Kpna2 (karyopherin subunit alpha 2) - Rat Genome Database

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Gene: Kpna2 (karyopherin subunit alpha 2) Rattus norvegicus
Analyze
Symbol: Kpna2
Name: karyopherin subunit alpha 2
RGD ID: 621419
Description: Predicted to enable several functions, including histone deacetylase binding activity; nuclear import signal receptor activity; and nuclear localization sequence binding activity. Involved in regulation of transcription by glucose. Predicted to be located in several cellular components, including cytoplasmic stress granule; cytosol; and nucleoplasm. Predicted to be part of NLS-dependent protein nuclear import complex. Predicted to be active in glutamatergic synapse; nucleus; and postsynaptic density. Predicted to be extrinsic component of postsynaptic specialization membrane. Orthologous to human KPNA2 (karyopherin subunit alpha 2); PARTICIPATES IN influenza A pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: importin; importin subunit alpha-1; importin subunit alpha-2; karyopherin (importin) alpha 2; karyopherin alpha 2; MGC108637; nuclear import protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21091,933,951 - 91,946,115 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1091,933,951 - 91,946,150 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1096,991,813 - 97,004,201 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01096,454,982 - 96,467,370 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01091,856,366 - 91,868,402 (-)NCBIRnor_WKY
Rnor_6.01095,200,029 - 95,212,111 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1095,200,030 - 95,212,111 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01094,940,856 - 94,952,938 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41096,342,214 - 96,352,613 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11096,356,583 - 96,366,983 (-)NCBI
Celera1090,599,417 - 90,611,576 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(S)-amphetamine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
buspirone  (EXP)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cyproterone acetate  (EXP)
cytarabine  (ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (ISO)
dioxygen  (ISO)
dopamine  (EXP)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenoldopam  (EXP)
finasteride  (EXP)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
hydrogen peroxide  (ISO)
hydroxyurea  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
lead diacetate  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
leflunomide  (EXP,ISO)
levofloxacin  (EXP)
lidocaine  (EXP)
lycopene  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorononanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
propiconazole  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sunitinib  (ISO)
testosterone  (ISO)
thioacetamide  (EXP)
topotecan  (EXP)
triadimefon  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
trovafloxacin  (EXP)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vincaleukoblastine  (ISO)
vincristine  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Karyopherin alpha2: a control step of glucose-sensitive gene expression in hepatic cells. Guillemain G, etal., Biochem J 2002 May 15;364(Pt 1):201-9.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:10869435   PMID:12695505   PMID:14675421   PMID:15603742   PMID:15689618   PMID:15719015   PMID:16906019   PMID:17324944   PMID:19946888   PMID:22681889   PMID:26340948   PMID:26526450  
PMID:27430620   PMID:28189564   PMID:31904090  


Genomics

Comparative Map Data
Kpna2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21091,933,951 - 91,946,115 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1091,933,951 - 91,946,150 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1096,991,813 - 97,004,201 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01096,454,982 - 96,467,370 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01091,856,366 - 91,868,402 (-)NCBIRnor_WKY
Rnor_6.01095,200,029 - 95,212,111 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1095,200,030 - 95,212,111 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01094,940,856 - 94,952,938 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41096,342,214 - 96,352,613 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11096,356,583 - 96,366,983 (-)NCBI
Celera1090,599,417 - 90,611,576 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
KPNA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381768,035,735 - 68,046,854 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1768,035,636 - 68,047,364 (+)EnsemblGRCh38hg38GRCh38
GRCh371766,031,851 - 66,042,970 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361763,462,310 - 63,473,432 (+)NCBINCBI36Build 36hg18NCBI36
Celera1762,601,848 - 62,612,972 (+)NCBICelera
Cytogenetic Map17q24.2NCBI
HuRef1761,416,714 - 61,427,908 (+)NCBIHuRef
CHM1_11766,096,665 - 66,107,785 (+)NCBICHM1_1
T2T-CHM13v2.01768,911,511 - 68,922,628 (+)NCBIT2T-CHM13v2.0
Kpna2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911106,879,455 - 106,890,351 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11106,879,455 - 106,890,367 (-)EnsemblGRCm39 Ensembl
GRCm3811106,988,629 - 106,999,525 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11106,988,629 - 106,999,541 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711106,849,943 - 106,860,839 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611106,804,719 - 106,815,615 (-)NCBIMGSCv36mm8
Celera11118,719,792 - 118,733,297 (-)NCBICelera
Cytogenetic Map11E1NCBI
Kpna2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554787,121,432 - 7,134,327 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554787,121,432 - 7,134,327 (+)NCBIChiLan1.0ChiLan1.0
KPNA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11767,161,908 - 67,173,410 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1767,161,908 - 67,173,410 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01761,968,807 - 61,979,954 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
KPNA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1912,546,912 - 12,556,163 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha913,442,712 - 13,451,963 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0914,205,539 - 14,214,799 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl914,205,541 - 14,214,742 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1913,154,710 - 13,163,965 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0914,370,477 - 14,379,722 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0914,369,408 - 14,378,660 (+)NCBIUU_Cfam_GSD_1.0
Kpna2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560213,965,860 - 13,977,209 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365415,217,362 - 5,228,846 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365415,217,389 - 5,228,816 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KPNA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1214,283,087 - 14,296,746 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11214,283,092 - 14,296,749 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
KPNA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11653,422,792 - 53,434,693 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1653,423,040 - 53,433,290 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607724,363,548 - 24,375,627 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kpna2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624870444,558 - 457,872 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624870444,551 - 457,986 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kpna2
81 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:36
Count of miRNA genes:36
Interacting mature miRNAs:36
Transcripts:ENSRNOT00000020795
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108400727295933025Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108400727295933025Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)108402232193995963Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
2313856Bp342Blood pressure QTL 3424.40.0001life span trait (VT:0005372)age at time of death (CMO:0001193)108730761796121100Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1088539139107211142Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1090404397107211142Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1090404397107211142Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1090404397107211142Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)90404397107211142Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)90404397107211142Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1090627439107057807Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090627439107211142Rat
1558652Bw57Body weight QTL 574.20.0008body mass (VT:0001259)body weight (CMO:0000012)1090910316107211142Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091228102104060283Rat

Markers in Region
PMC109067P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10q32.1UniSTS
RH133348  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10q32.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 51 41 19 41 1 66 33 39 11
Low 6 8 10 8 2 2 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000020795   ⟹   ENSRNOP00000020795
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1091,933,951 - 91,946,150 (-)Ensembl
Rnor_6.0 Ensembl1095,200,030 - 95,212,111 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000100211   ⟹   ENSRNOP00000076768
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1091,934,045 - 91,946,118 (-)Ensembl
RefSeq Acc Id: NM_001270802   ⟹   NP_001257731
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21091,933,951 - 91,946,115 (-)NCBI
Rnor_6.01095,200,029 - 95,212,111 (-)NCBI
Rnor_5.01094,940,856 - 94,952,938 (-)NCBI
Celera1090,599,417 - 90,611,576 (-)NCBI
Sequence:
RefSeq Acc Id: NM_053483   ⟹   NP_445935
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21091,933,951 - 91,946,115 (-)NCBI
Rnor_6.01095,200,029 - 95,212,111 (-)NCBI
Rnor_5.01094,940,856 - 94,952,938 (-)NCBI
RGSC_v3.41096,342,214 - 96,352,613 (-)RGD
Celera1090,599,417 - 90,611,576 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_445935   ⟸   NM_053483
- UniProtKB: Q6P6T9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257731   ⟸   NM_001270802
- UniProtKB: Q6P6T9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000020795   ⟸   ENSRNOT00000020795
RefSeq Acc Id: ENSRNOP00000076768   ⟸   ENSRNOT00000100211
Protein Domains
IBB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6P6T9-F1-model_v2 AlphaFold Q6P6T9 1-529 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697848
Promoter ID:EPDNEW_R8373
Type:single initiation site
Name:Kpna2_1
Description:karyopherin subunit alpha 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01095,212,113 - 95,212,173EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621419 AgrOrtholog
BioCyc Gene G2FUF-22916 BioCyc
Ensembl Genes ENSRNOG00000015329 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000020795 ENTREZGENE
  ENSRNOP00000020795.3 UniProtKB/TrEMBL
  ENSRNOP00000076768.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020795 ENTREZGENE
  ENSRNOT00000020795.7 UniProtKB/TrEMBL
  ENSRNOT00000100211.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.690 UniProtKB/TrEMBL
  1.25.10.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5621957 IMAGE-MGC_LOAD
  IMAGE:7326072 IMAGE-MGC_LOAD
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  Arm_3 UniProtKB/TrEMBL
  Armadillo UniProtKB/TrEMBL
  Importin-a-like_IBB-bd_dom UniProtKB/TrEMBL
  Importin-a_IBB_sf UniProtKB/TrEMBL
  Importing_su_alpha UniProtKB/TrEMBL
KEGG Report rno:85245 UniProtKB/TrEMBL
MGC_CLONE MGC:108637 IMAGE-MGC_LOAD
  MGC:72360 IMAGE-MGC_LOAD
NCBI Gene 85245 ENTREZGENE
Pfam Arm UniProtKB/TrEMBL
  Arm_3 UniProtKB/TrEMBL
  IBB UniProtKB/TrEMBL
PhenoGen Kpna2 PhenoGen
PIRSF Importin_alpha UniProtKB/TrEMBL
PROSITE ARM_REPEAT UniProtKB/TrEMBL
  IBB UniProtKB/TrEMBL
SMART ARM UniProtKB/TrEMBL
Superfamily-SCOP ARM-type_fold UniProtKB/TrEMBL
UniProt A0A8I5Y0C8_RAT UniProtKB/TrEMBL
  Q6P6T9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kpna2  karyopherin subunit alpha 2  Kpna2  karyopherin alpha 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-12-15 Kpna2  karyopherin alpha 2  Kpna2  karyopherin (importin) alpha 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Kpna2  karyopherin (importin) alpha 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Kpna2  karyopherin (importin) alpha 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_function regulates glucose-sensitive gene expression by transmitting a signal to the nucleus 633087