Agap2 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 2) - Rat Genome Database

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Gene: Agap2 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 2) Rattus norvegicus
Analyze
Symbol: Agap2
Name: ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
RGD ID: 628844
Description: Enables ionotropic glutamate receptor binding activity; protein kinase activator activity; and protein kinase binding activity. Involved in several processes, including cellular response to glycine; negative regulation of apoptotic process; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in dendrite and external side of plasma membrane. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human AGAP2 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 2); PARTICIPATES IN endocytosis pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AGAP-2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2; centaurin, gamma 1; centaurin-gamma-1; Centg1; cnt-g1; nuclear GTPase PIKE; phosphatidylinositol 3-kinase enhancer; phosphatidylinositol-3-kinase enhancer; Pike
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8764,782,618 - 64,799,624 (+)NCBIGRCr8
mRatBN7.2762,897,282 - 62,914,295 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl762,897,282 - 62,914,295 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx764,791,000 - 64,803,613 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0766,993,398 - 67,006,011 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0766,794,457 - 66,807,071 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0770,360,199 - 70,377,422 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl770,364,813 - 70,377,422 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0770,538,136 - 70,555,124 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4767,031,300 - 67,043,909 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1767,052,029 - 67,059,503 (+)NCBI
Celera760,045,054 - 60,057,649 (+)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. GGAP2/PIKE-a directly activates both the Akt and nuclear factor-kappaB pathways and promotes prostate cancer progression. Cai Y, etal., Cancer Res. 2009 Feb 1;69(3):819-27. doi: 10.1158/0008-5472.CAN-08-2537. Epub 2009 Jan 27.
2. Essential role of PIKE GTPases in neuronal protection against excitotoxic insults. Chan CB, etal., Adv Biol Regul. 2012 Jan;52(1):66-76. doi: 10.1016/j.advenzreg.2011.09.012.
3. Deficiency of phosphoinositide 3-kinase enhancer protects mice from diet-induced obesity and insulin resistance. Chan CB, etal., Diabetes. 2010 Apr;59(4):883-93. doi: 10.2337/db09-1404. Epub 2010 Jan 12.
4. PIKE-mediated PI3-kinase activity is required for AMPA receptor surface expression. Chan CB, etal., EMBO J. 2011 Aug 16;30(20):4274-86. doi: 10.1038/emboj.2011.281.
5. Phosphoinositide 3-kinase enhancer regulates neuronal dendritogenesis and survival in neocortex. Chan CB, etal., J Neurosci. 2011 Jun 1;31(22):8083-92. doi: 10.1523/JNEUROSCI.1129-11.2011.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Reduced expression of E-cadherin and p120-catenin and elevated expression of PLC-gamma1 and PIKE are associated with aggressiveness of oral squamous cell carcinoma. Jiang Y, etal., Int J Clin Exp Pathol. 2015 Aug 1;8(8):9042-51. eCollection 2015.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis. Rong R, etal., Nat Neurosci 2003 Nov;6(11):1153-61. Epub 2003 Oct 5.
14. Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B. Tang X, etal., Nat Cell Biol. 2008 Jun;10(6):698-706. doi: 10.1038/ncb1732. Epub 2008 May 11.
15. Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N. Ye K, etal., Cell 2000 Dec 8;103(6):919-30.
16. Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE. Ye K, etal., Nature. 2002 Jan 31;415(6871):541-4.
Additional References at PubMed
PMID:1238857   PMID:12388557   PMID:12640130   PMID:14761976   PMID:15385964   PMID:15598747   PMID:16263930   PMID:16841086   PMID:18374643   PMID:18570454   PMID:19946888   PMID:20075866  
PMID:24056044   PMID:24449917   PMID:29476059   PMID:30053369  


Genomics

Comparative Map Data
Agap2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8764,782,618 - 64,799,624 (+)NCBIGRCr8
mRatBN7.2762,897,282 - 62,914,295 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl762,897,282 - 62,914,295 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx764,791,000 - 64,803,613 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0766,993,398 - 67,006,011 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0766,794,457 - 66,807,071 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0770,360,199 - 70,377,422 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl770,364,813 - 70,377,422 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0770,538,136 - 70,555,124 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4767,031,300 - 67,043,909 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1767,052,029 - 67,059,503 (+)NCBI
Celera760,045,054 - 60,057,649 (+)NCBICelera
Cytogenetic Map7q22NCBI
AGAP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381257,723,761 - 57,742,161 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1257,723,761 - 57,742,157 (-)EnsemblGRCh38hg38GRCh38
GRCh371258,117,544 - 58,135,944 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361256,405,261 - 56,422,207 (-)NCBINCBI36Build 36hg18NCBI36
Build 341256,405,260 - 56,422,207NCBI
Celera1257,776,586 - 57,793,534 (-)NCBICelera
Cytogenetic Map12q14.1NCBI
HuRef1255,154,914 - 55,172,785 (-)NCBIHuRef
CHM1_11258,085,878 - 58,103,748 (-)NCBICHM1_1
T2T-CHM13v2.01257,692,114 - 57,710,515 (-)NCBIT2T-CHM13v2.0
Agap2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910126,911,154 - 126,929,039 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10126,911,153 - 126,929,038 (+)EnsemblGRCm39 Ensembl
GRCm3810127,075,269 - 127,093,170 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10127,075,284 - 127,093,169 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710126,515,963 - 126,530,225 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610126,481,856 - 126,496,118 (+)NCBIMGSCv36mm8
Celera10129,471,732 - 129,485,790 (+)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1074.5NCBI
Agap2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554585,436,630 - 5,448,057 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554585,436,544 - 5,448,201 (-)NCBIChiLan1.0ChiLan1.0
AGAP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21036,602,024 - 36,615,795 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11236,598,799 - 36,612,566 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01231,187,821 - 31,201,594 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
AGAP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1101,791,273 - 1,807,710 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl101,792,733 - 1,807,610 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha101,855,358 - 1,870,825 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0101,801,544 - 1,817,032 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl101,800,853 - 1,816,880 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1101,779,294 - 1,794,745 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0102,021,392 - 2,032,997 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0102,146,257 - 2,161,696 (-)NCBIUU_Cfam_GSD_1.0
Agap2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494556,989,185 - 57,005,081 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366461,865,395 - 1,876,453 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366461,865,154 - 1,881,614 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AGAP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl523,017,176 - 23,033,517 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1523,015,777 - 23,035,943 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
AGAP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11153,638,722 - 53,655,826 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1153,640,079 - 53,651,913 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037192,306,463 - 192,324,995 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Agap2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480210,205,375 - 10,218,288 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480210,205,376 - 10,219,977 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Agap2
26 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:314
Count of miRNA genes:180
Interacting mature miRNAs:226
Transcripts:ENSRNOT00000031230
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)759238038104238038Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)761074194106074194Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73429328279293282Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74659007091590070Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73796056982960569Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)74278731487787314Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74725178365728867Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)72940968374409683Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)753612714103945643Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)762004452101773158Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)762004452101773158Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74486753389867533Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73429328279293282Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72673740163902784Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)74765143992651439Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)74765143992651439Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73111283276112832Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)74765143992651439Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)74765143992651439Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)74765143992651439Rat
10755451Coatc11Coat color QTL 110coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)71794435762944357Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat

Markers in Region
RH132545  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2762,914,019 - 62,914,214 (+)MAPPERmRatBN7.2
Rnor_6.0770,377,147 - 70,377,341NCBIRnor6.0
Rnor_5.0770,554,849 - 70,555,043UniSTSRnor5.0
RGSC_v3.4767,043,634 - 67,043,828UniSTSRGSC3.4
Cytogenetic Map7q22UniSTS
RH140015  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2762,908,614 - 62,909,176 (+)MAPPERmRatBN7.2
Rnor_6.0770,371,742 - 70,372,303NCBIRnor6.0
Rnor_5.0770,549,444 - 70,550,005UniSTSRnor5.0
RGSC_v3.4767,038,229 - 67,038,790UniSTSRGSC3.4
Celera760,051,983 - 60,052,544UniSTS
RH 3.4 Map4512.1UniSTS
Cytogenetic Map7q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 8 19 68 10
Low 1 27 37 29 29 8 11 6 34 31 11 8
Below cutoff 16 12 12 12 1

Sequence


RefSeq Acc Id: ENSRNOT00000031230   ⟹   ENSRNOP00000029533
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl762,901,605 - 62,914,295 (+)Ensembl
Rnor_6.0 Ensembl770,364,813 - 70,377,422 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000084012   ⟹   ENSRNOP00000069597
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl762,901,605 - 62,914,295 (+)Ensembl
Rnor_6.0 Ensembl770,364,813 - 70,372,286 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000117693   ⟹   ENSRNOP00000093674
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl762,897,282 - 62,914,295 (+)Ensembl
RefSeq Acc Id: NM_023026   ⟹   NP_075415
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8764,787,015 - 64,799,624 (+)NCBI
mRatBN7.2762,901,686 - 62,914,295 (+)NCBI
Rnor_6.0770,364,813 - 70,377,422 (+)NCBI
Rnor_5.0770,538,136 - 70,555,124 (+)NCBI
RGSC_v3.4767,031,300 - 67,043,909 (+)RGD
Celera760,045,054 - 60,057,649 (+)RGD
Sequence:
RefSeq Acc Id: XM_006241499   ⟹   XP_006241561
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8764,785,954 - 64,799,624 (+)NCBI
mRatBN7.2762,900,957 - 62,913,345 (+)NCBI
Rnor_6.0770,364,055 - 70,376,472 (+)NCBI
Rnor_5.0770,538,136 - 70,555,124 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006241500   ⟹   XP_006241562
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8764,782,618 - 64,799,624 (+)NCBI
mRatBN7.2762,897,283 - 62,913,345 (+)NCBI
Rnor_6.0770,360,202 - 70,376,472 (+)NCBI
Rnor_5.0770,538,136 - 70,555,124 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063264227   ⟹   XP_063120297
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8764,782,618 - 64,799,624 (+)NCBI
RefSeq Acc Id: NP_075415   ⟸   NM_023026
- UniProtKB: Q9JHW8 (UniProtKB/Swiss-Prot),   Q8CGU4 (UniProtKB/Swiss-Prot),   A6HQS4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241562   ⟸   XM_006241500
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AM98 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241561   ⟸   XM_006241499
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JVS4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000029533   ⟸   ENSRNOT00000031230
RefSeq Acc Id: ENSRNOP00000069597   ⟸   ENSRNOT00000084012
RefSeq Acc Id: ENSRNOP00000093674   ⟸   ENSRNOT00000117693
RefSeq Acc Id: XP_063120297   ⟸   XM_063264227
- Peptide Label: isoform X2
Protein Domains
Arf-GAP   PH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CGU4-F1-model_v2 AlphaFold Q8CGU4 1-1186 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628844 AgrOrtholog
BioCyc Gene G2FUF-33774 BioCyc
Ensembl Genes ENSRNOG00000025584 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055026616 UniProtKB/Swiss-Prot
  ENSRNOG00060008102 UniProtKB/Swiss-Prot
  ENSRNOG00065016155 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000031230 ENTREZGENE
  ENSRNOT00000031230.7 UniProtKB/Swiss-Prot
  ENSRNOT00000084012.2 UniProtKB/TrEMBL
  ENSRNOT00000117693.1 UniProtKB/TrEMBL
  ENSRNOT00055045958 UniProtKB/Swiss-Prot
  ENSRNOT00060013414 UniProtKB/Swiss-Prot
  ENSRNOT00065026895 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.220.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.25.40.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARFGAP/RecO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ArfGAP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ArfGAP_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:65218 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 65218 ENTREZGENE
PANTHER ARF-GAP WITH GTPASE, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CENTAURIN-GAMMA-1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ArfGap UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ras UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Agap2 PhenoGen
PRINTS REVINTRACTNG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARFGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025584 RatGTEx
  ENSRNOG00055026616 RatGTEx
  ENSRNOG00060008102 RatGTEx
  ENSRNOG00065016155 RatGTEx
SMART ArfGap UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48403 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57863 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JVS4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AM98 ENTREZGENE, UniProtKB/TrEMBL
  A6HQS4 ENTREZGENE, UniProtKB/TrEMBL
  AGAP2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9JHW8 ENTREZGENE
UniProt Secondary Q9JHW8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-15 Agap2  ArfGAP with GTPase domain, ankyrin repeat and PH domain 2  Centg1  centaurin, gamma 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Centg1  centaurin, gamma 1      Symbol and Name updated 629477 APPROVED
2003-03-06 Centg1  centaurin, gamma 1  Pike  nuclear GTPase PIKE  Data merged from RGD:620459 628472 PROVISIONAL
2003-02-27 Centg1  centaurin, gamma 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-08-07 Pike  nuclear GTPase PIKE      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process enhances PI3kinase activity 632423
gene_protein 753 amino acid 632423