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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621673
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gli1
Name: GLI family zinc finger 1
Acc ID: CHEBI:3380
Term: captopril
Definition: A L-proline derivative in which L-proline is substituted on nitrogen with a (2S)-2-methyl-3-sulfanylpropanoyl group. It is used as an anti-hypertensive ACE inhibitor drug.
Chemical ID: MESH:D002216
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gli1multiple interactionsEXP 6480464CTD[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of GLI1 protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of GLI1 protein]PMID:31181250
Gli1multiple interactionsISOGLI1 (Homo sapiens)6480464CTD[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI1 protein]PMID:31181250
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