mutilation severity score (CMO:0002145)	7	9462246	98011544	Rat
1300132	Bp182	Blood pressure QTL 182	3.49		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	7	19654317	84928080	Rat
7411569	Bw137	Body weight QTL 137		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	7	21921195	66921195	Rat
1641885	Alcrsp9	Alcohol response QTL 9			alcohol metabolism trait (VT:0015089)	blood ethanol level (CMO:0000535)	7	24099606	69099606	Rat
1549840	Bss5	Bone structure and strength QTL 5	9.8		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	7	24751841	69751841	Rat
70190	Mcs6	Mammary carcinoma susceptibility QTL 6	2.29		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	7	26737401	63902784	Rat
10402855	Bp379	Blood pressure QTL 379		0.21	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	29409683	74409683	Rat
1300127	Srn1	Serum renin concentration QTL 1	3.87		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	7	29409683	84928080	Rat
10755453	Coatc12	Coat color QTL 12		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	31112832	76112832	Rat
7411605	Foco14	Food consumption QTL 14	24.1	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	34293282	79293282	Rat
631534	Lnnr1	Liver neoplastic nodule remodeling QTL 1	3.85	0.001	liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)	7	34293282	79293282	Rat
631513	Scl7	Serum cholesterol level QTL 7	4.1		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	7	37960569	82960569	Rat
61357	Bp38	Blood pressure QTL 38	1.6	0.052	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	41333674	119109060	Rat
634326	Hc3	Hypercalciuria QTL 3	2.1		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	7	42787314	87787314	Rat
10053722	Scort27	Serum corticosterone level QTL 27	2.41	0.0083	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	7	43228750	88228750	Rat
1358361	Sradr5	Stress Responsive Adrenal Weight QTL 5	5.55		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	7	43747012	108555253	Rat
1300179	Kidm5	Kidney mass QTL 5	3.51		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	43747012	135012528	Rat
1300149	Cm6	Cardiac mass QTL 6	4.09		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	7	43747099	102228765	Rat
631504	Cm27	Cardiac mass QTL 27	3.45		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	7	44421311	118198041	Rat
61428	Scl3	Serum cholesterol level QTL 3	3.2		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	7	44867533	89867533	Rat
738030	Anxrr8	Anxiety related response QTL 8	4.1		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	46590070	91590070	Rat
10059605	Kidm47	Kidney mass QTL 47	2.91	0.05	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	7	47251783	65728867	Rat
2293696	Bmd32	Bone mineral density QTL 32	5.1	0.0001	femur strength trait (VT:0010010)	femoral neck polar moment of inertia (CMO:0001670)	7	47651439	92651439	Rat
2293707	Bss32	Bone structure and strength QTL 32	7.64	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	7	47651439	92651439	Rat
2300178	Bmd54	Bone mineral density QTL 54	5.3	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	7	47651439	92651439	Rat
2293644	Bmd29	Bone mineral density QTL 29	5.4	0.0001	femur size trait (VT:1000369)	femoral neck cross-sectional area (CMO:0001697)	7	47651439	92651439	Rat
2293667	Bss42	Bone structure and strength QTL 42	7.25	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra cross-sectional area (CMO:0001689)	7	47651439	92651439	Rat
2293678	Bss24	Bone structure and strength QTL 24	6.71	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	7	47651439	92651439	Rat
2293685	Bmd21	Bone mineral density QTL 21	4.2	0.0003	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	7	47651439	92651439	Rat
1300151	Bp181	Blood pressure QTL 181	3.36		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	7	53612714	103945643	Rat
2317035	Aia16	Adjuvant induced arthritis QTL 16	2.71		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	7	59238038	104238038	Rat
1298528	Bp169	Blood pressure QTL 169		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	61074194	106074194	Rat
1559283	Emca4	Estrogen-induced mammary cancer QTL 4	3.7		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	7	62004452	101773158	Rat
1576303	Ept7	Estrogen-induced pituitary tumorigenesis QTL 7	3.7		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	7	62004452	101773158	Rat

Markers in Region

D7Rat45

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	63,902,608 - 63,902,784 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	71,351,952 - 71,352,127	NCBI	Rnor6.0
Rnor_5.0	7	71,522,185 - 71,522,360	UniSTS	Rnor5.0
RGSC_v3.4	7	68,056,925 - 68,057,251	RGD	RGSC3.4
RGSC_v3.4	7	68,056,997 - 68,057,172	UniSTS	RGSC3.4
RGSC_v3.1	7	68,077,655 - 68,077,981	RGD
Celera	7	61,034,295 - 61,034,470	UniSTS
FHH x ACI Map	7	33.46	RGD
FHH x ACI Map	7	33.46	UniSTS
Cytogenetic Map	7	q22	UniSTS

RH130952

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	63,906,389 - 63,906,575 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	71,355,752 - 71,355,937	NCBI	Rnor6.0
Rnor_5.0	7	71,525,824 - 71,526,009	UniSTS	Rnor5.0
RGSC_v3.4	7	68,061,791 - 68,061,976	UniSTS	RGSC3.4
Celera	7	61,038,076 - 61,038,261	UniSTS
Cytogenetic Map	7	q22	UniSTS

AU044268

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	63,906,539 - 63,906,674 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	71,355,902 - 71,356,036	NCBI	Rnor6.0
Rnor_5.0	7	71,525,974 - 71,526,108	UniSTS	Rnor5.0
RGSC_v3.4	7	68,061,941 - 68,062,075	UniSTS	RGSC3.4
Celera	7	61,038,226 - 61,038,360	UniSTS
Cytogenetic Map	7	q22	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	34	57	41	19	41	4	6	74	35	41	11	4
Low		9					4	5					4
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001012113	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC087129	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ225243	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000185	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000083959 ⟹ ENSRNOP00000071072

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	63,844,268 - 63,906,791 (+)	Ensembl
Rnor_6.0 Ensembl	7	71,293,388 - 71,355,417 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000087143 ⟹ ENSRNOP00000072374

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	63,844,729 - 63,906,787 (+)	Ensembl
Rnor_6.0 Ensembl	7	71,294,140 - 71,356,153 (+)	Ensembl

RefSeq Acc Id:

NM_001012113 ⟹ NP_001012113

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	63,845,017 - 63,906,791 (+)	NCBI
Rnor_6.0	7	71,294,140 - 71,356,153 (+)	NCBI
Rnor_5.0	7	71,466,006 - 71,526,225 (+)	NCBI
RGSC_v3.4	7	67,988,402 - 68,062,192 (+)	RGD
Celera	7	60,977,457 - 61,038,477 (+)	RGD

Sequence:

show sequence

CCCGGCCCCAGCGTCAGGCTAGTTTGCCGCTGCGGTCCTTCACTGCCGGGGTCCCAGCCTTCTC
GGGCCGGGGCCTCCGGCGCCGCGGCAGGACGGGGAGAAGAACTATGGCGTCCTGCGTAGGGAGC
AGGACTCTGAGCAAGGATGATGTGAACTACAGGATGCATTTCCGCATGATCAACGAGCAGCAAG
TGGAGGACATCACCATAGACTTCTTCTACCGGCCGCACACCATCACCCTGCTCAGCTTTACCAT
CATCAGCCTCATGTACTTCGCCTTCACCAGGGATGACTGTGTTCCTGAAGACAACATCTGGAGA
GGCATCCTTTCCGTTATCTTCTTCTTCCTCATCATCAGCGTGTTAGCATTCCCCAATGGCCCTT
TTACTCGGCCCCATCCAGCCTTATGGCGAATGGTTTTTGGCCTCAGTGTGCTGTACTTCCTCTT
CTTGGTATTCCTCCTGTTCCTGAACTTCGAGCAGGTTAAATCCCTGATGTATTGGCTCGACCCC
AATCTCCGATACGCCACCAGAGAAGCAGACATCATGGAGTATGCCGTGAACTGTCATGTGATCA
CCTGGGAGAGAATCGTTAGTCACTTTGATATATTTGCTTTTGGGCATTTCTGGGGCTGGGCCAT
GAAGGCCTTGTTGATCCGTAGTTATGGGCTCTGCTGGACAATCAGTATCACCTGGGAGCTGACA
GAGCTTTTCTTCATGCATCTTCTGCCCAACTTTGCTGAGTGCTGGTGGGACCAGGTCATTCTGG
ACATCCTGTTGTGTAATGGTGGTGGAATCTGGCTGGGCATGGTCGTTTGCCGGTTTTTGGAGAT
GAGGACTTACCACTGGGCAAGCTTCAAGGACATCCACACCACCACAGGGAAGATCAAGCGTGCT
GTGCTACAGTTCACCCCTGCTAGCTGGACCTACGTCAGGTGGTTTGACCCCAAGTCTTCCTTTC
AGAGAGTGGCTGGTATATACCTTTTCATGATCATCTGGCAGCTGACTGAGTTGAATACCTTCTT
CTTGAAGCACATCTTTGTGTTCCAAGCCAGCCATCCCTTAAGCTGGTGCAGAATTCTCTTCATC
GGCTGCATTACGGCTCCCACAGTGAGACAGTACTACGCCTACCTCACGGACACACAGTGCAAGC
GTGTGGGGACACAGTGCTGGGTATTTGGGGTCATTGGTTTCCTGGAAGCCATTGTTTGCATCAA
ATTTGGACAAGATCTCTTCTCTAAGACCCAGATACTCTACGTGGTGCTTTGGCTTCTTTGTGTG
GCCTTCACTACGTTCCTGTGTCTGTACGGCATGGTTTGGTATGCAGAGCACTATGGACACCGGG
AAAAGACCTATTCAGAGTGCGAAGATGGCACTTACAGTCCAGAGATCTCTTGGTATCACGGGAA
AGGCTCAAAAGGTTCTGAGGACAGCCCACCGAAGCATTCAAACAACAACGAAAGCCATTCTTCC
AGAAGAAGGAACCGGCATTCCAAGTCCAAAGTCACCAATGGAGTTGGGAAGAAATGAAGGAGGC
GAGTTAATGTCCGATGTTCCAGAGTGCCTAGACCTGAGAGGAAAACAGCACATTTGGACCTTCC
TATGCGGAGATCAAAATGTACAGAAAGAACAGAGGGAGCTTTGAGGATCATGATTTGAGGGTAT
AAGTCTTGTCTCCCATCCACCTGGACACAACACTAGGTTCACCATGGCTTGGGGCCCTTTGCCA
ACTGGAGTTGTTTCTTAACTTCAGCACATGGCTTGCGTTCTCTGGTAGCAATACAGTGTGCTGG
AAGGACAGGAGAGCTGTTTGTCCCCAGCTGCCAGCAGTGGCTCTATGCTGGTGTGTCTTGTGGA
TGTTGTATAAATGTCTTCATTCAGATGTTGACTTAACCGACTGGCTAATGAACTGGTCACTGGG
TTTTATTTTTATGAGTCTGCCTTTCCATTTGATTGATTGTTTACATTCAGTCAGTCTGCTCTTA
CTTAGTGTTTTCAAGTTAAAATGCTTAAAAGCTTCCAGAATCCACTGCTGAAACTGGGGGAGGG
TTCCTTCTGGAGAAACAAAGGGTGGAAGGAGCTTATATCCCTGCTTAGCATACTCAGTCCCCAG
CCACACGGCAGATGACCAGCAGCCTGAGTGAAGAGGCTGGCTGCTGGCCCTGGAGCCTCGGCTT
TAGATTAGAACTGTTTTTGTTCCCTTCCAAATACTGTCCAGACTGAGTGCACAAGAACGACCTT
GCTAGAGGGGCTGGGACACGGGCTCTCCTGCCAGGTGCCTTTTCCGCGTGCGTGGTTTTCCTTC
TGTGATGTGTTACCTTCTTCATCTTTCTGTCTCATGTGAGGTGCTAGTGAGTATTAACTAACCT
TCGTCTGTGCCATGCTCTACTAGAACATTCTCCGGGTCTACCCTGGATCCTTGTTTAAATAAAC
CAGTTCACATTAAAAAGTTCATCAAAGATCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001012113	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH87129	(Get FASTA)	NCBI Sequence Viewer
	Q5PQL5	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001012113 ⟸ NM_001012113

- UniProtKB:

Q5PQL5 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MASCVGSRTLSKDDVNYRMHFRMINEQQVEDITIDFFYRPHTITLLSFTIISLMYFAFTRDDCV
PEDNIWRGILSVIFFFLIISVLAFPNGPFTRPHPALWRMVFGLSVLYFLFLVFLLFLNFEQVKS
LMYWLDPNLRYATREADIMEYAVNCHVITWERIVSHFDIFAFGHFWGWAMKALLIRSYGLCWTI
SITWELTELFFMHLLPNFAECWWDQVILDILLCNGGGIWLGMVVCRFLEMRTYHWASFKDIHTT
TGKIKRAVLQFTPASWTYVRWFDPKSSFQRVAGIYLFMIIWQLTELNTFFLKHIFVFQASHPLS
WCRILFIGCITAPTVRQYYAYLTDTQCKRVGTQCWVFGVIGFLEAIVCIKFGQDLFSKTQILYV
VLWLLCVAFTTFLCLYGMVWYAEHYGHREKTYSECEDGTYSPEISWYHGKGSKGSEDSPPKHSN
NNESHSSRRRNRHSKSKVTNGVGKK

hide sequence

RefSeq Acc Id:

ENSRNOP00000072374 ⟸ ENSRNOT00000087143

RefSeq Acc Id:

ENSRNOP00000071072 ⟸ ENSRNOT00000083959

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5PQL5-F1-model_v2	AlphaFold	Q5PQL5	1-473	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695275

Promoter ID:

EPDNEW_R5800

Type:

initiation region

Name:

Ptdss1_1

Description:

phosphatidylserine synthase 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	71,294,137 - 71,294,197	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308949	AgrOrtholog
BioCyc Gene	G2FUF-33708	BioCyc
BioCyc Pathway	PWY-7501 [phosphatidylserine biosynthesis I]	BioCyc
Ensembl Genes	ENSRNOG00000052289	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000071072.2	UniProtKB/TrEMBL
	ENSRNOP00000072374	ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOP00000072374.2	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000083959.2	UniProtKB/TrEMBL
	ENSRNOT00000087143	ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOT00000087143.2	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7112273	IMAGE-MGC_LOAD
InterPro	PSS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:314553	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:94919	IMAGE-MGC_LOAD
NCBI Gene	314553	ENTREZGENE
PANTHER	PHOSPHATIDYLINOSITOL SYNTHASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PHOSPHATIDYLSERINE SYNTHASE 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	PSS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Ptdss1	PhenoGen
UniProt	A0A0G2JZJ5_RAT	UniProtKB/TrEMBL
	A0A0G2K2U0_RAT	UniProtKB/TrEMBL
	PTSS1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-12-06	Ptdss1	phosphatidylserine synthase 1	Ptdss1_predicted	phosphatidylserine synthase 1 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Ptdss1_predicted	phosphatidylserine synthase 1 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)