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Gene: Kcnj16 (potassium inwardly-rectifying channel, subfamily J, member 16) Rattus norvegicus

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Symbol:

Kcnj16

Name:

potassium inwardly-rectifying channel, subfamily J, member 16

RGD ID:

61824

Description:

Predicted to enable inward rectifier potassium channel activity. Involved in potassium ion transport; regulation of pH; and response to carbon dioxide. Located in basolateral plasma membrane. Used to study hypokalemia and metabolic acidosis. Orthologous to human KCNJ16 (potassium inwardly rectifying channel subfamily J member 16); INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil; acrolein.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

BIR9; inward rectifier K(+) channel Kir5.1; inward rectifier potassium channel 16; Kir5.1; potassium channel, inwardly rectifying subfamily J member 16; potassium channel, inwardly rectifying subfamily J, member 16; potassium voltage-gated channel subfamily J member 16

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Allele / Splice:

Kcnj16^em1Mcwi

Genetic Models:

SS-Kcnj16^em1Mcwi

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	96,489,329 - 96,520,745 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	10	96,460,331 - 96,566,075 (+)	Ensembl				GRCr8
mRatBN7.2	10	95,990,009 - 96,021,356 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	95,960,725 - 96,021,702 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	10	101,081,523 - 101,083,303 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	100,544,500 - 100,546,280 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	95,952,661 - 95,954,441 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	99,330,894 - 99,391,551 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	99,388,130 - 99,389,898 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	10	99,027,026 - 99,087,674 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	10	100,514,180 - 100,515,949 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	10	94,663,783 - 94,665,552 (+)	NCBI		Celera
RGSC_v3.1	10	100,528,549 - 100,530,318 (+)	NCBI
Cytogenetic Map	10	q32.1	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Brugada syndrome 1 (ISO)

hypokalemia (IMP)

Hypokalemic Tubulopathy and Deafness (ISO)

metabolic acidosis (IMP)

Respiratory Underresponsiveness to Hypoxia and Hypercapnia (IMP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2-amino-2-deoxy-D-glucopyranose (ISO)

4,4'-diaminodiphenylmethane (ISO)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

6-propyl-2-thiouracil (EXP)

acrolein (EXP)

aflatoxin B1 (ISO)

aldehydo-D-glucosamine (ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

ammonium chloride (EXP)

arsenite(3-) (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

beta-D-glucosamine (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

butanal (ISO)

cadmium dichloride (ISO)

CGP 52608 (ISO)

chenodeoxycholic acid (ISO)

chlordecone (ISO)

chlorpyrifos (ISO)

ciguatoxin CTX1B (ISO)

cobalt dichloride (EXP)

Cuprizon (EXP)

cyclosporin A (ISO)

deoxycholic acid (ISO)

dinophysistoxin 1 (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

ethanol (ISO)

fipronil (EXP)

flavonoids (EXP)

genistein (ISO)

glycidol (EXP)

glycochenodeoxycholic acid (ISO)

glycocholic acid (ISO)

glycodeoxycholic acid (ISO)

hydrogen peroxide (ISO)

lead diacetate (EXP)

menadione (ISO)

methimazole (EXP)

mono(2-ethylhexyl) phthalate (ISO)

monosodium L-glutamate (ISO)

naphthalene (EXP)

okadaic acid (ISO)

paclitaxel (EXP)

paracetamol (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorononanoic acid (ISO)

phenobarbital (ISO)

phenylarsine oxide (ISO)

phenylmercury acetate (ISO)

potassium atom (ISO)

potassium dichromate (ISO)

progesterone (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sulfadimethoxine (EXP)

tetrachloromethane (ISO)

trimellitic anhydride (ISO)

tunicamycin (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

monoatomic ion transmembrane transport (IEA)

monoatomic ion transport (IEA)

potassium ion import across plasma membrane (IBA)

potassium ion transmembrane transport (IEA,ISO)

potassium ion transport (IDA,IEA)

regulation of monoatomic ion transmembrane transport (IBA)

regulation of pH (IMP)

response to carbon dioxide (IMP)

Cellular Component

basolateral plasma membrane (IDA,IEA,ISO)

membrane (IEA)

monoatomic ion channel complex (IEA)

plasma membrane (IBA,IEA,ISO)

Molecular Function

inward rectifier potassium channel activity (IBA,IEA,ISO)

protein binding (IPI)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

decreased body weight (IMP)

decreased circulating aldosterone level (IMP)

decreased circulating bicarbonate level (IMP)

decreased circulating potassium level (IMP)

decreased heart rate (IMP)

decreased renal glomerular filtration rate (IMP)

decreased systemic arterial blood pressure (IMP)

decreased urine microalbumin level (IMP)

hypercapnia (IMP)

hyperventilation (IMP)

hypokalemia (IMP)

increased blood urea nitrogen level (IMP)

increased circulating chloride level (IMP)

increased circulating magnesium level (IMP)

increased susceptibility to induced morbidity/mortality (IMP)

metabolic acidosis (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
3.	Essential role of Kir5.1 channels in renal salt handling and blood pressure control.	Palygin O, etal., JCI Insight. 2017 Sep 21;2(18). pii: 92331. doi: 10.1172/jci.insight.92331. eCollection 2017 Sep 21.
4.	Genetic mutation of Kcnj16 identifies Kir5.1-containing channels as key regulators of acute and chronic pH homeostasis.	Puissant MM, etal., FASEB J. 2019 Apr;33(4):5067-5075. doi: 10.1096/fj.201802257R. Epub 2019 Jan 3.
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Kir5.1 underlies long-lived subconductance levels in heteromeric Kir4.1/Kir5.1 channels from Xenopus tropicalis.	Shang L, etal., Biochem Biophys Res Commun. 2009 Oct 23;388(3):501-5. doi: 10.1016/j.bbrc.2009.08.032. Epub 2009 Aug 8.
9.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
10.	In vivo formation of a proton-sensitive K+ channel by heteromeric subunit assembly of Kir5.1 with Kir4.1.	Tanemoto M, etal., J Physiol. 2000 Jun 15;525 Pt 3:587-92.
11.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
12.	pH dependence of the inwardly rectifying potassium channel, Kir5.1, and localization in renal tubular epithelia.	Tucker SJ, etal., J Biol Chem 2000 Jun 2;275(22):16404-7.

Additional References at PubMed

PMID:7874445	PMID:12456399	PMID:14750965	PMID:15292049	PMID:15310750	PMID:15775962	PMID:20926613	PMID:22871113	PMID:31799617	PMID:33232300	PMID:37535709	PMID:39414394

Genomics

Comparative Map Data

Kcnj16
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	96,489,329 - 96,520,745 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	10	96,460,331 - 96,566,075 (+)	Ensembl				GRCr8
mRatBN7.2	10	95,990,009 - 96,021,356 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	95,960,725 - 96,021,702 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	10	101,081,523 - 101,083,303 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	100,544,500 - 100,546,280 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	95,952,661 - 95,954,441 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	99,330,894 - 99,391,551 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	99,388,130 - 99,389,898 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	10	99,027,026 - 99,087,674 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	10	100,514,180 - 100,515,949 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	10	94,663,783 - 94,665,552 (+)	NCBI		Celera
RGSC_v3.1	10	100,528,549 - 100,530,318 (+)	NCBI
Cytogenetic Map	10	q32.1	NCBI

KCNJ16
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	70,075,225 - 70,135,608 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	70,053,429 - 70,135,608 (+)	Ensembl			hg38	GRCh38
GRCh37	17	68,071,366 - 68,131,749 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	65,583,021 - 65,643,344 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	17	65,612,589 - 65,643,339	NCBI
Celera	17	64,643,318 - 64,703,632 (+)	NCBI		Celera
Cytogenetic Map	17	q24.3	NCBI
HuRef	17	63,457,561 - 63,518,274 (+)	NCBI		HuRef
CHM1_1	17	68,137,477 - 68,197,868 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	17	70,953,535 - 71,013,930 (+)	NCBI		T2T-CHM13v2.0

Kcnj16
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	110,858,859 - 110,918,794 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	110,858,859 - 110,918,794 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	11	110,968,033 - 111,027,968 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	110,968,033 - 111,027,968 (+)	Ensembl			mm10	GRCm38
MGSCv37	11	110,829,347 - 110,889,282 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	11	110,835,677 - 110,844,058 (+)	NCBI		MGSCv36	mm8
Celera	11	122,716,155 - 122,778,458 (+)	NCBI		Celera
Cytogenetic Map	11	E2	NCBI
cM Map	11	75.01	NCBI

Kcnj16
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955478	2,775,702 - 2,802,501 (-)	Ensembl
ChiLan1.0	NW_004955478	2,775,702 - 2,833,821 (-)	NCBI	ChiLan1.0	ChiLan1.0

KCNJ16
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	86,125,515 - 86,157,672 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	90,946,509 - 90,978,647 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	64,005,085 - 64,065,153 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	69,389,581 - 69,449,593 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	69,411,032 - 69,447,343 (+)	Ensembl			panPan2	panpan1.1

KCNJ16
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	16,369,312 - 16,441,953 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	16,383,702 - 16,441,953 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	17,274,785 - 17,333,030 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	18,023,819 - 18,096,162 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	18,038,198 - 18,096,041 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	16,982,418 - 17,040,164 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	10,494,745 - 10,552,754 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	10,460,571 - 10,518,835 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Kcnj16
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	9,989,581 - 10,013,038 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936655	3,488,338 - 3,489,597 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936655	3,487,071 - 3,489,686 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

KCNJ16
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	10,393,179 - 10,558,169 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	12	10,393,172 - 10,538,423 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

KCNJ16
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	51,491,064 - 51,631,037 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	51,493,340 - 51,494,596 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666077	22,382,841 - 22,554,086 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Kcnj16
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624801	269,533 - 335,535 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624801	269,449 - 335,535 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Kcnj16
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	9	78,273,721 - 78,303,474 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Kcnj16
588 total Variants

miRNA Target Status (No longer updated)

Confirmed Target Of

miRNA Gene	Mature miRNA	Method Name	Result Type	Data Type	Support Type	PMID
Mir218-1	rno-miR-218a-5p	Mirtarbase	external_info	Microarray	Functional MTI (Weak)	18258830
Mir342	rno-miR-342-3p	Mirtarbase	external_info	Microarray	Functional MTI (Weak)	18258830
Mirlet7f2	rno-let-7f-5p	Mirtarbase	external_info	Microarray	Functional MTI (Weak)	18258830

Predicted Target Of

	Summary Value
Count of predictions:	82
Count of miRNA genes:	71
Interacting mature miRNAs:	74
Transcripts:	ENSRNOT00000006238
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354641	Bvd2	Brain ventricular dilatation QTL 2	6.36	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	10	93723381	107556066	Rat
1298069	Bp168	Blood pressure QTL 168	5.5		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	10	27023535	98502431	Rat
8657410	Bp374	Blood pressure QTL 374			heart left ventricle size trait (VT:0002753)	heart left ventricle end-diastolic diameter (CMO:0000982)	10	67476608	107713808	Rat
61449	Ciaa2	CIA Autoantibody QTL 2	7.1		blood autoantibody amount (VT:0003725)	calculated serum anti-type 2 collagen antibody titer (CMO:0001279)	10	63719161	107713808	Rat
61325	Aia5	Adjuvant induced arthritis QTL 5		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
1298078	Stresp5	Stress response QTL 5	2.99	0.00025	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	42546145	107713808	Rat
631558	Bp137	Blood pressure QTL 137		0.013	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	95224344	97335592	Rat
1549831	Bss6	Bone structure and strength QTL 6	4		lumbar vertebra strength trait (VT:0010574)	vertebra ultimate force (CMO:0001678)	10	58073360	103073360	Rat
12903252	Cm113	Cardiac mass QTL 113		0.047	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	66817119	107713808	Rat
70164	Bw21	Body weight QTL 21	4.36	0.00005	body mass (VT:0001259)	body weight (CMO:0000012)	10	54296336	99451733	Rat
2298548	Neuinf7	Neuroinflammation QTL 7	3.4		nervous system integrity trait (VT:0010566)	spinal cord RT1-B protein level (CMO:0002132)	10	64939013	107713808	Rat
1302404	Cia27	Collagen induced arthritis QTL 27	2.6	0.0045	joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	10	76951790	107713808	Rat
1300107	Rf18	Renal function QTL 18	3.41		urine output (VT:0003620)	timed urine volume (CMO:0000260)	10	79272424	102982300	Rat
70168	Eae12	Experimental allergic encephalomyelitis QTL 12		0.0009	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	10	73599825	107713808	Rat
70171	Cari1	Carrageenan-induced inflammation QTL 1	4.9	0.0005	hypodermis integrity trait (VT:0010550)	inflammatory exudate volume (CMO:0001429)	10	54296227	107713808	Rat
12903269	Am15	Aortic mass QTL 15		0.042	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	10	66817119	107713808	Rat
2313856	Bp342	Blood pressure QTL 342	4.4	0.0001	life span trait (VT:0005372)	age at time of death (CMO:0001193)	10	87807758	96620484	Rat
12903266	Cm114	Cardiac mass QTL 114		0.02	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	10	66817119	107713808	Rat
61354	Pia10	Pristane induced arthritis QTL 10		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
2292617	Ept18	Estrogen-induced pituitary tumorigenesis QTL 18	3.9		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	10	73950353	96620293	Rat
2313103	Bss80	Bone structure and strength QTL 80	2	0.0001	tibia strength trait (VT:1000284)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	10	62556066	107556066	Rat
12880372	Am12	Aortic mass QTL 12		0.003	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	10	66817119	107713808	Rat
70193	Mcs7	Mammary carcinoma susceptibility QTL 7	2.38		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	10	72724423	107713808	Rat
2313105	Bss79	Bone structure and strength QTL 79	1.8	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	62556066	107556066	Rat
12880375	Kidm66	Kidney mass QTL 66		0.009	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	10	66817119	107713808	Rat
61363	Oia3	Oil induced arthritis QTL 3		0.001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	87807758	107713808	Rat
1357344	Bp249	Blood pressure QTL 249		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	67241334	98502431	Rat
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14991535	107556066	Rat
12880370	Cm105	Cardiac mass QTL 105		0.008	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	10	66817119	107713808	Rat
12880371	Cm106	Cardiac mass QTL 106		0.007	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	66817119	107713808	Rat
2306970	Anxrr22	Anxiety related response QTL 22	5.95		fear/anxiety-related behavior trait (VT:1000241)	number of periods of voluntary immobility (CMO:0001045)	10	61843496	98710773	Rat
1300137	Bp186	Blood pressure QTL 186	3.57		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	10	91127270	107556066	Rat
11565453	Kidm58	Kidney mass QTL 58		0.002	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	10	66817119	107713808	Rat
1359017	Hrtrt21	Heart rate QTL 21	2.4		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	10	73695339	97272278	Rat
7387312	Bw125	Body weight QTL 125	3	0.0047	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight (CMO:0000356)	10	65390777	107713808	Rat
6893357	Bw102	Body weight QTL 102	0.5	0.36	body mass (VT:0001259)	body weight (CMO:0000012)	10	81012077	101828297	Rat
61387	Bp1	Blood pressure QTL 1	5.1		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	10	52269185	107713808	Rat
61396	Bp9	Blood pressure QTL 9	4.8	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	68920187	107713808	Rat
1358915	Stresp7	Stress response QTL 7	3.52		blood norepinephrine amount (VT:0005663)	plasma norepinephrine level (CMO:0001010)	10	65307813	107713808	Rat
634320	Niddm49	Non-insulin dependent diabetes mellitus QTL 49	4.41		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	10	89039175	107713808	Rat
70363	Bp71	Blood pressure QTL 71		0.04	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	61843496	106843496	Rat
70364	Bp72	Blood pressure QTL 72			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	88900501	96620484	Rat
6893366	Bw106	Body weight QTL 106	0.3	0.47	body mass (VT:0001259)	body weight (CMO:0000012)	10	70698731	107713808	Rat
1558643	Cm44	Cardiac mass QTL 44	4.8	0.0000368	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	10	61843496	100198886	Rat
631267	Cia20	Collagen induced arthritis QTL 20	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
631269	Cia22	Collagen induced arthritis QTL 22	8.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40535708	107713808	Rat
1576308	Schws1	Schwannoma susceptibility QTL 1		0.0041	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	10	40535708	107713808	Rat
631268	Cia21	Collagen induced arthritis QTL 21	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	14991535	107713808	Rat
631270	Cia23	Collagen induced arthritis QTL 23	3.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40535708	107713808	Rat
1581559	Eae18	Experimental allergic encephalomyelitis QTL 18		0.00002	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	10	66108888	107555881	Rat
6893336	Cm75	Cardiac mass QTL 75	0.1	0.87	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	10	61843496	100198886	Rat
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6864618	96620484	Rat
1600367	Mcs15	Mammary carcinoma susceptibility QTL 15	4.5		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	10	72724423	107713808	Rat
1358188	Ept9	Estrogen-induced pituitary tumorigenesis QTL 9	3.9		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	10	73950353	96620293	Rat
631537	Oia4	Oil induced arthritis QTL 4			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	76128947	107713808	Rat
634354	Rends3	Renal damage susceptibility QTL 3		0.05	kidney blood vessel morphology trait (VT:0000530)	organ lesion measurement (CMO:0000677)	10	61997479	106997479	Rat
61436	Cia5	Collagen induced arthritis QTL 5	4.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	91727883	107713808	Rat
2301405	Cm69	Cardiac mass QTL 69		0.031	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	10	66817119	107713808	Rat
631542	Bp82	Blood pressure QTL 82	6.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	27023535	99451848	Rat

Markers in Region

RH127731

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	96,019,298 - 96,019,480 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	99,389,494 - 99,389,675	NCBI	Rnor6.0
Rnor_5.0	10	99,085,617 - 99,085,798	UniSTS	Rnor5.0
RGSC_v3.4	10	100,515,544 - 100,515,725	UniSTS	RGSC3.4
Celera	10	94,665,147 - 94,665,328	UniSTS
Cytogenetic Map	10	q32.1	UniSTS

Genetic Models

This gene Kcnj16 is modified in the following models/strains:

SS-Kcnj16^em1Mcwi

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
11	9	20	154	73	71	42	31	42	6	220	78	10	128	81	74	29	10	10

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001439458	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_053314	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006247568	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006247569	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006247570	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF249676	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC078776	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000006238 ⟹ ENSRNOP00000006238

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	96,516,609 - 96,521,021 (+)	Ensembl
mRatBN7.2 Ensembl	10	96,017,341 - 96,021,696 (+)	Ensembl
Rnor_6.0 Ensembl	10	99,388,130 - 99,389,898 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000095753 ⟹ ENSRNOP00000089334

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	96,489,397 - 96,521,086 (+)	Ensembl
mRatBN7.2 Ensembl	10	95,989,956 - 96,021,702 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000099422 ⟹ ENSRNOP00000095581

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	95,960,856 - 96,021,702 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000102350 ⟹ ENSRNOP00000084131

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	95,976,654 - 96,021,702 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000104190 ⟹ ENSRNOP00000083795

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	95,960,856 - 96,021,702 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000108962 ⟹ ENSRNOP00000089990

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	96,498,343 - 96,520,998 (+)	Ensembl
mRatBN7.2 Ensembl	10	95,994,728 - 96,021,696 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000110126 ⟹ ENSRNOP00000093074

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	95,988,524 - 96,021,702 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000110709 ⟹ ENSRNOP00000080269

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	96,508,771 - 96,520,998 (+)	Ensembl
mRatBN7.2 Ensembl	10	95,960,725 - 96,021,702 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000111834 ⟹ ENSRNOP00000096926

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	95,980,563 - 96,021,702 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000133823 ⟹ ENSRNOP00000109666

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	96,460,331 - 96,566,075 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000134756 ⟹ ENSRNOP00000109077

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	96,517,167 - 96,529,326 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000143000 ⟹ ENSRNOP00000108016

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	96,517,167 - 96,550,903 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000150976 ⟹ ENSRNOP00000111396

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	96,494,318 - 96,566,044 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000161747 ⟹ ENSRNOP00000101865

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	96,486,614 - 96,529,326 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000169133 ⟹ ENSRNOP00000110668

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	96,489,585 - 96,540,173 (+)	Ensembl

RefSeq Acc Id:

NM_053314 ⟹ NP_445766

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	96,517,324 - 96,519,093 (+)	NCBI
mRatBN7.2	10	96,017,935 - 96,019,704 (+)	NCBI
Rnor_6.0	10	99,388,130 - 99,389,899 (+)	NCBI
Rnor_5.0	10	99,027,026 - 99,087,674 (+)	NCBI
RGSC_v3.4	10	100,514,180 - 100,515,949 (+)	RGD
Celera	10	94,663,783 - 94,665,552 (+)	RGD

Sequence:

show sequence

CTGACTCCTTTGGATGCCCTAAAGACCAAAAAAAAAAAAAAGAATGAGCTATTACGGAAGTAGC
TACCGGATTGTCAACGTGGACTCCAAATATCCAGGCTATCCTCCAGAGCATGCCATAGCCGAGA
AGAGAAGAGCGAGGAGGCGCCTGCTCCACAAAGATGGCAGCTGTAACGTGTACTTTAAACACAT
TTTTGGAGAATGGGGGAGCTACATGGTTGATATATTCACCACTCTTGTGGATACCAAGTGGCGC
CATATGTTTGTAATATTTTCTTTGTCTTACATTCTCTCCTGGTTGATATTCGGCTCCATATTTT
GGCTCATAGCCCTTCATCACGGAGACCTATTAAGCGATCCAGACATCACCCCGTGCGTGGACAA
CGTGCATTCATTTACGGCGGCGTTTTTATTCTCCCTTGAGACCCAAACCACCATCGGGTACGGT
TACCGTTGTGTCACGGAAGAATGCTCTGTGGCCGTGCTGACGGTCATCCTTCAGTCCATCCTGA
GCTGCATCATAAACACCTTCATCATTGGGGCAGCCTTGGCAAAGATGGCGACCGCCCGGAAGCG
AGCCCAGACCATCCGCTTCAGCTATTTCGCACTCATCGGCATGAGAGACGGGAAGCTTTGCCTC
ATGTGGCGCATAGGTGACTTCCGACCCAACCATGTGGTGGAGGGCACGGTGAGAGCCCAACTTC
TGCGCTATTCAGAAGACAGCGAAGGGCGGATGACGATGGCGTTTAAAGACCTCAAACTCGTCAA
TGACCAGATAATCCTGGTAACGCCAGTGACCATTGTCCATGAAATTGACCACGAGAGTCCTCTG
TATGCCCTTGACCGCAAGGCAGTGGCCAAAGATAATTTCGAGATTCTGGTGACATTTATTTATA
CTGGTGACTCTACTGGGACATCCCACCAGTCCAGAAGTTCCTACGTCCCCAGAGAAATTCTCTG
GGGACACAGGTTTCATGATGTATTGGAAGTGAAGAGAAAGTACTACAAGGTAAACTGCTTGCAG
TTTGAGGGAAGCGTGGAAGTCTACGCCCCCTTTTGCAGTGCCAAACAACTGGACTGGAAGGACC
AACAGCTCAACAACTTGGAGAAAACGTCCCCTGCCCGAGGATCCTGCACCTCGGACACCAACAC
CAGGAGGAGATCCTTCAGCGCAGTTGCCATGGTGAGCAGCTGTGAGAACCCAGAGGAGACCAGC
CTGTCCCCACAAGATGAGTGTAAGGAGGTCCCCTATCAGAAAGCCCTCCTGACTTTAAACAGGA
TCTCCATGGAATCCCAGATGTAGCCCTCCTCTCTGACCCTTACCTGAAGGCCCTGAGCTGCAAG
CACGATTTCTTAACAAAATGTTAGTTCTGTAATTTGCAGCGGGAACAGAAAGCAGAGCCAGTTA
AACTTGGCATAGAATCATTTGAAAGTTCCACAGTTTTCTAATATGAAAATTCGGCTTCCGTAGC
AGAGTTTGTATTAGGGAAGCGATTAAGAAGCCTAATTGATTACAATTAATCTCATTACTGCGCA
TGCTTGTGTCTCCTCTTGAAGGTGAGATAATTAGGAGTATGTGTGAGGGGAGGGGAGAAGAGGC
TGATAGACTAGATAAAAATAGAGAAACCGGTAAGCTAGATATTTGCATATAAATTAATTAATTA
TGGAATGAGGACTTATAACAATATCTTATCTCCTAAGCACAACAGATGAGATAAACGCCTCAGC
TTAGGAGCGTTGTGATAAGTAAATAAAATCCAGCCTGGTTTGAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006247570 ⟹ XP_006247632

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	96,489,329 - 96,520,745 (+)	NCBI
mRatBN7.2	10	95,990,009 - 96,021,356 (+)	NCBI
Rnor_6.0	10	99,359,906 - 99,391,551 (+)	NCBI
Rnor_5.0	10	99,027,026 - 99,087,674 (+)	NCBI

Sequence:

show sequence

GACTCATTCCTTCTTTTACCCCCAAAGGAAAGAAAGCAAAGAAAACAACCACAAATGAGAACAG
TTTCCAGAGAACATTTAATGTCCTTGGAACTAATACAAAGGTTGTTGATAATTTCTCTAGGGTC
ACCTACCACCTCGGAACCCATGCGAGATGATGTTGGGCAAGAGGCTGTTTGCCTTTGGTATAGG
GTTACATAGTCAGACAGGGTGTGTGTTTTCACAGAAAACTCTACTGTGACAGTGAGAGAGCCCA
CACATAAAAAGATCAGATTTGGATGAAGTTGTACCAGCCCTCAGATGTCAGCAGGAGAGGATTC
AGCCTTCTGGGTCAATGCGATGTTTAGGGGGCAGCATGTGGCCACTTGGTAATTTGAGGGATTC
TTGTCATTTAACAGGCTCCTAGAGCTGTGATCAAAGACTGTGTTGTAAATGAGCATAGAGAAAG
GGTATTTCTCCTAGTTTCTTGTTTTCTGTCAGCCCCCATTGGCAGGCATCTCTACCATGAGTAG
GCATGGGAACCAGTTAAAGAAAGTGTCGATTCAGTCAAGTAACGCTGAGAACTCTGGCTTTTGT
CTGTACTGAATGTGGCCGGAAAGGCAAAACAGAAGGAGATTCTGCTGTGGGGTTTCTCATCTCC
ATGGTGGTAGGTGCTGGCAGCCTCAGAAGGGGAACTGGAAGAGCGCAGAGAAGAGATCATGAGG
TGTATCTGCGCAGTCGTGTTGTAGATGAAAAGGCCCCAGGGTTGGGATCTGTAACTAAGGCTTT
AACAGAAAATCTTTGAACACGTAAAAGTCAGAATATACCTAGAACTTTTAACTGACTCCTTTGG
ATGCCCTAAAGACCAAAAAAAAAAAAAGAATGAGCTATTACGGAAGTAGCTACCGGATTGTCAA
CGTGGACTCCAAATATCCAGGCTATCCTCCAGAGCATGCCATAGCCGAGAAGAGAAGAGCGAGG
AGGCGCCTGCTCCACAAAGATGGCAGCTGTAACGTGTACTTTAAACACATTTTTGGAGAATGGG
GGAGCTACATGGTTGATATATTCACCACTCTTGTGGATACCAAGTGGCGCCATATGTTTGTAAT
ATTTTCTTTGTCTTACATTCTCTCCTGGTTGATATTCGGCTCCATATTTTGGCTCATAGCCCTT
CATCACGGAGACCTATTAAGCGATCCAGACATCACCCCGTGCGTGGACAACGTGCATTCATTTA
CGGCGGCGTTTTTATTCTCCCTTGAGACCCAAACCACCATCGGGTACGGTTACCGTTGTGTCAC
GGAAGAATGCTCTGTGGCCGTGCTGACGGTCATCCTTCAGTCCATCCTGAGCTGCATCATAAAC
ACCTTCATCATTGGGGCAGCCTTGGCAAAGATGGCGACCGCCCGGAAGCGAGCCCAGACCATCC
GCTTCAGCTATTTCGCACTCATCGGCATGAGAGACGGGAAGCTTTGCCTCATGTGGCGCATAGG
TGACTTCCGACCCAACCATGTGGTGGAGGGCACGGTGAGAGCCCAACTTCTGCGCTATTCAGAA
GACAGCGAAGGGCGGATGACGATGGCGTTTAAAGACCTCAAACTCGTCAATGACCAGATAATCC
TGGTAACGCCAGTGACCATTGTCCATGAAATTGACCACGAGAGTCCTCTGTATGCCCTTGACCG
CAAGGCAGTGGCCAAAGATAATTTCGAGATTCTGGTGACATTTATTTATACTGGTGACTCTACT
GGGACATCCCACCAGTCCAGAAGTTCCTACGTCCCCAGAGAAATTCTCTGGGGACACAGGTTTC
ATGATGTATTGGAAGTGAAGAGAAAGTACTACAAGGTAAACTGCTTGCAGTTTGAGGGAAGCGT
GGAAGTCTACGCCCCCTTTTGCAGTGCCAAACAACTGGACTGGAAGGACCAACAGCTCAACAAC
TTGGAGAAAACGTCCCCTGCCCGAGGATCCTGCACCTCGGACACCAACACCAGGAGGAGATCCT
TCAGCGCAGTTGCCATGGTGAGCAGCTGTGAGAACCCAGAGGAGACCAGCCTGTCCCCACAAGA
TGAGTGTAAGGAGGTCCCCTATCAGAAAGCCCTCCTGACTTTAAACAGGATCTCCATGGAATCC
CAGATGTAGCCCTCCTCTCTGACCCTTACCTGAAGGCCCTGAGCTGCAAGCACGATTTCTTAAC
AAAATGTTAGTTCTGTAATTTGCAGCGGGAACAGAAAGCAGAGCCAGTTAAACTTGGCATAGAA
TCATTTGAAAGTTCCACAGTTTTCTAATATGAAAATTCGGCTTCCGTAGCAGAGTTTGTATTAG
GGAAGCGATTAAGAAGCCTAATTGATTACAATTAATCTCATTACTGCGCATGCTTGTGTCTCCT
CTTGAAGGTGAGATAATTAGGAGTATGTGTGAGGGGAGGGGAGAAGAGGCTGATAGACTAGATA
AAAATAGAGAAACCGGTAAGCTAGATATTTGCATATAAATTAATTAATTATGGAATGAGGACTT
ATAACAATATCTTATCTCCTAAGCACAACAGATGAGATAAACGCCTCAGCTTAGGAGCGTTGTG
ATAAGTAAATAAAATCCAGCCTGGTTTGAGTTACTGTATGTGCCTCTCATTGTATCACAGTATC
AGGTACACAGAGACGTGGTTCCAAGACAGTGAAAATGCCATCCAGTCACAGATTTCTTTCAGTG
CTACTTGCCTAAAGGGTGGTTGGTGAATGCTGGAAGCCAGAACCAACCCTGTGACAGAAGAGAA
GGGGTACCATTGTGTGAAGAGGTATTTCTCTCTGAAACACCTAGGTTCCACCAAACCAATGGGG
AACAGAAGGGAGGCAGGGGATCCCTTCTCTGTGCTCCCTGGAGACGTCTCCTGGGCTCAGAGGC
AGGATTCGGGAGTGGGCAGCACTGTATGGAGAATAGATGCTGTTGGTTTCTGGTCCTGTGAGGC
TTCAGTGTGGGTTGAGAAGAATTCAAAGAGAGAGAGAGAGAGAGAGCCTTTTCTGAAGGCAAGG
GAGCTGTGTGTATGCTGGCTTGAGTGGCAGGTTGGAATAGTTTCGTCAACAATGCAGTGATGTT
GATCTGATGACCTACTAGAGGAGTAAGCTGCATGACAGAGGGCTGCTTCAATCTCAGACCAGGA
GATAAATGTGCATTCTCTGTTTTCACGTTAAAGGATGAAGTTAGCTCCTGATTCCTTTGAGCAT
AGACCCAGCCTCAGACACTGAAAGCTTTATAAACTGAAGAATTACTAGCAATGGCTTGGCATCA
TTTGTGTAATTTTTTCCCCACTGTTGCTGAGCTAGGAGCGAGTATATTATACAGCTGTTGTCTA
ATTTAAGCACACACATATTTTGCTTCTTTTAGTGACCCCCCCCACACACATACACACACTTAAA
CTTAATCCCATAAGCACCTTGAACGGAATCACACAACTCAAGGTTACCAAGCTACGTCAAGTAA
ATAGGTATTCGAAGGGGTCTCTTTTCCTGTCATATTTTTCTCCCTTTCCCTTTCTTGCTTTGCC
TCTCTCTGCTACCCAGGATCAATACAGAATACAGAGTATCTTTTCTAATGCACATGTGTAAATA
AATCTCTCATTCCTGCTGTCTTATAAATAAGAGGTCTCTCTGTTCAAGGGGCATGTTAAAAAAA
AATAACTGTCCTGAAACTTAATATCTGAAACCTAAATCATGTTTCACCTGCACTGCTTGGGAAT
GGAGAATCCATTAGTTAAACCATACAGCCATGTATTTATGTACCCACACATCTGGCACGCAGAC
ACACACACACACACACACACACACACACACACACACAGATACTCACACACCCATGGTGGGATGG
GACATGGGAGACAGACAAAGACAGGCAGAGATAATTTGGATTTTGTAGCAGGAATTACTTGTCT
AAATTAGAATATTACTCTTTCCAAGCCTGGTAAAGCATAACAATGTTTTCTCCACCGACTTGAA
TTTGTTTACCCAGAAGGCAGGTGCACTTCAACGCACTGTGCTTCCTTTGCTCTGTCCTCCCATG
ACCAGATCAGAACAGGGGAGTGGGGTTGGGGGAGCACGGGTCGCTGATTTCTGATAAAACAGAT
TCTCATACACTGTGTGTTCATGCACAGAGTGGAATGTGTGGTTAGCATTCATGTGCCCCATGCA
TCGCTCATTCTCTGTGCAGATTGATAACATGCTTTGGCACGCCTGATGAATTACTTAATAAAGA
TCTTAGACTGGTGCAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001426387	(Get FASTA)	NCBI Sequence Viewer
	NP_445766	(Get FASTA)	NCBI Sequence Viewer
	XP_006247632	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAF74265	(Get FASTA)	NCBI Sequence Viewer
	AAH78776	(Get FASTA)	NCBI Sequence Viewer
	EDM06495	(Get FASTA)	NCBI Sequence Viewer
	EDM06496	(Get FASTA)	NCBI Sequence Viewer
	EDM06497	(Get FASTA)	NCBI Sequence Viewer
	EDM06498	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000089334
GenBank Protein	P52191	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_445766 ⟸ NM_053314

- UniProtKB:

Q9JI87 (UniProtKB/Swiss-Prot), P52191 (UniProtKB/Swiss-Prot), Q68G21 (UniProtKB/TrEMBL), A0A8I5ZPC6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSYYGSSYRIVNVDSKYPGYPPEHAIAEKRRARRRLLHKDGSCNVYFKHIFGEWGSYMVDIFTT
LVDTKWRHMFVIFSLSYILSWLIFGSIFWLIALHHGDLLSDPDITPCVDNVHSFTAAFLFSLET
QTTIGYGYRCVTEECSVAVLTVILQSILSCIINTFIIGAALAKMATARKRAQTIRFSYFALIGM
RDGKLCLMWRIGDFRPNHVVEGTVRAQLLRYSEDSEGRMTMAFKDLKLVNDQIILVTPVTIVHE
IDHESPLYALDRKAVAKDNFEILVTFIYTGDSTGTSHQSRSSYVPREILWGHRFHDVLEVKRKY
YKVNCLQFEGSVEVYAPFCSAKQLDWKDQQLNNLEKTSPARGSCTSDTNTRRRSFSAVAMVSSC
ENPEETSLSPQDECKEVPYQKALLTLNRISMESQM

hide sequence

RefSeq Acc Id:

XP_006247632 ⟸ XM_006247570

- Peptide Label:

isoform X1

- Sequence:

show sequence

MSYYGSSYRIVNVDSKYPGYPPEHAIAEKRRARRRLLHKDGSCNVYFKHIFGEWGSYMVDIFTT
LVDTKWRHMFVIFSLSYILSWLIFGSIFWLIALHHGDLLSDPDITPCVDNVHSFTAAFLFSLET
QTTIGYGYRCVTEECSVAVLTVILQSILSCIINTFIIGAALAKMATARKRAQTIRFSYFALIGM
RDGKLCLMWRIGDFRPNHVVEGTVRAQLLRYSEDSEGRMTMAFKDLKLVNDQIILVTPVTIVHE
IDHESPLYALDRKAVAKDNFEILVTFIYTGDSTGTSHQSRSSYVPREILWGHRFHDVLEVKRKY
YKVNCLQFEGSVEVYAPFCSAKQLDWKDQQLNNLEKTSPARGSCTSDTNTRRRSFSAVAMVSSC
ENPEETSLSPQDECKEVPYQKALLTLNRISMESQM

hide sequence

Ensembl Acc Id:

ENSRNOP00000006238 ⟸ ENSRNOT00000006238

Ensembl Acc Id:

ENSRNOP00000093074 ⟸ ENSRNOT00000110126

Ensembl Acc Id:

ENSRNOP00000095581 ⟸ ENSRNOT00000099422

Ensembl Acc Id:

ENSRNOP00000089990 ⟸ ENSRNOT00000108962

Ensembl Acc Id:

ENSRNOP00000083795 ⟸ ENSRNOT00000104190

Ensembl Acc Id:

ENSRNOP00000096926 ⟸ ENSRNOT00000111834

Ensembl Acc Id:

ENSRNOP00000080269 ⟸ ENSRNOT00000110709

Ensembl Acc Id:

ENSRNOP00000084131 ⟸ ENSRNOT00000102350

Ensembl Acc Id:

ENSRNOP00000089334 ⟸ ENSRNOT00000095753

Ensembl Acc Id:

ENSRNOP00000101865 ⟸ ENSRNOT00000161747

Ensembl Acc Id:

ENSRNOP00000109666 ⟸ ENSRNOT00000133823

Ensembl Acc Id:

ENSRNOP00000109077 ⟸ ENSRNOT00000134756

Ensembl Acc Id:

ENSRNOP00000108016 ⟸ ENSRNOT00000143000

Ensembl Acc Id:

ENSRNOP00000111396 ⟸ ENSRNOT00000150976

Ensembl Acc Id:

ENSRNOP00000110668 ⟸ ENSRNOT00000169133

Protein Domains

Inward rectifier potassium channel C-terminal Potassium channel inwardly rectifying transmembrane

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P52191-F1-model_v2	AlphaFold	P52191	1-419	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:61824	AgrOrtholog
BioCyc Gene	G2FUF-22809	BioCyc
Ensembl Genes	ENSRNOG00000004713	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000095753	ENTREZGENE
Gene3D-CATH	1.10.287.70	UniProtKB/Swiss-Prot
	2.60.40.1400	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7107402	IMAGE-MGC_LOAD
InterPro	Ig_E-set	UniProtKB/Swiss-Prot
	IRK_C	UniProtKB/Swiss-Prot
	K_chnl_inward-rec_Kir	UniProtKB/Swiss-Prot
	K_chnl_inward-rec_Kir5	UniProtKB/Swiss-Prot
	K_chnl_inward-rec_Kir_cyto	UniProtKB/Swiss-Prot
	Kir_TM	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93314	IMAGE-MGC_LOAD
NCBI Gene	29719	ENTREZGENE
PANTHER	PTHR11767	UniProtKB/Swiss-Prot
	PTHR11767:SF24	UniProtKB/Swiss-Prot
Pfam	IRK	UniProtKB/Swiss-Prot
	IRK_C	UniProtKB/Swiss-Prot
PhenoGen	Kcnj16	PhenoGen
PIRSF	GIRK_kir	UniProtKB/Swiss-Prot
PRINTS	KIR5CHANNEL	UniProtKB/Swiss-Prot
	KIRCHANNEL	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000004713	RatGTEx
Superfamily-SCOP	SSF81296	UniProtKB/Swiss-Prot
	Voltage-gated potassium channels	UniProtKB/Swiss-Prot
TIGR	TC219640
UniProt	A0A8I5ZPC6	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0L0W8_RAT	UniProtKB/TrEMBL
	A0ABK0LFU1_RAT	UniProtKB/TrEMBL
	A0ABK0LT55_RAT	UniProtKB/TrEMBL
	A0ABK0LYE4_RAT	UniProtKB/TrEMBL
	A0ABK0M6H3_RAT	UniProtKB/TrEMBL
	KCJ16_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q68G21	ENTREZGENE, UniProtKB/TrEMBL
	Q9JI87	ENTREZGENE
UniProt Secondary	Q9JI87	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2002-06-10	Kcnj16	potassium inwardly-rectifying channel, subfamily J, member 16			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	highly expressed in renal tubular epithelial cells	61644

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Mammalian Phenotype

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Mammalian Phenotype