Nxph4 (neurexophilin 4) - Rat Genome Database

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Gene: Nxph4 (neurexophilin 4) Rattus norvegicus
Analyze
Symbol: Nxph4
Name: neurexophilin 4
RGD ID: 628723
Description: Predicted to enable signaling receptor binding activity. Predicted to be involved in modulation of chemical synaptic transmission. Predicted to be located in extracellular region. Predicted to be active in GABA-ergic synapse. Orthologous to human NXPH4 (neurexophilin 4); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: neurexophilin-4; Nph4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   SS.LEW-(D7Rat73-D7Rat128)/Ayd   LEW.SS-(D7Rat73-D7Rat128)/Ayd  
Candidate Gene For: Bp38
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8765,253,043 - 65,261,864 (-)NCBIGRCr8
mRatBN7.2763,367,758 - 63,376,579 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl763,367,761 - 63,376,579 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx765,257,030 - 65,265,843 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0767,459,457 - 67,468,270 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0767,260,672 - 67,269,477 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0770,833,662 - 70,842,523 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl770,833,663 - 70,842,405 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0771,006,677 - 71,014,869 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4767,502,668 - 67,516,839 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1767,523,398 - 67,537,569 (-)NCBI
Celera760,506,773 - 60,515,544 (-)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Neurexophilin binding to alpha-neurexins. A single LNS domain functions as an independently folding ligand-binding unit. Missler M, etal., J Biol Chem 1998 Dec 25;273(52):34716-23.
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Information Derived from GenBank Report RGD, Sept. 2003
7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:9570794   PMID:15489334  


Genomics

Comparative Map Data
Nxph4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8765,253,043 - 65,261,864 (-)NCBIGRCr8
mRatBN7.2763,367,758 - 63,376,579 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl763,367,761 - 63,376,579 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx765,257,030 - 65,265,843 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0767,459,457 - 67,468,270 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0767,260,672 - 67,269,477 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0770,833,662 - 70,842,523 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl770,833,663 - 70,842,405 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0771,006,677 - 71,014,869 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4767,502,668 - 67,516,839 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1767,523,398 - 67,537,569 (-)NCBI
Celera760,506,773 - 60,515,544 (-)NCBICelera
Cytogenetic Map7q22NCBI
NXPH4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381257,216,794 - 57,226,449 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1257,216,794 - 57,226,449 (+)EnsemblGRCh38hg38GRCh38
GRCh371257,610,577 - 57,620,232 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361255,896,845 - 55,906,493 (+)NCBINCBI36Build 36hg18NCBI36
Build 341255,896,844 - 55,906,493NCBI
Celera1257,272,891 - 57,274,464 (+)NCBICelera
Cytogenetic Map12q13.3NCBI
HuRef1254,657,541 - 54,659,114 (+)NCBIHuRef
CHM1_11257,578,686 - 57,588,330 (+)NCBICHM1_1
T2T-CHM13v2.01257,185,042 - 57,194,687 (+)NCBIT2T-CHM13v2.0
Nxph4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910127,361,342 - 127,370,428 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10127,361,342 - 127,370,428 (-)EnsemblGRCm39 Ensembl
GRCm3810127,525,473 - 127,534,559 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10127,525,473 - 127,534,559 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710126,962,529 - 126,971,615 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610126,928,422 - 126,937,508 (-)NCBIMGSCv36mm8
Celera10129,917,315 - 129,926,396 (-)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1074.51NCBI
Nxph4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554584,949,679 - 4,954,627 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554584,949,679 - 4,954,627 (+)NCBIChiLan1.0ChiLan1.0
NXPH4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21037,115,242 - 37,124,840 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11237,112,012 - 37,121,609 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01231,700,935 - 31,710,526 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11231,953,259 - 31,962,757 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1231,953,259 - 31,962,757 (-)Ensemblpanpan1.1panPan2
LOC607393
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1101,348,634 - 1,353,930 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl101,352,470 - 1,353,321 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha101,412,351 - 1,417,677 (+)NCBIDog10K_Boxer_Tasha
Nxph4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494557,448,852 - 57,459,298 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366461,410,931 - 1,421,531 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366461,410,937 - 1,421,383 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NXPH4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl522,522,952 - 22,531,660 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1522,522,932 - 22,536,614 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2524,357,067 - 24,366,467 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NXPH4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11153,128,704 - 53,138,272 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1153,128,863 - 53,137,569 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037192,834,187 - 192,843,757 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nxph4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480210,722,548 - 10,731,500 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480210,722,011 - 10,731,569 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nxph4
19 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:66
Count of miRNA genes:60
Interacting mature miRNAs:66
Transcripts:ENSRNOT00000047449
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)759238038104238038Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74725178365728867Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73796056982960569Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)74765143992651439Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73111283276112832Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)74278731487787314Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)74765143992651439Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73429328279293282Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)753612714103945643Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)762004452101773158Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74659007091590070Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73429328279293282Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)74765143992651439Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)74765143992651439Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72673740163902784Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)74765143992651439Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)761074194106074194Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74486753389867533Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)762004452101773158Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)72940968374409683Rat

Markers in Region
RH137131  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2763,367,778 - 63,367,963 (+)MAPPERmRatBN7.2
Rnor_6.0770,833,683 - 70,833,867NCBIRnor6.0
Rnor_5.0771,006,698 - 71,006,882UniSTSRnor5.0
RGSC_v3.4767,502,689 - 67,502,873UniSTSRGSC3.4
Celera760,506,794 - 60,506,978UniSTS
Cytogenetic Map7q22UniSTS


Related Rat Strains
The following Strains have been annotated to Nxph4


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 6 33 111 56 49 33 12 33 6 155 64 93 45 49 16

Sequence


Ensembl Acc Id: ENSRNOT00000047449   ⟹   ENSRNOP00000050310
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl763,367,761 - 63,376,579 (-)Ensembl
Rnor_6.0 Ensembl770,833,663 - 70,842,405 (-)Ensembl
RefSeq Acc Id: NM_021680   ⟹   NP_067712
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8765,253,043 - 65,261,864 (-)NCBI
mRatBN7.2763,367,758 - 63,376,579 (-)NCBI
Rnor_6.0770,833,662 - 70,842,405 (-)NCBI
Rnor_5.0771,006,677 - 71,014,869 (-)NCBI
RGSC_v3.4767,502,668 - 67,516,839 (-)RGD
Celera760,506,773 - 60,515,544 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_067712 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD02227 (Get FASTA)   NCBI Sequence Viewer  
  AAH81805 (Get FASTA)   NCBI Sequence Viewer  
  EDM16461 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000050310.2
GenBank Protein Q9Z2N4 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_067712   ⟸   NM_021680
- Peptide Label: precursor
- UniProtKB: A0A0G2JSW7 (UniProtKB/TrEMBL),   A6HQW1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000050310   ⟸   ENSRNOT00000047449

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z2N4-F1-model_v2 AlphaFold Q9Z2N4 1-304 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628723 AgrOrtholog
BioCyc Gene G2FUF-33735 BioCyc
Ensembl Genes ENSRNOG00000025059 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000047449.4 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7108207 IMAGE-MGC_LOAD
InterPro Nxph UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NXPH/NXPE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:59316 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93463 IMAGE-MGC_LOAD
NCBI Gene 59316 ENTREZGENE
PANTHER NEUREXOPHILIN-4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR17103 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Neurexophilin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nxph4 PhenoGen
PIRSF Neurexophilin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025059 RatGTEx
UniProt A0A0G2JSW7 ENTREZGENE, UniProtKB/TrEMBL
  A6HQW1 ENTREZGENE, UniProtKB/TrEMBL
  NXPH4_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q642D9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Nxph4  neurexophilin 4      Symbol and Name status set to approved 625702 APPROVED
2003-02-27 Nxph4  neurexophilin 4      Symbol and Name status set to provisional 70820 PROVISIONAL