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Gene: LRP1 (LDL receptor related protein 1) Sus scrofa

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Symbol:

LRP1

Name:

LDL receptor related protein 1

RGD ID:

13997726

Description:

ENCODES a protein that exhibits alpha-2 macroglobulin receptor activity (ortholog); apolipoprotein binding (ortholog); cargo receptor activity (ortholog); INVOLVED IN amyloid-beta clearance (ortholog); amyloid-beta clearance by cellular catabolic process (ortholog); amyloid-beta clearance by transcytosis (ortholog); PARTICIPATES IN platelet-derived growth factor signaling pathway; ASSOCIATED WITH Acute Liver Failure (ortholog); alcohol use disorder (ortholog); alcoholic hepatitis (ortholog); FOUND IN apical part of cell (ortholog); axonal growth cone (ortholog); basolateral plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

low density lipoprotein receptor-related protein 1; prolow-density lipoprotein receptor-related protein 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	5	22,435,636 - 22,519,276 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	24,186,409 - 24,202,094 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute Liver Failure (ISO)

alcohol use disorder (ISO)

alcoholic hepatitis (ISO)

Alzheimer's disease (ISO)

arteriosclerosis (ISO)

atrophoderma vermiculata (ISO)

autism spectrum disorder (ISO)

cardiomyopathy (ISO)

congenital diaphragmatic hernia (ISO)

Coronary Disease (ISO)

Developmental Disabilities (ISO)

Developmental Disease (ISO)

Developmental Dysplasia of the Hip 3 (ISO)

diabetes mellitus (ISO)

Experimental Autoimmune Encephalomyelitis (ISO)

gastroschisis (ISO)

keratosis pilaris atrophicans (ISO)

migraine (ISO)

migraine without aura (ISO)

myocardial infarction (ISO)

neuromuscular disease (ISO)

omphalocele (ISO)

prostate cancer (ISO)

prostate carcinoma in situ (ISO)

renal fibrosis (ISO)

Retinal Neovascularization (ISO)

schizophrenia (ISO)

sciatic neuropathy (ISO)

Spinal Cord Injuries (ISO)

tricuspid atresia (ISO)

X-linked amelogenesis imperfecta hypoplastic/hypomaturation 2 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

amyloid-beta clearance (ISO)

amyloid-beta clearance by cellular catabolic process (ISO)

amyloid-beta clearance by transcytosis (ISO)

aorta morphogenesis (ISO)

apoptotic cell clearance (ISO)

apoptotic process (ISO)

astrocyte activation involved in immune response (ISO)

atrioventricular valve development (ISO)

cardiac septum development (ISO)

cell migration (ISO)

cell motility (ISO)

cell population proliferation (ISO)

cellular response to amyloid-beta (ISO)

cerebral cortex development (ISO)

chemoattraction of axon (ISO)

cholesterol metabolic process (ISO)

coronary vasculature development (ISO)

endocytosis (IEA)

enzyme-linked receptor protein signaling pathway (ISO)

gene expression (ISO)

heart development (ISO)

lysosomal transport (ISO)

negative regulation of apoptotic process (ISO)

negative regulation of cell-substrate adhesion (ISO)

negative regulation of cytosolic calcium ion concentration (ISO)

negative regulation of focal adhesion assembly (ISO)

negative regulation of gene expression (ISO)

negative regulation of neuron apoptotic process (ISO)

negative regulation of neuron projection development (ISO)

negative regulation of platelet-derived growth factor receptor-beta signaling pathway (ISO)

negative regulation of SMAD protein signal transduction (ISO)

negative regulation of smooth muscle cell migration (ISO)

negative regulation of transforming growth factor beta receptor signaling pathway (ISO)

negative regulation of Wnt signaling pathway (ISO)

outflow tract morphogenesis (ISO)

phagocytosis (ISO)

positive regulation of amyloid-beta clearance (ISO)

positive regulation of axon extension (ISO)

positive regulation of axon extension involved in regeneration (ISO)

positive regulation of chemokine (C-X-C motif) ligand 2 production (ISO)

positive regulation of cholesterol efflux (ISO)

positive regulation of cholesterol import (ISO)

positive regulation of collateral sprouting of injured axon (ISO)

positive regulation of cytosolic calcium ion concentration (ISO)

positive regulation of endocytosis (ISO)

positive regulation of ERK1 and ERK2 cascade (ISO)

positive regulation of insulin secretion involved in cellular response to glucose stimulus (ISO)

positive regulation of lipid transport (ISO)

positive regulation of lysosomal protein catabolic process (ISO)

positive regulation of neuron projection development (ISO)

positive regulation of phagocytosis (ISO)

positive regulation of protein localization to plasma membrane (ISO)

positive regulation of protein transport (ISO)

positive regulation of reverse cholesterol transport (ISO)

positive regulation of Schwann cell migration (ISO)

positive regulation of transcytosis (ISO)

positive regulation of transport (IEA)

positive regulation of vascular associated smooth muscle cell migration (ISO)

receptor-mediated endocytosis (IEA,ISO)

regulation of actin cytoskeleton organization (ISO)

regulation of endocytosis (IEA)

regulation of extracellular matrix organization (ISO)

regulation of macromolecule metabolic process (IEA)

regulation of postsynaptic neurotransmitter receptor internalization (ISO)

regulation of pulmonary blood vessel remodeling (ISO)

transport across blood-brain barrier (ISO)

Cellular Component

apical part of cell (ISO)

axonal growth cone (ISO)

basolateral plasma membrane (ISO)

clathrin-coated pit (IEA)

clathrin-coated vesicle (ISO)

cytosol (ISO)

dendrite (ISO)

early endosome (ISO)

endosome (ISO)

external side of plasma membrane (ISO)

glutamatergic synapse (ISO)

insulin-responsive compartment (ISO)

membrane (IEA)

microtubule organizing center (IEA)

neuronal cell body (ISO)

nucleolus (ISO)

nucleus (IEA)

organelle (IEA)

plasma membrane (IEA)

postsynaptic density membrane (ISO)

receptor complex (ISO)

Molecular Function

alpha-2 macroglobulin receptor activity (ISO)

apolipoprotein binding (ISO)

calcium ion binding (IEA)

cargo receptor activity (ISO)

clathrin heavy chain binding (ISO)

coreceptor activity (ISO)

metal ion binding (IEA)

protease binding (ISO)

protein binding (ISO)

protein serine/threonine kinase binding (ISO)

protein-containing complex binding (ISO)

signaling receptor binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

platelet-derived growth factor signaling pathway (ISO)

References

Additional References at PubMed

PMID:21353438	PMID:22301074	PMID:22454363	PMID:23225066

Genomics

Comparative Map Data

LRP1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	5	22,435,636 - 22,519,276 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	24,186,409 - 24,202,094 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LRP1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	57,128,483 - 57,213,361 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	57,128,483 - 57,213,361 (+)	Ensembl			hg38	GRCh38
GRCh37	12	57,522,266 - 57,607,144 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	55,808,549 - 55,893,409 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	12	55,808,548 - 55,893,390	NCBI
Celera	12	57,176,220 - 57,261,424 (+)	NCBI		Celera
Cytogenetic Map	12	q13.3	NCBI
HuRef	12	54,625,579 - 54,646,229 (+)	NCBI		HuRef
HuRef	12	54,560,642 - 54,624,427 (+)	NCBI		HuRef
CHM1_1	12	57,489,966 - 57,575,252 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	57,096,318 - 57,181,610 (+)	NCBI		T2T-CHM13v2.0

Lrp1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	127,374,026 - 127,457,158 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	127,374,030 - 127,457,017 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	10	127,538,157 - 127,621,148 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	127,538,161 - 127,621,148 (-)	Ensembl			mm10	GRCm38
MGSCv37	10	126,975,213 - 127,058,204 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	10	126,941,137 - 127,024,078 (-)	NCBI		MGSCv36	mm8
Celera	10	129,930,007 - 130,012,542 (-)	NCBI		Celera
Cytogenetic Map	10	D3	NCBI
cM Map	10	74.52	NCBI

Lrp1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	65,265,639 - 65,346,196 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	65,265,639 - 65,346,196 (-)	Ensembl				GRCr8
mRatBN7.2	7	63,380,325 - 63,461,029 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	63,380,356 - 63,460,910 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	65,269,622 - 65,350,191 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	67,472,045 - 67,552,607 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	67,273,181 - 67,353,771 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	70,846,313 - 70,927,028 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	70,846,344 - 70,926,903 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	71,018,808 - 71,099,367 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	67,520,575 - 67,601,549 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	60,519,175 - 60,599,687 (-)	NCBI		Celera
RGSC_v3.1	7	67,541,343 - 67,622,669 (-)	NCBI
Cytogenetic Map	7	q22	NCBI

Lrp1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955458	4,861,431 - 4,941,146 (+)	Ensembl
ChiLan1.0	NW_004955458	4,861,431 - 4,941,939 (+)	NCBI	ChiLan1.0	ChiLan1.0

LRP1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	37,128,926 - 37,215,816 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	37,124,986 - 37,210,395 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	31,713,938 - 31,799,287 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	31,966,149 - 32,051,979 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	31,966,149 - 32,051,979 (-)	Ensembl			panPan2	panpan1.1

LRP1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	1,260,256 - 1,341,705 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	1,260,719 - 1,352,271 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	1,324,330 - 1,405,506 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	1,270,934 - 1,352,176 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	1,270,727 - 1,352,186 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	1,247,639 - 1,328,819 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	1,489,631 - 1,570,787 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	1,614,746 - 1,695,694 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Lrp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	57,463,638 - 57,543,337 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936646	1,327,374 - 1,406,456 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936646	1,326,900 - 1,407,236 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LRP1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	53,039,147 - 53,125,041 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	53,039,364 - 53,125,776 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666037	192,847,266 - 192,933,317 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lrp1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624802	10,734,263 - 10,812,763 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624802	10,734,907 - 10,812,888 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Lrp1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	205,988,653 - 206,069,334 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in LRP1
1563 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_021091826	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000033	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU633428	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GACC01000104	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GFLN01116246	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_021091826 ⟹ XP_020947485

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	5	22,435,636 - 22,519,276 (+)	NCBI

Sequence:

show sequence

CTTCCCCCCCCCTTTTTCTTTCCCCGCCCCTTCTCTCCCTCCCTCCTCTCCTGGTCCCCTCCCT
CTCCCCCCTCAGCCCGCCCCGCGACACCTCAGTCCGGGTAACAGTGGTGCGAGCTCCAGGCCCG
TGCACTGAGGAGGCGGAAACCAGGGGAGCCCCCAGAGCTCCATCAGGCCCCTTCCAAAGGCTCC
CCCACCCGGTCCACGCCCCCACCCCCCTACCCCGCCTCCTCCCAATTGTGCATTTTTGCAGCCG
GAGGCGGCTCGGAGATGGGGCTGTGAGCTTCGCCCGGGGAGAGGGGGAAAAGAGGAACGAGGAG
AACAGCAGGGGTGAAGGGTTTGGATTGGGGGGCTGGGGGTGCAGCTGGTCTGCAAGCCCTTCCC
AAGGGGGCTCCGAACTTACCTCGTCACCCACGCCCCTGGTGCGCTGTGCTGAAGGATAGGATAA
GAATAGAGGAGGAGAAGGGAGGAAGGAGGAAAAAGGGGGACCCCCCAATTGGGGGGGGCGACGG
CGAGAAGTAACAGGACCAGAGGGGAGAGGGCTGCTGCTTGCATCAGCCCACACCATGCTGACCC
CGCCGCCGCTGCTGTTGCTGCCCCTGCTCTCAGCTCTGGTCGCTGCCGCTATCGATGTCCCTAA
GACCTGCAGCCCTAAGCAGTTTGCCTGCAGAGACCAGATCACCTGTATCTCGAAAGGCTGGCGG
TGTGATGGTGAGAGGGACTGCCCGGATGGATCTGATGAGGCTCCTGAGATTTGTCCACAGAGTA
AGACCCAGCGGTGTCAGCCGAATGAGCACAATTGCCTGGGCACCGAGCTATGTATTCTCATGTC
CCGCCTCTGCAACGGGATCCAGGACTGCGCTGATGGGTCAGATGAGGGGCCCCACTGCCGAGAG
CAACGAGGACAGTGTTCTCATCTGGGCTGCCAGCACCACTGTGTTCCCACACTCAACGGGCCCA
CCTGCTATTGCAACAATAGCTTTCAACTGCAGGCGGATGGCAAGACCTGTAAAGACTTTGACGA
GTGCTCGGTGTATGGCACCTGCAGCCAGCTGTGCACAAACACAGACGGGTCCTTCACGTGCGGC
TGTGTGGAAGGGTACCTGCTGCAGCCAGACAACCGCTCCTGCAAGGCCAAGAATGAGCCAGTAG
ACCGGCCCCCCGTGCTGCTGATTGCCAATTCCCAGAATATCCTGGCTACGTACCTGAGTGGGGC
CCAGGTCTCTACCATCACGCCCACCAGCACTCGGCAGACCACGGCCATGGACTTCAGCTATGCC
AACGAGACTGTGTGCTGGGTGCACGTTGGGGACAGTGCTGCCCAGACACAGCTCAAGTGTGCCC
GCATGCCCGGCCTGAAGGGCTTCGTGGATGAGCACACCATCAACATTTCCCTCAGCCTGCACCA
CGTGGAGCAGATGGCCATCGACTGGCTGACGGGCAACTTCTACTTTGTGGATGACATCGATGAT
AGGATTTTTGTCTGCAACCGAAACGGGGACACGTGTGTCACTTTGCTAGACCTGGAGCTCTACA
ACCCCAAGGGCATTGCCCTGGACCCTGCCATGGGGAAGGTGTTCTTCACTGACTATGGGCAGAT
CCCAAAGGTGGAGCGCTGCGACATGGATGGGCAGAACCGCACCAAGCTGGTCGACAGCAAGATT
GTGTTTCCTCATGGCATCACGCTGGACCTGGTCAGCCGCCTCGTCTACTGGGCCGATGCCTACC
TGGACTACATTGAGGTGGTGGACTACGAGGGCAAGGGCCGGCAGACCATCATCCAGGGCATCCT
GATCGAGCATCTCTACGGCCTGACCGTGTTTGAGAACTACCTCTACGCCACCAACTCGGACAAC
GCCAATGCCCAGCAGAAGACGAGCGTGATCCGTGTGAACCGCTTCAACAGCACCGACTACCAGG
TCGTCACGCGTGTGGACAAGGGAGGGGCTCTGCACATCTACCACCAGCGGCGTCAGCCCCGAGT
GAGGAGCCATGCCTGCGAGAATGACCAGTATGGGAAGCCCGGCGGCTGCTCTGACATCTGCCTG
CTGGCCAACAGCCACAAGGCTCGGACCTGCCGTTGCCGCTCCGGCTTCAGCCTGGGCAGTGATG
GGAAGTCGTGCAAGAAGCCGGAGCACGAGCTATTCCTTGTGTACGGCAAGGGCCGGCCAGGCAT
CATCCGGGGCATGGACATGGGGGCCAAGGTCCCAGATGAGCACATGATCCCCATCGAGAACCTC
ATGAACCCCCGAGCCCTGGACTTCCATGCTGAGACTGGCTTCATCTACTTCGCCGACACCACCA
GCTACCTCATTGGCCGCCAGAAGATCGATGGCACTGAGCGGGAGACCATCCTGAAGGATGGCAT
CCACAATGTGGAGGGCGTGGCTGTGGACTGGATGGGGGACAATTTGTACTGGACGGATGATGGG
CCCAAGAAGACCATCAGCGTGGCCAGGCTGGAGAAAGCTGCTCAGACCCGCAAGACCTTAATCG
AGGGCAAAATGACACACCCCAGGGCCATTGTGGTAGATCCGCTCAATGGGTGGATGTACTGGAC
TGACTGGGAGGAGGACCCCAAGGACAGTCGGCGAGGGCGGCTGGAGAGGGCCTGGATGGACGGC
TCACACCGAGACATCTTTGTCACCTCCAAGACAGTGCTTTGGCCCAATGGGCTGAGCCTGGACA
TCCCAGCGGGGCGCCTCTACTGGGTGGATGCCTTCTATGACCGCATCGAGACCATCCTGCTTAA
TGGCACAGACCGGAAGATTGTGTACGAGGGTCCTGAGCTGAACCACGCCTTTGGCCTGTGTCAC
CATGGCAACTACCTCTTCTGGACTGAGTACCGGAGTGGTAGTGTCTACCGCTTGGAACGGGGCA
CAGGAGGTGCGCCCCCCATCGTGACCCTTCTGCGCAGCGAGCGACCCCCCATCTTTGAGATCCG
CATGTATGATGCCCAGCAGCAGCAAGTGGGTACCAACAAATGCCGGGTGAACAATGGCGGCTGC
AGCAGCCTGTGCTTGGCCACCCCTGGAAGCCGCCAGTGTGCCTGCGCCGAGGACCAGGTGTTGG
ACAAAGACGGTGTCACTTGCTTGGCAAACCCATCCTACGTGCCCCCACCCCAGTGCCAGCCGGG
CGAGTTCGCCTGCTCTAACAGCCGCTGCATCCAGGAGCGCTGGAAGTGCGACGGGGATAACGAC
TGCCTGGACAACAGCGATGAGGCCCCCGCCCTCTGCCATCAGCACACCTGCCCCTCTGACCGCT
TCAAGTGCGAGAACAACCGTTGCATCCCCAACCGCTGGCTCTGTGATGGGGACAACGACTGTGG
GAACAGTGAAGATGAGTCCAATGCCACGTGTTCAGCTCGCACCTGCCCACCCAACCAGTTCTCC
TGTGCCAGTGGTCGCTGCATCCCCATCTCCTGGACGTGCGATCTGGATGACGACTGTGGGGATC
GCTCTGATGAGTCAGCTCGTGTGGCTTATCCCACCTGCTTCCCCCTGACTCAGTTTACCTGCAA
CAATGGCAGATGTATCAACATCAACTGGAGATGTGACAATGACAATGACTGTGGGGACAATAGC
GACGAGGCTGGCTGCAGCCACTCTTGCTCTAGCACCCAGTTCAAGTGCAACAGCGGGCGCTGCA
TCCCCGAGCACTGGACCTGCGACGGGGACAACGACTGTGGGGACTACAGCGATGAAACACACGC
CAACTGCACCAACCAGGCCACAAGGCCTCCTGGCGGCTGCCACAATGATGAGTTCCAGTGCCGG
CTGGATGGTCTGTGCATCCCCCTGCGGTGGCGCTGCGATGGGGACACTGATTGCATGGACTCCA
GTGATGAGAAGAGCTGTGAGGGAGTGACCCACGTCTGTGACCCTAATGTCAAGTTTGGCTGCAA
GGACTCCGCTCGGTGCATCAGCAAAGCATGGGTGTGTGACGGTGACAGCGACTGTGAGGATAAC
TCGGACGAGGAGAACTGTGAGTCTCTGGCCTGCCGGCCACCCTCGCACCCCTGCGCCAACAACA
CCTCAGTCTGCCTGCCCCCTGACAAGCTGTGTGACGGCAACGATGACTGTGGAGACGGCTCGGA
TGAGGGCGAGCTCTGCGACCAGTGCTCCCTGAATAACGGTGGCTGCAGCCACAACTGCTCGGTG
GCACCTGGCGAAGGCATTGTGTGCTCGTGCCCTCTGGGCATGGAGCTGGGGCCTGACAACCATA
CCTGCCAGATCCAGAGCTACTGTGCCAAGCACCTCAAGTGCAGCCAGAAGTGCGACCAGAACAA
GTTTAGCGTGAAGTGCTCCTGCTACGAGGGCTGGGTGCTGGAGCCTGATGGCGAGAGCTGCCGC
AGCCTGGACCCCTTCAAGCCGTTTATCATCTTCTCCAACCGCCATGAGATCCGTCGCATTGACC
TTCACAAAGGGGACTACAGCGTCCTGGTGCCGGGGCTGCGCAACACCATCGCCCTGGACTTCCA
CCTCAGCCAGAGCGCCCTCTACTGGACCGACGTGGTGGAGGACAAGATCTACCGCGGGAAGCTG
CTGGACAACGGAGCCCTGACCAGTTTTGAGGTGGTGATTCAGTACGGCCTGGCCACACCCGAGG
GCCTGGCTGTAGACTGGATTGCAGGCAACATCTACTGGGTGGAGAGTAACCTGGACCAGATCGA
GGTAGCCAAGCTGGATGGGACCCTTAGGACCACCCTGCTGGCCGGTGACATTGAGCACCCAAGG
GCAATCGCACTGGATCCCCGGGATGGGATCCTGTTTTGGACGGACTGGGATGCCAGCCTGCCCC
GCATCGAGGCGGCCTCCATGAGTGGGGCCGGGCGCCGCACCATCCACCGGGAGACGGGCTCCGG
GGGCTGGCCCAACGGGCTCACCGTGGACTACCTGGAGAAGCGCATCCTCTGGATCGACGCCAGG
TCAGACGCCATTTACTCAGCCCGTTACGACGGCTCCGGTCACATGGAGGTGCTTCGGGGACACG
AGTTCCTGTCACACCCGTTTGCAGTGACACTGTATGGCGGCGAGGTGTACTGGACGGACTGGCG
GACAAACACGCTGGCCAAGGCCAACAAGTGGACCGGCCACAATGTCACCGTGGTACAGAGGACC
AACACCCAGCCCTTTGACCTGCAGGTGTACCACCCCTCTCGCCAGCCCATGGCTCCCAATCCCT
GTGAGGCCAATGGAGGCCGGGGCCCCTGCTCCCACCTGTGTCTCATCAACTATAACCGGACCGT
CTCCTGCGCCTGCCCGCACCTCATGAAGCTCCACAAGGACAACACCACCTGCTATGAGTTTAAG
AAGTTCCTGCTGTACGCACGTCAGATGGAGATCCGGGGTGTGGACCTGGACGCCCCCTACTACA
ACTACATCATCTCCTTCACGGTGCCCGATATTGACAACGTCACCGTGCTGGACTACGACGCCCG
CGAGCAGCGCGTTTACTGGTCCGACGTGCGGACACAGGCCATCAAGCGGGCCTTCATCAACGGC
ACGGGCGTGGAGACAGTCGTCTCTGCAGACTTGCCAAATGCCCACGGGCTGGCTGTCGATTGGG
TGTCCCGAAACCTGTACTGGACGAGCTACGACACCAACAAGAAGCAGATCAACGTGGCCCGGCT
GGATGGCTCTTTCAAGAACGCTGTGGTGCAGGGCCTGGAGCAGCCCCACGGCCTGGTGGTCCAC
CCCCTGCGCGGGAAGCTCTACTGGACAGACGGTGACAACATCAGCATGGCCAACATGGACGGCA
GCAACCGCACCCTGCTCTTCAGTGGCCAGAGGGGCCCCGTGGGCCTGGCTATCGACTTCCCGGA
AAGCAAACTCTACTGGATCAGCTCCAAGAATCACACCATCAACCGCTGCAACCTGGACGGGAGT
GGGCTGGAGGTCATCGATGCCATGTGGAGCCAGCTGGGCAAGGCCACCGCCCTGGCCATCATGG
GGGACAAGCTGTGGTGGGCAGATCAGGTGTCGGAGAAGATGGGCACCTGCAACAAGGCTGACGG
CTCAGGGTCCGTGGTCCTGAGGAACAGCACCACCCTGGTCATGCACATGAAGGTCTATGATGAG
AGCATCCAGCTGGACCACGAGGGCACCAACCCCTGCAGTGTCAATAACGGCGACTGCTCCCAGC
TCTGCCTGCCCACGTCGGAGACCACCCGCTCCTGCATGTGCACCGCCGGCTACAGCCTCCGGAG
TGGCCAGCAGGCCTGCGAGGGTGTGGGCTCCTTTCTCCTGTACTCTGTGCACGAGGGAATCCGG
GGGATACCCCTGGATCCCAATGACAAGTCTGATGCCCTGGTCCCAGTGTCGGGGACCTCCCTGG
CTGTCGGCATTGACTTCCATGCTGAAAATGACACCATTTACTGGGTGGACATGGGCCTAAGCAC
CATCAGCCGGGCTAAGCGAGACCAGACATGGCGTGAGGACGTGGTGACCAATGGCATTGGCCGA
GTGGAGGGCATCGCAGTGGACTGGATCGCAGGCAACATCTACTGGACAGACCAGGGCTTTGACG
TCATCGAGGTTGCCCGGCTCAATGGCTCTTTCCGCTATGTGGTCATCTCCCAGGGTCTGGATAA
GCCCCGGGCTATCACCGTCCACCCGGAGAAGGGGTACTTGTTCTGGACTGAGTGGGGCCAGTAT
CCGCGTATAGAGAGGTCTCGGCTTGATGGCACTGAGCGAGTTGTGCTGGTTAACGTCAGCATCA
GCTGGCCCAACGGCATCTCGGTGGACTATGAGGATGGGAAGCTGTACTGGTGCGACGCCCGAAC
AGACAAGATTGAGCGGATTGACCTGGAGACGGGAGAGGACCGAGAGGTGGTTCTGTCCAGCAAC
AACATGGACATGTTCTCGGTGTCTGTGTTTGAAGAGTTCATCTACTGGAGTGACAGGACGCACG
CCAATGGCTCCATCAAGCGCGGGAGCAAGGACAATGCCACCGACTCCGTGCCCCTGCGGACTGG
CATCGGCGTCCAACTCAAAGACATCAAAGTCTTCAACCGGGACCGGCAGAAAGGCACCAACGTG
TGTGCAGTGGCCAATGGCGGGTGCCAGCAGCTGTGCCTGTACCGGGGCGGCGGGCAGCGGGCCT
GCGCCTGCGCCCACGGGATGCTGGCTGAAGACGGGGCCACGTGCCGCGAGTATGCGGGCTACCT
GCTCTACTCGGAGCGCACCATCCTCAAGAGCATCCACCTGTCGGACGAGCGCAACCTCAACGCT
CCGGTGCAGCCCTTCGAGGACCCCGAGCACATGAAGAACGTCATCGCTCTGGCCTTCGACTACC
GAGCAGGCACCTCCCCGGGCACCCCCAACCGCATCTTCTTCAGCGACATCCACTTTGGGAACAT
CCAGCAGATCAATGACGATGGCTCGAGCAGGACCACCATTGTGGAGAATGTGGGCTCCGTGGAA
GGCTTGGCCTATCACCGCGGCTGGGACACTCTCTACTGGACAAGCTACACGACATCCACCATCA
CCCGCCACACAGTGGACCAGACCCGCCCAGGGGCCTTCGAGCGAGAGACGGTCATCACCATGTC
TGGAGACGACCACCCCCGGGCCTTTGTGTTGGACGAGTGCCAGAACCTGATGTTCTGGACCAAC
TGGAATGAGCAGCACCCCAGCATCATGCGGGCAGCCCTGTCGGGAGCTAATGTCCTGACTCTCA
TCGAGAAGGACATCCGCACCCCCAACGGCCTGGCCATCGACCACCGGGCGGAGAAGCTCTACTT
CTCCGATGCCACCCTGGACAAGATCGAGCGGTGCGAGTATGACGGCTCCCATCGCTACGTGATC
CTGAAGTCAGAGCCGGTGCACCCCTTCGGGCTGGCAGTGTACGGGGAGCACATCTTCTGGACTG
ACTGGGTGCGGCGGGCCGTGCAGCGGGCCAACAAGTACGTGGGCAGCGACATGAAGCTGCTGCG
TGTGGACATCCCCCAGCAGCCCATGGGCATCATCGCCGTGGCCAATGACACCAACAGCTGCGAA
CTCTCCCCTTGCCGCATCAACAATGGGGGCTGCCAGGACCTGTGTCTGCTCACCCACCAAGGCC
ATGTCAACTGCTCCTGCCGAGGGGGCCGCATCCTTCAGGAGGACCTCACCTGCCAGGCGGTGAA
TTCCTCGTGCCGAGCACAAGATGAGTTTGAGTGTGCCAACGGCGAGTGCATCAACTTCAGCCTG
ACATGTGACGGCGTCTCCCACTGCAAGGACAAGTCTGACGAGAAGCCGTCCTACTGCAACACAC
GCCGCTGCAAGAAGACCTTCCGCCAGTGCAACAACGGGCGCTGTGTGTCCAACATGCTGTGGTG
CAACGGGGCAGATGACTGCGGGGATGGCTCTGATGAGATTCCCTGCAACAAGACGGCCTGCAGT
GTGGGCGAATTCCGCTGCCGGGACGGCACCTGCATCGGGAACTCCAGCCGCTGCAACCAGTTTG
TGGACTGTGAGGATGCCTCGGACGAGATGAACTGCAGCGCCACCGACTGCAGCAGCTACTTCCG
CCTGGGGGTGAAGGGTGTGCGCTTCCAGCCCTGTGAGCGGACGTCCCTCTGCTACGCGCCCAGC
TGGGTGTGTGATGGCGCCAACGACTGTGGGGACTACAGCGACGAGCGCGACTGCCCAGGTGTGA
AGCGTCCCAGGTGCCCCCTCAACTACTTTGCCTGCCCCAGTGGGCGCTGCATCCCCATGAGCTG
GACGTGTGACAAGGAGGATGACTGTGAACATGGCGAGGATGAGACCCACTGCAACAAGTTCTGC
TCAGAGGCCCAGTTTGAGTGCCAGAACCATCGTTGCATCTCCAAGCAGTGGCTGTGTGACGGCA
GTGATGACTGCGGAGACGGCTCAGACGAGGCAGCTCACTGCGAAGGCAAGACCTGTGGCCCCAA
CTCCTTCTCCTGCCCGGGCACCCACATGTGTGTCCCTGAGCGCTGGCTCTGTGACGGTGACAAG
GACTGTGCTGACGGCGCAGATGAGAGCATCACAGCCGGCTGCTTGTACAACAACACCTGTGATG
ACCGCGAGTTCATGTGTCAGAACCGCCAGTGCATCCCCAAGCATTTCATGTGTGACCACGACCG
TGACTGCGCCGACGGTTCTGACGAGTCCCCCGAGTGTGAGTACCCGACCTGCGGCCCCAATGAG
TTCCGATGCGCCAACGGCCGCTGCTTGAGCTCCCGCCAGTGGGAGTGTGATGGTGAAAATGACT
GCCATGACCAGAGTGACGAGGCCCCCAAGAACCCGCATTGCACCAGCCCAGAGCACAAGTGCAA
CGCCTCCTCGCAGTTCCTGTGCAGCAGCGGGCGCTGTGTGGCCGAGGCACTGCTGTGCAACGGC
CAGGATGACTGCGGTGATGGCTCAGATGAGCGCGGCTGCCACGTCAATGAGTGTCTCAGCCACA
AGCTCAGCGGCTGCAGCCAGGACTGCGAGGACCTCAAGATCGGCTTTAAGTGCCGCTGCCGCCC
TGGCTTCCGCCTGAAGGACGACGGCCGGACATGCGCCGACGTGGACGAGTGCAGCACCACCTTC
CCCTGCAGCCAGCGCTGCATCAACACCCACGGCAGCTACAAGTGTCTGTGTGTGGAGGGCTACG
CCCCCCGCGGCGGCGACCCCCACAGCTGCAAGGCTGTGACTGATGAGGAGCCATTTCTGATCTT
CGCCAACCGCTACTACCTGCGCAAGCTCAACCTGGACGGCTCCAACTACACGCTGCTTAAGCAG
GGCCTAAACAACGCTGTCGCCTTGGACTTTGACTACCGAGAGCAGATGATTTACTGGACAGATG
TGACAACCCAGGGCAGCATGATCCGCAGGATGCACCTTAACGGGAGCAACGTGCAGGTGCTGCA
CCGGACGGGCCTCAGCAACCCCGACGGGCTGGCTGTGGACTGGGTTGGTGGCAACCTGTACTGG
TGTGACAAAGGCCGGGACACCATCGAAGTGTCCAAACTCAACGGGGCCTATCGCACAGTGCTGG
TCAGCTCCGGCCTCCGTGAGCCCAGGGCTCTGGTTGTGGATGTGCAGAATGGGTACCTGTACTG
GACAGACTGGGGGGACCACTCACTGATCGGCCGGATCGGCATGGATGGGTCTGGCCGCAGTGTC
ATCGTGGACACCAAGATCACGTGGCCCAACGGCCTGACACTGGACTATGTCACCGAGCGCATCT
ACTGGGCTGACGCCCGTGAGGACTACATTGAGTTTGCCAGCCTGGATGGCTCCAACCGTCACGT
CGTGCTGAGCCAGGATATCCCACACATCTTCGCCCTGACCCTGTTTGAGGACTATGTCTACTGG
ACCGACTGGGAGACCNAATCCATCAACCGAGCCCACAAGACCACGGGCACCAACAAGACTCTCC
TCATCAGCACGCTGCACNCGCCCATGGACCTGCACGTCTTCCACGCCCTGCGCCAGCCCGATGT
ACCCAATCACCCCTGCAAGGTCAACAACGGCGGCTGCAGCAACCTGTGCCTGCTGTCTCCTGGG
GGTGGCCACAAGTGTGCCTGTCCCACCAACTTCTACCTGGGCGGTGATGGGCGCAACTGTGTGT
CCAACTGCACAGCCAGCCAGTTTGTGTGCAAGAACGACAAGTGCATCCCCTTCTGGTGGAAGTG
TGACACGGAGGACGACTGCGGGGACCACTCGGACGAGCCCCCGGACTGTCCCGAGTTCAAGTGC
CGCCCCGGACAGTTCCAGTGCTCGACAGGCATCTGCACGAACCCTGCCTTCATCTGCGACGGGG
ACAATGACTGCCAGGACAACAGTGACGAGGCCAACTGCGACATCCACGTCTGCTTGCCCAGTCA
GTTCAAGTGCACCAACACCAACCGCTGTATTCCTGGCATCTTCCGCTGCAACGGGCAGGACAAC
TGCGGAGACGGGGAGGATGAGAGGGACTGCCCCGAGGTGACCTGTGCCCCCAACCAGTTCCAGT
GCTCCATTACCAAGCGCTGCATCCCCCGAGTCTGGGTCTGTGACCGAGACAACGACTGCGTGGA
CGGCAGTGATGAGCCTGCCAACTGCACCCAGATGACCTGCGGAGTGGATGAGTTCCGATGCAAG
GACTCGGGCCGCTGTATCCCGGCACGCTGGAAGTGTGACGGAGAGGACGACTGTGGGGACGGCT
CGGATGAGCCTAAAGAGGAGTGTGATGAGCGCACCTGTGAGCCCTACCAGTTCCGCTGCAAGAA
CAACCGCTGTGTGCCCGGCCGCTGGCAGTGCGATTACGACAATGACTGTGGGGACAACTCTGAT
GAGGAGAGCTGCACCCCTCGGCCCTGCTCTGAGAGTGAGTTCTCCTGTGCCAACGGTCGCTGCA
TCGCCGGGCGCTGGAAATGCGACNGGGATCATGACTGCGCAGACGGCTCAGATGAGAAAGACTG
CACCCCCCGCTGTGACATGGACCAGTTCCAGTGCAAGAGCGGCCACTGCATCCCCCTGCGCTGG
CGCTGTGATGCAGATGCTGACTGCATGGACGGCAGTGATGAGGAAGCCTGCAGCACTGGTGTGC
GGACCTGCCCCCTGGACGAATTCCAGTGCAACAACACCCTGTGCAAGCCGCTGGCATGGAAGTG
CGATGGAGAGGATGACTGCGGGGACAACTCAGATGAGAACCCAGAGGAATGCGCCCGTTTTGTA
TGCCCTCCAAACCGGCCCTTCCGTTGCAAGAACGACCGCGTCTGCCTGTGGATCGGGCGCCAGT
GCGATGGCACCGACAACTGCGGAGATGGGACTGATGAGGAGGACTGTGAGCCGCCCACGGCCCA
GAGCCCCCACTGCAAAGACAAGAAGGAGTTTCTGTGCCGGAACCAGCGCTGCCTCTCCTCCTCG
CTGCGCTGCAACATGTTCGATGACTGCGGCGACGGCTCTGACGAGGAGGACTGCAGCATCGACC
CCAAGCTGACCAGCTGCGCCACCAATGCCAGCATCTGTGGGGATGAGGCACGCTGCGTGCGCAC
GGAGAAAGCCGCATACTGTGCCTGCCGCTCCGGCTTCCACACGGTGCCCGGCCAGCCCGGATGC
CAAGACATCAACGAGTGCCTGCGCTTCGGCACCTGCTCTCAGCTCTGCAACAACACCAAGGGCG
GCCACCTGTGCAGCTGCGCTCGGAACTTCATGAAGACGCACAACACCTGCAAGGCAGAAGGCTC
TGAGTATCAGGTCCTGTACATCGCTGACGACAATGAGATCCGCAGCCTGTTCCCCAGTCACCCC
CATTCAGCGTACGAGCAGGCCTTCCAGGGTGACGAGAGCGTCCGCATCGATGCCATGGATGTCC
ACGTCAAGGCTGGCCGCGTCTACTGGACCAACTGGCACACAGGCACCATCTCCTTCCGCAGCCT
GCCACCTGCTGCGCCTCCTACCACTTCCAATCGGCATCGGCGACAGATTGACCGGGGTGTCACC
CACCTCAATATTTCAGGGCTCAAGATGCCGAGAGGCATCGCCATTGACTGGGTGGCTGGGAACG
TGTACTGGACTGACTCGGGCCGAGATGTGATCGAGGTGGCACAGATGAAGGGCGAGAACCGCAA
GACACTCATCTCCGGCATGATTGACGAACCCCACGCCATTGTGGTGGATCCGCTGAGGGGCACC
ATGTACTGGTCAGATTGGGGGAACCACCCCAAGATTGAAACAGCAGCGATGGATGGGACCCTTC
GGGAGACACTGGTACAGGACAACATCCAGTGGCCCACAGGCCTGGCCGTGGATTACCACAATGA
ACGACTGTACTGGGCAGATGCCAAGCTCTCGGTCATCGGCAGCATCCGGCTCAACGGCACAGAC
CCCATCGTGGCTGCTGACAGCAAACGAGGCCTCAGTCACCCCTTCAGCATCGATGTCTTTGAGG
ATTACATCTATGGCGTCACCTACATCAATAATCGTGTCTTCAAGATCCATAAGTTTGGACACAG
CCCCTTGATCAACCTGACAGGGGGCCTGAGCCATGCCTCCGACGTGGTGCTGTACCACCAACAC
AAGCAGCCGGAAGTGACCAATCCCTGTGACCGCAAGAAGTGCGAGTGGCTCTGCCTGCTGAGCC
CCAGTGGGCCTGTCTGCACCTGTCCCAATGGGAAGCGACTGGACAATGGCACCTGTGTGGCTGT
GCCCTCGCCAACACTCCCACCAGATGCTCCGCGGCCTGGAACCTGTAACCTGCAGTGCTTCAAT
GGTGGCAGCTGCTTCCTCAACGCGCGGAGGCAGCCCAAGTGCCGCTGCCAGCCCCGCTACACAG
GCGACAAGTGTGAGCTGGACCAGTGCTGGGAATACTGTCGCAACGGGGGCACTTGCGCTGCCTC
CCCCTCCGGCATGCCCACGTGCCGGTGCCCCACGGGCTTTACGGGCCCCAAATGCACCCAGCAG
GTGTGTGCGGGCCACTGTGCCAACAACAGCACCTGCACCGTCAACCAGGGCAACCAGCCCCAGT
GCCGATGCCTCCCTGGCTTCCTGGGTGACCGCTGCCAGTACCGGCAGTGCTCTGGCTACTGTGA
GAACTTTGGCACGTGCCAAATGGCTGCTGACGGCTCCCGGCAGTGCCGCTGCACCGCCTACTTC
GAGGGGGCCAGGTGCGAGGTGAACAAGTGTAGCCGCTGTCTCGACGGGGCCTGTGTGGTCAACA
AGCAGAGTGGGGACGTCACCTGCAACTGCTCTGATGGCCGGGTGGCCCCCAGCTGTCTGACCTG
TGTTGGCCACTGCAGCAATGGCGGATCCTGCACCATGAACAGCAAAATGATGCCTGAGTGCCAG
TGCCCACCCCACATGGCAGGACCTCGGTGTGAAGAACAAGTAGTCAGCCCACAGCAGCCTGGAC
ATATGGCCTCCATCCTAATCCCTCTGCTGTTGCTGCTACTAATGCTGCTGGTAGCCGGAGTGGT
ATTCTGGTACAAGCGGCGAGTCCGAGGGGCTAAAGGCTTCCAGCACCAGCGGATGACCAATGGG
GCCATGAACGTGGAGATTGGGAACCCCACCTACAAGATGTACGAAGGCGGGGAGCCTGATGATG
TAGGGGGCCTACTGGATCCTGAATTTGCCCTGGACCCTGACAAGCCCACCAACTTCACCAACCC
CGTGTACGCCACACTCTACATGGGTGGTCACGGTAGCCGCCACTCCCTGGCCAGCACGGACGAG
AAGCGAGAACTCCTGGGCCGGGGCCCTGAGGACGAGATAGGGGACCCCTTGGCATAGGGTTCTG
CGCAATCGGACTTCCCCAGAGAGCCTCCTGCCTGCCCTGCCAGAGAAGTCCTTCAACGAACCCT
CTCCTGCCCAGCCAACCCCTCCCCGGCCCCGCCGGGATGTATAAATGTAAAAATGAAGGAATTA
CTTTTTATATGTGAGCAAGCGAGCAAGCGAGCACAGTATTATCTCTTTCCGTTCTCCTTCCTGC
CTGCTCCTCAGCAACCCCCCCCATGCTGCCTTCCAGGAGGGGGGGCAGGGAGGGAGTTCTGCAA
CTTACAGGTACGAGGGGCCCCGCCTCCCACCTTCCCACCAAAACTGCACCCCCACTGGGAGAGC
TGGTGGTGCTGCTTCCCCCACCCCTGTACAAGACACTTTGTCAAGGCTCTCCCCTCTCATCCCC
CCACCCCTGCCTCCAGCTCCCTAAGGGCTGATTCTAGGATTCTGGGGGGGATGAGCCCTTTGCT
GCCCCTGTCTGGAAAATTTGGCTCTGGCTGAGGTAGGAAGAAAAGGATGGAGATTTTTAGTTCC
CTGTCGGGGAAGCCATCCCATGCCCCTGCCCCTACTCTAGGGGCACCTCTGAGATGGCCAGGCT
CAGTATCCCAGACAGGCCCTCCCCCTCCCCAGTGCCCCCACCATGGCTCCCAGGACTGGAGACT
TTCTTTGGTAAAACAGTCCCCCAGGCTCCCCTCCCCTGGGGACTAGGAGGAAGTGGGGCACACC
AAGGAAGGGCAAGCAAGCGGGCAGCCCCGTTTTGGGGATGTGAACGTTTTAATAATTTTTGCTG
AATTCCTTTACAACTAAATAACACAGATATTGTTATAAATAAAATTAAAAAAAAAAAAAAAGAA
AAAAGAAAGAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_020947485	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00015037642.1
	ENSSSCP00015038104.1
	ENSSSCP00015038658.1
	ENSSSCP00015039092.1
	ENSSSCP00015039784.1
	ENSSSCP00015039795.1
	ENSSSCP00025009746.1
	ENSSSCP00030031039.1
	ENSSSCP00030031161.1
	ENSSSCP00030031263.1
	ENSSSCP00030031358.1
	ENSSSCP00030031499.1
	ENSSSCP00035037904.1
	ENSSSCP00040005399.1
	ENSSSCP00045038038.1
	ENSSSCP00050004773.1
	ENSSSCP00055027048.1
	ENSSSCP00060032556.1
	ENSSSCP00060032603.1
	ENSSSCP00060032666.1
	ENSSSCP00060032729.1
	ENSSSCP00060032763.1
	ENSSSCP00065010996.1
	ENSSSCP00070049842.1
	ENSSSCP00070049847.1
GenBank Protein	JAA53703	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_020947485 ⟸ XM_021091826

- UniProtKB:

A0A480YRT7 (UniProtKB/TrEMBL), A0A8D1W3Z2 (UniProtKB/TrEMBL), K9IVL7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLTPPPLLLLPLLSALVAAAIDVPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEIC
PQSKTQRCQPNEHNCLGTELCILMSRLCNGIQDCADGSDEGPHCREQRGQCSHLGCQHHCVPTL
NGPTCYCNNSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFTCGCVEGYLLQPDNRSCKAKN
EPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQL
KCARMPGLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDL
ELYNPKGIALDPAMGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWA
DAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVNRFNST
DYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSL
GSDGKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFA
DTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGDNLYWTDDGPKKTISVARLEKAAQTRK
TLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFVTSKTVLWPNGL
SLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELNHAFGLCHHGNYLFWTEYRSGSVYRL
ERGTGGAPPIVTLLRSERPPIFEIRMYDAQQQQVGTNKCRVNNGGCSSLCLATPGSRQCACAED
QVLDKDGVTCLANPSYVPPPQCQPGEFACSNSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCP
SDRFKCENNRCIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDD
CGDRSDESARVAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDEAGCSHSCSSTQFKCNS
GRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHNDEFQCRLDGLCIPLRWRCDGDTDC
MDSSDEKSCEGVTHVCDPNVKFGCKDSARCISKAWVCDGDSDCEDNSDEENCESLACRPPSHPC
ANNTSVCLPPDKLCDGNDDCGDGSDEGELCDQCSLNNGGCSHNCSVAPGEGIVCSCPLGMELGP
DNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVLEPDGESCRSLDPFKPFIIFSNRHEIR
RIDLHKGDYSVLVPGLRNTIALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLA
TPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDA
SLPRIEAASMSGAGRRTIHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVL
RGHEFLSHPFAVTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMA
PNPCEANGGRGPCSHLCLINYNRTVSCACPHLMKLHKDNTTCYEFKKFLLYARQMEIRGVDLDA
PYYNYIISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLA
VDWVSRNLYWTSYDTNKKQINVARLDGSFKNAVVQGLEQPHGLVVHPLRGKLYWTDGDNISMAN
MDGSNRTLLFSGQRGPVGLAIDFPESKLYWISSKNHTINRCNLDGSGLEVIDAMWSQLGKATAL
AIMGDKLWWADQVSEKMGTCNKADGSGSVVLRNSTTLVMHMKVYDESIQLDHEGTNPCSVNNGD
CSQLCLPTSETTRSCMCTAGYSLRSGQQACEGVGSFLLYSVHEGIRGIPLDPNDKSDALVPVSG
TSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTWREDVVTNGIGRVEGIAVDWIAGNIYWTDQ
GFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQYPRIERSRLDGTERVVLVN
VSISWPNGISVDYEDGKLYWCDARTDKIERIDLETGEDREVVLSSNNMDMFSVSVFEEFIYWSD
RTHANGSIKRGSKDNATDSVPLRTGIGVQLKDIKVFNRDRQKGTNVCAVANGGCQQLCLYRGGG
QRACACAHGMLAEDGATCREYAGYLLYSERTILKSIHLSDERNLNAPVQPFEDPEHMKNVIALA
FDYRAGTSPGTPNRIFFSDIHFGNIQQINDDGSSRTTIVENVGSVEGLAYHRGWDTLYWTSYTT
STITRHTVDQTRPGAFERETVITMSGDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAALSGANV
LTLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAVYGEHI
FWTDWVRRAVQRANKYVGSDMKLLRVDIPQQPMGIIAVANDTNSCELSPCRINNGGCQDLCLLT
HQGHVNCSCRGGRILQEDLTCQAVNSSCRAQDEFECANGECINFSLTCDGVSHCKDKSDEKPSY
CNTRRCKKTFRQCNNGRCVSNMLWCNGADDCGDGSDEIPCNKTACSVGEFRCRDGTCIGNSSRC
NQFVDCEDASDEMNCSATDCSSYFRLGVKGVRFQPCERTSLCYAPSWVCDGANDCGDYSDERDC
PGVKRPRCPLNYFACPSGRCIPMSWTCDKEDDCEHGEDETHCNKFCSEAQFECQNHRCISKQWL
CDGSDDCGDGSDEAAHCEGKTCGPNSFSCPGTHMCVPERWLCDGDKDCADGADESITAGCLYNN
TCDDREFMCQNRQCIPKHFMCDHDRDCADGSDESPECEYPTCGPNEFRCANGRCLSSRQWECDG
ENDCHDQSDEAPKNPHCTSPEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDGSDERGCHVNEC
LSHKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCADVDECSTTFPCSQRCINTHGSYKCLCV
EGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSNYTLLKQGLNNAVALDFDYREQMIY
WTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYR
TVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSGRSVIVDTKITWPNGLTLDYVT
ERIYWADAREDYIEFASLDGSNRHVVLSQDIPHIFALTLFEDYVYWTDWETXSINRAHKTTGTN
KTLLISTLHXPMDLHVFHALRQPDVPNHPCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGGDGR
NCVSNCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCSTGICTNPAFI
CDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPN
QFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDC
GDGSDEPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCAN
GRCIAGRWKCDXDHDCADGSDEKDCTPRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACS
TGVRTCPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWI
GRQCDGTDNCGDGTDEEDCEPPTAQSPHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDC
SIDPKLTSCATNASICGDEARCVRTEKAAYCACRSGFHTVPGQPGCQDINECLRFGTCSQLCNN
TKGGHLCSCARNFMKTHNTCKAEGSEYQVLYIADDNEIRSLFPSHPHSAYEQAFQGDESVRIDA
MDVHVKAGRVYWTNWHTGTISFRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWV
AGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIETAAMD
GTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSKRGLSHPFSID
VFEDYIYGVTYINNRVFKIHKFGHSPLINLTGGLSHASDVVLYHQHKQPEVTNPCDRKKCEWLC
LLSPSGPVCTCPNGKRLDNGTCVAVPSPTLPPDAPRPGTCNLQCFNGGSCFLNARRQPKCRCQP
RYTGDKCELDQCWEYCRNGGTCAASPSGMPTCRCPTGFTGPKCTQQVCAGHCANNSTCTVNQGN
QPQCRCLPGFLGDRCQYRQCSGYCENFGTCQMAADGSRQCRCTAYFEGARCEVNKCSRCLDGAC
VVNKQSGDVTCNCSDGRVAPSCLTCVGHCSNGGSCTMNSKMMPECQCPPHMAGPRCEEQVVSPQ
QPGHMASILIPLLLLLLMLLVAGVVFWYKRRVRGAKGFQHQRMTNGAMNVEIGNPTYKMYEGGE
PDDVGGLLDPEFALDPDKPTNFTNPVYATLYMGGHGSRHSLASTDEKRELLGRGPEDEIGDPLA

hide sequence

Protein Domains

EGF-like

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00015068508	UniProtKB/TrEMBL
	ENSSSCG00025017023	UniProtKB/TrEMBL
	ENSSSCG00030048465	UniProtKB/TrEMBL
	ENSSSCG00035067055	UniProtKB/TrEMBL
	ENSSSCG00040010681	UniProtKB/TrEMBL
	ENSSSCG00045031402	UniProtKB/TrEMBL
	ENSSSCG00050008128	UniProtKB/TrEMBL
	ENSSSCG00055016485	UniProtKB/TrEMBL
	ENSSSCG00060055300	UniProtKB/TrEMBL
	ENSSSCG00065019948	UniProtKB/TrEMBL
	ENSSSCG00070029176	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00015092070.1	UniProtKB/TrEMBL
	ENSSSCT00015093076.1	UniProtKB/TrEMBL
	ENSSSCT00015094294.1	UniProtKB/TrEMBL
	ENSSSCT00015095221.1	UniProtKB/TrEMBL
	ENSSSCT00015096764.1	UniProtKB/TrEMBL
	ENSSSCT00015096792.1	UniProtKB/TrEMBL
	ENSSSCT00025023323.1	UniProtKB/TrEMBL
	ENSSSCT00030067791.1	UniProtKB/TrEMBL
	ENSSSCT00030068120.1	UniProtKB/TrEMBL
	ENSSSCT00030068392.1	UniProtKB/TrEMBL
	ENSSSCT00030068650.1	UniProtKB/TrEMBL
	ENSSSCT00030068973.1	UniProtKB/TrEMBL
	ENSSSCT00035090458.1	UniProtKB/TrEMBL
	ENSSSCT00040013985.1	UniProtKB/TrEMBL
	ENSSSCT00045054614.1	UniProtKB/TrEMBL
	ENSSSCT00050011123.1	UniProtKB/TrEMBL
	ENSSSCT00055034036.1	UniProtKB/TrEMBL
	ENSSSCT00060075366.1	UniProtKB/TrEMBL
	ENSSSCT00060075479.1	UniProtKB/TrEMBL
	ENSSSCT00060075602.1	UniProtKB/TrEMBL
	ENSSSCT00060075725.1	UniProtKB/TrEMBL
	ENSSSCT00060075809.1	UniProtKB/TrEMBL
	ENSSSCT00065026739.1	UniProtKB/TrEMBL
	ENSSSCT00070058607.1	UniProtKB/TrEMBL
	ENSSSCT00070058613.1	UniProtKB/TrEMBL
Gene3D-CATH	2.120.10.30	UniProtKB/TrEMBL
	4.10.400.10	UniProtKB/TrEMBL
	EGF-type module	UniProtKB/TrEMBL
	Laminin	UniProtKB/TrEMBL
InterPro	6-blade_b-propeller_TolB-like	UniProtKB/TrEMBL
	cEGF	UniProtKB/TrEMBL
	DUF5050	UniProtKB/TrEMBL
	EGF-like_Ca-bd_dom	UniProtKB/TrEMBL
	EGF-like_dom	UniProtKB/TrEMBL
	EGF-type_Asp/Asn_hydroxyl_site	UniProtKB/TrEMBL
	EGF_Ca-bd_CS	UniProtKB/TrEMBL
	Growth_fac_rcpt_cys_sf	UniProtKB/TrEMBL
	LDL_receptor-like_sf	UniProtKB/TrEMBL
	LDLR-related	UniProtKB/TrEMBL
	LDLR_class-A_CS	UniProtKB/TrEMBL
	LDLR_classB_rpt	UniProtKB/TrEMBL
	LDrepeatLR_classA_rpt	UniProtKB/TrEMBL
	NOTCH1_EGF-like	UniProtKB/TrEMBL
NCBI Gene	LRP1	ENTREZGENE
PANTHER	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED	UniProtKB/TrEMBL
	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B	UniProtKB/TrEMBL
	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED	UniProtKB/TrEMBL
Pfam	cEGF	UniProtKB/TrEMBL
	DUF5050	UniProtKB/TrEMBL
	EGF_CA	UniProtKB/TrEMBL
	FXa_inhibition	UniProtKB/TrEMBL
	Ldl_recept_a	UniProtKB/TrEMBL
	Ldl_recept_b	UniProtKB/TrEMBL
PRINTS	LDLRECEPTOR	UniProtKB/TrEMBL
PROSITE	ASX_HYDROXYL	UniProtKB/TrEMBL
	EGF_1	UniProtKB/TrEMBL
	EGF_2	UniProtKB/TrEMBL
	EGF_3	UniProtKB/TrEMBL
	EGF_CA	UniProtKB/TrEMBL
	LDLRA_1	UniProtKB/TrEMBL
	LDLRA_2	UniProtKB/TrEMBL
	LDLRB	UniProtKB/TrEMBL
SMART	EGF	UniProtKB/TrEMBL
	EGF_CA	UniProtKB/TrEMBL
	LDLa	UniProtKB/TrEMBL
	SM00135	UniProtKB/TrEMBL
Superfamily-SCOP	EGF/Laminin	UniProtKB/TrEMBL
	SSF57184	UniProtKB/TrEMBL
	SSF57424	UniProtKB/TrEMBL
	YWTD domain	UniProtKB/TrEMBL
UniProt	A0A480YRT7	ENTREZGENE, UniProtKB/TrEMBL
	A0A4X1W838_PIG	UniProtKB/TrEMBL
	A0A8D0JN16_PIG	UniProtKB/TrEMBL
	A0A8D0PVI5_PIG	UniProtKB/TrEMBL
	A0A8D0X548_PIG	UniProtKB/TrEMBL
	A0A8D0X5E9_PIG	UniProtKB/TrEMBL
	A0A8D1W1P1_PIG	UniProtKB/TrEMBL
	A0A8D1W3Z2	ENTREZGENE, UniProtKB/TrEMBL
	A0A8D1XZW2_PIG	UniProtKB/TrEMBL
	K9IVL7	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - PID (archival)