RGD Reference Report - PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis. - Rat Genome Database

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PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis.

Authors: Rong, R  Ahn, JY  Huang, H  Nagata, E  Kalman, D  Kapp, JA  Tu, J  Worley, PF  Snyder, SH  Ye, K 
Citation: Rong R, etal., Nat Neurosci 2003 Nov;6(11):1153-61. Epub 2003 Oct 5.
RGD ID: 1299350
Pubmed: PMID:14528310   (View Abstract at PubMed)
DOI: DOI:10.1038/nn1134   (Journal Full-text)

Phosphoinositide 3 kinase enhancer (PIKE) is a recently identified nuclear GTPase that activates nuclear phosphoinositide 3-kinase (PI3 kinase). We have identified, cloned and characterized a new form of PIKE, designated PIKE-L, which, unlike the nuclear PIKE-S, localizes to both the cytoplasm and the nucleus. We demonstrate physiologic binding of PIKE-L to Homer, an adaptor protein known to link metabotropic glutamate receptors to multiple intracellular targets including the inositol 1,4,5-trisphosphate receptor (IP3R). We show that activation of group I metabotropic glutamate receptors (mGluRIs) enhances formation of an mGluRI-Homer-PIKE-L complex, leading to activation of PI3 kinase activity and prevention of neuronal apoptosis. Our findings indicate that this complex mediates the well-known ability of agonists of mGluRI to prevent neuronal apoptosis.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
protein binding enablesIPIUniProtKB:Q9Z214-11299350PMID:14528310IntAct 
protein binding enablesIPIUniProtKB:Q8CGU41299350PMID:14528310IntAct 

Objects Annotated

Genes (Rattus norvegicus)
Agap2  (ArfGAP with GTPase domain, ankyrin repeat and PH domain 2)
Homer1  (homer scaffold protein 1)


Additional Information