Crhr1 (corticotropin releasing hormone receptor 1) - Rat Genome Database

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Gene: Crhr1 (corticotropin releasing hormone receptor 1) Rattus norvegicus
Analyze
Symbol: Crhr1
Name: corticotropin releasing hormone receptor 1
RGD ID: 61276
Description: Enables several functions, including G-protein alpha-subunit binding activity; corticotropin-releasing hormone binding activity; and corticotropin-releasing hormone receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; learning or memory; and regulation of secretion by cell. Located in several cellular components, including multivesicular body; neuronal cell body; and trans-Golgi network. Used to study hypertension. Biomarker of several diseases, including depressive disorder; functional colonic disease; irritable bowel syndrome; thromboangiitis obliterans; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and obesity. Orthologous to several human genes including CRHR1 (corticotropin releasing hormone receptor 1); PARTICIPATES IN corticotropin-releasing hormone signaling pathway; G protein mediated signaling pathway via Galphas family; long term depression; INTERACTS WITH (R)-noradrenaline; 2,4,6-trinitrobenzenesulfonic acid; ammonium chloride.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: Corticotrophin releasing hormone receptor 1; corticotropin releasing hormone 1; corticotropin-releasing factor receptor 1; corticotropin-releasing hormone receptor 1; CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1; CRFR1; CRH-R; CRH-R 1; CRH-R-1; CRH-R1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Eau3 Pia10
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81089,540,192 - 89,583,466 (+)NCBIGRCr8
mRatBN7.21089,040,186 - 89,083,481 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1089,040,203 - 89,083,481 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1094,077,228 - 94,120,402 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01093,540,746 - 93,583,916 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01088,936,545 - 88,979,697 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01092,191,473 - 92,233,662 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1092,191,718 - 92,232,645 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01091,953,470 - 91,995,414 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41093,312,405 - 93,354,229 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11093,326,247 - 93,368,673 (+)NCBI
Celera1087,735,518 - 87,777,693 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(R)-noradrenaline  (EXP)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
3',5'-cyclic AMP  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,5,6-trichloro-2-pyridinol  (ISO)
3,5,6-trichloropyridine-2-one  (ISO)
3-phenoxybenzoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acetic acid  (ISO)
alcohol  (ISO)
alpha-Zearalanol  (ISO)
ammonium chloride  (EXP)
antalarmin  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
astressin  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (EXP)
CGP 52608  (ISO)
cocaine  (EXP)
corticosterone  (EXP)
corticotropin-releasing hormone  (EXP)
D-gluconic acid  (EXP)
DDE  (ISO)
decabromodiphenyl ether  (EXP)
dextran sulfate  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
diethyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
disodium selenite  (ISO)
ethanol  (ISO)
fluoxetine  (EXP)
genistein  (EXP)
glyphosate  (EXP)
hydrogen peroxide  (ISO)
kainic acid  (EXP)
lead(0)  (ISO)
linsidomine  (EXP)
lipopolysaccharide  (EXP,ISO)
methamphetamine  (EXP)
methoxychlor  (EXP)
morphine  (EXP,ISO)
N,N-diethyl-m-toluamide  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
naloxone  (EXP,ISO)
nitric oxide  (EXP)
ochratoxin A  (ISO)
paracetamol  (ISO)
pentachlorophenol  (ISO)
pentanal  (ISO)
pentobarbital  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
permethrin  (EXP)
progesterone  (ISO)
propanal  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
tebuconazole  (ISO)
titanium dioxide  (ISO)
triazoles  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IBA,IDA,IEA,ISO,ISS)
adenylate cyclase-modulating G protein-coupled receptor signaling pathway  (IDA)
adrenal gland development  (IEA,ISO)
behavioral response to cocaine  (IMP)
behavioral response to ethanol  (IEA,ISO)
behavioral response to pain  (IMP)
cell surface receptor signaling pathway  (IEA)
cellular response to corticotropin-releasing hormone stimulus  (IEA,ISO,ISS)
corticotropin secretion  (IEA,ISO,ISS)
epithelial cell differentiation  (IMP)
exploration behavior  (IEA,ISO)
fear response  (IEA,ISO)
feeding behavior  (IMP)
G protein-coupled receptor signaling pathway  (IEA)
general adaptation syndrome, behavioral process  (IEA,ISO)
hormone-mediated signaling pathway  (IEA)
hypothalamus development  (IEP)
locomotory exploration behavior  (IMP)
long-term synaptic potentiation  (IMP)
memory  (IMP)
negative regulation of epinephrine secretion  (IMP)
negative regulation of feeding behavior  (IMP)
negative regulation of neuron apoptotic process  (IMP)
negative regulation of voltage-gated calcium channel activity  (ISO)
neuropeptide signaling pathway  (IDA)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IDA)
positive regulation of cAMP/PKA signal transduction  (IMP)
positive regulation of cytosolic calcium ion concentration  (IMP)
positive regulation of mast cell degranulation  (IMP)
regulation of corticosterone secretion  (IEA,ISO,ISS)
regulation of synaptic plasticity  (IMP)
response to electrical stimulus  (IMP)
response to hypoxia  (IMP)
response to immobilization stress  (IEP)
visual learning  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Sex differences in corticotropin-releasing factor receptor signaling and trafficking: potential role in female vulnerability to stress-related psychopathology. Bangasser DA, etal., Mol Psychiatry. 2010 Sep;15(9):877, 896-904. Epub 2010 Jun 15.
2. Augmented Cocaine Seeking in Response to Stress or CRF Delivered into the Ventral Tegmental Area Following Long-Access Self-Administration Is Mediated by CRF Receptor Type 1 But Not CRF Receptor Type 2. Blacktop JM, etal., J Neurosci. 2011 Aug 3;31(31):11396-403.
3. Alterations in the central CRF system of two different rat models of comorbid depression and functional gastrointestinal disorders. Bravo JA, etal., Int J Neuropsychopharmacol. 2011 Jun;14(5):666-83. Epub 2010 Sep 22.
4. Antalarmin blockade of corticotropin releasing hormone-induced hypertension in rats. Briscoe RJ, etal., Brain Res. 2000 Oct 27;881(2):204-7.
5. Corticotropin-releasing hormone (CRH) downregulates the function of its receptor (CRF1) and induces CRF1 expression in hippocampal and cortical regions of the immature rat brain. Brunson KL, etal., Exp Neurol 2002 Jul;176(1):75-86.
6. Genetic variation in the corticotrophin-releasing factor receptors: identification of single-nucleotide polymorphisms and association studies with obesity in UK Caucasians. Challis BG, etal., Int J Obes Relat Metab Disord. 2004 Mar;28(3):442-6.
7. Identification of a seven transmembrane helix receptor for corticotropin-releasing factor and sauvagine in mammalian brain. Chang CP, etal., Neuron 1993 Dec;11(6):1187-95.
8. Genetically encoded chemical probes in cells reveal the binding path of urocortin-I to CRF class B GPCR. Coin I, etal., Cell. 2013 Dec 5;155(6):1258-69. doi: 10.1016/j.cell.2013.11.008. Epub 2013 Nov 27.
9. Maternal deprivation alters epithelial secretory cell lineages in rat duodenum: role of CRF-related peptides. Estienne M, etal., Gut. 2010 Jun;59(6):744-51.
10. Gestational hypoxia alone or combined with restraint sensitizes the hypothalamic-pituitary-adrenal axis and induces anxiety-like behavior in adult male rat offspring. Fan JM, etal., Neuroscience. 2009 Apr 10;159(4):1363-73. Epub 2009 Feb 12.
11. Enduring, handling-evoked enhancement of hippocampal memory function and glucocorticoid receptor expression involves activation of the corticotropin-releasing factor type 1 receptor. Fenoglio KA, etal., Endocrinology. 2005 Sep;146(9):4090-6. Epub 2005 Jun 2.
12. Role of corticotrophin-releasing hormone in the impairment of counterregulatory responses to hypoglycemia. Flanagan DE, etal., Diabetes 2003 Mar;52(3):605-13.
13. Long-term potentiation (LTP) in the central amygdala (CeA) is enhanced after prolonged withdrawal from chronic cocaine and requires CRF1 receptors. Fu Y, etal., J Neurophysiol. 2007 Jan;97(1):937-41. Epub 2006 Nov 1.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
16. Activation of corticotropin-releasing factor receptor 2 mediates the colonic motor coping response to acute stress in rodents. Gourcerol G, etal., Gastroenterology. 2011 May;140(5):1586-96.e6. Epub 2011 Jan 26.
17. Cocaine withdrawal enhances long-term potentiation in rat hippocampus via changing the activity of corticotropin-releasing factor receptor subtype 2. Guan X, etal., Neuroscience. 2009 Jul 7;161(3):665-70. Epub 2009 Apr 17.
18. Variation at the rat Crhr1 locus and sensitivity to relapse into alcohol seeking induced by environmental stress. Hansson AC, etal., Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15236-41. Epub 2006 Oct 2.
19. Corticotropin-releasing factor CRF1, but not CRF2, receptors mediate anxiogenic-like behavior. Heinrichs SC, etal., Regul Pept. 1997 Jul 23;71(1):15-21.
20. The molecular mechanisms underlying the regulation of the biological activity of corticotropin-releasing hormone receptors: implications for physiology and pathophysiology. Hillhouse EW and Grammatopoulos DK, Endocr Rev. 2006 May;27(3):260-86. Epub 2006 Feb 16.
21. Ligand affinity for amino-terminal and juxtamembrane domains of the corticotropin releasing factor type I receptor: regulation by G-protein and nonpeptide antagonists. Hoare SR, etal., Biochemistry. 2004 Apr 6;43(13):3996-4011.
22. Pain-related anxiety-like behavior requires CRF1 receptors in the amygdala. Ji G, etal., Mol Pain. 2007 Jun 5;3:13.
23. Modulation of Ca2+ influx by corticotropin-releasing factor (CRF) family of peptides via CRF receptors in rat pancreatic beta-cells. Kageyama K, etal., Peptides. 2006 Jul;27(7):1814-9. Epub 2006 Feb 28.
24. Corticotropin-releasing hormone receptor-1 and 2 activity produces divergent resistance against stress-induced pulmonary Streptococcus pneumoniae infection. Kim BJ, etal., J Neuroimmunol. 2011 Jul 18.
25. Over-expression of neuropeptide urocortin and its receptors in human allergic nasal mucosa. Kim TH, etal., Laryngoscope. 2007 Sep;117(9):1513-8.
26. Association between CRHR1 polymorphism and improved lung function in response to inhaled corticosteroid in patients with COPD. Kim WJ, etal., Respirology. 2009 Mar;14(2):260-3. doi: 10.1111/j.1440-1843.2008.01425.x. Epub 2008 Dec 11.
27. Corticotrophin-releasing factor alters the timing of puberty in the female rat. Kinsey-Jones JS, etal., J Neuroendocrinol. 2010 Feb;22(2):102-9. Epub 2009 Dec 4.
28. Interactive effects of prenatal alcohol exposure and chronic stress in adulthood on anxiety-like behavior and central stress-related receptor mRNA expression: Sex- and time-dependent effects. Lam VYY, etal., Psychoneuroendocrinology. 2018 Nov;97:8-19. doi: 10.1016/j.psyneuen.2018.06.018. Epub 2018 Jun 23.
29. Anorectic actions of prolactin-releasing peptide are mediated by corticotropin-releasing hormone receptors. Lawrence CB, etal., Am J Physiol Regul Integr Comp Physiol 2004 Jan;286(1):R101-7. Epub 2003 Sep 25.
30. Dopamine-dependent responses to cocaine depend on corticotropin-releasing factor receptor subtypes. Lu L, etal., J Neurochem 2003 Mar;84(6):1378-86.
31. The use of H-2 mutants as models for the study of T cell activation. McKenzie IF, etal., Immunol Rev 1977;35:179-230.
32. Stress and glucocorticoids regulated corticotropin releasing factor in rat prefrontal cortex. Meng QY, etal., Mol Cell Endocrinol. 2011 Aug 6;342(1-2):54-63. Epub 2011 Jun 1.
33. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
34. Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress. Muller MB, etal., Nat Neurosci 2003 Oct;6(10):1100-7. Epub 2003 Sep 14.
35. Alcohol Withdrawal and Proopiomelanocortin Neuropeptides in an Animal Model of Alcohol Dependence. Müschen LH, etal., Neuropsychobiology. 2019;78(3):118-127. doi: 10.1159/000499844. Epub 2019 May 22.
36. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
37. Alterations in colonic corticotropin-releasing factor receptors in the maternally separated rat model of irritable bowel syndrome: differential effects of acute psychological and physical stressors. O'Malley D, etal., Peptides. 2010 Apr;31(4):662-70. Epub 2010 Jan 21.
38. Urocortin, but not urocortin II, protects cultured hippocampal neurons from oxidative and excitotoxic cell death via corticotropin-releasing hormone receptor type I. Pedersen WA, etal., J Neurosci 2002 Jan 15;22(2):404-12.
39. Cloning and functional expression of a rat brain corticotropin releasing factor (CRF) receptor. Perrin MH, etal., Endocrinology 1993 Dec;133(6):3058-61.
40. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
41. Impact of adolescent stress on the expression of stress-related receptors in the hippocampus of animals exposed to alcohol prenatally. Raineki C, etal., Hippocampus. 2018 Mar;28(3):201-216. doi: 10.1002/hipo.22823. Epub 2018 Jan 8.
42. GOA pipeline RGD automated data pipeline
43. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
44. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
45. Predictors of poor response during asthma therapy differ with definition of outcome. Rogers AJ, etal., Pharmacogenomics. 2009 Aug;10(8):1231-42.
46. Corticotropin-releasing factor as well as opioid and dopamine are involved in tail-pinch-induced food intake of rats. Samarghandian S, etal., Neuroscience 2003;116(2):519-24.
47. The pseudo signal peptide of the corticotropin-releasing factor receptor type 2a decreases receptor expression and prevents Gi-mediated inhibition of adenylyl cyclase activity. Schulz K, etal., J Biol Chem. 2010 Oct 22;285(43):32878-87. Epub 2010 Aug 3.
48. Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptors. Sillaber I, etal., Science 2002 May 3;296(5569):931-3.
49. Identification of genomic regions controlling experimental autoimmune uveoretinitis in rats. Sun SH, etal., Int Immunol 1999 Apr;11(4):529-34
50. Corticotropin-releasing factor receptor types 1 and 2 are differentially expressed in pre- and post-synaptic elements in the post-natal developing rat cerebellum. Swinny JD, etal., Eur J Neurosci. 2003 Aug;18(3):549-62.
51. Functional expression of corticotropin-releasing hormone (CRH) receptor 1 in cultured rat microglia. Wang W, etal., J Neurochem 2002 Jan;80(2):287-94.
52. Asthma steroid pharmacogenetics: a study strategy to identify replicated treatment responses. Weiss ST, etal., Proc Am Thorac Soc. 2004;1(4):364-7.
53. Alterations in central neuropeptide expression, release, and receptor binding in rats bred for high anxiety: critical role of vasopressin. Wigger A, etal., Neuropsychopharmacology 2004 Jan;29(1):1-14.
54. Enhanced intracellular calcium induced by urocortin is involved in degranulation of rat lung mast cells. Wu Y, etal., Cell Physiol Biochem. 2008;21(1-3):173-82. Epub 2008 Jan 16.
55. CRH receptor type 1 mediates continual hypoxia-induced changes of immunoreactive prolactin and prolactin mRNA expression in rat pituitary. Xu JF, etal., Horm Behav. 2006 Feb;49(2):181-9. Epub 2005 Aug 15.
56. Urocortin promotes the development of vasculitis in a rat model of thromboangiitis obliterans via corticotrophin-releasing factor type 1 receptors. Xu Y, etal., Br J Pharmacol. 2009 Aug;157(8):1368-79. Epub 2009 Jun 30.
57. Regulatory mechanism of hypothalamo-pituitary-adrenal (HPA) axis and neuronal changes after adrenalectomy in type 2 diabetes. Yi SS, etal., J Chem Neuroanat. 2010 Oct;40(2):130-9. Epub 2010 May 21.
58. Reduced hypothalamic POMC and anterior pituitary CRF1 receptor mRNA levels after acute, but not chronic, daily "binge" intragastric alcohol administration. Zhou Y, etal., Alcohol Clin Exp Res. 2000 Oct;24(10):1575-82.
59. Alterations in hypothalamic-pituitary-adrenal axis activity and in levels of proopiomelanocortin and corticotropin-releasing hormone-receptor 1 mRNAs in the pituitary and hypothalamus of the rat during chronic 'binge' cocaine and withdrawal. Zhou Y, etal., Brain Res. 2003 Feb 28;964(2):187-99.
Additional References at PubMed
PMID:8662941   PMID:9423932   PMID:9655498   PMID:11179443   PMID:11567096   PMID:12631246   PMID:12733706   PMID:12746300   PMID:12855401   PMID:14599712   PMID:14675144   PMID:15049852  
PMID:15174080   PMID:15178552   PMID:15228587   PMID:15252011   PMID:15365580   PMID:15670850   PMID:15901239   PMID:16139950   PMID:16195412   PMID:16253420   PMID:16300406   PMID:16337313  
PMID:16614059   PMID:16741581   PMID:16769145   PMID:16820021   PMID:16867181   PMID:17578887   PMID:17900576   PMID:17921249   PMID:17945210   PMID:18079206   PMID:18292205   PMID:18308857  
PMID:18358620   PMID:18400885   PMID:18534257   PMID:18574791   PMID:18631323   PMID:18922964   PMID:19003957   PMID:19120136   PMID:19407218   PMID:19844206   PMID:19901333   PMID:20130533  
PMID:20159948   PMID:20206673   PMID:20399020   PMID:20424584   PMID:20881118   PMID:21333691   PMID:21449919   PMID:21468623   PMID:21643675   PMID:21720754   PMID:21854167   PMID:21964377  
PMID:22113086   PMID:22249942   PMID:22314225   PMID:23117932   PMID:23133512   PMID:23164543   PMID:23205497   PMID:23376701   PMID:23410057   PMID:23529784   PMID:23538210   PMID:23576434  
PMID:23645119   PMID:23726318   PMID:23732652   PMID:23863939   PMID:23869743   PMID:23893957   PMID:24040053   PMID:24269607   PMID:24330252   PMID:24630468   PMID:24856473   PMID:24867333  
PMID:25146699   PMID:25146701   PMID:25260340   PMID:25260633   PMID:25275258   PMID:25433848   PMID:25480379   PMID:25665407   PMID:25882722   PMID:26302762   PMID:26333123   PMID:26454419  
PMID:26630389   PMID:26696011   PMID:26925271   PMID:27303056   PMID:27538655   PMID:27637621   PMID:27801962   PMID:27844053   PMID:28431969   PMID:28498394   PMID:28612996   PMID:28647536  
PMID:28684600   PMID:28689880   PMID:28833238   PMID:29543532   PMID:29700576   PMID:30355627   PMID:30898126   PMID:31130301   PMID:32950560   PMID:33810797   PMID:33839941   PMID:34097788  
PMID:34215021   PMID:34331656   PMID:35478009   PMID:36147561  


Genomics

Comparative Map Data
Crhr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81089,540,192 - 89,583,466 (+)NCBIGRCr8
mRatBN7.21089,040,186 - 89,083,481 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1089,040,203 - 89,083,481 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1094,077,228 - 94,120,402 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01093,540,746 - 93,583,916 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01088,936,545 - 88,979,697 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01092,191,473 - 92,233,662 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1092,191,718 - 92,232,645 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01091,953,470 - 91,995,414 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41093,312,405 - 93,354,229 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11093,326,247 - 93,368,673 (+)NCBI
Celera1087,735,518 - 87,777,693 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
CRHR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381745,784,320 - 45,835,828 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1745,784,277 - 45,835,828 (+)EnsemblGRCh38hg38GRCh38
GRCh371743,861,686 - 43,913,194 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361741,217,449 - 41,268,973 (+)NCBINCBI36Build 36hg18NCBI36
Build 341741,217,448 - 41,268,973NCBI
Celera1740,531,648 - 40,560,471 (+)NCBICelera
Cytogenetic Map17q21.31NCBI
HuRef1739,361,592 - 39,576,987 (+)NCBIHuRef
CHM1_11743,944,546 - 44,160,028 (+)NCBICHM1_1
T2T-CHM13v2.01746,645,948 - 46,697,461 (+)NCBIT2T-CHM13v2.0
Crhr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911104,021,289 - 104,066,349 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11104,023,681 - 104,066,349 (+)EnsemblGRCm39 Ensembl
GRCm3811104,130,463 - 104,175,523 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11104,132,855 - 104,175,523 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711103,994,196 - 104,036,832 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611103,948,972 - 103,991,608 (+)NCBIMGSCv36mm8
Celera11115,848,962 - 115,891,878 (+)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1167.77NCBI
Crhr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547810,379,287 - 10,404,825 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547810,380,185 - 10,390,838 (-)NCBIChiLan1.0ChiLan1.0
CRHR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21918,776,127 - 18,830,425 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11720,740,074 - 20,796,106 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01711,261,435 - 11,313,630 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11711,650,057 - 11,701,208 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1711,650,057 - 11,701,208 (-)Ensemblpanpan1.1panPan2
CRHR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.199,708,696 - 9,763,281 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl99,714,204 - 9,763,402 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha910,534,693 - 10,589,270 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0911,300,691 - 11,355,268 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl911,305,292 - 11,355,905 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1910,311,424 - 10,365,925 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0917,155,750 - 17,210,325 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0917,104,721 - 17,159,330 (+)NCBIUU_Cfam_GSD_1.0
Crhr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560216,857,781 - 16,905,751 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365412,288,841 - 2,331,689 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365412,288,847 - 2,333,129 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CRHR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1217,252,020 - 17,306,285 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11217,251,361 - 17,306,308 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21217,367,191 - 17,420,472 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103243260
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11660,070,156 - 60,120,857 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1660,070,066 - 60,120,712 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607730,792,373 - 30,842,988 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Crhr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248492,484,109 - 2,528,223 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248492,484,144 - 2,528,130 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Crhr1
494 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:116
Count of miRNA genes:87
Interacting mature miRNAs:97
Transcripts:ENSRNOT00000006764, ENSRNOT00000032941
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
2313856Bp342Blood pressure QTL 3424.40.0001life span trait (VT:0005372)age at time of death (CMO:0001193)108730761796121100Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1064890616107211142Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)108402232193995963Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1088539139107211142Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108400727295933025Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108400727295933025Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat

Markers in Region
D10Chm230  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21680,431,285 - 80,432,894 (+)MAPPERmRatBN7.2
mRatBN7.21089,041,768 - 89,042,046 (+)MAPPERmRatBN7.2
Rnor_6.01092,193,039 - 92,193,312NCBIRnor6.0
Rnor_6.01686,249,151 - 86,250,759NCBIRnor6.0
Rnor_5.01685,682,353 - 85,683,961UniSTSRnor5.0
Rnor_5.01091,954,791 - 91,955,064UniSTSRnor5.0
RGSC_v3.41093,313,726 - 93,313,999UniSTSRGSC3.4
RGSC_v3.41685,822,186 - 85,823,794UniSTSRGSC3.4
Celera1678,214,016 - 78,215,624UniSTS
Celera1087,737,084 - 87,737,317UniSTS
Cytogenetic Map10q32.1UniSTS
AW531488  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21089,043,923 - 89,044,111 (+)MAPPERmRatBN7.2
Rnor_6.01092,195,190 - 92,195,377NCBIRnor6.0
Rnor_5.01091,956,942 - 91,957,129UniSTSRnor5.0
RGSC_v3.41093,315,877 - 93,316,064UniSTSRGSC3.4
Celera1087,739,195 - 87,739,382UniSTS
RH 3.4 Map10922.0UniSTS
Cytogenetic Map10q32.1UniSTS
Crhr1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21089,076,401 - 89,076,830 (+)MAPPERmRatBN7.2
Rnor_6.01092,227,662 - 92,228,090NCBIRnor6.0
Rnor_5.01091,989,414 - 91,989,842UniSTSRnor5.0
RGSC_v3.41093,348,346 - 93,348,774UniSTSRGSC3.4
Celera1087,771,673 - 87,772,101UniSTS
Cytogenetic Map10q32.1UniSTS
UniSTS:497478  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01092,230,756 - 92,232,008NCBIRnor6.0
Rnor_5.01091,992,508 - 91,993,760UniSTSRnor5.0
Celera1087,774,767 - 87,776,039UniSTS
Cytogenetic Map10q32.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
8 16 100 10 6 4 4 4 6 70 21 93 37 53 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001301812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_030999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_126013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_126014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006247542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010055231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF039203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH006791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU012436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU012437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU012438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L24096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L25438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U53499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U53500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000006764   ⟹   ENSRNOP00000006764
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1089,040,203 - 89,083,481 (+)Ensembl
Rnor_6.0 Ensembl1092,191,718 - 92,232,645 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000032941   ⟹   ENSRNOP00000035994
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1089,040,203 - 89,083,481 (+)Ensembl
Rnor_6.0 Ensembl1092,191,718 - 92,232,645 (+)Ensembl
RefSeq Acc Id: NM_001301812   ⟹   NP_001288741
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81089,540,192 - 89,583,466 (+)NCBI
mRatBN7.21089,040,186 - 89,083,481 (+)NCBI
Rnor_6.01092,191,473 - 92,233,662 (+)NCBI
Celera1087,735,518 - 87,777,693 (+)NCBI
Sequence:
RefSeq Acc Id: NM_030999   ⟹   NP_112261
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81089,540,192 - 89,583,466 (+)NCBI
mRatBN7.21089,040,186 - 89,083,481 (+)NCBI
Rnor_6.01092,191,473 - 92,233,662 (+)NCBI
Rnor_5.01091,953,470 - 91,995,414 (+)NCBI
RGSC_v3.41093,312,405 - 93,354,229 (+)RGD
Celera1087,735,518 - 87,777,693 (+)NCBI
Sequence:
RefSeq Acc Id: NR_126013
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81089,540,209 - 89,583,466 (+)NCBI
mRatBN7.21089,040,203 - 89,083,481 (+)NCBI
Rnor_6.01092,191,473 - 92,233,662 (+)NCBI
Celera1087,735,518 - 87,777,693 (+)NCBI
Sequence:
RefSeq Acc Id: NR_126014
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81089,540,209 - 89,583,466 (+)NCBI
mRatBN7.21089,040,203 - 89,083,481 (+)NCBI
Rnor_6.01092,191,473 - 92,233,662 (+)NCBI
Celera1087,735,518 - 87,777,693 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063269740   ⟹   XP_063125810
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81089,540,587 - 89,583,466 (+)NCBI
RefSeq Acc Id: XM_063269741   ⟹   XP_063125811
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81089,565,064 - 89,583,466 (+)NCBI
RefSeq Acc Id: XR_010055231
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81089,540,580 - 89,581,550 (+)NCBI
RefSeq Acc Id: NP_112261   ⟸   NM_030999
- Peptide Label: isoform 1 precursor
- UniProtKB: P35353 (UniProtKB/Swiss-Prot),   A6HJT9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001288741   ⟸   NM_001301812
- Peptide Label: isoform 2 precursor
- UniProtKB: B3SXS3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006764   ⟸   ENSRNOT00000006764
Ensembl Acc Id: ENSRNOP00000035994   ⟸   ENSRNOT00000032941
RefSeq Acc Id: XP_063125810   ⟸   XM_063269740
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063125811   ⟸   XM_063269741
- Peptide Label: isoform X2
Protein Domains
G-protein coupled receptors family 2 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35353-F1-model_v2 AlphaFold P35353 1-415 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61276 AgrOrtholog
BioCyc Gene G2FUF-23023 BioCyc
Ensembl Genes ENSRNOG00000004900 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00055028694 UniProtKB/Swiss-Prot
  ENSRNOG00060014769 UniProtKB/Swiss-Prot
  ENSRNOG00065031411 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000006764.8 UniProtKB/TrEMBL
  ENSRNOT00000032941.3 UniProtKB/TrEMBL
  ENSRNOT00055049662 UniProtKB/Swiss-Prot
  ENSRNOT00060025266 UniProtKB/Swiss-Prot
  ENSRNOT00065054188 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.1240.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_CRF1_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_CRF_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_extracell_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_extracellular_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_secretin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_secretin-like_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:58959 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 58959 ENTREZGENE
PANTHER CORTICOTROPIN-RELEASING FACTOR RECEPTOR 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDF RECEPTOR-LIKE PROTEIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CRHR1 RGD
PhenoGen Crhr1 PhenoGen
PRINTS CRFRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CRFRECEPTOR1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRSECRETIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004900 RatGTEx
  ENSRNOG00055028694 RatGTEx
  ENSRNOG00060014769 RatGTEx
  ENSRNOG00065031411 RatGTEx
SMART HormR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF111418 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2Q2C2_RAT UniProtKB/TrEMBL
  A6HJT9 ENTREZGENE, UniProtKB/TrEMBL
  B3SXS3 ENTREZGENE, UniProtKB/TrEMBL
  B3SXS4_RAT UniProtKB/TrEMBL
  B3SXS5_RAT UniProtKB/TrEMBL
  CRFR1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Crhr1  corticotropin releasing hormone receptor 1    corticotropin releasing hormone 1  Name updated 629478 APPROVED
2002-06-10 Crhr1  corticotropin releasing hormone 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains seven membrane spanning domains 61558
gene_function receptor for corticotrophin releasing hormone, urocortin, and urocortin II 68686
gene_process mediates hippocampal neuron protection from oxidative and exitotoxic stress-induced injury through signaling pathways that involve protein kinase C, cAMP-dependent protein kinase, and mitogen-activated protein kinase 70397
gene_process regulates the neuroendocrine stress response 727638