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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3395
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prkca
Name: protein kinase C, alpha
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prkcadecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of PRKCA mRNAPMID:25181051 PMID:30816183 PMID:32528016 PMID:34947998
Prkcaincreases expressionEXP 6480464CTDbisphenol A results in increased expression of PRKCA mRNAPMID:29097150
Prkcamultiple interactionsEXP 6480464CTD[bisphenol A co-treated with Estradiol] results in decreased expression of PRKCA mRNA; [Phytochemicals co-treated with bisphenol A] affects the expression of PRKCAPMID:20136622 PMID:26496021
Prkcadecreases methylationISOPRKCA (Homo sapiens)6480464CTDbisphenol A results in decreased methylation of PRKCA genePMID:31601247
Prkcaincreases phosphorylationISOPRKCA (Homo sapiens)6480464CTDbisphenol A results in increased phosphorylation of PRKCA proteinPMID:22564983
Prkcamultiple interactionsISOPRKCA (Homo sapiens)6480464CTD[naringenin co-treated with bisphenol A] results in increased expression of PRKCA mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of PRKCA mRNAPMID:36235125
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