Gli1 (GLI family zinc finger 1) - Rat Genome Database

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Gene: Gli1 (GLI family zinc finger 1) Rattus norvegicus
Symbol: Gli1
Name: GLI family zinc finger 1
RGD ID: 621673
Description: Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and microtubule binding activity. Involved in liver regeneration; prostate gland development; and spermatid development. Predicted to be located in axoneme; cytosol; and nucleoplasm. Predicted to be part of GLI-SUFU complex. Predicted to be active in cytoplasm and nucleus. Biomarker of ocular hypertension and pre-malignant neoplasm. Human ortholog(s) of this gene implicated in gallbladder cancer. Orthologous to human GLI1 (GLI family zinc finger 1); PARTICIPATES IN altered Hedgehog signaling pathway; Hedgehog signaling pathway; pancreatic cancer pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Previously known as: Gli; GLI-Kruppel family member GLI; GLI-Kruppel family member GLI1; zinc finger protein GLI1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8765,042,237 - 65,054,888 (-)NCBIGRCr8
mRatBN7.2763,156,926 - 63,169,579 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl763,156,926 - 63,169,251 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx765,046,190 - 65,055,360 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0767,248,614 - 67,257,790 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0767,049,942 - 67,059,124 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0770,620,794 - 70,633,171 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl770,620,766 - 70,630,338 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0770,795,073 - 70,807,702 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4767,288,291 - 67,297,461 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1767,311,850 - 67,313,540 (-)NCBI
Celera760,297,162 - 60,306,332 (-)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (EXP,ISO)
3',5'-cyclic AMP  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
Ac-Ser-Asp-Lys-Pro-OH  (EXP,ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (EXP)
apigenin  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
aspartame  (ISO)
baicalein  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (EXP)
captopril  (EXP,ISO)
CGP 52608  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
clothianidin  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
Cyclopamine  (EXP,ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP,ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
dichromium trioxide  (ISO)
diethylstilbestrol  (ISO)
diiodine  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
embelin  (ISO)
ethanol  (ISO)
ethylparaben  (ISO)
fulvestrant  (EXP)
genistein  (ISO)
glucose  (ISO)
goralatide  (EXP,ISO)
hydrogen peroxide  (EXP)
ipriflavone  (ISO)
iron dichloride  (ISO)
itraconazole  (EXP,ISO)
L-ascorbic acid  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (EXP,ISO)
LY294002  (ISO)
melittin  (ISO)
methamphetamine  (EXP)
methylarsonic acid  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (ISO)
ochratoxin A  (EXP)
paracetamol  (EXP)
paraquat  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
piperonyl butoxide  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
quercetin  (ISO)
quercetin 3-O-beta-D-galactopyranoside  (EXP)
quinacrine  (ISO)
resveratrol  (EXP,ISO)
Salinomycin  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
sonidegib  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
tetramethylpyrazine  (ISO)
theaflavin  (ISO)
tofacitinib  (ISO)
tolnaftate  (ISO)
trans-piceid  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
vismodegib  (ISO)
zinc oxide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axoneme  (ISO)
cilium  (ISO)
cytoplasm  (ISO)
cytosol  (ISO)
GLI-SUFU complex  (ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Dynamic changes of Sonic Hedgehog signaling pathway in gastric mucosa of rats with MNNG-induced gastric precancerous lesions. Cai D, etal., J Cell Physiol. 2019 Jul;234(7):10827-10834. doi: 10.1002/jcp.27908. Epub 2018 Dec 7.
2. The role of hedgehog signaling pathway in liver regeneration. Cai Y, etal., Hepatogastroenterology. 2011 Nov-Dec;58(112):2071-6. doi: 10.5754/hge11155.
3. Hedgehog signaling update. Cohen MM, Am J Med Genet A. 2010 Aug;152A(8):1875-914. doi: 10.1002/ajmg.a.32909.
4. SCP2-mediated cholesterol membrane trafficking promotes the growth of pituitary adenomas via Hedgehog signaling activation. Ding X, etal., J Exp Clin Cancer Res. 2019 Sep 13;38(1):404. doi: 10.1186/s13046-019-1411-9.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Significance of sonic hedgehog signaling after massive hepatectomy in a rat. Hanaoka J, etal., Surg Today. 2013 Mar;43(3):300-7. doi: 10.1007/s00595-012-0248-z. Epub 2012 Jul 12.
7. Blockade of the sonic hedgehog signalling pathway inhibits choroidal neovascularization in a laser-induced rat model. He H, etal., J Huazhong Univ Sci Technolog Med Sci. 2010 Oct;30(5):659-65. doi: 10.1007/s11596-010-0560-z. Epub 2010 Nov 10.
8. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Jones S, etal., Science. 2008 Sep 26;321(5897):1801-6. Epub 2008 Sep 4.
9. Hedgehog signaling and therapeutics in pancreatic cancer. Kelleher FC Carcinogenesis. 2011 Apr;32(4):445-51. Epub 2010 Dec 24.
10. Expression of hedgehog signal pathway in articular cartilage is associated with the severity of cartilage damage in rats with adjuvant-induced arthritis. Li R, etal., J Inflamm (Lond). 2015 Mar 28;12:24. doi: 10.1186/s12950-015-0072-5. eCollection 2015.
11. The role of the sonic hedgehog signaling pathway in early brain injury after experimental subarachnoid hemorrhage in rats. Li T, etal., Neurosci Lett. 2013 Sep 27;552:81-6. doi: 10.1016/j.neulet.2013.07.042. Epub 2013 Aug 7.
12. Sonic Hedgehog Signaling Affected by Promoter Hypermethylation Induces Aberrant Gli2 Expression in Spina Bifida. Lu XL, etal., Mol Neurobiol. 2016 Oct;53(8):5413-24. doi: 10.1007/s12035-015-9447-0. Epub 2015 Oct 7.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Frequent deregulations in the hedgehog signaling network and cross-talks with the epidermal growth factor receptor pathway involved in cancer progression and targeted therapies. Mimeault M and Batra SK, Pharmacol Rev. 2010 Sep;62(3):497-524.
15. Hedgehog signalling promotes germ cell survival in the rat testis. Mäkelä JA, etal., Reproduction. 2011 Nov;142(5):711-21. doi: 10.1530/REP-11-0110. Epub 2011 Sep 5.
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. PTC gene mutations and expression of SHH, PTC, SMO, and GLI-1 in odontogenic keratocysts. Ohki K, etal., Int J Oral Maxillofac Surg. 2004 Sep;33(6):584-92.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
20. Sonic hedgehog-patched Gli signaling in the developing rat prostate gland: lobe-specific suppression by neonatal estrogens reduces ductal growth and branching. Pu Y, etal., Dev Biol 2004 Sep 15;273(2):257-75.
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Comprehensive gene review and curation RGD comprehensive gene curation
25. [Expression of Smo protein and the downstream transcription factor Gli1 protein in Sonic hedgehog signal transduction pathway in gastric carcinoma]. Rong ZX, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2006 Dec;26(12):1728-31.
26. gli, a zinc finger transcription factor and oncogene, is expressed during normal mouse development. Walterhouse D, etal., Dev Dyn 1993 Feb;196(2):91-102.
27. Expression and clinical significance of hedgehog signaling pathway related components in colorectal cancer. Wang H, etal., Asian Pac J Cancer Prev. 2012;13(5):2319-24. doi: 10.7314/apjcp.2012.13.5.2319.
28. Sonic hedgehog expression in a rat model of chronic pancreatitis. Wang LW, etal., World J Gastroenterol. 2014 Apr 28;20(16):4712-7. doi: 10.3748/wjg.v20.i16.4712.
29. Paradoxical dysregulation of the neural stem cell pathway sonic hedgehog-Gli1 in autoimmune encephalomyelitis and multiple sclerosis. Wang Y, etal., Ann Neurol. 2008 Oct;64(4):417-27. doi: 10.1002/ana.21457.
30. Neuroprotective effect of up-regulated Sonic hedgehog in retinal ganglion cells following chronic ocular hypertension. Wu J, etal., Invest Ophthalmol Vis Sci. 2010 Jan 13.
31. Association of Wnt signaling pathway genetic variants in gallbladder cancer susceptibility and survival. Yadav A, etal., Tumour Biol. 2016 Jun;37(6):8083-95. doi: 10.1007/s13277-015-4728-9. Epub 2015 Dec 29.
32. [Expression of sonic hedgehog signaling pathw ay and its inhibition by cyclopamine in rat liver with chronic fluorosis]. Zhao L, etal., Zhonghua Bing Li Xue Za Zhi. 2014 Dec;43(12):814-9.
Additional References at PubMed
PMID:9118802   PMID:9769173   PMID:10504446   PMID:10693759   PMID:10725236   PMID:10806483   PMID:11238441   PMID:11717126   PMID:11821712   PMID:12165851   PMID:15614767   PMID:16229683  
PMID:16254602   PMID:16316410   PMID:16342201   PMID:16396903   PMID:16489008   PMID:16571625   PMID:16611981   PMID:16936075   PMID:17035233   PMID:17442700   PMID:18298960   PMID:18449196  
PMID:18559511   PMID:18924150   PMID:19124651   PMID:19684112   PMID:19706761   PMID:19878745   PMID:20232216   PMID:21110116   PMID:22133807   PMID:22493482   PMID:23740243   PMID:24388991  
PMID:24816261   PMID:26552406   PMID:28583401   PMID:30266964   PMID:30502245   PMID:31868509   PMID:32298032   PMID:35810662   PMID:37516284  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8765,042,237 - 65,054,888 (-)NCBIGRCr8
mRatBN7.2763,156,926 - 63,169,579 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl763,156,926 - 63,169,251 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx765,046,190 - 65,055,360 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0767,248,614 - 67,257,790 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0767,049,942 - 67,059,124 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0770,620,794 - 70,633,171 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl770,620,766 - 70,630,338 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0770,795,073 - 70,807,702 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4767,288,291 - 67,297,461 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1767,311,850 - 67,313,540 (-)NCBI
Celera760,297,162 - 60,306,332 (-)NCBICelera
Cytogenetic Map7q22NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381257,459,785 - 57,472,268 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1257,459,785 - 57,472,268 (+)EnsemblGRCh38hg38GRCh38
GRCh371257,853,568 - 57,866,051 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361256,140,201 - 56,152,312 (+)NCBINCBI36Build 36hg18NCBI36
Build 341256,140,200 - 56,152,312NCBI
Celera1257,507,905 - 57,520,038 (+)NCBICelera
Cytogenetic Map12q13.3NCBI
HuRef1254,891,792 - 54,903,925 (+)NCBIHuRef
CHM1_11257,822,031 - 57,834,164 (+)NCBICHM1_1
T2T-CHM13v2.01257,428,074 - 57,440,557 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3910127,165,751 - 127,177,448 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10127,165,751 - 127,177,843 (-)EnsemblGRCm39 Ensembl
GRCm3810127,329,882 - 127,341,579 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10127,329,882 - 127,341,974 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710126,766,938 - 126,778,635 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610126,732,834 - 126,744,528 (-)NCBIMGSCv36mm8
Celera10129,722,485 - 129,734,187 (-)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1074.5NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554585,185,225 - 5,193,196 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554585,181,761 - 5,193,500 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v21036,868,015 - 36,880,285 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11236,864,791 - 36,877,075 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01231,453,759 - 31,466,194 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11231,710,051 - 31,722,473 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1231,710,057 - 31,722,473 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1101,565,306 - 1,575,971 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl101,565,244 - 1,575,982 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha101,628,322 - 1,639,223 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0101,574,108 - 1,585,023 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl101,573,578 - 1,585,034 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1101,552,194 - 1,563,093 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0101,793,705 - 1,804,582 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0101,919,034 - 1,929,946 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494557,240,448 - 57,247,984 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366461,622,308 - 1,629,779 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366461,622,308 - 1,629,787 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl522,739,900 - 22,747,421 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1522,736,325 - 22,747,421 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2524,835,305 - 24,838,895 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11153,371,929 - 53,384,339 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1153,375,558 - 53,385,269 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037192,582,687 - 192,595,094 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462480210,483,219 - 10,498,609 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480210,483,279 - 10,494,539 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Gli1
14 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:143
Count of miRNA genes:119
Interacting mature miRNAs:126
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72673740163902784Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)72940968374409683Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73111283276112832Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73429328279293282Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73429328279293282Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73796056982960569Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)74278731487787314Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74486753389867533Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74659007091590070Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74725178365728867Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)74765143992651439Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)74765143992651439Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)74765143992651439Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)74765143992651439Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)74765143992651439Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)753612714103945643Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)759238038104238038Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)761074194106074194Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)762004452101773158Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)762004452101773158Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2763,156,604 - 63,156,716 (+)MAPPERmRatBN7.2
Rnor_6.0770,620,473 - 70,620,584NCBIRnor6.0
Rnor_5.0770,794,752 - 70,794,863UniSTSRnor5.0
RGSC_v3.4767,287,970 - 67,288,081UniSTSRGSC3.4
Celera760,296,841 - 60,296,952UniSTS
Cytogenetic Map7q22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2763,156,736 - 63,156,954 (+)MAPPERmRatBN7.2
Rnor_6.0770,620,605 - 70,620,822NCBIRnor6.0
Rnor_5.0770,794,884 - 70,795,101UniSTSRnor5.0
RGSC_v3.4767,288,102 - 67,288,319UniSTSRGSC3.4
Celera760,296,973 - 60,297,190UniSTS
Cytogenetic Map7q22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2763,157,099 - 63,157,502 (+)MAPPERmRatBN7.2
Rnor_6.0770,620,968 - 70,621,370NCBIRnor6.0
Rnor_5.0770,795,247 - 70,795,649UniSTSRnor5.0
RGSC_v3.4767,288,465 - 67,288,867UniSTSRGSC3.4
Celera760,297,336 - 60,297,738UniSTS
Cytogenetic Map7q22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2763,158,828 - 63,159,707 (+)MAPPERmRatBN7.2
Rnor_6.0770,622,697 - 70,623,574NCBIRnor6.0
Rnor_5.0770,796,976 - 70,797,853UniSTSRnor5.0
RGSC_v3.4767,290,194 - 67,291,071UniSTSRGSC3.4
Celera760,299,065 - 60,299,942UniSTS
Cytogenetic Map7q22UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 2 2 2 18 20 27
Low 3 31 30 14 18 14 6 9 56 9 14 11 6
Below cutoff 12 21 21 1 21 2 2 6 2


RefSeq Acc Id: ENSRNOT00000009803   ⟹   ENSRNOP00000009803
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl763,156,926 - 63,169,251 (-)Ensembl
Rnor_6.0 Ensembl770,620,766 - 70,630,338 (-)Ensembl
RefSeq Acc Id: NM_001191910   ⟹   NP_001178839
Rat AssemblyChrPosition (strand)Source
GRCr8765,042,237 - 65,051,407 (-)NCBI
mRatBN7.2763,156,926 - 63,166,097 (-)NCBI
Rnor_6.0770,620,794 - 70,629,964 (-)NCBI
Rnor_5.0770,795,073 - 70,807,702 (-)NCBI
Celera760,297,162 - 60,306,332 (-)NCBI
RefSeq Acc Id: XM_006241442   ⟹   XP_006241504
Rat AssemblyChrPosition (strand)Source
GRCr8765,042,237 - 65,054,888 (-)NCBI
mRatBN7.2763,156,927 - 63,169,579 (-)NCBI
Rnor_6.0770,620,795 - 70,633,171 (-)NCBI
Rnor_5.0770,795,073 - 70,807,702 (-)NCBI
RefSeq Acc Id: XM_006241443   ⟹   XP_006241505
Rat AssemblyChrPosition (strand)Source
GRCr8765,042,237 - 65,054,888 (-)NCBI
mRatBN7.2763,156,927 - 63,169,579 (-)NCBI
Rnor_6.0770,620,795 - 70,633,171 (-)NCBI
Rnor_5.0770,795,073 - 70,807,702 (-)NCBI
RefSeq Acc Id: XM_008765375   ⟹   XP_008763597
Rat AssemblyChrPosition (strand)Source
GRCr8765,042,237 - 65,054,888 (-)NCBI
mRatBN7.2763,156,927 - 63,169,579 (-)NCBI
Rnor_6.0770,620,795 - 70,633,171 (-)NCBI
RefSeq Acc Id: XM_017594631   ⟹   XP_017450120
Rat AssemblyChrPosition (strand)Source
GRCr8765,042,237 - 65,054,464 (-)NCBI
mRatBN7.2763,156,927 - 63,169,151 (-)NCBI
Rnor_6.0770,620,795 - 70,633,035 (-)NCBI
RefSeq Acc Id: NP_001178839   ⟸   NM_001191910
- UniProtKB: G3V6X8 (UniProtKB/TrEMBL),   A6HQV2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241505   ⟸   XM_006241443
- Peptide Label: isoform X1
- UniProtKB: G3V6X8 (UniProtKB/TrEMBL),   A6HQV2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241504   ⟸   XM_006241442
- Peptide Label: isoform X1
- UniProtKB: G3V6X8 (UniProtKB/TrEMBL),   A6HQV2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008763597   ⟸   XM_008765375
- Peptide Label: isoform X1
- UniProtKB: G3V6X8 (UniProtKB/TrEMBL),   A6HQV2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450120   ⟸   XM_017594631
- Peptide Label: isoform X1
- UniProtKB: G3V6X8 (UniProtKB/TrEMBL),   A6HQV2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000009803   ⟸   ENSRNOT00000009803
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V6X8-F1-model_v2 AlphaFold G3V6X8 1-1109 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621673 AgrOrtholog
BioCyc Gene G2FUF-33750 BioCyc
Ensembl Genes ENSRNOG00000025120 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009803.8 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
InterPro GLI-like UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report rno:140589 UniProtKB/TrEMBL
  PTHR45718:SF2 UniProtKB/TrEMBL
Pfam zf-C2H2 UniProtKB/TrEMBL
PhenoGen Gli1 PhenoGen
RatGTEx ENSRNOG00000025120 RatGTEx
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-03-09 Gli1  GLI family zinc finger 1  Gli1  GLI-Kruppel family member GLI1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Gli1  GLI-Kruppel family member GLI1  Gli  GLI-Kruppel family member GLI  Symbol and Name updated 1299863 APPROVED
2002-08-07 Gli  GLI-Kruppel family member GLI      Symbol and Name status set to provisional 70820 PROVISIONAL