Crhr1 (corticotropin releasing hormone receptor 1) - Rat Genome Database

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Gene: Crhr1 (corticotropin releasing hormone receptor 1) Rattus norvegicus
Analyze
Symbol: Crhr1
Name: corticotropin releasing hormone receptor 1
RGD ID: 61276
Description: Exhibits several functions, including G-protein alpha-subunit binding activity; corticotropin-releasing hormone binding activity; and corticotropin-releasing hormone receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; learning or memory; and regulation of secretion by cell. Localizes to several cellular components, including multivesicular body; neuronal cell body; and trans-Golgi network. Used to study hypertension. Biomarker of functional colonic disease; irritable bowel syndrome; mental depression; thromboangiitis obliterans; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and obesity. Orthologous to several human genes including LINC02210-CRHR1 (LINC02210-CRHR1 readthrough); PARTICIPATES IN corticotropin-releasing hormone signaling pathway; G protein mediated signaling pathway via Galphas family; long term depression; INTERACTS WITH (R)-noradrenaline; 2,4,6-trinitrobenzenesulfonic acid; ammonium chloride.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Corticotrophin releasing hormone receptor 1; corticotropin releasing hormone 1; corticotropin-releasing factor receptor 1; corticotropin-releasing hormone receptor 1; CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1; CRFR1; CRH-R 1; CRH-R-1; CRH-R1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21089,040,203 - 89,083,481 (+)NCBI
Rnor_6.0 Ensembl1092,191,718 - 92,232,645 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01092,191,473 - 92,233,662 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01091,953,470 - 91,995,414 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41093,312,405 - 93,354,229 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11093,326,247 - 93,368,673 (+)NCBI
Celera1087,735,518 - 87,777,693 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IBA,IDA,ISO,ISS)
adenylate cyclase-modulating G protein-coupled receptor signaling pathway  (IBA,IDA)
adrenal gland development  (ISO)
behavioral response to cocaine  (IMP)
behavioral response to ethanol  (ISO)
behavioral response to pain  (IMP)
cell surface receptor signaling pathway  (IEA)
cellular response to corticotropin-releasing hormone stimulus  (ISO,ISS)
corticotropin secretion  (ISO,ISS)
epithelial cell differentiation  (IMP)
fear response  (ISO)
feeding behavior  (IMP)
G protein-coupled receptor signaling pathway  (IEA)
general adaptation syndrome, behavioral process  (ISO)
hormone-mediated signaling pathway  (IEA)
hypothalamus development  (IEP)
locomotory exploration behavior  (IMP)
long-term synaptic potentiation  (IMP)
memory  (IMP)
negative regulation of epinephrine secretion  (IMP)
negative regulation of feeding behavior  (IMP)
negative regulation of neuron death  (IMP)
negative regulation of voltage-gated calcium channel activity  (ISO)
neuropeptide signaling pathway  (IDA)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IDA)
positive regulation of cAMP-mediated signaling  (IMP)
positive regulation of cytosolic calcium ion concentration  (IMP)
positive regulation of mast cell degranulation  (IMP)
regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway  (ISO)
regulation of corticosterone secretion  (ISO,ISS)
regulation of synaptic plasticity  (IMP)
response to electrical stimulus  (IMP)
response to hypoxia  (IMP)
response to immobilization stress  (IEP)
visual learning  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
1. Bangasser DA, etal., Mol Psychiatry. 2010 Sep;15(9):877, 896-904. Epub 2010 Jun 15.
2. Blacktop JM, etal., J Neurosci. 2011 Aug 3;31(31):11396-403.
3. Bravo JA, etal., Int J Neuropsychopharmacol. 2011 Jun;14(5):666-83. Epub 2010 Sep 22.
4. Briscoe RJ, etal., Brain Res. 2000 Oct 27;881(2):204-7.
5. Brunson KL, etal., Exp Neurol 2002 Jul;176(1):75-86.
6. Challis BG, etal., Int J Obes Relat Metab Disord. 2004 Mar;28(3):442-6.
7. Chang CP, etal., Neuron 1993 Dec;11(6):1187-95.
8. Coin I, etal., Cell. 2013 Dec 5;155(6):1258-69. doi: 10.1016/j.cell.2013.11.008. Epub 2013 Nov 27.
9. Estienne M, etal., Gut. 2010 Jun;59(6):744-51.
10. Fan JM, etal., Neuroscience. 2009 Apr 10;159(4):1363-73. Epub 2009 Feb 12.
11. Fenoglio KA, etal., Endocrinology. 2005 Sep;146(9):4090-6. Epub 2005 Jun 2.
12. Flanagan DE, etal., Diabetes 2003 Mar;52(3):605-13.
13. Fu Y, etal., J Neurophysiol. 2007 Jan;97(1):937-41. Epub 2006 Nov 1.
14. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. GOA data from the GO Consortium
16. Gourcerol G, etal., Gastroenterology. 2011 May;140(5):1586-96.e6. Epub 2011 Jan 26.
17. Guan X, etal., Neuroscience. 2009 Jul 7;161(3):665-70. Epub 2009 Apr 17.
18. Hansson AC, etal., Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15236-41. Epub 2006 Oct 2.
19. Heinrichs SC, etal., Regul Pept. 1997 Jul 23;71(1):15-21.
20. Hillhouse EW and Grammatopoulos DK, Endocr Rev. 2006 May;27(3):260-86. Epub 2006 Feb 16.
21. Hoare SR, etal., Biochemistry. 2004 Apr 6;43(13):3996-4011.
22. Ji G, etal., Mol Pain. 2007 Jun 5;3:13.
23. Kageyama K, etal., Peptides. 2006 Jul;27(7):1814-9. Epub 2006 Feb 28.
24. Kim BJ, etal., J Neuroimmunol. 2011 Jul 18.
25. Kim TH, etal., Laryngoscope. 2007 Sep;117(9):1513-8.
26. Kim WJ, etal., Respirology. 2009 Mar;14(2):260-3. doi: 10.1111/j.1440-1843.2008.01425.x. Epub 2008 Dec 11.
27. Kinsey-Jones JS, etal., J Neuroendocrinol. 2010 Feb;22(2):102-9. Epub 2009 Dec 4.
28. Lawrence CB, etal., Am J Physiol Regul Integr Comp Physiol 2004 Jan;286(1):R101-7. Epub 2003 Sep 25.
29. Lu L, etal., J Neurochem 2003 Mar;84(6):1378-86.
30. McKenzie IF, etal., Immunol Rev 1977;35:179-230.
31. Meng QY, etal., Mol Cell Endocrinol. 2011 Aug 6;342(1-2):54-63. Epub 2011 Jun 1.
32. MGD data from the GO Consortium
33. Muller MB, etal., Nat Neurosci 2003 Oct;6(10):1100-7. Epub 2003 Sep 14.
34. NCBI rat LocusLink and RefSeq merged data July 26, 2002
35. O'Malley D, etal., Peptides. 2010 Apr;31(4):662-70. Epub 2010 Jan 21.
36. Pedersen WA, etal., J Neurosci 2002 Jan 15;22(2):404-12.
37. Perrin MH, etal., Endocrinology 1993 Dec;133(6):3058-61.
38. Pipeline to import KEGG annotations from KEGG into RGD
39. RGD automated data pipeline
40. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
41. RGD automated import pipeline for gene-chemical interactions
42. Rogers AJ, etal., Pharmacogenomics. 2009 Aug;10(8):1231-42.
43. Samarghandian S, etal., Neuroscience 2003;116(2):519-24.
44. Schulz K, etal., J Biol Chem. 2010 Oct 22;285(43):32878-87. Epub 2010 Aug 3.
45. Sillaber I, etal., Science 2002 May 3;296(5569):931-3.
46. Sun SH, etal., Int Immunol 1999 Apr;11(4):529-34
47. Swinny JD, etal., Eur J Neurosci. 2003 Aug;18(3):549-62.
48. Wang W, etal., J Neurochem 2002 Jan;80(2):287-94.
49. Weiss ST, etal., Proc Am Thorac Soc. 2004;1(4):364-7.
50. Wigger A, etal., Neuropsychopharmacology 2004 Jan;29(1):1-14.
51. Wu Y, etal., Cell Physiol Biochem. 2008;21(1-3):173-82. Epub 2008 Jan 16.
52. Xu JF, etal., Horm Behav. 2006 Feb;49(2):181-9. Epub 2005 Aug 15.
53. Xu Y, etal., Br J Pharmacol. 2009 Aug;157(8):1368-79. Epub 2009 Jun 30.
54. Yi SS, etal., J Chem Neuroanat. 2010 Oct;40(2):130-9. Epub 2010 May 21.
55. Zhou Y, etal., Brain Res. 2003 Feb 28;964(2):187-99.
Additional References at PubMed
PMID:8662941   PMID:9423932   PMID:9655498   PMID:11179443   PMID:11567096   PMID:12631246   PMID:12733706   PMID:12746300   PMID:12855401   PMID:14599712   PMID:14675144   PMID:15049852  
PMID:15174080   PMID:15178552   PMID:15228587   PMID:15252011   PMID:15365580   PMID:15670850   PMID:15901239   PMID:16139950   PMID:16195412   PMID:16253420   PMID:16300406   PMID:16337313  
PMID:16614059   PMID:16741581   PMID:16769145   PMID:16820021   PMID:16867181   PMID:17578887   PMID:17900576   PMID:17921249   PMID:17945210   PMID:18079206   PMID:18292205   PMID:18308857  
PMID:18358620   PMID:18400885   PMID:18534257   PMID:18574791   PMID:18631323   PMID:18922964   PMID:19003957   PMID:19120136   PMID:19407218   PMID:19844206   PMID:19901333   PMID:20130533  
PMID:20159948   PMID:20206673   PMID:20399020   PMID:20424584   PMID:20881118   PMID:21333691   PMID:21449919   PMID:21468623   PMID:21643675   PMID:21720754   PMID:21854167   PMID:21964377  
PMID:22113086   PMID:22249942   PMID:22314225   PMID:23117932   PMID:23133512   PMID:23164543   PMID:23205497   PMID:23376701   PMID:23410057   PMID:23529784   PMID:23538210   PMID:23576434  
PMID:23645119   PMID:23726318   PMID:23732652   PMID:23863939   PMID:23869743   PMID:23893957   PMID:24040053   PMID:24269607   PMID:24330252   PMID:24630468   PMID:24856473   PMID:24867333  
PMID:25146699   PMID:25146701   PMID:25260340   PMID:25260633   PMID:25275258   PMID:25433848   PMID:25480379   PMID:25665407   PMID:25882722   PMID:26302762   PMID:26333123   PMID:26454419  
PMID:26630389   PMID:26696011   PMID:26925271   PMID:27303056   PMID:27538655   PMID:27637621   PMID:27801962   PMID:27844053   PMID:28431969   PMID:28498394   PMID:28612996   PMID:28647536  
PMID:28684600   PMID:28689880   PMID:28833238   PMID:29543532   PMID:29700576   PMID:30355627   PMID:30898126   PMID:31130301  


Genomics

Candidate Gene Status
Crhr1 is a candidate Gene for QTL Eau3
Crhr1 is a candidate Gene for QTL Pia10
Comparative Map Data
Crhr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21089,040,203 - 89,083,481 (+)NCBI
Rnor_6.0 Ensembl1092,191,718 - 92,232,645 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01092,191,473 - 92,233,662 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01091,953,470 - 91,995,414 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41093,312,405 - 93,354,229 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11093,326,247 - 93,368,673 (+)NCBI
Celera1087,735,518 - 87,777,693 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
CRHR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1745,784,280 - 45,835,828 (+)EnsemblGRCh38hg38GRCh38
GRCh381745,784,320 - 45,835,828 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371743,861,686 - 43,913,194 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361741,217,449 - 41,268,973 (+)NCBINCBI36hg18NCBI36
Build 341741,217,448 - 41,268,973NCBI
Celera1740,531,648 - 40,560,471 (+)NCBI
Cytogenetic Map17q21.31NCBI
HuRef1739,361,592 - 39,576,987 (+)NCBIHuRef
CHM1_11744,108,469 - 44,160,028 (+)NCBICHM1_1
Crhr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911104,021,289 - 104,066,349 (+)NCBIGRCm39mm39
GRCm39 Ensembl11104,023,681 - 104,066,349 (+)Ensembl
GRCm3811104,130,463 - 104,175,523 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11104,132,855 - 104,175,523 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711103,994,196 - 104,036,832 (+)NCBIGRCm37mm9NCBIm37
MGSCv3611103,948,972 - 103,991,608 (+)NCBImm8
Celera11115,848,962 - 115,891,878 (+)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1167.77NCBI
Crhr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547810,379,287 - 10,404,825 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547810,380,185 - 10,390,838 (-)NCBIChiLan1.0ChiLan1.0
CRHR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11711,650,057 - 11,701,208 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1711,650,057 - 11,701,208 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01711,261,435 - 11,313,630 (+)NCBIMhudiblu_PPA_v0panPan3
CRHR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.199,708,696 - 9,763,281 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl99,714,204 - 9,763,402 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha910,534,693 - 10,589,270 (+)NCBI
ROS_Cfam_1.0911,300,691 - 11,355,268 (-)NCBI
UMICH_Zoey_3.1910,311,424 - 10,365,925 (-)NCBI
UNSW_CanFamBas_1.0917,155,750 - 17,210,325 (+)NCBI
UU_Cfam_GSD_1.0917,104,721 - 17,159,330 (+)NCBI
Crhr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560216,857,781 - 16,905,751 (-)NCBI
SpeTri2.0NW_0049365412,288,847 - 2,333,129 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CRHR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1217,252,018 - 17,306,319 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11217,251,361 - 17,306,308 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21217,367,191 - 17,420,472 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103243260
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11660,070,156 - 60,120,857 (-)NCBI
ChlSab1.1 Ensembl1660,070,066 - 60,120,712 (-)Ensembl
Crhr1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248492,484,144 - 2,528,130 (-)NCBI

Position Markers
D10Chm230  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01686,249,151 - 86,250,759NCBIRnor6.0
Rnor_6.01092,193,039 - 92,193,312NCBIRnor6.0
Rnor_5.01685,682,353 - 85,683,961UniSTSRnor5.0
Rnor_5.01091,954,791 - 91,955,064UniSTSRnor5.0
RGSC_v3.41685,822,186 - 85,823,794UniSTSRGSC3.4
RGSC_v3.41093,313,726 - 93,313,999UniSTSRGSC3.4
Celera1678,214,016 - 78,215,624UniSTS
Celera1087,737,084 - 87,737,317UniSTS
Cytogenetic Map10q32.1UniSTS
AW531488  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01092,195,190 - 92,195,377NCBIRnor6.0
Rnor_5.01091,956,942 - 91,957,129UniSTSRnor5.0
RGSC_v3.41093,315,877 - 93,316,064UniSTSRGSC3.4
Celera1087,739,195 - 87,739,382UniSTS
RH 3.4 Map10922.0UniSTS
Cytogenetic Map10q32.1UniSTS
Crhr1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01092,227,662 - 92,228,090NCBIRnor6.0
Rnor_5.01091,989,414 - 91,989,842UniSTSRnor5.0
RGSC_v3.41093,348,346 - 93,348,774UniSTSRGSC3.4
Celera1087,771,673 - 87,772,101UniSTS
Cytogenetic Map10q32.1UniSTS
UniSTS:497478  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01092,230,756 - 92,232,008NCBIRnor6.0
Rnor_5.01091,992,508 - 91,993,760UniSTSRnor5.0
Celera1087,774,767 - 87,776,039UniSTS
Cytogenetic Map10q32.1UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10642907599492409Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109841807108540162Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101482789492423564Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014827894107857673Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014827894110992275Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)1020170031102897474Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102290149793886300Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1023861015112626471Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1024483076107857673Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1024483076107857673Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1024483076107857673Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)1027237530101482600Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1027237530102427718Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103618592995845311Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1041260363106105607Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1041260363107857673Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1041260363107857673Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1043289657108540162Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104659302198939209Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)105063833795638337Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105310471898104718Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1053621375112626471Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1053621375112626471Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105362581598939209Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105363748594807701Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)1055224855100224855Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1055678976112626471Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)1055679084102427604Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1056698730101698730Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1060450007105450007Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1060875260105875260Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1060875260105875260Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1060875260105875260Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1062096293107096293Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)1064648175101691360Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1064648175102149713Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1064648175102149713Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1065590122110590122Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1065992275110992275Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1065992275110992275Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1067880046112626471Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1067988218110992091Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1069123603101482600Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1069385595112626471Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1069385595112626471Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1070166960112626471Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1070800069112626471Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1071692298112626471Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1073008136112626471Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1073008136112626471Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1073008136112626471Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1073467158112626471Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107504539197308358Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1075544754112626471Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1075544754112626471Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107598380599492217Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107598380599492217Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107705574198282519Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107897027998282519Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1078970279112626471Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1079927661112626471Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1080239190112626471Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1081515116101758478Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108338982894488181Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1083389828104994768Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1085079943112626471Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108551382295638337Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1086566908112626471Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108696256399303173Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108696256399303173Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)108697786197308569Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1088544136107545372Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1090041957112626471Rat
2313856Bp342Blood pressure QTL 3424.40.0001life span trait (VT:0005372)age at time of death (CMO:0001193)109029689799492409Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1090296897112626471Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)109154814599492409Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1091689348112626471Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:116
Count of miRNA genes:87
Interacting mature miRNAs:97
Transcripts:ENSRNOT00000006764, ENSRNOT00000032941
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system nervous system renal system reproductive system
High
Medium 49 4
Low 2 23 14 13
Below cutoff 2 12 4 2 2 2 2 15 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001301812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_030999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_126013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_126014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006247542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF039203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH006791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU012436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU012437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU012438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L24096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L25438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U53499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U53500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000006764   ⟹   ENSRNOP00000006764
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1092,191,718 - 92,232,645 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000032941   ⟹   ENSRNOP00000035994
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1092,191,718 - 92,232,645 (+)Ensembl
RefSeq Acc Id: NM_001301812   ⟹   NP_001288741
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21089,040,203 - 89,083,481 (+)NCBI
Rnor_6.01092,191,473 - 92,233,662 (+)NCBI
Celera1087,735,518 - 87,777,693 (+)NCBI
Sequence:
RefSeq Acc Id: NM_030999   ⟹   NP_112261
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21089,040,203 - 89,083,481 (+)NCBI
Rnor_6.01092,191,473 - 92,233,662 (+)NCBI
Rnor_5.01091,953,470 - 91,995,414 (+)NCBI
RGSC_v3.41093,312,405 - 93,354,229 (+)RGD
Celera1087,735,518 - 87,777,693 (+)NCBI
Sequence:
RefSeq Acc Id: NR_126013
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21089,040,203 - 89,083,481 (+)NCBI
Rnor_6.01092,191,473 - 92,233,662 (+)NCBI
Celera1087,735,518 - 87,777,693 (+)NCBI
Sequence:
RefSeq Acc Id: NR_126014
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21089,040,203 - 89,083,481 (+)NCBI
Rnor_6.01092,191,473 - 92,233,662 (+)NCBI
Celera1087,735,518 - 87,777,693 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006247542   ⟹   XP_006247604
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01092,216,832 - 92,233,662 (+)NCBI
Rnor_5.01091,953,470 - 91,995,414 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017597490   ⟹   XP_017452979
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01092,192,379 - 92,233,662 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_112261   ⟸   NM_030999
- Peptide Label: isoform 1 precursor
- UniProtKB: P35353 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006247604   ⟸   XM_006247542
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: NP_001288741   ⟸   NM_001301812
- Peptide Label: isoform 2 precursor
- UniProtKB: B3SXS3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452979   ⟸   XM_017597490
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000006764   ⟸   ENSRNOT00000006764
RefSeq Acc Id: ENSRNOP00000035994   ⟸   ENSRNOT00000032941
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61276 AgrOrtholog
Ensembl Genes ENSRNOG00000004900 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000006764 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000035994 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006764 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000032941 UniProtKB/TrEMBL
Gene3D-CATH 4.10.1240.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_CRF1_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_CRF_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_extracell_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_extracellular_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_secretin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_secretin-like_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:58959 UniProtKB/Swiss-Prot
NCBI Gene 58959 ENTREZGENE
Pfam 7tm_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CRHR1 RGD
PhenoGen Crhr1 PhenoGen
PRINTS CRFRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CRFRECEPTOR1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRSECRETIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HormR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF111418 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B3SXS3 ENTREZGENE, UniProtKB/TrEMBL
  B3SXS4_RAT UniProtKB/TrEMBL
  B3SXS5_RAT UniProtKB/TrEMBL
  CRFR1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Crhr1  corticotropin releasing hormone receptor 1    corticotropin releasing hormone 1  Name updated 629478 APPROVED
2002-06-10 Crhr1  corticotropin releasing hormone 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains seven membrane spanning domains 61558
gene_function receptor for corticotrophin releasing hormone, urocortin, and urocortin II 68686
gene_process mediates hippocampal neuron protection from oxidative and exitotoxic stress-induced injury through signaling pathways that involve protein kinase C, cAMP-dependent protein kinase, and mitogen-activated protein kinase 70397
gene_process regulates the neuroendocrine stress response 727638