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Gene: Sost (sclerostin) Rattus norvegicus
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Symbol: Sost
Name: sclerostin
Description: Predicted to have transcription factor binding activity. Involved in ossification. Localizes to the Golgi apparatus; extracellular space; and protein-containing complex. Human ortholog(s) of this gene implicated in SOST-related sclerosing bone dysplasia; sclerosteosis; and sclerosteosis 1. Orthologous to human SOST (sclerostin); PARTICIPATES IN Wnt signaling, canonical pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; aflatoxin B1; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: sclerosteosis
Orthologs:
Homo sapiens (human) : SOST (sclerostin)  HGNC  Alliance
Mus musculus (house mouse) : Sost (sclerostin)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sost (sclerostin)
Pan paniscus (bonobo/pygmy chimpanzee) : SOST (sclerostin)
Canis lupus familiaris (dog) : SOST (sclerostin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sost (sclerostin)
Sus scrofa (pig) : SOST (sclerostin)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01089,897,087 - 89,900,131 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,897,087 - 89,900,131 (-)Ensembl
Rnor_5.01089,689,512 - 89,692,559 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41091,023,712 - 91,026,759 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11091,038,081 - 91,041,129 (-)NCBI
Celera1085,631,705 - 85,634,749 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Sost
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69358
Created: 2001-11-14
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.