Exhibits several functions, including fibronectin binding activity; low-density lipoprotein particle receptor binding activity; and metal ion binding activity. Involved in several processes, including animal organ development; embryonic hindlimb morphogenesis; and estrous cycle. Localizes to several cellular components, including Golgi apparatus; intercellular canaliculus; and lysosome. Used to study brain ischemia; degenerative disc disease; and myocardial infarction. Biomarker of several diseases, including degenerative disc disease; gastric ulcer; liver cirrhosis (multiple); meningococcal meningitis; and silicosis. Human ortholog(s) of this gene implicated in anodontia; artery disease (multiple); osteoarthritis; ovarian carcinoma; and spondyloepimetaphyseal dysplasia, Missouri type. Orthologous to human MMP13 (matrix metallopeptidase 13); INTERACTS WITH (+)-schisandrin B; (-)-epigallocatechin 3-gallate; 2,3,7,8-tetrachlorodibenzodioxine.
Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA], Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]
Glucosamine inhibits the reaction [IL1B results in increased expression of MMP13 mRNA], IL1B promotes the reaction [Glucosamine results in increased expression of MMP13 mRNA]
Deoxyglucose inhibits the reaction [IL1B protein results in increased expression of MMP13 protein], Deoxyglucose inhibits the reaction [TNF protein results in increased expression of MMP13 protein]
[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP13 mRNA, TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP13 mRNA]
Glucosamine inhibits the reaction [IL1B results in increased expression of MMP13 mRNA], IL1B promotes the reaction [Glucosamine results in increased expression of MMP13 mRNA]
acetovanillone inhibits the reaction [IL1B protein results in increased expression of MMP13 protein], acetovanillone inhibits the reaction [TNF protein results in increased expression of MMP13 protein]
Isotretinoin inhibits the reaction [Arachidonic Acid results in increased expression of MMP13 mRNA], Isotretinoin inhibits the reaction [Arachidonic Acid results in increased secretion of MMP13 protein]
Glucosamine inhibits the reaction [IL1B results in increased expression of MMP13 mRNA], IL1B promotes the reaction [Glucosamine results in increased expression of MMP13 mRNA]
[BQ 788 co-treated with cycloTrp-Asp-Pro-Val-Leu] inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP13 protein], cycloTrp-Asp-Pro-Val-Leu inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP13 protein]
Oxygen deficiency promotes the reaction [Chloroquine results in increased expression of MMP13 mRNA], TLR9 protein promotes the reaction [Oxygen deficiency promotes the reaction [Chloroquine results in increased expression of MMP13 mRNA]]
Chloroquine inhibits the reaction [CPG-oligonucleotide results in increased expression of MMP13 mRNA], Chloroquine inhibits the reaction [CPG-oligonucleotide results in increased secretion of MMP13 protein]
Ciprofloxacin inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA], Ciprofloxacin inhibits the reaction [IL1B protein results in increased secretion of MMP13 protein]
[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP13 mRNA, TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP13 mRNA]
[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in decreased expression of MMP13 mRNA, IL1B protein inhibits the reaction [[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in decreased expression of MMP13 mRNA]
[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP13 mRNA more ...
[Paraquat co-treated with Oxygen] results in decreased expression of MMP13 mRNA, sarpogrelate inhibits the reaction [Oxygen deficiency results in increased expression of MMP13 mRNA]
Oxygen deficiency promotes the reaction [Chloroquine results in increased expression of MMP13 mRNA], TLR9 protein promotes the reaction [Oxygen deficiency promotes the reaction [Chloroquine results in increased expression of MMP13 mRNA]]
Doxycycline analog inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA], Doxycycline inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]
Selenium inhibits the reaction [T-2 Toxin results in increased expression of MMP13 mRNA], Selenium inhibits the reaction [T-2 Toxin results in increased expression of MMP13 protein]
[1-methylanthracene co-treated with fluoranthene] results in increased expression of MMP13 mRNA, SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of MMP13 mRNA]
[Dimethylnitrosamine co-treated with gadolinium chloride] results in increased expression of MMP13 mRNA, SB 203580 inhibits the reaction [gadolinium chloride results in increased expression of MMP13 mRNA]
Isotretinoin inhibits the reaction [Arachidonic Acid results in increased expression of MMP13 mRNA], Isotretinoin inhibits the reaction [Arachidonic Acid results in increased secretion of MMP13 protein]
[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in decreased expression of MMP13 mRNA, IL1B protein inhibits the reaction [[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in decreased expression of MMP13 mRNA]
Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA], Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]
2-4-morpholinyl-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Chloramphenicol results in increased expression of MMP13 mRNA], 2-4-morpholinyl-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [VEGFA protein results in increased activity of MMP13 protein]
Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of and results in increased secretion of MMP13 protein] more ...
Acetylcysteine inhibits the reaction [FN1 protein modified form results in increased expression of and results in increased secretion of MMP13 protein]
[Dimethylnitrosamine co-treated with gadolinium chloride] results in increased expression of MMP13 mRNA, Plant Extracts inhibits the reaction [Dimethylnitrosamine results in increased expression of MMP13 mRNA]
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of MMP13 protein], Naproxen inhibits the reaction [Capsaicin results in increased expression of MMP13 protein]
[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP13 mRNA, TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP13 mRNA]
Norfloxacin inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA], Norfloxacin inhibits the reaction [IL1B protein results in increased secretion of MMP13 protein]
[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of MMP13 mRNA, NR1I3 protein affects the reaction [Phenobarbital results in increased expression of MMP13 mRNA]
Tetradecanoylphorbol Acetate results in increased expression of MMP13 mRNA, Tetradecanoylphorbol Acetate results in increased expression of MMP13 protein
SB 203580 inhibits the reaction [gadolinium chloride results in increased expression of MMP13 mRNA], SB 203580 inhibits the reaction [halofuginone results in increased expression of MMP13 mRNA]
Selenium inhibits the reaction [T-2 Toxin results in increased expression of MMP13 mRNA], Selenium inhibits the reaction [T-2 Toxin results in increased expression of MMP13 protein]
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of MMP13 protein], Sumatriptan inhibits the reaction [Capsaicin results in increased expression of MMP13 protein]
Selenium inhibits the reaction [T-2 Toxin results in increased expression of MMP13 mRNA], Selenium inhibits the reaction [T-2 Toxin results in increased expression of MMP13 protein]
[Carbon Tetrachloride co-treated with 1-trifluoromethoxyphenyl-3-1-propionylpiperidine-4-ylurea] results in increased expression of MMP13 mRNA more ...
Tetracycline analog inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA], Tetracycline inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]
Coffee inhibits the reaction [Thioacetamide results in increased expression of MMP13 protein], halofuginone promotes the reaction [Thioacetamide results in increased expression of MMP13 mRNA]
[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP13 mRNA, TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP13 mRNA]
[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP13 mRNA, TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP13 mRNA]
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
