LRP1 (LDL receptor related protein 1) - Rat Genome Database

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Gene: LRP1 (LDL receptor related protein 1) Canis lupus familiaris
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Symbol: LRP1
Name: LDL receptor related protein 1
RGD ID: 12415572
Description: ENCODES a protein that exhibits cargo receptor activity (ortholog); coreceptor activity (ortholog); protease binding (ortholog); INVOLVED IN aging (ortholog); amyloid-beta clearance (ortholog); aorta morphogenesis (ortholog); PARTICIPATES IN platelet-derived growth factor signaling pathway; ASSOCIATED WITH Acute Liver Failure (ortholog); Alzheimer's disease (ortholog); arteriosclerosis (ortholog); FOUND IN apical part of cell (ortholog); axonal growth cone (ortholog); clathrin-coated vesicle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor); LOW QUALITY PROTEIN: prolow-density lipoprotein receptor-related protein 1; prolow-density lipoprotein receptor-related protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1101,260,256 - 1,341,705 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl101,260,719 - 1,352,271 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha101,324,330 - 1,405,506 (+)NCBI
ROS_Cfam_1.0101,270,934 - 1,352,176 (+)NCBI
UMICH_Zoey_3.1101,247,639 - 1,328,819 (+)NCBI
UNSW_CanFamBas_1.0101,489,631 - 1,570,787 (+)NCBI
UU_Cfam_GSD_1.0101,614,746 - 1,695,694 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
amyloid-beta clearance  (ISO)
amyloid-beta clearance by cellular catabolic process  (IEA)
amyloid-beta clearance by transcytosis  (IEA)
aorta morphogenesis  (ISO)
apoptotic cell clearance  (ISO)
astrocyte activation involved in immune response  (ISO)
cardiac septum development  (ISO)
cell population proliferation  (ISO)
cellular lipid catabolic process  (ISO)
cellular response to amyloid-beta  (ISO)
cerebral cortex development  (ISO)
chemoattraction of axon  (ISO)
cholesterol metabolic process  (ISO)
coronary vasculature development  (ISO)
endocytosis  (IEA)
lipoprotein metabolic process  (ISO)
lysosomal transport  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cell death  (ISO)
negative regulation of cell-substrate adhesion  (ISO)
negative regulation of cytosolic calcium ion concentration  (ISO)
negative regulation of focal adhesion assembly  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of neuron projection development  (ISO)
negative regulation of platelet-derived growth factor receptor-beta signaling pathway  (ISO)
negative regulation of smooth muscle cell migration  (ISO)
negative regulation of Wnt signaling pathway  (ISO)
phagocytosis  (IEA)
positive regulation of amyloid-beta clearance  (ISO)
positive regulation of axon extension  (ISO)
positive regulation of axon extension involved in regeneration  (ISO)
positive regulation of cell death  (IEA)
positive regulation of chemokine (C-X-C motif) ligand 2 production  (ISO)
positive regulation of cholesterol efflux  (ISO)
positive regulation of cholesterol import  (ISO)
positive regulation of collateral sprouting of injured axon  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of endocytosis  (IEA)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (ISO)
positive regulation of lipid transport  (ISO)
positive regulation of lysosomal protein catabolic process  (IEA)
positive regulation of neuron projection development  (ISO)
positive regulation of phagocytosis  (ISO)
positive regulation of protein binding  (IEA)
positive regulation of protein localization to plasma membrane  (IEA)
positive regulation of protein transport  (ISO)
positive regulation of Schwann cell migration  (ISO)
positive regulation of transcytosis  (ISO)
positive regulation of vascular associated smooth muscle cell migration  (ISO)
protein kinase C-activating G protein-coupled receptor signaling pathway  (ISO)
receptor-mediated endocytosis  (IEA,ISO)
regulation of actin cytoskeleton organization  (ISO)
regulation of cholesterol transport  (ISO)
regulation of phospholipase A2 activity  (ISO)
transport across blood-brain barrier  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
LRP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1101,260,256 - 1,341,705 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl101,260,719 - 1,352,271 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha101,324,330 - 1,405,506 (+)NCBI
ROS_Cfam_1.0101,270,934 - 1,352,176 (+)NCBI
UMICH_Zoey_3.1101,247,639 - 1,328,819 (+)NCBI
UNSW_CanFamBas_1.0101,489,631 - 1,570,787 (+)NCBI
UU_Cfam_GSD_1.0101,614,746 - 1,695,694 (+)NCBI
LRP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1257,128,483 - 57,213,361 (+)EnsemblGRCh38hg38GRCh38
GRCh381257,128,401 - 57,213,377 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371257,522,266 - 57,607,144 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361255,808,549 - 55,893,409 (+)NCBINCBI36hg18NCBI36
Build 341255,808,548 - 55,893,390NCBI
Celera1257,176,220 - 57,261,424 (+)NCBI
Cytogenetic Map12q13.3NCBI
HuRef1254,560,642 - 54,624,427 (+)NCBIHuRef
HuRef1254,625,579 - 54,646,229 (+)NCBIHuRef
CHM1_11257,489,966 - 57,575,252 (+)NCBICHM1_1
Lrp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910127,374,026 - 127,457,158 (-)NCBIGRCm39mm39
GRCm39 Ensembl10127,374,030 - 127,457,017 (-)Ensembl
GRCm3810127,538,157 - 127,621,148 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10127,538,161 - 127,621,148 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710126,975,213 - 127,058,204 (-)NCBIGRCm37mm9NCBIm37
MGSCv3610126,941,137 - 127,024,078 (-)NCBImm8
Celera10129,930,007 - 130,012,542 (-)NCBICelera
Cytogenetic Map10D3NCBI
Lrp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2763,380,325 - 63,461,029 (-)NCBI
Rnor_6.0 Ensembl770,846,344 - 70,926,903 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0770,846,313 - 70,927,028 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0771,018,808 - 71,099,367 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4767,520,575 - 67,601,549 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1767,541,343 - 67,622,669 (-)NCBI
Celera760,519,175 - 60,599,687 (-)NCBICelera
Cytogenetic Map7q22NCBI
Lrp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554584,861,431 - 4,941,146 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554584,861,431 - 4,941,939 (+)NCBIChiLan1.0ChiLan1.0
LRP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11231,966,149 - 32,051,979 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1231,966,149 - 32,051,979 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01231,713,938 - 31,799,287 (-)NCBIMhudiblu_PPA_v0panPan3
Lrp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494557,463,638 - 57,543,337 (-)NCBI
SpeTri2.0NW_0049366461,326,900 - 1,407,236 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1522,435,636 - 22,519,276 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2524,186,409 - 24,202,094 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LRP1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11153,039,147 - 53,125,041 (+)NCBI
ChlSab1.1 Ensembl1153,039,364 - 53,125,776 (+)Ensembl
Lrp1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462480210,734,907 - 10,812,888 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 1 21 6 6 6 6 12 9 6
Low 4 1 6 8 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000000295   ⟹   ENSCAFP00000000266
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl101,260,719 - 1,341,165 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000049824   ⟹   ENSCAFP00000039944
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl101,260,719 - 1,341,165 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000060767   ⟹   ENSCAFP00000058480
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl101,260,719 - 1,286,380 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000078799   ⟹   ENSCAFP00000064154
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl101,260,719 - 1,352,271 (+)Ensembl
RefSeq Acc Id: XM_022424083   ⟹   XP_022279791
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1101,260,256 - 1,341,705 (+)NCBI
Dog10K_Boxer_Tasha101,324,330 - 1,405,506 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038487853   ⟹   XP_038343781
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1101,247,639 - 1,328,819 (+)NCBI
RefSeq Acc Id: XM_038487854   ⟹   XP_038343782
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1101,247,895 - 1,327,992 (+)NCBI
RefSeq Acc Id: XM_038549747   ⟹   XP_038405675
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0101,614,746 - 1,695,694 (+)NCBI
RefSeq Acc Id: XM_038613707   ⟹   XP_038469635
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0101,489,631 - 1,570,787 (+)NCBI
RefSeq Acc Id: XM_038613708   ⟹   XP_038469636
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0101,489,890 - 1,569,960 (+)NCBI
RefSeq Acc Id: XM_038679069   ⟹   XP_038534997
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0101,270,934 - 1,352,176 (+)NCBI
RefSeq Acc Id: XM_038679070   ⟹   XP_038534998
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0101,271,193 - 1,351,349 (+)NCBI
RefSeq Acc Id: XM_538245   ⟹   XP_538245
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1101,260,719 - 1,340,845 (+)NCBI
Dog10K_Boxer_Tasha101,324,589 - 1,404,679 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_538245   ⟸   XM_538245
- Peptide Label: isoform X2
- UniProtKB: J9P315 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022279791   ⟸   XM_022424083
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSCAFP00000064154   ⟸   ENSCAFT00000078799
RefSeq Acc Id: ENSCAFP00000039944   ⟸   ENSCAFT00000049824
RefSeq Acc Id: ENSCAFP00000058480   ⟸   ENSCAFT00000060767
RefSeq Acc Id: ENSCAFP00000000266   ⟸   ENSCAFT00000000295
RefSeq Acc Id: XP_038343781   ⟸   XM_038487853
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038343782   ⟸   XM_038487854
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038469635   ⟸   XM_038613707
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038469636   ⟸   XM_038613708
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038534997   ⟸   XM_038679069
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038534998   ⟸   XM_038679070
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038405675   ⟸   XM_038549747
- Peptide Label: isoform X2
Protein Domains
EGF-like

Promoters
RGD ID:13684880
Promoter ID:EPDNEW_C2948
Type:initiation region
Name:LRP1_1
Description:LDL receptor related protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1101,260,734 - 1,260,794EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000178 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000000266 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFP00000039944 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFP00000058480 UniProtKB/TrEMBL
  ENSCAFP00000064154 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000000295 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFT00000049824 UniProtKB/TrEMBL
  ENSCAFT00000060767 UniProtKB/TrEMBL
  ENSCAFT00000078799 UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.30 UniProtKB/TrEMBL
  4.10.400.10 UniProtKB/TrEMBL
InterPro 6-blade_b-propeller_TolB-like UniProtKB/TrEMBL
  cEGF UniProtKB/TrEMBL
  DUF5050 UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  Growth_fac_rcpt_ UniProtKB/TrEMBL
  LDL_receptor-like_sf UniProtKB/TrEMBL
  LDLR_class-A_CS UniProtKB/TrEMBL
  LDLR_classB_rpt UniProtKB/TrEMBL
  LDrepeatLR_classA_rpt UniProtKB/TrEMBL
NCBI Gene LRP1 ENTREZGENE
Pfam cEGF UniProtKB/TrEMBL
  DUF5050 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  Ldl_recept_a UniProtKB/TrEMBL
  Ldl_recept_b UniProtKB/TrEMBL
PRINTS LDLRECEPTOR UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/TrEMBL
  EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  LDLRA_1 UniProtKB/TrEMBL
  LDLRA_2 UniProtKB/TrEMBL
  LDLRB UniProtKB/TrEMBL
SMART EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  LDLa UniProtKB/TrEMBL
  SM00135 UniProtKB/TrEMBL
Superfamily-SCOP SSF57184 UniProtKB/TrEMBL
  SSF57424 UniProtKB/TrEMBL
UniProt A0A5F4CYC3_CANLF UniProtKB/TrEMBL
  A0A5F4DBL7_CANLF UniProtKB/TrEMBL
  E2R4Q1_CANLF UniProtKB/TrEMBL
  J9P315 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:42771 ENTREZGENE