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Gene: PRKCB (protein kinase C beta) Homo sapiens
Symbol: PRKCB
Name: protein kinase C beta
Description: Exhibits several functions, including androgen receptor binding activity; protein kinase C binding activity; and protein serine/threonine kinase activity. Involved in histone H3-T6 phosphorylation; regulation of glucose transmembrane transport; and regulation of transcription by RNA polymerase II. Localizes to cytosol; nucleoplasm; and plasma membrane. Implicated in dilated cardiomyopathy and lung non-small cell carcinoma. Biomarker of Alzheimer's disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: MGC41878; PKC-B; PKC-beta; PKCB; PKCbeta; PKCI(2); PRKCB1; PRKCB2; protein kinase C beta 1; protein kinase C beta type; protein kinase C, beta 1 polypeptide
Mus musculus (house mouse) : Prkcb (protein kinase C, beta)  MGI  Alliance
Rattus norvegicus (Norway rat) : Prkcb (protein kinase C, beta)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Prkcb (protein kinase C beta)
Pan paniscus (bonobo/pygmy chimpanzee) : PRKCB (protein kinase C beta)
Canis lupus familiaris (dog) : PRKCB (protein kinase C beta)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prkcb (protein kinase C beta)
Sus scrofa (pig) : PRKCB (protein kinase C beta)
Chlorocebus sabaeus (African green monkey) : PRKCB (protein kinase C beta)
Heterocephalus glaber (naked mole-rat) : Prkcb (protein kinase C beta)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1623,835,983 - 24,220,611 (+)EnsemblGRCh38hg38GRCh38
GRCh381623,835,983 - 24,220,611 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371623,847,300 - 24,231,932 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361623,754,823 - 24,139,063 (+)NCBINCBI36hg18NCBI36
Build 341623,754,822 - 24,139,063NCBI
Celera1622,625,642 - 23,009,889 (+)NCBI
Cytogenetic Map16p12.2-p12.1NCBI
HuRef1621,938,281 - 22,322,666 (+)NCBIHuRef
CHM1_11624,859,040 - 25,244,985 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PRKCB
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731404
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-04-21
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.