GRN (granulin precursor) - Rat Genome Database

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Gene: GRN (granulin precursor) Canis lupus familiaris
Analyze
Symbol: GRN
Name: granulin precursor
RGD ID: 12338558
Description: ENCODES a protein that exhibits chaperone binding (ortholog); INVOLVED IN astrocyte activation involved in immune response (ortholog); blastocyst hatching (ortholog); chondrocyte proliferation (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); amyotrophic lateral sclerosis (ortholog); atherosclerosis (ortholog); FOUND IN endoplasmic reticulum (ortholog); endosome (ortholog); extracellular region (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: granulins; progranulin
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1919,077,430 - 19,085,443 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl919,077,427 - 19,082,268 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha918,467,174 - 18,474,620 (-)NCBI
ROS_Cfam_1.0919,771,801 - 19,779,240 (-)NCBI
UMICH_Zoey_3.1918,625,608 - 18,633,045 (-)NCBI
UNSW_CanFamBas_1.0918,808,582 - 18,816,025 (-)NCBI
UU_Cfam_GSD_1.0918,952,849 - 18,960,290 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
astrocyte activation involved in immune response  (ISO)
blastocyst hatching  (ISO)
chondrocyte proliferation  (ISO)
embryo implantation  (ISO)
locomotory exploration behavior  (ISO)
lysosomal lumen acidification  (ISO)
lysosomal protein catabolic process  (ISO)
lysosomal transport  (ISO)
lysosome organization  (ISO)
male mating behavior  (ISO)
microglial cell activation involved in immune response  (ISO)
negative regulation of hydrolase activity  (ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of innate immune response  (ISO)
negative regulation of microglial cell activation  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of neutrophil activation  (ISO)
negative regulation of respiratory burst involved in inflammatory response  (ISO)
neural precursor cell proliferation  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of aspartic-type peptidase activity  (ISO)
positive regulation of axon regeneration  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of defense response to bacterium  (ISO)
positive regulation of dendritic spine development  (ISO)
positive regulation of endothelial cell migration  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of inflammatory response to wounding  (ISO)
positive regulation of lysosome organization  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of protein folding  (ISO)
protein stabilization  (ISO)
regulation of lysosome organization  (ISO)
response to estradiol  (ISO)
retina development in camera-type eye  (ISO)
synaptic vesicle endocytosis  (ISO)

Cellular Component

Molecular Function

References

Genomics

Comparative Map Data
GRN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1919,077,430 - 19,085,443 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl919,077,427 - 19,082,268 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha918,467,174 - 18,474,620 (-)NCBI
ROS_Cfam_1.0919,771,801 - 19,779,240 (-)NCBI
UMICH_Zoey_3.1918,625,608 - 18,633,045 (-)NCBI
UNSW_CanFamBas_1.0918,808,582 - 18,816,025 (-)NCBI
UU_Cfam_GSD_1.0918,952,849 - 18,960,290 (-)NCBI
GRN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1744,345,246 - 44,353,106 (+)EnsemblGRCh38hg38GRCh38
GRCh381744,345,302 - 44,353,106 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371742,422,670 - 42,430,474 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361739,778,017 - 39,785,996 (+)NCBINCBI36hg18NCBI36
Build 341739,778,016 - 39,785,996NCBI
Celera1739,132,112 - 39,140,095 (+)NCBI
Cytogenetic Map17q21.31NCBI
HuRef1738,186,768 - 38,194,753 (+)NCBIHuRef
CHM1_11742,658,166 - 42,666,146 (+)NCBICHM1_1
Grn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911102,321,333 - 102,327,635 (+)NCBIGRCm39mm39
GRCm39 Ensembl11102,321,141 - 102,327,874 (+)Ensembl
GRCm3811102,430,507 - 102,436,809 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11102,430,315 - 102,437,048 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711102,291,636 - 102,298,123 (+)NCBIGRCm37mm9NCBIm37
MGSCv3611102,246,597 - 102,252,895 (+)NCBImm8
Celera11114,140,482 - 114,146,970 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1166.29NCBI
Grn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21087,387,672 - 87,393,777 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl1090,376,933 - 90,383,205 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01090,377,103 - 90,383,207 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01090,165,634 - 90,171,738 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41091,536,135 - 91,542,239 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11091,552,883 - 91,556,599 (+)NCBI
Celera1086,096,583 - 86,102,687 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
Grn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545117,368,428 - 17,372,377 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545117,368,600 - 17,371,981 (+)NCBIChiLan1.0ChiLan1.0
GRN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11713,211,784 - 13,219,793 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1713,211,784 - 13,219,609 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01713,046,329 - 13,054,236 (-)NCBIMhudiblu_PPA_v0panPan3
Grn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560218,390,156 - 18,401,106 (-)NCBI
SpeTri2.0NW_004936541793,548 - 800,271 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1218,893,770 - 18,900,446 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11218,893,772 - 18,900,444 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21219,212,414 - 19,216,283 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GRN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11662,037,344 - 62,045,765 (-)NCBI
ChlSab1.1 Ensembl1662,036,412 - 62,045,614 (-)Ensembl
Vero_WHO_p1.0NW_02366607732,804,031 - 32,812,724 (-)NCBI
Grn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624795704,066 - 708,721 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 5 12 8 10 6
Low 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022423909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038485338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038485339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038547105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038547106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038611073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038611074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038629365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038629366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038676258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038676259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000022483   ⟹   ENSCAFP00000020876
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl919,077,427 - 19,082,268 (-)Ensembl
RefSeq Acc Id: XM_022423909   ⟹   XP_022279617
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1919,077,430 - 19,085,443 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038485338   ⟹   XP_038341266
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1918,625,608 - 18,633,045 (-)NCBI
RefSeq Acc Id: XM_038485339   ⟹   XP_038341267
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1918,625,608 - 18,632,899 (-)NCBI
RefSeq Acc Id: XM_038547105   ⟹   XP_038403033
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0918,952,849 - 18,960,290 (-)NCBI
RefSeq Acc Id: XM_038547106   ⟹   XP_038403034
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0918,952,849 - 18,960,144 (-)NCBI
RefSeq Acc Id: XM_038611073   ⟹   XP_038467001
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0918,808,582 - 18,816,025 (-)NCBI
RefSeq Acc Id: XM_038611074   ⟹   XP_038467002
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0918,808,582 - 18,815,879 (-)NCBI
RefSeq Acc Id: XM_038629365   ⟹   XP_038485293
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha918,467,174 - 18,474,620 (-)NCBI
RefSeq Acc Id: XM_038629366   ⟹   XP_038485294
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha918,467,174 - 18,474,474 (-)NCBI
RefSeq Acc Id: XM_038676258   ⟹   XP_038532186
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0919,771,801 - 19,779,240 (-)NCBI
RefSeq Acc Id: XM_038676259   ⟹   XP_038532187
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0919,771,801 - 19,779,094 (-)NCBI
Reference Sequences
RefSeq Acc Id: XP_022279617   ⟸   XM_022423909
- Sequence:
RefSeq Acc Id: ENSCAFP00000020876   ⟸   ENSCAFT00000022483
RefSeq Acc Id: XP_038341266   ⟸   XM_038485338
RefSeq Acc Id: XP_038341267   ⟸   XM_038485339
RefSeq Acc Id: XP_038467001   ⟸   XM_038611073
RefSeq Acc Id: XP_038467002   ⟸   XM_038611074
RefSeq Acc Id: XP_038532186   ⟸   XM_038676258
RefSeq Acc Id: XP_038532187   ⟸   XM_038676259
RefSeq Acc Id: XP_038485293   ⟸   XM_038629365
RefSeq Acc Id: XP_038485294   ⟸   XM_038629366
RefSeq Acc Id: XP_038403033   ⟸   XM_038547105
RefSeq Acc Id: XP_038403034   ⟸   XM_038547106
Protein Domains
G_PROTEIN_RECEP_F2_3

Promoters
RGD ID:13684487
Promoter ID:EPDNEW_C2556
Type:initiation region
Name:GRN_1
Description:granulin precursor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1919,085,349 - 19,085,409EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000014165 Ensembl, ENTREZGENE
NCBI Gene GRN ENTREZGENE
VGNC ID VGNC:41516 ENTREZGENE