Pld1 (phospholipase D1) - Rat Genome Database

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Gene: Pld1 (phospholipase D1) Rattus norvegicus
Analyze
Symbol: Pld1
Name: phospholipase D1
RGD ID: 3349
Description: Enables phospholipase D activity. Involved in phospholipid catabolic process; positive regulation of cell migration; and response to peptide hormone. Acts upstream of or within phosphatidic acid biosynthetic process. Located in Golgi cisterna; lamellipodium; and vesicle. Is active in synapse. Biomarker of visual epilepsy. Human ortholog(s) of this gene implicated in developmental cardiac valvular defect. Orthologous to human PLD1 (phospholipase D1); PARTICIPATES IN mTOR signaling pathway; ceramide signaling pathway; endocytosis pathway; INTERACTS WITH 1-octadec-9-enoylglycero-3-phosphate; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: choline phosphatase 1; Phoshpolipase D gene 1; Phoshpolipase D gene 1 probably with two splicing variants A and B; phosphatidylcholine-hydrolyzing phospholipase D1; phospholipase D gene 1; phospholipase D gene 1 probably with two splicing variants A and B; phospholipase D gene 1, probably with two splicing variants A and B; phospholipase D1, phosphatidylcholine-specific; PLD 1; Pld1a; Pld1b; Plda; Pldb; rPLD1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22110,849,205 - 111,047,692 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2110,893,608 - 111,047,692 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2117,548,080 - 117,700,325 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02115,660,662 - 115,812,852 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02110,374,318 - 110,526,587 (+)NCBIRnor_WKY
Rnor_6.02113,651,967 - 113,849,403 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2113,652,348 - 113,849,403 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02133,357,235 - 133,554,180 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42115,306,940 - 115,460,518 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12115,251,901 - 115,405,480 (+)NCBI
Celera2106,084,707 - 106,238,116 (+)NCBICelera
Cytogenetic Map2q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,3-bisphospho-D-glyceric acid  (ISO)
2,3-bisphosphoglyceric acid  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-naphthylamine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
8-Br-cAMP  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butan-1-ol  (EXP,ISO)
cadmium atom  (EXP)
caffeine  (ISO)
cannabidiol  (ISO)
cannabigerol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
formaldehyde  (ISO)
furan  (EXP)
ganglioside GM1  (EXP)
genistein  (EXP)
glyphosate  (ISO)
Goe 6976  (EXP,ISO)
hexadecanoic acid  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
indometacin  (EXP)
irinotecan  (EXP)
isoprenaline  (ISO)
Licochalcone B  (ISO)
lithium chloride  (ISO)
lithocholic acid  (ISO)
melanins  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
metformin  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury(1+)  (EXP)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
nicotine  (ISO)
nitrofen  (EXP)
oleic acid  (ISO)
oxaliplatin  (EXP)
oxycodone  (EXP)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenylarsine oxide  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
phosphatidic acid  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium cyanide  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
prostaglandin E2  (ISO)
quercetin  (ISO)
reactive oxygen species  (EXP,ISO)
resveratrol  (ISO)
rotenone  (EXP)
rottlerin  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
Soman  (EXP)
sotorasib  (ISO)
sulforaphane  (ISO)
testosterone  (ISO)
tetracycline  (ISO)
titanium dioxide  (ISO)
topiramate  (EXP)
topotecan  (EXP)
trametinib  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Involvement of phospholipase D in the cAMP-regulated exocytosis of rat parotid acinar cells. Dohke Y, etal., Biochem Biophys Res Commun 2002 Dec 13;299(4):663-8.
2. Phospholipase D2 is localized to the rims of the Golgi apparatus in mammalian cells. Freyberg Z, etal., Mol Biol Cell. 2002 Nov;13(11):3930-42.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Simultaneous high expression of PLD1 and Sp1 predicts a poor prognosis for pancreatic ductal adenocarcinoma patients. Hu J, etal., Oncotarget. 2016 Nov 29;7(48):78557-78565. doi: 10.18632/oncotarget.12447.
6. Mechanisms of regulation of phospholipase D1 by protein kinase Calpha. Hu T and Exton JH, J Biol Chem 2003 Jan 24;278(4):2348-55.
7. A role for phospholipase D1 in neurotransmitter release. Humeau Y, etal., Proc Natl Acad Sci U S A 2001 Dec 18;98(26):15300-5.
8. Stability of phospholipase D in primary astrocytes. Jin S, etal., Biochem Biophys Res Commun 2002 Sep 27;297(3):545-51.
9. Differential expression of phospholipase D isozymes in the hippocampus following kainic acid-induced seizures. Kim SY, etal., J Neuropathol Exp Neurol. 2004 Aug;63(8):812-20.
10. Subcellular distribution and characterization of rat pancreatic phospholipase D isoforms. Laine J, etal., Pancreas. 2000 May;20(4):323-36.
11. Phospholipase D is essential for keratocyte-like migration of NBT-II cells. Nagasaki A, etal., Cell Struct Funct. 2008;33(1):27-33. Epub 2008 Mar 13.
12. Molecular cloning and chromosome mapping of rat phospholipase D genes, Pld1a, Pld1b and Pld2. Nakashima S, etal., Cytogenet Cell Genet 1997;79(1-2):109-13.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. P2X7 receptors on osteoblasts couple to production of lysophosphatidic acid: a signaling axis promoting osteogenesis. Panupinthu N, etal., J Cell Biol. 2008 Jun 2;181(5):859-71. doi: 10.1083/jcb.200708037.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. Antigen-stimulated activation of phospholipase D1b by Rac1, ARF6, and PKCalpha in RBL-2H3 cells. Powner DJ, etal., Mol Biol Cell 2002 Apr;13(4):1252-62.
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Parathyroid hormone stimulates phosphatidylethanolamine hydrolysis by phospholipase D in osteoblastic cells. Singh AT, etal., Lipids. 2005 Nov;40(11):1135-40.
21. Differential mRNA expression of phospholipase D (PLD) isozymes during cAMP-induced differentiation in C6 glioma cells. Yoshimura S, etal., Biochem Biophys Res Commun 1996 Aug 14;225(2):494-9.
22. Phospholipase D prevents apoptosis in v-Src-transformed rat fibroblasts and MDA-MB-231 breast cancer cells. Zhong M, etal., Biochem Biophys Res Commun 2003 Mar 14;302(3):615-9.
Additional References at PubMed
PMID:9188501   PMID:9361006   PMID:9445394   PMID:11121416   PMID:11544318   PMID:11665609   PMID:11812783   PMID:12054584   PMID:12388770   PMID:12429840   PMID:12472177   PMID:12642902  
PMID:12876278   PMID:14660552   PMID:14718562   PMID:14744865   PMID:14769825   PMID:15087463   PMID:15187091   PMID:15199126   PMID:15210717   PMID:15475361   PMID:15601581   PMID:15616193  
PMID:15752728   PMID:15980073   PMID:16339153   PMID:16842757   PMID:17146759   PMID:17540765   PMID:17897319   PMID:18541525   PMID:18550821   PMID:19010519   PMID:19161391   PMID:19261846  
PMID:19741172   PMID:19794068   PMID:19946888   PMID:20965153   PMID:21525000   PMID:21916846   PMID:22544632   PMID:22674271   PMID:22797597   PMID:23932932   PMID:24269608   PMID:24728967  
PMID:24986006   PMID:25361009   PMID:28648601   PMID:28729535   PMID:30207376   PMID:31356881   PMID:32337269   PMID:34431424   PMID:36162649  


Genomics

Comparative Map Data
Pld1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22110,849,205 - 111,047,692 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2110,893,608 - 111,047,692 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2117,548,080 - 117,700,325 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02115,660,662 - 115,812,852 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02110,374,318 - 110,526,587 (+)NCBIRnor_WKY
Rnor_6.02113,651,967 - 113,849,403 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2113,652,348 - 113,849,403 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02133,357,235 - 133,554,180 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42115,306,940 - 115,460,518 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12115,251,901 - 115,405,480 (+)NCBI
Celera2106,084,707 - 106,238,116 (+)NCBICelera
Cytogenetic Map2q24NCBI
PLD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383171,600,404 - 171,810,483 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl3171,600,404 - 171,810,950 (-)EnsemblGRCh38hg38GRCh38
GRCh373171,318,194 - 171,528,273 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363172,801,339 - 172,938,566 (-)NCBINCBI36Build 36hg18NCBI36
Build 343172,801,346 - 172,938,574NCBI
Celera3169,718,435 - 169,928,143 (-)NCBICelera
Cytogenetic Map3q26.31NCBI
HuRef3168,688,221 - 168,898,341 (-)NCBIHuRef
CHM1_13171,281,084 - 171,491,135 (-)NCBICHM1_1
T2T-CHM13v2.03174,384,521 - 174,594,617 (-)NCBIT2T-CHM13v2.0
Pld1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39327,992,636 - 28,187,511 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl327,992,844 - 28,187,511 (+)EnsemblGRCm39 Ensembl
GRCm38327,938,459 - 28,133,362 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl327,938,695 - 28,133,362 (+)EnsemblGRCm38mm10GRCm38
MGSCv37327,837,602 - 28,032,284 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36328,215,231 - 28,324,307 (+)NCBIMGSCv36mm8
Celera327,897,052 - 28,088,894 (+)NCBICelera
Cytogenetic Map3A3NCBI
cM Map311.15NCBI
Pld1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554201,696,751 - 1,892,741 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554201,697,716 - 1,892,741 (-)NCBIChiLan1.0ChiLan1.0
PLD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13176,790,736 - 176,999,974 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3176,790,753 - 176,961,033 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03168,606,342 - 168,816,383 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PLD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13435,917,759 - 36,080,383 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3435,921,058 - 36,121,631 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3444,928,877 - 45,133,990 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03436,000,267 - 36,205,332 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3436,000,274 - 36,205,751 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13435,940,863 - 36,145,600 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03435,903,822 - 36,109,331 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03436,165,953 - 36,370,780 (-)NCBIUU_Cfam_GSD_1.0
Pld1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602102,572,478 - 102,777,840 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936593930,637 - 1,046,821 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936593844,634 - 1,049,478 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13110,154,874 - 110,376,294 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113110,152,268 - 110,376,319 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213119,138,285 - 119,362,303 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11517,667,079 - 17,871,452 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1517,706,030 - 17,870,266 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606326,423,171 - 26,629,555 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pld1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473049,665,432 - 49,885,184 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473049,665,432 - 49,885,242 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pld1
1412 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:953
Count of miRNA genes:299
Interacting mature miRNAs:383
Transcripts:ENSRNOT00000039296, ENSRNOT00000039308
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)243162366111362592Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)259134147127460910Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)259324377141596857Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
7411551Bw131Body weight QTL 13129.60.001body mass (VT:0001259)body weight gain (CMO:0000420)267942638112942638Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)278665616143657569Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)280270434125270434Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)281018907126018907Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)282345893130923501Rat
7207808Bmd89Bone mineral density QTL 894.1femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)288862519133862519Rat
2300165Bmd49Bone mineral density QTL 494.80.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)288862519133862519Rat
2300170Bmd45Bone mineral density QTL 4512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
2300185Bmd46Bone mineral density QTL 468.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
1598862Glom9Glomerulus QTL 93.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)292337601137337601Rat
1598863Cm65Cardiac mass QTL 652.3heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)292337601137337601Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2102803808147803808Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2104559726149559726Rat

Markers in Region
RH139663  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22111,046,730 - 111,046,946 (+)MAPPERmRatBN7.2
Rnor_6.02113,848,442 - 113,848,657NCBIRnor6.0
Rnor_5.02133,553,219 - 133,553,434UniSTSRnor5.0
RGSC_v3.42115,459,557 - 115,459,772UniSTSRGSC3.4
Celera2106,237,155 - 106,237,370UniSTS
RH 3.4 Map2703.0UniSTS
Cytogenetic Map2q23.3-q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 2 1 1 6 1 8 27 11 10
Low 41 56 40 13 40 8 11 66 8 30 1 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000039296   ⟹   ENSRNOP00000034466
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2110,893,608 - 111,047,339 (+)Ensembl
Rnor_6.0 Ensembl2113,652,348 - 113,849,038 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000039308   ⟹   ENSRNOP00000035045
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2110,893,623 - 111,047,692 (+)Ensembl
Rnor_6.0 Ensembl2113,696,154 - 113,849,403 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000091545   ⟹   ENSRNOP00000073521
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2113,696,259 - 113,847,533 (+)Ensembl
RefSeq Acc Id: NM_030992   ⟹   NP_112254
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22110,893,623 - 111,047,692 (+)NCBI
Rnor_6.02113,696,154 - 113,849,403 (+)NCBI
Rnor_5.02133,357,235 - 133,554,180 (+)NCBI
RGSC_v3.42115,306,940 - 115,460,518 (+)RGD
Celera2106,084,707 - 106,238,116 (+)RGD
Sequence:
RefSeq Acc Id: XM_006232205   ⟹   XP_006232267
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22110,893,566 - 111,047,304 (+)NCBI
Rnor_6.02113,695,376 - 113,849,015 (+)NCBI
Rnor_5.02133,357,235 - 133,554,180 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006232206   ⟹   XP_006232268
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22110,849,205 - 111,047,304 (+)NCBI
Rnor_6.02113,651,967 - 113,849,015 (+)NCBI
Rnor_5.02133,357,235 - 133,554,180 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_112254   ⟸   NM_030992
- UniProtKB: D4A318 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232268   ⟸   XM_006232206
- Peptide Label: isoform X1
- UniProtKB: F1LMG4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232267   ⟸   XM_006232205
- Peptide Label: isoform X1
- UniProtKB: F1LMG4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073521   ⟸   ENSRNOT00000091545
RefSeq Acc Id: ENSRNOP00000034466   ⟸   ENSRNOT00000039296
RefSeq Acc Id: ENSRNOP00000035045   ⟸   ENSRNOT00000039308
Protein Domains
PH   PLD phosphodiesterase   PX

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70496-F1-model_v2 AlphaFold P70496 1-1074 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691272
Promoter ID:EPDNEW_R1790
Type:initiation region
Name:Pld1_2
Description:phospholipase D1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R1791  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02113,652,315 - 113,652,375EPDNEW
RGD ID:13691266
Promoter ID:EPDNEW_R1791
Type:initiation region
Name:Pld1_1
Description:phospholipase D1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R1790  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02113,696,154 - 113,696,214EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3349 AgrOrtholog
BioCyc Gene G2FUF-53495 BioCyc
Ensembl Genes ENSRNOG00000028156 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000034466 ENTREZGENE
  ENSRNOP00000034466.4 UniProtKB/TrEMBL
  ENSRNOP00000035045 ENTREZGENE
  ENSRNOP00000035045.3 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000039296 ENTREZGENE
  ENSRNOT00000039296.7 UniProtKB/TrEMBL
  ENSRNOT00000039308 ENTREZGENE
  ENSRNOT00000039308.5 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.1520.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Phox UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLD-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLipase_D/transphosphatidylase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLipase_D_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLipase_D_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PX_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25096 UniProtKB/Swiss-Prot
NCBI Gene 25096 ENTREZGENE
PANTHER PTHR18896 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PF00169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00787 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLDc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLDc_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pld1 PhenoGen
PIRSF Phospholipase_D_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50195 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PLDc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00312 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF64268 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D4A318 ENTREZGENE, UniProtKB/TrEMBL
  F1LMG4 ENTREZGENE, UniProtKB/TrEMBL
  P70496 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary O08959 UniProtKB/Swiss-Prot
  O35856 UniProtKB/Swiss-Prot
  O54765 UniProtKB/Swiss-Prot
  P70497 UniProtKB/Swiss-Prot
  Q9QWJ6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-30 Pld1  phospholipase D1  Pld1  phospholipase D1, phosphatidylcholine-specific  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-05-07 Pld1  phospholipase D1, phosphatidylcholine-specific  Pld1  phospholipase D1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Pld1  Phoshpolipase D gene 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_drugs inhibited by neomycin 628523
gene_expression expressed in neuron plasma membrane 70245
gene_function hydrolyzes phosphatidylcholine to produce choline and phosphatidic acid 70245
gene_function exhibits transphosphatidylation activity 628523
gene_physical_interaction binds PKC-alpha through the N terminus 729596
gene_process involved in cAMP-regulated exocytosis in rat parotid acinar cells 628523
gene_process may have a post-docking role in Ca2+ dependent exocytosis 628523
gene_product member of the phospholipase superfamily 628523
gene_regulation activated by small molecular mass GTP-binding proteins 628523
gene_transcript may have two splice variants, A and B 70245