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Gene: Grn (granulin precursor) Rattus norvegicus
Symbol: Grn
Name: granulin precursor
Description: Predicted to have chaperone binding activity. Involved in several processes, including chondrocyte proliferation; positive regulation of dendritic spine development; and response to estradiol. Predicted to localize to several cellular components, including late endosome; lysosomal membrane; and trans-Golgi network. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); and neuronal ceroid lipofuscinosis 11. Orthologous to human GRN (granulin precursor); INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: acrogranin; epithelin; granulin; granulins; PEPI; PGRN; proepithelin; progranulin; progranulin ; prostate cancer cell-derived growth factor
Homo sapiens (human) : GRN (granulin precursor)  HGNC  Alliance
Mus musculus (house mouse) : Grn (granulin)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Grn (granulin precursor)
Pan paniscus (bonobo/pygmy chimpanzee) : GRN (granulin precursor)
Canis lupus familiaris (dog) : GRN (granulin precursor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Grn (granulin precursor)
Sus scrofa (pig) : GRN (granulin precursor)
Chlorocebus sabaeus (African green monkey) : GRN (granulin precursor)
Heterocephalus glaber (naked mole-rat) : Grn (granulin precursor)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01090,377,103 - 90,383,207 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1090,376,933 - 90,383,205 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01090,165,634 - 90,171,738 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41091,536,135 - 91,542,239 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11091,552,883 - 91,556,599 (+)NCBI
Celera1086,096,583 - 86,102,687 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Grn
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 61983
Created: 2001-04-11
Species: Rattus norvegicus
Last Modified: 2020-07-07
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.