Avil (advillin) - Rat Genome Database

Name: Avil
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Avil (advillin) Rattus norvegicus

Analyze

Symbol:

Avil

Name:

advillin

RGD ID:

620301

Description:

Exhibits actin binding activity. Involved in nervous system development and positive regulation of neuron projection development. Localizes to neuron projection. Human ortholog(s) of this gene implicated in familial nephrotic syndrome. Orthologous to human AVIL (advillin); INTERACTS WITH 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

peripheral nervous system villin-like protein; pervin

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	AVIL (advillin)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Avil (advillin)	HGNC	EggNOG, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Avil (advillin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	AVIL (advillin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	AVIL (advillin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Avil (advillin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	AVIL (advillin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	AVIL (advillin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Avil (advillin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	AVIL (advillin)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Mus musculus (house mouse):	Avil (advillin)	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Gel	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	7	62,825,459 - 62,844,103 (+)	NCBI
Rnor_6.0 Ensembl	7	70,292,565 - 70,310,588 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	7	70,292,565 - 70,310,588 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	7	70,468,814 - 70,486,801 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	7	59,970,228 - 59,988,243 (+)	NCBI		Celera
Cytogenetic Map	7	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

combined oxidative phosphorylation deficiency 3 (ISO)

nephrotic syndrome type 2 (ISO)

Nephrotic Syndrome Type 21 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-catechin (ISO)

1,2-dimethylhydrazine (ISO)

1,3-dinitrobenzene (EXP)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4-hydroxynon-2-enal (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (EXP)

aflatoxin B1 (ISO)

aflatoxin B2 (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

beta-naphthoflavone (EXP)

bisphenol A (EXP)

cadmium atom (ISO)

cannabidiol (ISO)

cisplatin (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

decabromodiphenyl ether (EXP)

diarsenic trioxide (ISO)

dichloroacetic acid (ISO)

endosulfan (EXP)

fenvalerate (EXP)

flavonoids (EXP)

furan (EXP)

genistein (ISO)

manganese(II) chloride (EXP)

methapyrilene (ISO)

N-methyl-4-phenylpyridinium (EXP)

N-nitrosodiethylamine (EXP)

nickel atom (ISO)

ochratoxin A (EXP,ISO)

pentanal (ISO)

potassium dichromate (ISO)

rotenone (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium dichromate (ISO)

sunitinib (ISO)

testosterone (ISO)

titanium dioxide (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin filament organization (ISO,ISS)

actin filament severing (IBA)

actin polymerization or depolymerization (IBA)

barbed-end actin filament capping (IBA)

cilium assembly (ISO,ISS)

nervous system development (IDA)

positive regulation of lamellipodium assembly (ISO,ISS)

positive regulation of neuron projection development (IDA,ISO)

regulation of diacylglycerol biosynthetic process (ISO,ISS)

Cellular Component

actin cytoskeleton (IBA)

actin filament (ISO,ISS)

axon (IEA)

cell projection (IDA)

cytoplasm (IBA)

focal adhesion (ISO,ISS)

lamellipodium (ISO,ISS)

neuron projection (IDA)

Molecular Function

actin binding (IDA,TAS)

actin filament binding (IBA,ISO,ISS)

Arp2/3 complex binding (ISO,ISS)

phosphatidylinositol-4,5-bisphosphate binding (IBA)

protein binding (ISO)

References

References - curated


1.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA data from the GO Consortium
3.	MGD data from the GO Consortium
4.	NCBI rat LocusLink and RefSeq merged data July 26, 2002
5.	Ravenall SJ, etal., Eur J Neurosci 2002 Jan;15(2):281-90.
6.	RGD automated data pipeline
7.	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:15247299	PMID:20393563	PMID:29058690

Genomics

Comparative Map Data

Avil
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	7	62,825,459 - 62,844,103 (+)	NCBI
Rnor_6.0 Ensembl	7	70,292,565 - 70,310,588 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	7	70,292,565 - 70,310,588 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	7	70,468,814 - 70,486,801 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	7	59,970,228 - 59,988,243 (+)	NCBI		Celera
Cytogenetic Map	7	q22	NCBI

AVIL
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	12	57,797,376 - 57,818,704 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	12	57,797,376 - 57,818,704 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	12	58,191,159 - 58,209,852 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	56,477,710 - 56,496,119 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	12	56,477,709 - 56,496,119	NCBI
Celera	12	57,849,081 - 57,867,775 (-)	NCBI
Cytogenetic Map	12	q14.1	NCBI
HuRef	12	55,228,126 - 55,246,820 (-)	NCBI		HuRef
CHM1_1	12	58,158,950 - 58,177,640 (-)	NCBI		CHM1_1

Avil
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	126,835,933 - 126,856,863 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	10	126,836,578 - 126,856,863 (+)	Ensembl
GRCm38	10	127,000,065 - 127,020,994 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	127,000,709 - 127,020,994 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	126,437,765 - 126,458,050 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	10	126,403,688 - 126,423,937 (+)	NCBI			mm8
Celera	10	129,392,671 - 129,412,930 (+)	NCBI		Celera
Cytogenetic Map	10	D3	NCBI

Avil
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955458	5,499,652 - 5,520,137 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955458	5,499,392 - 5,523,463 (-)	NCBI	ChiLan1.0	ChiLan1.0

AVIL
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	12	31,369,872 - 31,389,847 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	31,369,872 - 31,389,847 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	12	31,108,569 - 31,129,307 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

AVIL
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	10	1,856,162 - 1,872,303 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	10	1,855,598 - 1,875,156 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Avil
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936646	1,930,447 - 1,952,069 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

AVIL
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	23,087,956 - 23,132,465 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	23,087,946 - 23,110,602 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

AVIL
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	53,708,969 - 53,732,219 (-)	NCBI
ChlSab1.1 Ensembl	11	53,707,566 - 53,728,894 (-)	Ensembl

Avil
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624802	10,134,518 - 10,154,274 (+)	NCBI

Position Markers

RH139372

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	7	70,295,558 - 70,295,776	NCBI	Rnor6.0
Rnor_5.0	7	70,471,807 - 70,472,025	UniSTS	Rnor5.0
Celera	7	59,973,221 - 59,973,439	UniSTS

RH131678

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	7	70,310,355 - 70,310,568	NCBI	Rnor6.0
Rnor_5.0	7	70,486,568 - 70,486,781	UniSTS	Rnor5.0
Celera	7	59,988,010 - 59,988,223	UniSTS

RH143505

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	7	70,295,509 - 70,295,609	NCBI	Rnor6.0
Rnor_5.0	7	70,471,758 - 70,471,858	UniSTS	Rnor5.0
Celera	7	59,973,172 - 59,973,272	UniSTS

AW527064

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	7	70,297,131 - 70,297,299	NCBI	Rnor6.0
Rnor_5.0	7	70,473,380 - 70,473,548	UniSTS	Rnor5.0
Celera	7	59,974,794 - 59,974,962	UniSTS

Avil

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	7	70,296,126 - 70,297,530	NCBI	Rnor6.0
Rnor_5.0	7	70,472,375 - 70,473,779	UniSTS	Rnor5.0
Celera	7	59,973,789 - 59,975,193	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	2920071	124838025	Rat
1643004	Pain2	Pain QTL 2	1		mechanical nociception trait (VT:0002734)	self mutilation severity score (CMO:0002145)	7	12328467	106995532	Rat
1300132	Bp182	Blood pressure QTL 182	3.49		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	7	25365633	93155402	Rat
7411569	Bw137	Body weight QTL 137		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	7	28204653	73204653	Rat
1641885	Alcrsp9	Alcohol response QTL 9			alcohol metabolism trait (VT:0015089)	blood ethanol level (CMO:0000535)	7	31381529	76381529	Rat
1549840	Bss5	Bone structure and strength QTL 5	9.8		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	7	32035053	77035053	Rat
61439	Cia8	Collagen induced arthritis QTL 8	5.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	7	32572942	77572942	Rat
70190	Mcs6	Mammary carcinoma susceptibility QTL 6	2.29		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	7	33044449	71352127	Rat
10402855	Bp379	Blood pressure QTL 379		0.21	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	35867729	80867729	Rat
1300127	Srn1	Serum renin concentration QTL 1	3.87		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	7	35867729	93155402	Rat
10755453	Coatc12	Coat color QTL 12		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	38547706	83547706	Rat
631534	Lnnr1	Liver neoplastic nodule remodeling QTL 1	3.85	0.001	liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)	7	40872682	85872682	Rat
7411605	Foco14	Food consumption QTL 14	24.1	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	40872682	85872682	Rat
631513	Scl7	Serum cholesterol level QTL 7	4.1		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	7	45301573	90301573	Rat
61357	Bp38	Blood pressure QTL 38	1.6	0.052	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	48118835	128611831	Rat
634326	Hc3	Hypercalciuria QTL 3	2.1		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	7	50252103	95252103	Rat
631504	Cm27	Cardiac mass QTL 27	3.45		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	7	50704769	128085642	Rat
10053722	Scort27	Serum corticosterone level QTL 27	2.41	0.0083	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	7	50793818	95793818	Rat
1358361	Sradr5	Stress Responsive Adrenal Weight QTL 5	5.55		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	7	51251919	118477612	Rat
1300179	Kidm5	Kidney mass QTL 5	3.51		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	51251919	145729302	Rat
1300149	Cm6	Cardiac mass QTL 6	4.09		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	7	51252005	111589099	Rat
61428	Scl3	Serum cholesterol level QTL 3	3.2		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	7	53200344	98200344	Rat
738030	Anxrr8	Anxiety related response QTL 8	4.1		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	54259512	99259512	Rat
10059605	Kidm47	Kidney mass QTL 47	2.91	0.05	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	7	54534996	73293934	Rat
2316947	Rf58	Renal function QTL 58	7.8		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	7	55072862	123602998	Rat
2316952	Pur22	Proteinuria QTL 22	5.2		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	7	55072862	123602998	Rat
2316955	Stl24	Serum triglyceride level QTL 24	7.1		blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	7	55072862	123602998	Rat
2300178	Bmd54	Bone mineral density QTL 54	5.3	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	7	55495689	100495689	Rat
2293644	Bmd29	Bone mineral density QTL 29	5.4	0.0001	femur size trait (VT:1000369)	femoral neck cross-sectional area (CMO:0001697)	7	55495689	100495689	Rat
2293667	Bss42	Bone structure and strength QTL 42	7.25	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra cross-sectional area (CMO:0001689)	7	55495689	100495689	Rat
2293678	Bss24	Bone structure and strength QTL 24	6.71	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	7	55495689	100495689	Rat
2293685	Bmd21	Bone mineral density QTL 21	4.2	0.0003	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	7	55495689	100495689	Rat
2293696	Bmd32	Bone mineral density QTL 32	5.1	0.0001	femur strength trait (VT:0010010)	femoral neck polar moment of inertia (CMO:0001670)	7	55495689	100495689	Rat
2293707	Bss32	Bone structure and strength QTL 32	7.64	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	7	55495689	100495689	Rat
1300151	Bp181	Blood pressure QTL 181	3.36		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	7	61047589	113228378	Rat
2317035	Aia16	Adjuvant induced arthritis QTL 16	2.71		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	7	68518460	113518460	Rat
1576303	Ept7	Estrogen-induced pituitary tumorigenesis QTL 7	3.7		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	7	69399586	111043530	Rat
1559283	Emca4	Estrogen-induced mammary cancer QTL 4	3.7		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	7	69399586	111043530	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	184
Count of miRNA genes:	127
Interacting mature miRNAs:	139
Transcripts:	ENSRNOT00000073237
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	1											4
Low	2	43	41	25	19	25	8	11	74	35	39	7	8
Below cutoff			16	16		16					2

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_024401	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039079941	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF099929	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473950	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000185	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000073237 ⟹ ENSRNOP00000067218

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	7	70,292,565 - 70,310,588 (+)	Ensembl

RefSeq Acc Id:

NM_024401 ⟹ NP_077377

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	62,826,076 - 62,844,101 (+)	NCBI
Rnor_6.0	7	70,292,565 - 70,310,588 (+)	NCBI
Rnor_5.0	7	70,468,814 - 70,486,801 (+)	NCBI
Celera	7	59,970,228 - 59,988,243 (+)	NCBI

Sequence:

show sequence

GAAACAGGCTTCAGGACCCGAGGTCGCCTGCTTCGGGACCGCTCGTCAGTACTTCACCTGCTGC
TTTGCTGGGAAAGGGAGAACAGAGGGTCAGTTCCAGGAAGACAGACACTATGTCTCTGAGCAGT
GCCTTCAGGACTGTGACCAATGACCCCGGGATTATCACGTGGAGAATTGAGAAAATGGAGCTGG
TGCTGGTGCCCCTGAGTGCTCATGGCAACTTCTATGAGGGAGACTGCTACATCATCCTCTCGAC
CCGGAGAGTGGGCAGCCTTCTCTCCCAAAACATCCACTTTTGGATCGGGAAGGACTCCTCCCAA
GATGAGCAGAGCTGTGCAGCCATCTATACCACACAGCTGGATGACTACCTGGGAGGCAGCCCCG
TGCAGCACCGTGAGGTCCAGTACCATGAGTCTGACACCTTCCGTGGCTACTTCAAGCGGGGCAT
CATCTATAAAAAGGGGGGTGTGGCCTCTGGGATGAAGCATGTGGAGACCAACACCTATGATGTG
AAGAGGCTGTTACATGTGAAGGGGAAAAGAAACATCAGAGCCACTGAGGTGGAAATGAGCTGGG
ACAGTTTTAACCAAGGTGATGTCTTCTTGCTGGACCTCGGGATGGTCATCATCCAGTGGAATGG
CCCGGAGAGCAACAGTGGGGAACGCCTCAAGGCTATGCTTCTAGCAAAGGACATTCGGGACAGG
GAGCGAGGGGGCCGAGCTGAAATCGGGGTGATTGAGGGAGACAAAGAGGCAGCCAGCCCAGAAC
TGATGACGGTTCTCCAGAATACCCTTGGCCGACGCTCCATTATCAAGCCCGCAGTTCCTGATGA
GGTCACCGATCAGCAGCAGAAGTCAACCATCATGTTGTATCATGTCTCCGACACAACTGGGCAG
CTGTCGGTCACAGAAGTGGCAACAAGGCCCCTGGTCCAGGAGCTACTGAACCATGATGACTGCT
ATATCCTGGACCAAAGTGGCACCAAGATCTACGTATGGAAAGGCAAAGGAGCCACCAAGGTGGA
GAAACAGGCGGCCATGTCCAAAGCCCTGGATTTCATCAAGATGAAGGGTTATCCCAGCAGCACC
AACGTAGAGACCGTCAACGATGGCGCAGAGTCGGCCATGTTCAAACAGTTGTTCCAGAAATGGT
CGGTGAAGGACCAGACCACTGGCTTGGGGAAAACATTCAGCATTGGTAAAATTGCTAAAATCTT
CCAGGACAAGTTCGACGTGACTCTGCTACACACTAAGCCAGAAGTGGCTGCTCAGGAAAGAATG
GTGGACGACGGCAACGGCAAGGTTGAGGTCTGGAGAATTGAGAACCTGGAGCTGGTCCCTGTGG
AATACCAGTGGCATGGCTTCTTCTACGGGGGAGACTGCTATCTGGTTCTCTACACGTATGATGT
GAACGGGAAACCCTGTTACATCTTGTATATCTGGCAGGGACGCCACGCTTCCCAGGATGAGCTG
GCAGCCTCGGCCTACCAGGCGGTGGAGGTGGATCAGCAGTTTGGTGGAGCCCCGGTGCAAGTCC
GGGTTAGCATGGGGAAAGAGCCACGCCACTTCATGGCCATCTTCAAAGGGAAGCTGGTTATCTA
TGAGGGCGGGACTTCCAGGAAGGGAAATGTGGAGCCTGACCCTCCAGTAAGACTCTTCCAGATC
CACGGGAACGACAAATCCAATACCAAAGCAGTGGAAGTCTCGGCCTCCGCTTCCTCCCTCAACT
CTAATGATGTCTTTCTGCTTTGGACTCAGGCGGAGCACTACCTGTGGTATGGCAAGGGGTCAAG
TGGGGACGAACGGGCGATGGCTAAGGAGCTGGCAGAGCTTCTCTGTGATGGTGACGCAGACACT
GTAGCTGAGGGCCAGGAGCCACCTGAGTTCTGGGACCTTCTGGGAGGAAAAGCCCCCTACGCTA
ACGACAAAAGGCTGCAGCAGGAAACCCTGGACATCCAGGTCCGGCTTTTTGAATGTTCTAATAA
GACCGGCCGGTTCCTTGTTACTGAGGTCACGGACTTCACCCAGGATGACCTGAGCCCAGGTGAT
GTGATGCTCCTGGACACCTGGGACCAGGTGTTCCTGTGGATAGGAGCGGAGGCCAATGCCACAG
AGAAGGAGGGGGCCCTCTCGACTGCTCAGGAGTACCTGGTAACACACCCCAGTGGCCGAGACCC
CGACACACCGATCCTGATCATCAAACAGGGCTTTGAGCCCCCCACTTTCACAGGCTGGTTCCTG
GCATGGGACCCTCACATTTGGAGTGAAGGAAAATCATATGAGCAGTTAAAGAACGAGCTGGGAG
ATGCCACTGCTATCGTGCGAATCACCACGGACATGAAGAACGCAACCCTCTCCCTGAATTCTAG
TGAAAGTGGGCCAAAGTACTACCCTGTGGAGGTTCTGCTGAAAAGTCAGGACCAGGAGCTGCCT
GAGGATGTGGACCCCACCAAAAAGGAGAATTACCTCTCGGAACGAGATTTTGTCTCTGTGTTTG
GCATCACCAGAGGGCAGTTTGTCTCTCTGCCTGGCTGGAAACAGCTCCAGCTGAAGAAAGAAGC
AGGCCTTTTCTAGAACAAGGCGTGACCACAGGAGAGGGCTAATGCAGTGCCAACATCAGCAAAG
GTTCATCTACGACTGAGCCCGACACACGCTGCCCTAGATACGACAGATCTCAGGGTCGTGTATT
CTGTCTTTTGCATTCATCCTTGCATTTCTAGGTTGCTATACACTAGATGCCAACTATTTGCCTT
TTAGCTTTGGTGGTCCTTTAGCGAAAGCCTCAGCAGAGAGAGTGAAGGCATAAAGGTAGAGAGA
ACTAGAAACTAAGCTCAAAATATTTAATGCATCAGGACCCACATTTGCTTTGAACTATACCCTG
CAATCCCCAAAGTGGTGGAGTCAGCACACGCTTCCTGCAGGCCGGACTCCAAATGCCCAGGTCT
ACCATGTGCCACACCATGTTCATGTGCCACACCATGTTCAGCCTTTCAAATAAAGAGGCCATGT
GCCATG

hide sequence

RefSeq Acc Id:

XM_039079941 ⟹ XP_038935869

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	62,825,459 - 62,844,103 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_077377	(Get FASTA)	NCBI Sequence Viewer
	XP_038935869	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAD22523	(Get FASTA)	NCBI Sequence Viewer
	EDM16510	(Get FASTA)	NCBI Sequence Viewer
	Q9WU06	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_077377 ⟸ NM_024401

- UniProtKB:

M0RCA6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSLSSAFRTVTNDPGIITWRIEKMELVLVPLSAHGNFYEGDCYIILSTRRVGSLLSQNIHFWIG
KDSSQDEQSCAAIYTTQLDDYLGGSPVQHREVQYHESDTFRGYFKRGIIYKKGGVASGMKHVET
NTYDVKRLLHVKGKRNIRATEVEMSWDSFNQGDVFLLDLGMVIIQWNGPESNSGERLKAMLLAK
DIRDRERGGRAEIGVIEGDKEAASPELMTVLQNTLGRRSIIKPAVPDEVTDQQQKSTIMLYHVS
DTTGQLSVTEVATRPLVQELLNHDDCYILDQSGTKIYVWKGKGATKVEKQAAMSKALDFIKMKG
YPSSTNVETVNDGAESAMFKQLFQKWSVKDQTTGLGKTFSIGKIAKIFQDKFDVTLLHTKPEVA
AQERMVDDGNGKVEVWRIENLELVPVEYQWHGFFYGGDCYLVLYTYDVNGKPCYILYIWQGRHA
SQDELAASAYQAVEVDQQFGGAPVQVRVSMGKEPRHFMAIFKGKLVIYEGGTSRKGNVEPDPPV
RLFQIHGNDKSNTKAVEVSASASSLNSNDVFLLWTQAEHYLWYGKGSSGDERAMAKELAELLCD
GDADTVAEGQEPPEFWDLLGGKAPYANDKRLQQETLDIQVRLFECSNKTGRFLVTEVTDFTQDD
LSPGDVMLLDTWDQVFLWIGAEANATEKEGALSTAQEYLVTHPSGRDPDTPILIIKQGFEPPTF
TGWFLAWDPHIWSEGKSYEQLKNELGDATAIVRITTDMKNATLSLNSSESGPKYYPVEVLLKSQ
DQELPEDVDPTKKENYLSERDFVSVFGITRGQFVSLPGWKQLQLKKEAGLF

hide sequence

RefSeq Acc Id:

ENSRNOP00000067218 ⟸ ENSRNOT00000073237

RefSeq Acc Id:	XP_038935869 ⟸ XM_039079941
- Peptide Label:	isoform X1

Protein Domains

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695243

Promoter ID:

EPDNEW_R5768

Type:

single initiation site

Name:

Avil_1

Description:

advillin

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	70,292,559 - 70,292,619	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Damaging Variants

Assembly: Rnor_5.0

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
7	70484347	70484348	C	T	snv	SDLEF7/Barth (UDEL)

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620301	AgrOrtholog
Ensembl Genes	ENSRNOG00000050419	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSRNOP00000067218	ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000073237	ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH	1.10.950.10	UniProtKB/Swiss-Prot
	3.40.20.10	UniProtKB/Swiss-Prot
InterPro	ADF-H/Gelsolin-like_dom_sf	UniProtKB/Swiss-Prot
	Gelsolin-like_dom	UniProtKB/Swiss-Prot
	Gelsolin-like_dom_sf	UniProtKB/Swiss-Prot
	Villin/Gelsolin	UniProtKB/Swiss-Prot
	Villin_headpiece	UniProtKB/Swiss-Prot
	Villin_headpiece_dom_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:79253	UniProtKB/Swiss-Prot
NCBI Gene	79253	ENTREZGENE
PANTHER	PTHR11977	UniProtKB/Swiss-Prot
Pfam	Gelsolin	UniProtKB/Swiss-Prot
	VHP	UniProtKB/Swiss-Prot
PhenoGen	Avil	PhenoGen
PRINTS	GELSOLIN	UniProtKB/Swiss-Prot
PROSITE	PS51089	UniProtKB/Swiss-Prot
SMART	GEL	UniProtKB/Swiss-Prot
	VHP	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF47050	UniProtKB/Swiss-Prot
	SSF82754	UniProtKB/Swiss-Prot
UniProt	AVIL_RAT	UniProtKB/Swiss-Prot
	M0RCA6	ENTREZGENE
	Q9WU06	ENTREZGENE
UniProt Secondary	M0RCA6	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-01-20	Avil	advillin		pervin	Name updated	1299863	APPROVED
2002-08-07	Avil	pervin			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_physical_interaction	interacts with actin	634623
gene_protein	820 amino acids	634623

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM