Mrc2 (mannose receptor, C type 2) - Rat Genome Database

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Gene: Mrc2 (mannose receptor, C type 2) Rattus norvegicus
Analyze
Symbol: Mrc2
Name: mannose receptor, C type 2
RGD ID: 1559436
Description: Enables collagen binding activity. Predicted to be involved in collagen catabolic process. Predicted to be located in plasma membrane. Orthologous to human MRC2 (mannose receptor C type 2); PARTICIPATES IN phagocytosis pathway; tuberculosis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C-type mannose receptor 2; collagen-binding factor Endo180; Endo180; endocytic receptor 180; macrophage mannose receptor 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81090,761,751 - 90,823,055 (+)NCBIGRCr8
mRatBN7.21090,261,986 - 90,323,187 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1090,261,394 - 90,322,856 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1095,311,188 - 95,371,461 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01094,774,366 - 94,834,633 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01090,192,581 - 90,252,833 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01093,520,272 - 93,581,599 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1093,520,132 - 93,581,296 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01093,278,729 - 93,340,436 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41094,689,202 - 94,752,076 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1088,945,048 - 89,004,845 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
alpha-pinene  (ISO)
amitrole  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
coumarin  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
DDE  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dioxygen  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
furan  (EXP)
gentamycin  (EXP)
inulin  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
miconazole  (ISO)
N,N-dimethylformamide  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
naphthalene  (ISO)
nickel atom  (ISO)
niclosamide  (ISO)
ochratoxin A  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
phosgene  (ISO)
potassium chromate  (ISO)
pyrethrins  (EXP)
SB 431542  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tetrachloromethane  (ISO)
thiram  (ISO)
triclosan  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Endo180 binds to the C-terminal region of type I collagen. Thomas EK, etal., J Biol Chem. 2005 Jun 17;280(24):22596-605. Epub 2005 Apr 6.
Additional References at PubMed
PMID:10636902   PMID:12972549   PMID:15506989   PMID:16210410   PMID:21423176  


Genomics

Comparative Map Data
Mrc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81090,761,751 - 90,823,055 (+)NCBIGRCr8
mRatBN7.21090,261,986 - 90,323,187 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1090,261,394 - 90,322,856 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1095,311,188 - 95,371,461 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01094,774,366 - 94,834,633 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01090,192,581 - 90,252,833 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01093,520,272 - 93,581,599 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1093,520,132 - 93,581,296 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01093,278,729 - 93,340,436 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41094,689,202 - 94,752,076 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1088,945,048 - 89,004,845 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
MRC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381762,627,670 - 62,693,597 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1762,627,670 - 62,693,597 (+)EnsemblGRCh38hg38GRCh38
GRCh371760,705,031 - 60,770,958 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361758,058,494 - 58,124,685 (+)NCBINCBI36Build 36hg18NCBI36
Build 341758,058,852 - 58,123,754NCBI
Celera1755,092,664 - 55,158,832 (+)NCBICelera
Cytogenetic Map17q23.2NCBI
HuRef1756,071,831 - 56,137,989 (+)NCBIHuRef
CHM1_11760,769,070 - 60,835,272 (+)NCBICHM1_1
T2T-CHM13v2.01763,497,612 - 63,563,512 (+)NCBIT2T-CHM13v2.0
Mrc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911105,183,440 - 105,241,971 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11105,183,469 - 105,241,965 (+)EnsemblGRCm39 Ensembl
GRCm3811105,292,093 - 105,351,146 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11105,292,643 - 105,351,139 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711105,153,960 - 105,212,459 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611105,108,773 - 105,166,059 (+)NCBIMGSCv36mm8
Celera11117,025,216 - 117,084,582 (+)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1168.73NCBI
Mrc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554789,034,521 - 9,062,704 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554789,035,436 - 9,062,706 (-)NCBIChiLan1.0ChiLan1.0
MRC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21978,781,860 - 78,849,976 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11783,601,790 - 83,666,383 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01756,692,163 - 56,757,966 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11761,842,236 - 61,907,029 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1761,842,236 - 61,907,029 (+)Ensemblpanpan1.1panPan2
MRC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1910,816,079 - 10,872,467 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl910,816,094 - 10,871,369 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha911,843,854 - 11,898,231 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0912,479,449 - 12,534,085 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl912,479,449 - 12,532,983 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1911,427,827 - 11,482,194 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0916,051,063 - 16,105,351 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0916,055,104 - 16,109,504 (-)NCBIUU_Cfam_GSD_1.0
Mrc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560215,707,062 - 15,732,631 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365413,421,257 - 3,487,562 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365413,461,985 - 3,487,536 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MRC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1216,059,768 - 16,119,571 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11216,059,759 - 16,119,571 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21215,951,690 - 16,010,380 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MRC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11658,582,150 - 58,648,552 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1658,582,134 - 58,648,363 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607729,218,894 - 29,284,363 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mrc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624849160,091 - 214,399 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624849160,063 - 213,839 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mrc2
419 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:67
Count of miRNA genes:62
Interacting mature miRNAs:67
Transcripts:ENSRNOT00000055137
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
2313856Bp342Blood pressure QTL 3424.40.0001life span trait (VT:0005372)age at time of death (CMO:0001193)108730761796121100Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)108402232193995963Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1088539139107211142Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1558652Bw57Body weight QTL 574.20.0008body mass (VT:0001259)body weight (CMO:0000012)108932701790930437Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108400727295933025Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108400727295933025Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat

Markers in Region
D10Got137  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21090,262,792 - 90,262,933 (+)MAPPERmRatBN7.2
Rnor_6.01093,521,091 - 93,521,231NCBIRnor6.0
Rnor_5.01093,279,573 - 93,279,713UniSTSRnor5.0
RGSC_v3.41094,689,856 - 94,689,997RGDRGSC3.4
RGSC_v3.41094,689,857 - 94,689,997UniSTSRGSC3.4
RGSC_v3.11094,704,227 - 94,704,367RGD
Celera1088,945,703 - 88,945,843UniSTS
RH 3.4 Map10931.4RGD
RH 3.4 Map10931.4UniSTS
Cytogenetic Map10q32.1UniSTS
BF398330  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21090,277,254 - 90,277,479 (+)MAPPERmRatBN7.2
Rnor_6.01093,535,821 - 93,536,045NCBIRnor6.0
Rnor_5.01093,294,303 - 93,294,527UniSTSRnor5.0
RGSC_v3.41094,704,317 - 94,704,541UniSTSRGSC3.4
Celera1088,960,161 - 88,960,385UniSTS
RH 3.4 Map10926.4UniSTS
Cytogenetic Map10q32.1UniSTS
RH128903  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21090,289,236 - 90,289,418 (+)MAPPERmRatBN7.2
Rnor_6.01093,547,803 - 93,547,984NCBIRnor6.0
Rnor_5.01093,306,285 - 93,306,466UniSTSRnor5.0
RGSC_v3.41094,716,813 - 94,716,994UniSTSRGSC3.4
Celera1088,972,135 - 88,972,316UniSTS
RH 3.4 Map5959.81UniSTS
Cytogenetic Map10q32.1UniSTS
BF396623  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21090,260,829 - 90,260,983 (+)MAPPERmRatBN7.2
Rnor_6.01093,519,126 - 93,519,279NCBIRnor6.0
Rnor_5.01093,277,608 - 93,277,761UniSTSRnor5.0
RGSC_v3.41094,687,892 - 94,688,045UniSTSRGSC3.4
Celera1088,943,738 - 88,943,891UniSTS
RH 3.4 Map10927.49UniSTS
Cytogenetic Map10q32.1UniSTS
AU047906  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21090,311,589 - 90,311,746 (+)MAPPERmRatBN7.2
Rnor_6.01093,569,996 - 93,570,152NCBIRnor6.0
Rnor_5.01093,328,478 - 93,328,634UniSTSRnor5.0
RGSC_v3.41094,740,444 - 94,740,600UniSTSRGSC3.4
Celera1088,994,367 - 88,994,523UniSTS
Cytogenetic Map10q32.1UniSTS
AU049984  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21090,311,610 - 90,311,759 (+)MAPPERmRatBN7.2
Rnor_6.01093,570,017 - 93,570,165NCBIRnor6.0
Rnor_5.01093,328,499 - 93,328,647UniSTSRnor5.0
RGSC_v3.41094,740,465 - 94,740,613UniSTSRGSC3.4
Celera1088,994,388 - 88,994,536UniSTS
Cytogenetic Map10q32.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 28 9 6 11 6 2 2 45 31 35 11 2
Low 3 15 44 31 8 31 6 9 29 4 6 6
Below cutoff 4 4 4

Sequence


RefSeq Acc Id: ENSRNOT00000055137   ⟹   ENSRNOP00000052010
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1090,261,394 - 90,322,856 (+)Ensembl
Rnor_6.0 Ensembl1093,520,132 - 93,581,296 (+)Ensembl
RefSeq Acc Id: NM_001024687   ⟹   NP_001019858
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81090,761,878 - 90,823,055 (+)NCBI
mRatBN7.21090,262,013 - 90,323,187 (+)NCBI
Rnor_6.01093,520,436 - 93,580,474 (+)NCBI
Rnor_5.01093,278,729 - 93,340,436 (+)NCBI
RGSC_v3.41094,689,202 - 94,752,076 (+)RGD
Celera1088,945,048 - 89,004,845 (+)RGD
Sequence:
RefSeq Acc Id: XM_006247631   ⟹   XP_006247693
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81090,761,751 - 90,823,055 (+)NCBI
mRatBN7.21090,261,986 - 90,323,187 (+)NCBI
Rnor_6.01093,520,272 - 93,581,599 (+)NCBI
Rnor_5.01093,278,729 - 93,340,436 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001019858 (Get FASTA)   NCBI Sequence Viewer  
  XP_006247693 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAY53886 (Get FASTA)   NCBI Sequence Viewer  
  EDM06333 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000052010.3
GenBank Protein Q4TU93 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001019858   ⟸   NM_001024687
- Peptide Label: precursor
- UniProtKB: Q4TU93 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006247693   ⟸   XM_006247631
- Peptide Label: isoform X1
- UniProtKB: F1LMA7 (UniProtKB/TrEMBL),   A6HJX8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000052010   ⟸   ENSRNOT00000055137
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4TU93-F1-model_v2 AlphaFold Q4TU93 1-1480 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697827
Promoter ID:EPDNEW_R8351
Type:initiation region
Name:Mrc2_1
Description:mannose receptor, C type 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01093,520,309 - 93,520,369EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1559436 AgrOrtholog
BioCyc Gene G2FUF-23000 BioCyc
Ensembl Genes ENSRNOG00000006548 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000055137.3 UniProtKB/TrEMBL
Gene3D-CATH 2.10.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.80.10.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.10.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C-type_lectin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CD209-like_CTLD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTDL_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN_type2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN_type2_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ricin_B-like_lectins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ricin_B_lectin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:498011 UniProtKB/Swiss-Prot
NCBI Gene 498011 ENTREZGENE
PANTHER C-TYPE MANNOSE RECEPTOR 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam fn2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lectin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mrc2 PhenoGen
PRINTS FNTYPEII UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE C_TYPE_LECTIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RICIN_B_LECTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006548 RatGTEx
SMART CLECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RICIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50370 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56436 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57440 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6HJX8 ENTREZGENE, UniProtKB/TrEMBL
  F1LMA7 ENTREZGENE, UniProtKB/TrEMBL
  MRC2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-01-31 Mrc2  mannose receptor, C type 2  Endo180  collagen-binding factor Endo180  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2006-02-09 Endo180  collagen-binding factor Endo180      Symbol and Name status set to provisional 70820 PROVISIONAL