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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621673
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gli1
Name: GLI family zinc finger 1
Acc ID: CHEBI:90863
Term: sonidegib
Definition: A member of the classo of biphenyls that is the amide obtained by formal condensation of the carboxy group of 2-methyl-4'-(trifluoromethoxy)[1,1'-biphenyl]-3-carboxylic acid with the amino group of 6-(2,6-dimethylmorpholin-4-yl)pyridin-3-amine. Used (as its phosphate salt) for treatment of locally advanced basal cell carcinoma.
Chemical ID: MESH:C561435
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gli1decreases expressionISOGli1 (Mus musculus)6480464CTDsonidegib results in decreased expression of GLI1 mRNAPMID:24973920
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