Gene: Gli1 (GLI family zinc finger 1) Rattus norvegicus
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Symbol:
Gli1
Name:
GLI family zinc finger 1
Description:
Predicted to have several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and microtubule binding activity. Involved in liver regeneration and prostate gland development. Predicted to localize to axoneme; cytosol; and nucleoplasm. Biomarker of ocular hypertension. Orthologous to human GLI1 (GLI family zinc finger 1); PARTICIPATES IN altered Hedgehog signaling pathway; Hedgehog signaling pathway; pancreatic cancer pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 6-propyl-2-thiouracil.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
Gli; GLI-Kruppel family member GLI; GLI-Kruppel family member GLI1; zinc finger protein GLI1
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
GLI1 (GLI family zinc finger 1) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):
Gli1 (GLI-Kruppel family member GLI1) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Gli1 (GLI family zinc finger 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
GLI1 (GLI family zinc finger 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
GLI1 (GLI family zinc finger 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Gli1 (GLI family zinc finger 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
GLI1 (GLI family zinc finger 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
GLI1 (GLI family zinc finger 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Gli1 (GLI family zinc finger 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
GLI1 (GLI family zinc finger 1)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|TreeFam)
Mus musculus (house mouse):
Gli1 (GLI-Kruppel family member GLI1)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|TreeFam)
Drosophila melanogaster (fruit fly):
ci
Alliance
DIOPT (Ensembl Compara|Hieranoid|OrthoFinder|OrthoInspector|PANTHER|TreeFam)
Caenorhabditis elegans (roundworm):
tra-1
Alliance
DIOPT (OrthoInspector|TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 7 70,620,794 - 70,633,171 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 7 70,620,766 - 70,630,338 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 7 70,795,073 - 70,807,702 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 7 67,288,291 - 67,297,461 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 7 67,311,850 - 67,313,540 (-) NCBI Celera 7 60,297,162 - 60,306,332 (-) NCBI Celera Cytogenetic Map 7 q22 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
Imported Annotations - ClinVar
Bardet-Biedl syndrome ISO RGD:1344225 8554872 ClinVar Annotator: match by term: Bardet-Biedl syndrome ClinVar PMID:29127258 Postaxial Polydactyly, Type A8 ISO RGD:1344225 8554872 ClinVar Annotator: match by term: POLYDACTYLY, POSTAXIAL, TYPE A8 ClinVar PMID:28973407 Preaxial Polydactyly I ISO RGD:1344225 8554872 ClinVar Annotator: match by term: Polydactyly, preaxial I ClinVar PMID:25741868 , PMID:30620395 prostate cancer ISO RGD:1344225 8554872 ClinVar Annotator: match by term: Prostate cancer ClinVar PMID:23265383
Imported Annotations - CTD
acute promyelocytic leukemia ISO RGD:1344225 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:23867347 diffuse large B-cell lymphoma ISO RGD:1344225 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21625222 gastrointestinal stromal tumor ISO RGD:1344225 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:27793025 hepatocellular carcinoma ISO RGD:1344225 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:26189965 peripheral nervous system disease ISO RGD:1344225 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20864405 urinary bladder cancer ISO RGD:1344225 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20179202 Imported Annotations - OMIM
Postaxial Polydactyly, Type A8 ISO RGD:1344225 7240710 OMIM Preaxial Polydactyly I ISO RGD:1344225 7240710 OMIM
(-)-epigallocatechin 3-gallate decreases expression ISO RGD:1550011 6480464 epigallocatechin gallate results in decreased expression of GLI1 mRNA, epigallocatechin gallate results in decreased expression of GLI1 protein CTD PMID:20395211 (-)-epigallocatechin 3-gallate multiple interactions ISO RGD:1550011 6480464 epigallocatechin gallate inhibits the reaction [Diethylnitrosamine results in increased expression of GLI1 mRNA], epigallocatechin gallate inhibits the reaction [Diethylnitrosamine results in increased expression of GLI1 protein] CTD PMID:27058323 17alpha-ethynylestradiol affects expression ISO RGD:1550011 6480464 Ethinyl Estradiol affects the expression of GLI1 mRNA CTD PMID:17555576 17alpha-ethynylestradiol affects expression EXP 6480464 Ethinyl Estradiol affects the expression of GLI1 mRNA CTD PMID:17109907 17alpha-ethynylestradiol multiple interactions ISO RGD:1550011 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of GLI1 mRNA CTD PMID:17942748 17alpha-ethynylestradiol decreases expression ISO RGD:1550011 6480464 Ethinyl Estradiol results in decreased expression of GLI1 mRNA CTD PMID:17942748 17beta-estradiol multiple interactions ISO RGD:1344225 6480464 [Estradiol co-treated with TGFB1 protein] results in increased expression of GLI1 mRNA, Estradiol inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA] CTD PMID:20434536 , PMID:30165855 17beta-estradiol decreases expression EXP 6480464 Estradiol results in decreased expression of GLI1 mRNA CTD PMID:15328011 more ... 17beta-estradiol multiple interactions EXP 6480464 Estradiol promotes the reaction [Plant Preparations results in decreased expression of GLI1 mRNA] CTD PMID:26945725 17beta-estradiol decreases expression ISO RGD:1550011 6480464 Estradiol results in decreased expression of GLI1 mRNA CTD PMID:15289156 17beta-estradiol multiple interactions ISO RGD:1550011 6480464 [Estradiol co-treated with Progesterone] results in increased expression of GLI1 mRNA, Estradiol inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA] CTD PMID:20434536 , PMID:22958837 17beta-hydroxy-5alpha-androstan-3-one increases expression ISO RGD:1550011 6480464 Dihydrotestosterone results in increased expression of GLI1 mRNA CTD PMID:29367455 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1550011 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of GLI1 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1550011 6480464 Tetrachlorodibenzodioxin affects the expression of GLI1 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1550011 6480464 Tetrachlorodibenzodioxin results in decreased expression of GLI1 mRNA CTD PMID:17942748 2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one decreases expression ISO RGD:1550011 6480464 Itraconazole analog results in decreased expression of GLI1 mRNA CTD PMID:21936514 3,4-methylenedioxymethamphetamine increases expression ISO RGD:1550011 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in increased expression of GLI1 mRNA CTD PMID:26251327 4,4'-sulfonyldiphenol decreases expression ISO RGD:1344225 6480464 bis(4-hydroxyphenyl)sulfone results in decreased expression of GLI1 mRNA CTD PMID:27685785 4,4'-sulfonyldiphenol increases expression ISO RGD:1550011 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of GLI1 mRNA CTD PMID:30951980 5-aza-2'-deoxycytidine increases expression ISO RGD:1550011 6480464 Decitabine results in increased expression of GLI1 mRNA CTD PMID:27915011 5-aza-2'-deoxycytidine multiple interactions ISO RGD:1344225 6480464 [[Decitabine affects the methylation of HHIP promoter] which affects the expression of HHIP protein] which affects the expression of GLI1 mRNA CTD PMID:18559595 5-fluorouracil decreases expression ISO RGD:1344225 6480464 Fluorouracil results in decreased expression of GLI1 mRNA CTD PMID:18776995 5-fluorouracil multiple interactions ISO RGD:1344225 6480464 GLI1 protein inhibits the reaction [Fluorouracil affects the localization of PTCH1 protein] CTD PMID:18776995 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of GLI1 mRNA CTD PMID:24780913 , PMID:25825206 aflatoxin B1 decreases expression ISO RGD:1344225 6480464 Aflatoxin B1 results in decreased expression of GLI1 mRNA CTD PMID:22100608 aflatoxin B1 increases expression ISO RGD:1344225 6480464 Aflatoxin B1 results in increased expression of GLI1 mRNA CTD PMID:28965971 aflatoxin B1 increases methylation ISO RGD:1344225 6480464 Aflatoxin B1 results in increased methylation of GLI1 gene CTD PMID:27153756 aldehydo-D-glucose multiple interactions ISO RGD:1550011 6480464 [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of GLI1 mRNA more ... CTD PMID:27481074 all-trans-retinoic acid multiple interactions ISO RGD:1344225 6480464 [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of GLI1 mRNA CTD PMID:17085092 all-trans-retinoic acid affects expression EXP 6480464 Tretinoin affects the expression of GLI1 mRNA CTD PMID:22262565 all-trans-retinoic acid increases expression EXP 6480464 Tretinoin results in increased expression of GLI1 mRNA CTD PMID:20488242 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of GLI1 mRNA CTD PMID:16483693 apigenin decreases expression ISO RGD:1550011 6480464 Apigenin results in decreased expression of GLI1 mRNA, Apigenin results in decreased expression of GLI1 protein CTD PMID:20395211 Aroclor 1254 decreases expression ISO RGD:1550011 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of GLI1 mRNA, Chlorodiphenyl (54% Chlorine) results in decreased expression of GLI1 protein CTD PMID:30578594 arsane affects expression ISO RGD:1344225 6480464 Arsenic affects the expression of GLI1 mRNA CTD PMID:28615018 arsenic atom affects expression ISO RGD:1344225 6480464 Arsenic affects the expression of GLI1 mRNA CTD PMID:28615018 arsenous acid decreases expression ISO RGD:1344225 6480464 Arsenic Trioxide results in decreased expression of GLI1 mRNA, Arsenic Trioxide results in decreased expression of GLI1 protein CTD PMID:23861973 , PMID:25945059 arsenous acid increases response to substance ISO RGD:1344225 6480464 GLI1 protein results in increased susceptibility to Arsenic Trioxide CTD PMID:21183792 baicalein decreases expression ISO RGD:1550011 6480464 baicalein results in decreased expression of GLI1 mRNA, baicalein results in decreased expression of GLI1 protein CTD PMID:20395211 bis(2-ethylhexyl) phthalate decreases expression ISO RGD:1550011 6480464 Diethylhexyl Phthalate results in decreased expression of GLI1 mRNA CTD PMID:28123099 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of GLI mRNA CTD PMID:18180321 bisphenol A increases expression ISO RGD:1344225 6480464 bisphenol A results in increased expression of GLI1 protein CTD PMID:29307715 bisphenol A increases expression ISO RGD:1550011 6480464 bisphenol A results in increased expression of GLI1 mRNA CTD PMID:30951980 bisphenol A affects methylation ISO RGD:1550011 6480464 bisphenol A affects the methylation of GLI1 promoter CTD PMID:27334623 bisphenol A decreases expression ISO RGD:1344225 6480464 bisphenol A results in decreased expression of GLI1 mRNA CTD PMID:27685785 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of GLI1 mRNA CTD PMID:25181051 bisphenol F increases expression ISO RGD:1550011 6480464 bisphenol F results in increased expression of GLI1 mRNA CTD PMID:30951980 cadmium dichloride multiple interactions ISO RGD:1344225 6480464 [sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of GLI1 mRNA CTD PMID:12634122 cadmium dichloride decreases expression EXP 6480464 Cadmium Chloride results in decreased expression of GLI1 mRNA CTD PMID:30506660 cadmium dichloride increases expression ISO RGD:1550011 6480464 Cadmium Chloride results in increased expression of GLI1 mRNA CTD PMID:19818801 cannabidiol affects methylation EXP 6480464 Cannabidiol affects the methylation of GLI1 gene CTD PMID:30521419 captopril multiple interactions ISO RGD:1344225 6480464 [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI1 protein] CTD PMID:31181250 captopril multiple interactions EXP 6480464 [goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of GLI1 protein], Captopril inhibits the reaction [Silicon Dioxide results in increased expression of GLI1 protein] CTD PMID:31181250 chromium(6+) multiple interactions ISO RGD:1550011 6480464 [Potassium Dichromate results in increased abundance of chromium hexavalent ion] which results in increased expression of GLI1 mRNA, SHH protein affects the reaction [[Potassium Dichromate results in increased abundance of chromium hexavalent ion] which results in increased expression of GLI1 mRNA] CTD PMID:31756458 cisplatin multiple interactions ISO RGD:1344225 6480464 [Cisplatin co-treated with jinfukang] results in decreased expression of GLI1 mRNA CTD PMID:27392435 cisplatin decreases expression ISO RGD:1344225 6480464 Cisplatin results in decreased expression of GLI1 mRNA CTD PMID:27392435 clothianidin decreases expression ISO RGD:1344225 6480464 clothianidin results in decreased expression of GLI1 mRNA CTD PMID:31626844 copper atom multiple interactions EXP 6480464 [Copper co-treated with Dietary Sucrose] results in increased expression of GLI1 mRNA CTD PMID:26033743 copper atom increases expression EXP 6480464 Copper deficiency results in increased expression of GLI1 mRNA, Copper results in increased expression of GLI1 mRNA CTD PMID:26033743 , PMID:30556269 copper(0) multiple interactions EXP 6480464 [Copper co-treated with Dietary Sucrose] results in increased expression of GLI1 mRNA CTD PMID:26033743 copper(0) increases expression EXP 6480464 Copper deficiency results in increased expression of GLI1 mRNA, Copper results in increased expression of GLI1 mRNA CTD PMID:26033743 , PMID:30556269 copper(II) sulfate affects expression ISO RGD:1344225 6480464 Copper Sulfate affects the expression of GLI1 mRNA CTD PMID:19549813 curcumin decreases expression ISO RGD:1550011 6480464 Curcumin results in decreased expression of GLI1 mRNA, Curcumin results in decreased expression of GLI1 protein CTD PMID:20395211 Cyclopamine multiple interactions ISO RGD:1344225 6480464 cyclopamine inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA] CTD PMID:20434536 , PMID:31642701 Cyclopamine affects expression ISO RGD:1344225 6480464 cyclopamine affects the expression of GLI1 protein CTD PMID:20032413 Cyclopamine decreases expression EXP 6480464 cyclopamine results in decreased expression of GLI1 mRNA CTD PMID:21703336 Cyclopamine decreases expression ISO RGD:1550011 6480464 cyclopamine results in decreased expression of GLI1 mRNA, cyclopamine results in decreased expression of GLI1 protein CTD PMID:20179202 , PMID:20395211 Cyclopamine multiple interactions EXP 6480464 cyclopamine inhibits the reaction [Resveratrol results in increased expression of GLI1 protein] more ... CTD PMID:21110116 more ... Cyclopamine multiple interactions ISO RGD:1550011 6480464 cyclopamine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of GLI1 mRNA] more ... CTD PMID:20395211 more ... cyclosporin A decreases methylation ISO RGD:1344225 6480464 Cyclosporine results in decreased methylation of GLI1 promoter CTD PMID:27989131 D-glucose multiple interactions ISO RGD:1550011 6480464 [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of GLI1 mRNA more ... CTD PMID:27481074 DDE multiple interactions ISO RGD:1344225 6480464 GLI1 affects the reaction [Dichlorodiphenyl Dichloroethylene results in increased expression of CCND1 protein], GLI1 affects the reaction [Dichlorodiphenyl Dichloroethylene results in increased expression of MYC protein] CTD PMID:25386960 DDE increases expression ISO RGD:1344225 6480464 Dichlorodiphenyl Dichloroethylene results in increased expression of GLI1 protein CTD PMID:25386960 diarsenic trioxide decreases expression ISO RGD:1344225 6480464 Arsenic Trioxide results in decreased expression of GLI1 mRNA, Arsenic Trioxide results in decreased expression of GLI1 protein CTD PMID:23861973 , PMID:25945059 diarsenic trioxide increases response to substance ISO RGD:1344225 6480464 GLI1 protein results in increased susceptibility to Arsenic Trioxide CTD PMID:21183792 dibenzo[a,l]pyrene decreases expression ISO RGD:1550011 6480464 dibenzo(a, l)pyrene results in decreased expression of GLI1 mRNA CTD PMID:25908611 dibutyl phthalate decreases expression ISO RGD:1550011 6480464 Dibutyl Phthalate results in decreased expression of GLI1 mRNA CTD PMID:21266533 dibutyl phthalate decreases expression EXP 6480464 Dibutyl Phthalate results in decreased expression of GLI1 mRNA, Dibutyl Phthalate results in decreased expression of GLI1 protein CTD PMID:21266533 , PMID:31568847 dichromium trioxide multiple interactions ISO RGD:1344225 6480464 [sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of GLI1 mRNA CTD PMID:12634122 diethylstilbestrol decreases expression ISO RGD:1550011 6480464 Diethylstilbestrol results in decreased expression of GLI1 mRNA CTD PMID:15289156 dioxygen multiple interactions ISO RGD:1550011 6480464 [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of GLI1 mRNA more ... CTD PMID:27481074 embelin decreases expression ISO RGD:1344225 6480464 embelin results in decreased expression of GLI1 protein CTD PMID:24694877 embelin decreases expression ISO RGD:1550011 6480464 embelin results in decreased expression of GLI1 protein CTD PMID:24694877 fulvestrant increases expression EXP 6480464 fulvestrant results in increased expression of GLI1 mRNA CTD PMID:20232216 genistein increases expression ISO RGD:1550011 6480464 Genistein results in increased expression of GLI1 mRNA CTD PMID:21810550 genistein multiple interactions ISO RGD:1550011 6480464 Genistein inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA] CTD PMID:20395211 genistein decreases expression ISO RGD:1550011 6480464 Genistein results in decreased expression of GLI1 mRNA, Genistein results in decreased expression of GLI1 protein CTD PMID:15289156 , PMID:20395211 glucose multiple interactions ISO RGD:1550011 6480464 [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of GLI1 mRNA more ... CTD PMID:27481074 hydrogen peroxide increases expression EXP 6480464 Hydrogen Peroxide results in increased expression of GLI1 mRNA, Hydrogen Peroxide results in increased expression of GLI1 protein CTD PMID:31326407 hydrogen peroxide multiple interactions EXP 6480464 hyperoside promotes the reaction [Hydrogen Peroxide results in increased expression of GLI1 mRNA], hyperoside promotes the reaction [Hydrogen Peroxide results in increased expression of GLI1 protein] CTD PMID:31326407 ipriflavone multiple interactions ISO RGD:1550011 6480464 ipriflavone inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA] CTD PMID:20434536 ipriflavone multiple interactions ISO RGD:1344225 6480464 ipriflavone inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA] CTD PMID:20434536 itraconazole decreases expression ISO RGD:1550011 6480464 Itraconazole analog results in decreased expression of GLI1 mRNA CTD PMID:21936514 lead diacetate multiple interactions ISO RGD:1344225 6480464 [sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of GLI1 mRNA CTD PMID:12634122 lipopolysaccharide increases expression ISO RGD:1344225 6480464 Lipopolysaccharides results in increased expression of GLI1 protein CTD PMID:25069516 lipopolysaccharide decreases expression EXP 6480464 Lipopolysaccharides results in decreased expression of GLI1 mRNA CTD PMID:21110116 lipopolysaccharide multiple interactions EXP 6480464 cyclopamine inhibits the reaction [SHH protein inhibits the reaction [Lipopolysaccharides results in decreased expression of and results in decreased localization of GLI1 protein]] more ... CTD PMID:21110116 lipopolysaccharide multiple interactions ISO RGD:1344225 6480464 resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of GLI1 protein] CTD PMID:25069516 LY294002 decreases expression ISO RGD:1344225 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of GLI1 protein CTD PMID:25945059 melittin decreases expression ISO RGD:1344225 6480464 Melitten results in decreased expression of GLI1 protein CTD PMID:26189965 methamphetamine decreases expression EXP 6480464 Methamphetamine results in decreased expression of GLI1 mRNA CTD PMID:19564919 N-ethyl-N-nitrosourea increases mutagenesis ISO RGD:1550011 6480464 Ethylnitrosourea results in increased mutagenesis of GLI1 mRNA CTD PMID:27776689 N-nitrosodiethylamine increases expression ISO RGD:1550011 6480464 Diethylnitrosamine results in increased expression of GLI1 mRNA, Diethylnitrosamine results in increased expression of GLI1 protein CTD PMID:27058323 N-nitrosodiethylamine multiple interactions ISO RGD:1550011 6480464 epigallocatechin gallate inhibits the reaction [Diethylnitrosamine results in increased expression of GLI1 mRNA] more ... CTD PMID:27058323 ochratoxin A decreases expression EXP 6480464 ochratoxin A results in decreased expression of GLI1 mRNA CTD PMID:21703336 ochratoxin A multiple interactions EXP 6480464 SHH protein modified form inhibits the reaction [ochratoxin A results in decreased expression of GLI1 mRNA] CTD PMID:21703336 piperonyl butoxide decreases expression ISO RGD:1550011 6480464 Piperonyl Butoxide results in decreased expression of GLI1 mRNA CTD PMID:31642701 piperonyl butoxide multiple interactions ISO RGD:1344225 6480464 Piperonyl Butoxide inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA] CTD PMID:31642701 piperonyl butoxide multiple interactions ISO RGD:1550011 6480464 Piperonyl Butoxide affects the reaction [PTCH1 protein affects the expression of GLI1 protein] more ... CTD PMID:31642701 potassium dichromate multiple interactions ISO RGD:1550011 6480464 [Potassium Dichromate results in increased abundance of chromium hexavalent ion] which results in increased expression of GLI1 mRNA, SHH protein affects the reaction [[Potassium Dichromate results in increased abundance of chromium hexavalent ion] which results in increased expression of GLI1 mRNA] CTD PMID:31756458 progesterone multiple interactions ISO RGD:1550011 6480464 [Estradiol co-treated with Progesterone] results in increased expression of GLI1 mRNA CTD PMID:22958837 quercetin decreases expression ISO RGD:1550011 6480464 Quercetin results in decreased expression of GLI1 mRNA, Quercetin results in decreased expression of GLI1 protein CTD PMID:20395211 quercetin 3-O-beta-D-galactopyranoside multiple interactions EXP 6480464 hyperoside promotes the reaction [Hydrogen Peroxide results in increased expression of GLI1 mRNA], hyperoside promotes the reaction [Hydrogen Peroxide results in increased expression of GLI1 protein] CTD PMID:31326407 quercetin 3-O-beta-D-galactopyranoside increases expression EXP 6480464 hyperoside results in increased expression of GLI1 mRNA, hyperoside results in increased expression of GLI1 protein CTD PMID:31326407 quinacrine decreases expression ISO RGD:1344225 6480464 Quinacrine results in decreased expression of GLI1 protein CTD PMID:28720477 quinacrine multiple interactions ISO RGD:1344225 6480464 GSK3B protein affects the reaction [Quinacrine results in decreased expression of GLI1 protein] CTD PMID:28720477 resveratrol decreases activity ISO RGD:1344225 6480464 resveratrol results in decreased activity of GLI1 protein CTD PMID:22397755 resveratrol multiple interactions EXP 6480464 cyclopamine inhibits the reaction [resveratrol results in increased expression of GLI1 protein], resveratrol results in increased expression of and affects the localization of GLI1 protein CTD PMID:24464877 resveratrol multiple interactions ISO RGD:1344225 6480464 resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of GLI1 protein] CTD PMID:25069516 resveratrol decreases expression ISO RGD:1550011 6480464 resveratrol results in decreased expression of GLI1 mRNA, resveratrol results in decreased expression of GLI1 protein CTD PMID:20395211 resveratrol decreases expression ISO RGD:1344225 6480464 resveratrol results in decreased expression of GLI1 CTD PMID:22301921 Salinomycin decreases expression ISO RGD:1344225 6480464 salinomycin results in decreased expression of GLI1 mRNA, salinomycin results in decreased expression of GLI1 protein CTD PMID:25499043 , PMID:30273566 silicon dioxide decreases expression ISO RGD:1344225 6480464 Silicon Dioxide analog results in decreased expression of GLI1 mRNA CTD PMID:25895662 silicon dioxide increases expression EXP 6480464 Silicon Dioxide results in increased expression of GLI1 protein CTD PMID:31181250 silicon dioxide multiple interactions EXP 6480464 [goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of GLI1 protein] more ... CTD PMID:31181250 silicon dioxide increases expression ISO RGD:1344225 6480464 Silicon Dioxide analog results in increased expression of GLI1 mRNA CTD PMID:23806026 sodium arsenite multiple interactions ISO RGD:1344225 6480464 [sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of GLI1 mRNA CTD PMID:12634122 sodium arsenite increases expression ISO RGD:1550011 6480464 sodium arsenite results in increased expression of GLI1 mRNA, sodium arsenite results in increased expression of GLI1 protein CTD PMID:20179202 sodium fluoride multiple interactions EXP 6480464 cyclopamine inhibits the reaction [Sodium Fluoride results in increased expression of GLI1 mRNA], cyclopamine inhibits the reaction [Sodium Fluoride results in increased expression of GLI1 protein] CTD PMID:24388991 sodium fluoride increases expression EXP 6480464 Sodium Fluoride results in increased expression of GLI1 mRNA, Sodium Fluoride results in increased expression of GLI1 protein CTD PMID:24388991 sonidegib decreases expression ISO RGD:1550011 6480464 sonidegib results in decreased expression of GLI1 mRNA CTD PMID:24973920 tamoxifen affects expression ISO RGD:1550011 6480464 Tamoxifen affects the expression of GLI1 mRNA CTD PMID:17555576 tetrachloromethane increases expression ISO RGD:1550011 6480464 Carbon Tetrachloride results in increased expression of GLI1 mRNA, Carbon Tetrachloride results in increased expression of GLI1 protein CTD PMID:31816328 tetrachloromethane multiple interactions ISO RGD:1550011 6480464 GANT 61 inhibits the reaction [Carbon Tetrachloride results in increased expression of GLI1 mRNA], GANT 61 inhibits the reaction [Carbon Tetrachloride results in increased expression of GLI1 protein] CTD PMID:31816328 theaflavin multiple interactions ISO RGD:1550011 6480464 theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of GLI1 mRNA], theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of GLI1 protein] CTD PMID:27058323 tofacitinib increases expression ISO RGD:1344225 6480464 tofacitinib results in increased expression of GLI1 mRNA CTD PMID:25487280 tolnaftate multiple interactions ISO RGD:1344225 6480464 Tolnaftate inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA] CTD PMID:20434536 tolnaftate multiple interactions ISO RGD:1550011 6480464 Tolnaftate inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA] CTD PMID:20434536 trans-piceid multiple interactions ISO RGD:1550011 6480464 cyclopamine inhibits the reaction [polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of GLI1 mRNA]] more ... CTD PMID:27481074 triptonide decreases expression ISO RGD:1344225 6480464 triptonide results in decreased expression of GLI1 mRNA, triptonide results in decreased expression of GLI1 protein CTD PMID:30610878 valproic acid increases expression ISO RGD:1344225 6480464 Valproic Acid results in increased expression of GLI1 mRNA CTD PMID:19101580 vincristine increases response to substance ISO RGD:1344225 6480464 GLI1 gene SNP results in increased susceptibility to Vincristine CTD PMID:20864405 vismodegib multiple interactions ISO RGD:1344225 6480464 [GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in decreased expression of BCL2 protein] more ... CTD PMID:22087285 more ... vismodegib decreases expression ISO RGD:1550011 6480464 HhAntag691 results in decreased expression of GLI1 mRNA CTD PMID:24973920 , PMID:27585885 vismodegib decreases expression ISO RGD:1344225 6480464 HhAntag691 results in decreased expression of GLI1 mRNA CTD PMID:22087285
Gene-Chemical Interaction Annotations
