Enables several functions, including fibronectin binding activity; low-density lipoprotein particle receptor binding activity; and metal ion binding activity. Involved in several processes, including embryonic hindlimb morphogenesis; endochondral ossification; and estrous cycle. Located in several cellular components, including Golgi apparatus; intercellular canaliculus; and lysosome. Used to study brain ischemia; degenerative disc disease; and myocardial infarction. Biomarker of several diseases, including bone disease (multiple); gastric ulcer; liver cirrhosis (multiple); meningococcal meningitis; and silicosis. Human ortholog(s) of this gene implicated in anodontia; artery disease (multiple); bone disease (multiple); and ovarian carcinoma. Orthologous to human MMP13 (matrix metallopeptidase 13); INTERACTS WITH (+)-schisandrin B; (-)-epigallocatechin 3-gallate; (R)-lipoic acid.
Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA], Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]
Glucosamine inhibits the reaction [IL1B results in increased expression of MMP13 mRNA], IL1B promotes the reaction [Glucosamine results in increased expression of MMP13 mRNA]
Deoxyglucose inhibits the reaction [IL1B protein results in increased expression of MMP13 protein], Deoxyglucose inhibits the reaction [TNF protein results in increased expression of MMP13 protein]
[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP13 mRNA, TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP13 mRNA]
Glucosamine inhibits the reaction [IL1B results in increased expression of MMP13 mRNA], IL1B promotes the reaction [Glucosamine results in increased expression of MMP13 mRNA]
acetovanillone inhibits the reaction [IL1B protein results in increased expression of MMP13 protein], acetovanillone inhibits the reaction [TNF protein results in increased expression of MMP13 protein]
Isotretinoin inhibits the reaction [Arachidonic Acid results in increased expression of MMP13 mRNA], Isotretinoin inhibits the reaction [Arachidonic Acid results in increased secretion of MMP13 protein]
Glucosamine inhibits the reaction [IL1B results in increased expression of MMP13 mRNA], IL1B promotes the reaction [Glucosamine results in increased expression of MMP13 mRNA]
[BQ 788 co-treated with cyclo(Trp-Asp-Pro-Val-Leu)] inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP13 protein], cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP13 protein]
Oxygen deficiency promotes the reaction [Chloroquine results in increased expression of MMP13 mRNA], TLR9 protein promotes the reaction [Oxygen deficiency promotes the reaction [Chloroquine results in increased expression of MMP13 mRNA]]
Chloroquine inhibits the reaction [CPG-oligonucleotide results in increased expression of MMP13 mRNA], Chloroquine inhibits the reaction [CPG-oligonucleotide results in increased secretion of MMP13 protein]
Ciprofloxacin inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA], Ciprofloxacin inhibits the reaction [IL1B protein results in increased secretion of MMP13 protein]
[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP13 mRNA, TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP13 mRNA]
[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in decreased expression of MMP13 mRNA, IL1B protein inhibits the reaction [[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in decreased expression of MMP13 mRNA]
[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP13 mRNA more ...
[Paraquat co-treated with Oxygen] results in decreased expression of MMP13 mRNA, sarpogrelate inhibits the reaction [Oxygen deficiency results in increased expression of MMP13 mRNA]
Oxygen deficiency promotes the reaction [Chloroquine results in increased expression of MMP13 mRNA], TLR9 protein promotes the reaction [Oxygen deficiency promotes the reaction [Chloroquine results in increased expression of MMP13 mRNA]]
Doxycycline analog inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA], Doxycycline inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]
Selenium inhibits the reaction [T-2 Toxin results in increased expression of MMP13 mRNA], Selenium inhibits the reaction [T-2 Toxin results in increased expression of MMP13 protein]
[1-methylanthracene co-treated with fluoranthene] results in increased expression of MMP13 mRNA, SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of MMP13 mRNA]
[Dimethylnitrosamine co-treated with gadolinium chloride] results in increased expression of MMP13 mRNA, SB 203580 inhibits the reaction [gadolinium chloride results in increased expression of MMP13 mRNA]
irigenin inhibits the reaction [TNF protein results in increased expression of MMP13 mRNA], irigenin inhibits the reaction [TNF protein results in increased expression of MMP13 protein]
Isotretinoin inhibits the reaction [Arachidonic Acid results in increased expression of MMP13 mRNA], Isotretinoin inhibits the reaction [Arachidonic Acid results in increased secretion of MMP13 protein]
[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in decreased expression of MMP13 mRNA, IL1B protein inhibits the reaction [[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in decreased expression of MMP13 mRNA]
Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA], Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]
Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of and results in increased secretion of MMP13 protein] more ...
Acetylcysteine inhibits the reaction [FN1 protein modified form results in increased expression of and results in increased secretion of MMP13 protein] more ...
[Dimethylnitrosamine co-treated with gadolinium chloride] results in increased expression of MMP13 mRNA, Plant Extracts inhibits the reaction [Dimethylnitrosamine results in increased expression of MMP13 mRNA]
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of MMP13 protein], Naproxen inhibits the reaction [Capsaicin results in increased expression of MMP13 protein]
[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP13 mRNA, TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP13 mRNA]
Norfloxacin inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA], Norfloxacin inhibits the reaction [IL1B protein results in increased secretion of MMP13 protein]
[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of MMP13 mRNA, NR1I3 protein affects the reaction [Phenobarbital results in increased expression of MMP13 mRNA]
Tetradecanoylphorbol Acetate results in increased expression of MMP13 mRNA, Tetradecanoylphorbol Acetate results in increased expression of MMP13 protein
[salubrinal co-treated with T-2 Toxin] results in increased expression of MMP13 mRNA, salubrinal inhibits the reaction [T-2 Toxin results in increased expression of MMP13 protein]
SB 203580 inhibits the reaction [gadolinium chloride results in increased expression of MMP13 mRNA], SB 203580 inhibits the reaction [halofuginone results in increased expression of MMP13 mRNA]
Selenium inhibits the reaction [T-2 Toxin results in increased expression of MMP13 mRNA], Selenium inhibits the reaction [T-2 Toxin results in increased expression of MMP13 protein]
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of MMP13 protein], Sumatriptan inhibits the reaction [Capsaicin results in increased expression of MMP13 protein]
4-(4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide inhibits the reaction [T-2 Toxin results in increased expression of MMP13 mRNA] more ...
[salubrinal co-treated with T-2 Toxin] results in increased expression of MMP13 mRNA, salubrinal inhibits the reaction [T-2 Toxin results in increased expression of MMP13 protein]
[Carbon Tetrachloride co-treated with 1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea] results in increased expression of MMP13 mRNA more ...
Tetracycline analog inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA], Tetracycline inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]
Coffee inhibits the reaction [Thioacetamide results in increased expression of MMP13 protein], halofuginone promotes the reaction [Thioacetamide results in increased expression of MMP13 mRNA]
[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP13 mRNA, TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP13 mRNA]
[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP13 mRNA, TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP13 mRNA]
Different bone growth rates are associated with changes in the expression pattern of types II and X collagens and collagenase 3 in proximal growth plates of the rat tibia.
Spatial and temporal pattern of expression of interstitial collagenase, stromelysin/transin, gelatinase A, and TIMP-1 during experimental gastric ulcer healing.
Clinical relevance of matrix metalloproteinase-13 determined with a new highly specific and sensitive ELISA in ascitic fluid of advanced ovarian carcinoma patients.
Enhanced interstitial collagenase (matrix metalloproteinase-13) production of Kupffer cell by gadolinium chloride prevents pig serum-induced rat liver fibrosis.
Matrix metalloproteinase-2, -9 and -13 are involved in fibronectin degradation of rat lung granulomatous fibrosis caused by Angiostrongylus cantonensis.
Combination of tumor necrosis factor-alpha ablation and matrix metalloproteinase inhibition prevents heart failure after pressure overload in tissue inhibitor of metalloproteinase-3 knock-out mice.
Effects of 17 beta-estradiol on the expression of interstitial collagenases-8 and -13 (MMP-8 and MMP-13) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in ovariectomized rat osteoblastic cells.
The functional polymorphisms on promoter region of matrix metalloproteinase-12, -13 genes may alter the risk of epithelial ovarian carcinoma in chinese.
Distinct expression of gelatinase A [matrix metalloproteinase (MMP)-2], collagenase-3 (MMP-13), membrane type MMP 1 (MMP-14), and tissue inhibitor of MMPs type 1 mediated by physiological signals during formation and regression of the rat corpus luteum.
Comparative effect of nimesulide and ibuprofen on the urinary levels of collagen type II C-telopeptide degradation products and on the serum levels of hyaluronan and matrix metalloproteinases-3 and -13 in patients with flare-up of osteoarthritis.
Collagenase-3 induction in rat lung fibroblasts requires the combined effects of tumor necrosis factor-alpha and 12-lipoxygenase metabolites: a model of macrophage-induced, fibroblast-driven extracellular matrix remodeling during inflammatory lung injury.
Rebamipide attenuates pain severity and cartilage degeneration in a rat model of osteoarthritis by downregulating oxidative damage and catabolic activity in chondrocytes.
Collagenase-3 expression in breast myofibroblasts as a molecular marker of transition of ductal carcinoma in situ lesions to invasive ductal carcinomas.
Macrophage migration inhibitory factor up-regulates matrix metalloproteinase-9 and -13 in rat osteoblasts. Relevance to intracellular signaling pathways.
Parathyroid hormone regulates the rat collagenase-3 promoter in osteoblastic cells through the cooperative interaction of the activator protein-1 site and the runt domain binding sequence.
Deletion of the transforming growth factor beta receptor type II gene in articular chondrocytes leads to a progressive osteoarthritis-like phenotype in mice.
Acute and chronic hypoxia as well as 7-day recovery from chronic hypoxia affects the distribution of pulmonary mast cells and their MMP-13 expression in rats.
[Comparison of doxycycline, losartan, and their combination on the expression of matrix metalloproteinase, tissue inhibitor of matrix metalloproteinase, and collagen remodeling in the noninfarcted myocardium after acute myocardial infarction in rats]
