Map3k3 (mitogen activated protein kinase kinase kinase 3) - Rat Genome Database

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Gene: Map3k3 (mitogen activated protein kinase kinase kinase 3) Rattus norvegicus
Analyze
Symbol: Map3k3
Name: mitogen activated protein kinase kinase kinase 3
RGD ID: 1304575
Description: Predicted to enable protein kinase activity. Predicted to be involved in positive regulation of canonical NF-kappaB signal transduction. Predicted to act upstream of or within several processes, including blood vessel development; positive regulation of p38MAPK cascade; and protein autophosphorylation. Orthologous to human MAP3K3 (mitogen-activated protein kinase kinase kinase 3); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; Erk5 MAPK signaling pathway; interleukin-1 signaling pathway; INTERACTS WITH 2,6-dinitrotoluene; amphetamine; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC303604; mitogen-activated protein kinase kinase kinase 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81091,519,976 - 91,588,651 (+)NCBIGRCr8
mRatBN7.21091,020,174 - 91,088,852 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1091,020,174 - 91,088,848 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1096,075,116 - 96,143,482 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01095,538,287 - 95,606,652 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01090,949,010 - 91,017,411 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01094,280,703 - 94,349,372 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1094,280,703 - 94,349,368 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01094,029,306 - 94,098,042 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41095,482,303 - 95,551,065 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11095,496,690 - 95,565,451 (+)NCBI
Celera1089,696,294 - 89,764,939 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Map3k3RatCerebral Cavernous Malformation 5  ISOMAP3K3 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25741868 more ...
Map3k3Ratverrucous keratotic hemangioma  ISOMAP3K3 (Homo sapiens)8554872ClinVar Annotator: match by term: Verrucous venous malformationClinVarPMID:25741868 more ...
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Map3k3RatEsophageal Neoplasms  ISOMAP3K3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17068819
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Map3k3RatCerebral Cavernous Malformation 5  ISOMAP3K3 (Homo sapiens)7240710 OMIM 

1 to 20 of 67 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Map3k3Rat1,2-dimethylhydrazine affects expressionISOMap3k3 (Mus musculus)64804641 and 2-Dimethylhydrazine affects the expression of MAP3K3 mRNACTDPMID:22206623
Map3k3Rat17beta-estradiol increases expressionISOMAP3K3 (Homo sapiens)6480464Estradiol results in increased expression of MAP3K3 mRNACTDPMID:23094148
Map3k3Rat2,3',4,4',5-Pentachlorobiphenyl decreases expressionISOMap3k3 (Mus musculus)64804642 more ...CTDPMID:31388691
Map3k3Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOMap3k3 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of MAP3K3 mRNACTDPMID:21570461
Map3k3Rat2,6-dinitrotoluene affects expressionEXP 64804642 and 6-dinitrotoluene affects the expression of MAP3K3 mRNACTDPMID:21346803
Map3k3Rat2-hydroxypropanoic acid increases expressionISOMAP3K3 (Homo sapiens)6480464Lactic Acid results in increased expression of MAP3K3 mRNACTDPMID:30851411
Map3k3Rat2-palmitoylglycerol increases expressionISOMAP3K3 (Homo sapiens)64804642-palmitoylglycerol results in increased expression of MAP3K3 mRNACTDPMID:37199045
Map3k3Rat3,4-methylenedioxymethamphetamine increases expressionISOMap3k3 (Mus musculus)6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of MAP3K3 mRNACTDPMID:20188158
Map3k3Rat4-vinylcyclohexene dioxide affects expressionISOMap3k3 (Mus musculus)64804644-vinyl-1-cyclohexene dioxide affects the expression of MAP3K3 mRNACTDPMID:20829426
Map3k3Rat5-aza-2'-deoxycytidine multiple interactionsISOMAP3K3 (Homo sapiens)6480464[Decitabine co-treated with Depsipeptides] results in increased expression of MAP3K3 mRNACTDPMID:17064661
Map3k3Ratall-trans-retinoic acid increases expressionISOMAP3K3 (Homo sapiens)6480464Tretinoin results in increased expression of MAP3K3 mRNACTDPMID:33167477
Map3k3Ratamphetamine increases expressionEXP 6480464Amphetamine results in increased expression of MAP3K3 mRNACTDPMID:30779732
Map3k3Ratarsenite(3-) multiple interactionsISOMAP3K3 (Homo sapiens)6480464arsenite inhibits the reaction [G3BP1 protein binds to MAP3K3 mRNA]CTDPMID:32406909
Map3k3Ratbis(2-ethylhexyl) phthalate multiple interactionsISOMAP3K3 (Homo sapiens)6480464[Diethylhexyl Phthalate results in increased abundance of mono-(2-ethylhexyl)phthalate] which results in increased methylation of MAP3K3 geneCTDPMID:33872906
Map3k3Ratbisphenol A affects expressionEXP 6480464bisphenol A affects the expression of MAP3K3 mRNACTDPMID:25181051
Map3k3Ratbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of MAP3K3 mRNACTDPMID:30816183
Map3k3Ratbisphenol A increases methylationEXP 6480464bisphenol A results in increased methylation of MAP3K3 geneCTDPMID:28505145
Map3k3Ratbufalin decreases expressionISOMAP3K3 (Homo sapiens)6480464bufalin results in decreased expression of MAP3K3 proteinCTDPMID:23949904
Map3k3RatC60 fullerene increases expressionEXP 6480464fullerene C60 results in increased expression of MAP3K3 mRNACTDPMID:19167457
Map3k3Ratcadmium dichloride increases expressionEXP 6480464Cadmium Chloride results in increased expression of MAP3K3 mRNACTDPMID:33453195

1 to 20 of 67 rows

Biological Process
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1 to 10 of 10 rows

Molecular Function
1 to 11 of 11 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Map3k3RatATP binding enablesIEAInterPro:IPR0007191600115GO_REF:0000002InterProGO_REF:0000002
Map3k3RatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
Map3k3Ratkinase activity enablesIEAUniProtKB-KW:KW-04181600115GO_REF:0000043UniProtGO_REF:0000043
Map3k3Ratnucleotide binding enablesIEAUniProtKB-KW:KW-05471600115GO_REF:0000043UniProtGO_REF:0000043
Map3k3Ratprotein binding enablesISOMAP3K3 (Homo sapiens)1624291UniProtKB:P27348 more ...RGDPMID:12392720 more ...
Map3k3Ratprotein binding enablesISOMap3k3 (Mus musculus)1624291UniProtKB:P70196 more ...RGDPMID:12912994 more ...
Map3k3Ratprotein kinase activity enablesIEAUniProtKB:Q99759 and ensembl:ENSP000003544851600115GO_REF:0000107EnsemblGO_REF:0000107
Map3k3Ratprotein kinase activity enablesISOMAP3K3 (Homo sapiens)1624291 PMID:15001576 more ...RGDPMID:15001576 more ...
Map3k3Ratprotein kinase activity enablesIEAInterPro:IPR0007191600115GO_REF:0000002InterProGO_REF:0000002
Map3k3Ratprotein serine/threonine kinase activity enablesIEAUniProtKB-KW:KW-07231600115GO_REF:0000043UniProtGO_REF:0000043
Map3k3Rattransferase activity enablesIEAUniProtKB-KW:KW-08081600115GO_REF:0000043UniProtGO_REF:0000043
1 to 11 of 11 rows

RGD Manual Annotations


  

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Map3k3Ratgonadotropin-releasing hormone signaling pathway  IEA 6907045 KEGGrno:04912
Map3k3Ratmitogen activated protein kinase signaling pathway   IEA 6907045 KEGGrno:04010
Map3k3Ratneurotrophic factor signaling pathway  IEA 6907045 KEGGrno:04722

Imported Annotations - PID (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Map3k3Ratinterleukin-1 signaling pathway   ISOMAP3K3 (Homo sapiens)6484113 PIDPID:200089
Map3k3Ratp38 MAPK signaling pathway   ISOMAP3K3 (Homo sapiens)6484113 PIDPID:200018
Map3k3Rattumor necrosis factor mediated signaling pathway   ISOMAP3K3 (Homo sapiens)6484113 PIDPID:200102

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#
Reference Title
Reference Citation
1. Mechanisms and functions of p38 MAPK signalling. Cuadrado A and Nebreda AR, Biochem J. 2010 Aug 1;429(3):403-17. doi: 10.1042/BJ20100323.
2. p38 MAP-kinases pathway regulation, function and role in human diseases. Cuenda A and Rousseau S, Biochim Biophys Acta. 2007 Aug;1773(8):1358-75. Epub 2007 Mar 24.
3. MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42. Fanger GR, etal., EMBO J. 1997 Aug 15;16(16):4961-72.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. The c-jun kinase/stress-activated pathway: regulation, function and role in human disease. Johnson GL and Nakamura K, Biochim Biophys Acta. 2007 Aug;1773(8):1341-8. Epub 2007 Jan 4.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. Regulation of cellular functions by the ERK5 signalling pathway. Wang X and Tournier C, Cell Signal. 2006 Jun;18(6):753-60. Epub 2006 Jan 6.
1 to 13 of 13 rows
PMID:10700190   PMID:12477932   PMID:12650640   PMID:12761501   PMID:15001576  



Map3k3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81091,519,976 - 91,588,651 (+)NCBIGRCr8
mRatBN7.21091,020,174 - 91,088,852 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1091,020,174 - 91,088,848 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1096,075,116 - 96,143,482 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01095,538,287 - 95,606,652 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01090,949,010 - 91,017,411 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01094,280,703 - 94,349,372 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1094,280,703 - 94,349,368 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01094,029,306 - 94,098,042 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41095,482,303 - 95,551,065 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11095,496,690 - 95,565,451 (+)NCBI
Celera1089,696,294 - 89,764,939 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
MAP3K3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381763,622,417 - 63,696,305 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1763,622,415 - 63,696,305 (+)EnsemblGRCh38hg38GRCh38
GRCh371761,699,777 - 61,773,665 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361759,053,533 - 59,127,402 (+)NCBINCBI36Build 36hg18NCBI36
Build 341759,053,532 - 59,127,401NCBI
Celera1756,087,919 - 56,161,790 (+)NCBICelera
Cytogenetic Map17q23.3NCBI
HuRef1757,077,975 - 57,141,816 (+)NCBIHuRef
CHM1_11761,764,216 - 61,838,082 (+)NCBICHM1_1
T2T-CHM13v2.01764,493,028 - 64,567,209 (+)NCBIT2T-CHM13v2.0
Map3k3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911105,975,358 - 106,047,482 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11105,975,439 - 106,046,272 (+)EnsemblGRCm39 Ensembl
GRCm3811106,084,587 - 106,156,656 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11106,084,613 - 106,155,446 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711105,946,216 - 106,016,760 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611105,900,992 - 105,971,536 (+)NCBIMGSCv36mm8
Celera11117,815,382 - 117,885,664 (+)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1168.89NCBI
Map3k3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554788,125,436 - 8,199,253 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554788,122,999 - 8,185,138 (-)NCBIChiLan1.0ChiLan1.0
MAP3K3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21979,794,119 - 79,868,489 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11784,611,585 - 84,685,943 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01757,702,242 - 57,776,601 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11762,858,655 - 62,922,874 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1762,858,635 - 62,922,874 (+)Ensemblpanpan1.1panPan2
MAP3K3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1911,612,527 - 11,678,407 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl911,612,994 - 11,675,838 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha912,572,499 - 12,638,395 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0913,276,493 - 13,339,186 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl913,276,310 - 13,338,713 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1912,220,815 - 12,286,279 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0915,245,905 - 15,311,520 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0915,248,794 - 15,314,683 (-)NCBIUU_Cfam_GSD_1.0
Map3k3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560214,849,361 - 14,918,227 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365414,276,371 - 4,344,008 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365414,276,371 - 4,345,239 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP3K3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1215,230,182 - 15,298,784 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11215,228,979 - 15,298,784 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21215,215,673 - 15,285,409 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAP3K3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11657,594,770 - 57,670,047 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1657,597,288 - 57,669,720 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607728,205,915 - 28,279,700 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map3k3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248491,118,492 - 1,185,777 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248491,118,275 - 1,186,244 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Map3k3
240 total Variants


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
10 94092006 94092007 T C snv ZFDM (KyushuU) View more Information

Predicted Target Of
Summary Value
Count of predictions:369
Count of miRNA genes:190
Interacting mature miRNAs:257
Transcripts:ENSRNOT00000011406
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 80 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat

1 to 10 of 80 rows
RH129350  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21091,088,537 - 91,088,753 (+)MAPPERmRatBN7.2
Rnor_6.01094,349,058 - 94,349,273NCBIRnor6.0
Rnor_5.01094,097,728 - 94,097,943UniSTSRnor5.0
RGSC_v3.41095,550,767 - 95,550,982UniSTSRGSC3.4
Celera1089,764,625 - 89,764,840UniSTS
RH 3.4 Map10979.2UniSTS
Cytogenetic Map10q32.1UniSTS
RH133214  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21091,082,543 - 91,082,731 (+)MAPPERmRatBN7.2
Rnor_6.01094,343,064 - 94,343,251NCBIRnor6.0
Rnor_5.01094,091,734 - 94,091,921UniSTSRnor5.0
RGSC_v3.41095,544,773 - 95,544,960UniSTSRGSC3.4
Celera1089,758,631 - 89,758,818UniSTS
RH 3.4 Map10979.5UniSTS
Cytogenetic Map10q32.1UniSTS
AW548911  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21091,086,805 - 91,086,912 (+)MAPPERmRatBN7.2
Rnor_6.01094,347,326 - 94,347,432NCBIRnor6.0
Rnor_5.01094,095,996 - 94,096,102UniSTSRnor5.0
RGSC_v3.41095,549,035 - 95,549,141UniSTSRGSC3.4
Celera1089,762,893 - 89,762,999UniSTS
Cytogenetic Map10q32.1UniSTS
RH124538  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21091,086,008 - 91,086,440 (+)MAPPERmRatBN7.2
Rnor_6.01094,346,529 - 94,346,960NCBIRnor6.0
Rnor_5.01094,095,199 - 94,095,630UniSTSRnor5.0
RGSC_v3.41095,548,238 - 95,548,669UniSTSRGSC3.4
Celera1089,762,096 - 89,762,527UniSTS
Cytogenetic Map10q32.1UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000088656   ⟹   ENSRNOP00000074780
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1091,020,174 - 91,088,848 (+)Ensembl
Rnor_6.0 Ensembl1094,280,703 - 94,349,368 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095570   ⟹   ENSRNOP00000085202
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1091,032,107 - 91,088,848 (+)Ensembl
RefSeq Acc Id: NM_001107058   ⟹   NP_001100528
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81091,519,976 - 91,588,651 (+)NCBI
mRatBN7.21091,020,174 - 91,088,852 (+)NCBI
Rnor_6.01094,280,703 - 94,349,372 (+)NCBI
Rnor_5.01094,029,306 - 94,098,042 (+)NCBI
RGSC_v3.41095,482,303 - 95,551,065 (+)RGD
Celera1089,696,294 - 89,764,939 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063269201   ⟹   XP_063125271
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81091,520,334 - 91,588,651 (+)NCBI
Protein RefSeqs NP_001100528 (Get FASTA)   NCBI Sequence Viewer  
  XP_063125271 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI68979 (Get FASTA)   NCBI Sequence Viewer  
  EDM06356 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000074780
  ENSRNOP00000074780.1
  ENSRNOP00000085202
  ENSRNOP00000085202.1
RefSeq Acc Id: NP_001100528   ⟸   NM_001107058
- UniProtKB: B5DF98 (UniProtKB/TrEMBL),   A6HK01 (UniProtKB/TrEMBL),   A0A8I6A3I3 (UniProtKB/TrEMBL),   A0A0G2K8Y1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074780   ⟸   ENSRNOT00000088656
Ensembl Acc Id: ENSRNOP00000085202   ⟸   ENSRNOT00000095570
RefSeq Acc Id: XP_063125271   ⟸   XM_063269201
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A3I3 (UniProtKB/TrEMBL)
PB1   Protein kinase

Name Modeler Protein Id AA Range Protein Structure
AF-B5DF98-F1-model_v2 AlphaFold B5DF98 1-626 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13697833
Promoter ID:EPDNEW_R8358
Type:multiple initiation site
Name:Map3k3_1
Description:mitogen activated protein kinase kinase kinase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01094,280,662 - 94,280,722EPDNEW


1 to 32 of 32 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-22964 BioCyc
Ensembl Genes ENSRNOG00000061424 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000088656 ENTREZGENE
  ENSRNOT00000088656.2 UniProtKB/TrEMBL
  ENSRNOT00000095570 ENTREZGENE
  ENSRNOT00000095570.1 UniProtKB/TrEMBL
Gene3D-CATH Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom UniProtKB/TrEMBL
  OPR_PB1 UniProtKB/TrEMBL
  PB1-like UniProtKB/TrEMBL
  PB1_MEKK2/3 UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
KEGG Report rno:303604 UniProtKB/TrEMBL
NCBI Gene 303604 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3 UniProtKB/TrEMBL
  SERINE/THREONINE PROTEIN KINASE UniProtKB/TrEMBL
Pfam PB1 UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PhenoGen Map3k3 PhenoGen
PROSITE PB1 UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
RatGTEx ENSRNOG00000061424 RatGTEx
SMART PB1 UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP CAD & PB1 domains UniProtKB/TrEMBL
  Kinase_like UniProtKB/TrEMBL
UniProt A0A0G2K8Y1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A3I3 ENTREZGENE, UniProtKB/TrEMBL
  A6HK01 ENTREZGENE, UniProtKB/TrEMBL
  B5DF98 ENTREZGENE
UniProt Secondary B5DF98 UniProtKB/TrEMBL
1 to 32 of 32 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Map3k3  mitogen activated protein kinase kinase kinase 3   Map3k3_predicted  mitogen activated protein kinase kinase kinase 3 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Map3k3_predicted  mitogen activated protein kinase kinase kinase 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED