Acox1 (acyl-CoA oxidase 1) - Rat Genome Database

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Gene: Acox1 (acyl-CoA oxidase 1) Rattus norvegicus
Analyze
Symbol: Acox1
Name: acyl-CoA oxidase 1
RGD ID: 619757
Description: Enables anion binding activity; palmitoyl-CoA oxidase activity; and protein homodimerization activity. Involved in fatty acid beta-oxidation using acyl-CoA oxidase. Located in peroxisome. Biomarker of obesity and steatotic liver disease. Human ortholog(s) of this gene implicated in Mitchell syndrome and peroxisomal acyl-CoA oxidase deficiency. Orthologous to human ACOX1 (acyl-CoA oxidase 1); PARTICIPATES IN alpha-linolenic acid metabolic pathway; eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; fatty acid metabolic pathway; INTERACTS WITH (R)-lipoic acid; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ACO; aCoA; acyl-coA oxidase; acyl-CoA oxidase 1, palmitoyl; acyl-Coenzyme A oxidase 1; acyl-Coenzyme A oxidase 1, palmitoyl; AOX; LOC100910385; palmitoyl-CoA oxidase; peroxisomal acyl-coenzyme A oxidase 1; peroxisomal acyl-coenzyme A oxidase 1-like; peroxisomal fatty acyl-CoA oxidase; RATACOA1; straight-chain acyl-CoA oxidase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810101,905,083 - 101,930,136 (-)NCBIGRCr8
mRatBN7.210101,406,197 - 101,431,252 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10101,406,197 - 101,431,232 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10106,470,116 - 106,493,643 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010105,933,212 - 105,956,739 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010101,328,652 - 101,352,160 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010104,724,534 - 104,748,003 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10104,722,958 - 104,748,050 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010103,537,761 - 103,561,087 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410106,281,977 - 106,319,382 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110106,294,947 - 106,310,607 (-)NCBI
Celera1099,981,033 - 100,004,515 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
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Original Reference(s)
Acox1Ratobesity treatmentIEP 401960083 RGD 
Acox1Ratsteatotic liver disease treatmentIEP 401960083 RGD 
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Original Reference(s)
Acox1RatCharcot-Marie-Tooth disease axonal type 2K  ISOACOX1 (Homo sapiens)8554872ClinVar Annotator: match by term: Charcot-Marie-Tooth disease type 2KClinVarPMID:25326637 and PMID:28492532
Acox1RatCharcot-Marie-Tooth disease recessive intermediate A  ISOACOX1 (Homo sapiens)8554872ClinVar Annotator: match by term: Charcot-Marie-Tooth disease recessive intermediate AClinVarPMID:25326637 and PMID:28492532
Acox1Ratgenetic disease  ISOACOX1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 more ...
Acox1RatMitchell syndrome  ISOACOX1 (Homo sapiens)8554872ClinVar Annotator: match by term: Mitchell syndromeClinVarPMID:16199547 more ...
Acox1RatMuscle Weakness  ISOACOX1 (Homo sapiens)8554872ClinVar Annotator: match by term: Muscle weaknessClinVarPMID:25741868
Acox1Ratperoxisomal acyl-CoA oxidase deficiency  ISOACOX1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11815777 more ...
Acox1Ratperoxisomal acyl-CoA oxidase deficiency  ISOACOX1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11815777 more ...
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Original Reference(s)
Acox1RatExperimental Diabetes Mellitus  ISOACOX1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:14563825
Acox1Rathepatocellular carcinoma  ISOACOX1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12771043 and PMID:15565109
Acox1Ratperoxisomal acyl-CoA oxidase deficiency  ISOACOX1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
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Original Reference(s)
Acox1Ratperoxisomal acyl-CoA oxidase deficiency  ISSAcox1 (Mus musculus)13592920OMIM:264470MouseDO 
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Original Reference(s)
Acox1RatMitchell syndrome  ISOACOX1 (Homo sapiens)7240710 OMIM 
Acox1Ratperoxisomal acyl-CoA oxidase deficiency  ISOACOX1 (Homo sapiens)7240710 OMIM 

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Acox1Rat(+)-dexrazoxane decreases expressionISOAcox1 (Mus musculus)6480464Dexrazoxane results in decreased expression of ACOX1 mRNACTDPMID:26873546
Acox1Rat(1->4)-beta-D-glucan multiple interactionsISOAcox1 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of ACOX1 mRNACTDPMID:36331819
Acox1Rat(R)-lipoic acid multiple interactionsEXP 6480464Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of ACOX1 mRNA]CTDPMID:22464149
Acox1Rat1,2-dichloroethane decreases expressionISOAcox1 (Mus musculus)6480464ethylene dichloride results in decreased expression of ACOX1 mRNACTDPMID:28960355
Acox1Rat1,2-dimethylhydrazine affects expressionISOAcox1 (Mus musculus)64804641 and 2-Dimethylhydrazine affects the expression of ACOX1 mRNACTDPMID:22206623
Acox1Rat1,2-dimethylhydrazine multiple interactionsISOAcox1 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of ACOX1 mRNACTDPMID:22206623
Acox1Rat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of ACOX1 mRNACTDPMID:12883083
Acox1Rat1-naphthyl isothiocyanate multiple interactionsISOAcox1 (Mus musculus)6480464[1-Naphthylisothiocyanate co-treated with Uric Acid] results in decreased expression of ACOX1 mRNA and Allopurinol inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of ACOX1 mRNA]CTDPMID:33749747
Acox1Rat1-naphthyl isothiocyanate decreases expressionISOAcox1 (Mus musculus)64804641-Naphthylisothiocyanate results in decreased expression of ACOX1 mRNACTDPMID:33749747
Acox1Rat17alpha-ethynylestradiol multiple interactionsISOAcox1 (Mus musculus)6480464Ethinyl Estradiol promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of ACOX1 mRNA]CTDPMID:24440342
Acox1Rat17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of ACOX1 mRNA and Estradiol results in decreased expression of ACOX1 proteinCTDPMID:32145629
Acox1Rat17beta-estradiol decreases expressionISOAcox1 (Mus musculus)6480464Estradiol results in decreased expression of ACOX1 mRNACTDPMID:39298647
Acox1Rat2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsISOAcox1 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with 2 more ...CTDPMID:28433925
Acox1Rat2,2',4,4'-Tetrabromodiphenyl ether multiple interactionsISOAcox1 (Mus musculus)6480464[Flame Retardants results in increased abundance of 2 more ...CTDPMID:38995820
Acox1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOAcox1 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of ACOX1 mRNA and Tetrachlorodibenzodioxin results in increased expression of ACOX1 proteinCTDPMID:10497882 and PMID:23864506
Acox1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of ACOX1 mRNACTDPMID:21215274 and PMID:33387578
Acox1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOACOX1 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of ACOX1 mRNACTDPMID:12377990 and PMID:15345368
Acox1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOAcox1 (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of ACOX1 mRNACTDPMID:16214954 and PMID:18796159
Acox1Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOAcox1 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with 2 more ...CTDPMID:10497882 more ...
Acox1Rat2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionISOAcox1 (Mus musculus)64804642 more ...CTDPMID:38648751

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Biological Process
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Original Reference(s)
Acox1Ratalpha-linolenic acid metabolic process involved_inISOAcox1 (Mus musculus)1624291MGI:1857811 PMID:11734571 and PMID:8798738RGDPMID:11734571 and PMID:8798738
Acox1Ratalpha-linolenic acid metabolic process involved_inIEAUniProtKB:Q9R0H0 and ensembl:ENSMUSP000000727171600115GO_REF:0000107EnsemblGO_REF:0000107
Acox1Ratcholesterol homeostasis involved_inISOACOX1 (Homo sapiens) and UniProtKB:Q15067-11624291UniProtKB:Q9R0H0 and PMID:20195242RGDPMID:20195242
Acox1Ratfatty acid beta-oxidation involved_inIEAInterPro:IPR0026551600115GO_REF:0000002InterProGO_REF:0000002
Acox1Ratfatty acid beta-oxidation involved_inIEAARBA:ARBA000286921600115GO_REF:0000117UniProtGO_REF:0000117
Acox1Ratfatty acid beta-oxidation using acyl-CoA oxidase  IDA 2299949 RGD 
Acox1Ratfatty acid beta-oxidation using acyl-CoA oxidase involved_inIEAUniProtKB:Q15067 and ensembl:ENSP000002932171600115GO_REF:0000107EnsemblGO_REF:0000107
Acox1Ratfatty acid beta-oxidation using acyl-CoA oxidase involved_inIEAUniPathway:UPA006611600115GO_REF:0000041UniProtGO_REF:0000041
Acox1Ratfatty acid beta-oxidation using acyl-CoA oxidase involved_inIBAFB:FBgn0027572 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Acox1Ratfatty acid beta-oxidation using acyl-CoA oxidase involved_inISOACOX1 (Homo sapiens)1624291 PMID:18536048RGDPMID:18536048
Acox1Ratfatty acid beta-oxidation using acyl-CoA oxidase involved_inIEAInterPro:IPR0341711600115GO_REF:0000002InterProGO_REF:0000002
Acox1Ratfatty acid catabolic process involved_inISOACOX1 (Homo sapiens)1624291 PMID:32169171RGDPMID:32169171
Acox1Ratfatty acid catabolic process involved_inIEAUniProtKB:Q15067 and ensembl:ENSP000002932171600115GO_REF:0000107EnsemblGO_REF:0000107
Acox1Ratfatty acid derivative biosynthetic process involved_inISOAcox1 (Mus musculus)1624291MGI:1857811 PMID:11734571 and PMID:8798738RGDPMID:11734571 and PMID:8798738
Acox1Ratfatty acid derivative biosynthetic process involved_inIEAUniProtKB:Q9R0H0 and ensembl:ENSMUSP000000727171600115GO_REF:0000107EnsemblGO_REF:0000107
Acox1Ratfatty acid metabolic process involved_inIEAUniProtKB-KW:KW-02761600115GO_REF:0000043UniProtGO_REF:0000043
Acox1Ratfatty acid metabolic process involved_inIEAInterPro:IPR0122581600115GO_REF:0000002InterProGO_REF:0000002
Acox1Ratfatty acid oxidation involved_inISOAcox1 (Mus musculus)1624291 PMID:20195242RGDPMID:20195242
Acox1Ratfatty acid oxidation involved_inIEAUniProtKB:Q15067 and ensembl:ENSP000002932171600115GO_REF:0000107EnsemblGO_REF:0000107
Acox1Ratfatty acid oxidation involved_inIEAUniProtKB:Q9R0H0 and ensembl:ENSMUSP000000727171600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component
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Acox1Ratcytoplasm located_inISOAcox1 (Mus musculus)1624291 PMID:11156684RGDPMID:11156684
Acox1Ratcytoplasm located_inIEAUniProtKB:Q9R0H0 and ensembl:ENSMUSP000000727171600115GO_REF:0000107EnsemblGO_REF:0000107
Acox1Ratperoxisomal matrix located_inTAS 1600115Reactome:R-NUL-9034341ReactomeReactome:R-NUL-9034341
Acox1Ratperoxisomal matrix is_active_inIEAUniProtKB:Q9R0H0 and ensembl:ENSMUSP000000727171600115GO_REF:0000107EnsemblGO_REF:0000107
Acox1Ratperoxisomal matrix is_active_inISOAcox1 (Mus musculus)1624291MGI:1857811 PMID:8798738RGDPMID:8798738
Acox1Ratperoxisomal membrane located_inIEAUniProtKB:Q9R0H0 and ensembl:ENSMUSP000000727171600115GO_REF:0000107EnsemblGO_REF:0000107
Acox1Ratperoxisomal membrane located_inISOAcox1 (Mus musculus)1624291 PMID:12915479RGDPMID:12915479
Acox1Ratperoxisome  IDA 2299949 RGD 
Acox1Ratperoxisome located_inIEAUniProtKB:Q15067 and ensembl:ENSP000002932171600115GO_REF:0000107EnsemblGO_REF:0000107
Acox1Ratperoxisome located_inIEAUniProtKB:Q9R0H0 and ensembl:ENSMUSP000000727171600115GO_REF:0000107EnsemblGO_REF:0000107
Acox1Ratperoxisome located_inIEAUniProtKB-SubCell:SL-02041600115GO_REF:0000044UniProtGO_REF:0000044
Acox1Ratperoxisome is_active_inIBAFB:FBgn0032775 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Acox1Ratperoxisome located_inISOAcox1 (Mus musculus)1624291 PMID:17881773RGDPMID:17881773
Acox1Ratperoxisome located_inIEAInterPro:IPR002655 and InterPro:IPR0122581600115GO_REF:0000002InterProGO_REF:0000002
Acox1Ratperoxisome located_inIEAARBA:ARBA000285891600115GO_REF:0000117UniProtGO_REF:0000117
Acox1Ratperoxisome located_inIEAUniProtKB-KW:KW-05761600115GO_REF:0000043UniProtGO_REF:0000043
Acox1Ratperoxisome located_inISOACOX1 (Homo sapiens)1624291 PMID:17881773 more ...RGDPMID:17881773 more ...
Acox1Ratperoxisome located_inIDA 12793024PMID:11872165UniProt 
Acox1Ratperoxisome located_inISSUniProtKB:Q150671600115GO_REF:0000024UniProtGO_REF:0000024
Acox1Ratperoxisome is_active_inISOACOX1 (Homo sapiens)1624291 PMID:32169171RGDPMID:32169171
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Molecular Function
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Original Reference(s)
Acox1Ratacyl-CoA oxidase activity enablesISOACOX1 (Homo sapiens) more ...1624291UniProtKB:P13711 and PMID:17458872RGDPMID:17458872
Acox1Ratacyl-CoA oxidase activity enablesIEAEC:1.3.3.61600115GO_REF:0000003UniProtGO_REF:0000003
Acox1Ratacyl-CoA oxidase activity enablesIEARHEA:389591600115GO_REF:0000116RHEAGO_REF:0000116
Acox1Ratacyl-CoA oxidase activity enablesISOAcox1 (Mus musculus)1624291MGI:1857811 PMID:8798738RGDPMID:8798738
Acox1Ratacyl-CoA oxidase activity enablesIEAUniProtKB:Q9R0H0 and ensembl:ENSMUSP000000727171600115GO_REF:0000107EnsemblGO_REF:0000107
Acox1Ratacyl-CoA oxidase activity enablesISOACOX1 (Homo sapiens)1624291 PMID:18536048 more ...RGDPMID:18536048 more ...
Acox1Ratacyl-CoA oxidase activity enablesIDA 14402446PMID:7462191UniProt 
Acox1Ratacyl-CoA oxidase activity enablesISSUniProtKB:Q150671600115GO_REF:0000024UniProtGO_REF:0000024
Acox1Ratacyl-CoA oxidase activity enablesIEAUniProtKB:Q15067 and ensembl:ENSP000002932171600115GO_REF:0000107EnsemblGO_REF:0000107
Acox1Ratacyl-CoA oxidase activity enablesIEAInterPro:IPR002655 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Acox1RatFAD binding enablesIEAInterPro:IPR012258 and InterPro:IPR0341711600115GO_REF:0000002InterProGO_REF:0000002
Acox1RatFAD binding enablesISOACOX1 (Homo sapiens) more ...1624291 PMID:17603022RGDPMID:17603022
Acox1Ratfatty acid binding  IDA 2299949 RGD 
Acox1Ratfatty acid binding enablesIBAPANTHER:PTN000097533 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Acox1Ratfatty acid binding enablesIEAInterPro:IPR0341711600115GO_REF:0000002InterProGO_REF:0000002
Acox1Ratflavin adenine dinucleotide binding enablesIDA 12793024PMID:11872165UniProt 
Acox1Ratflavin adenine dinucleotide binding enablesIEAInterPro:IPR0370691600115GO_REF:0000002InterProGO_REF:0000002
Acox1Ratflavin adenine dinucleotide binding enablesIBAPANTHER:PTN000097533 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Acox1Ratoxidoreductase activity enablesIEAUniProtKB-KW:KW-05601600115GO_REF:0000043UniProtGO_REF:0000043
Acox1Ratoxidoreductase activity, acting on the CH-CH group of donors enablesIEAInterPro:IPR006091 more ...1600115GO_REF:0000002InterProGO_REF:0000002
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Imported Annotations - KEGG (archival)

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Original Reference(s)
Acox1Ratalpha-linolenic acid metabolic pathway  IEA 6907045 KEGGrno:00592
Acox1Rateicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma  IEA 6907045 KEGGrno:03320
Acox1Ratfatty acid metabolic pathway  IEA 6907045 KEGGrno:00071
Acox1Ratunsaturated fatty acid biosynthetic pathway  IEA 6907045 KEGGrno:01040

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Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Stereochemistry of dehydrogenation catalyzed by Acyl-CoA oxidase. Kawaguchi A, etal., J Biochem. 1980 Nov;88(5):1481-6. doi: 10.1093/oxfordjournals.jbchem.a133118.
3. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Complete nucleotide sequence of cDNA and predicted amino acid sequence of rat acyl-CoA oxidase. Miyazawa S, etal., J Biol Chem 1987 Jun 15;262(17):8131-7.
6. Three-dimensional structure of the flavoenzyme acyl-CoA oxidase-II from rat liver, the peroxisomal counterpart of mitochondrial acyl-CoA dehydrogenase. Nakajima Y, etal., J Biochem. 2002 Mar;131(3):365-74.
7. Differential impacts of mineralocorticoid receptor antagonist potassium canrenoate on liver and renal changes in high fat diet-mediated early hepatocarcinogenesis model rats. Nakamura M, etal., J Toxicol Sci. 2018;43(10):611-621. doi: 10.2131/jts.43.611.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Substrate specificities of rat liver peroxisomal acyl-CoA oxidases: palmitoyl-CoA oxidase (inducible acyl-CoA oxidase), pristanoyl-CoA oxidase (non-inducible acyl-CoA oxidase), and trihydroxycoprostanoyl-CoA oxidase. Van Veldhoven PP, etal., J Biol Chem. 1992 Oct 5;267(28):20065-74.
14. Effect of Creosote Bush-Derived NDGA on Expression of Genes Involved in Lipid Metabolism in Liver of High-Fructose Fed Rats: Relevance to NDGA Amelioration of Hypertriglyceridemia and Hepatic Steatosis. Zhang H, etal., PLoS One. 2015 Sep 22;10(9):e0138203. doi: 10.1371/journal.pone.0138203. eCollection 2015.
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PMID:3036801   PMID:7876265   PMID:8117268   PMID:8798738   PMID:8943006   PMID:11156684   PMID:12477932   PMID:12915479   PMID:14651853   PMID:15489334   PMID:16236453   PMID:17458872  
PMID:17603022   PMID:17881773   PMID:18281296   PMID:18421861   PMID:18536048   PMID:19946888   PMID:20178365   PMID:20195242   PMID:23209302   PMID:26092479   PMID:27923787   PMID:28077576  



Acox1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810101,905,083 - 101,930,136 (-)NCBIGRCr8
mRatBN7.210101,406,197 - 101,431,252 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10101,406,197 - 101,431,232 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10106,470,116 - 106,493,643 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010105,933,212 - 105,956,739 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010101,328,652 - 101,352,160 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010104,724,534 - 104,748,003 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10104,722,958 - 104,748,050 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010103,537,761 - 103,561,087 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410106,281,977 - 106,319,382 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110106,294,947 - 106,310,607 (-)NCBI
Celera1099,981,033 - 100,004,515 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
ACOX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381775,941,507 - 75,979,166 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1775,941,507 - 75,979,177 (-)EnsemblGRCh38hg38GRCh38
GRCh371773,937,588 - 73,975,247 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361771,449,183 - 71,487,039 (-)NCBINCBI36Build 36hg18NCBI36
Build 341771,453,259 - 71,487,020NCBI
Celera1770,527,638 - 70,565,551 (-)NCBICelera
Cytogenetic Map17q25.1ENTREZGENE
HuRef1769,363,233 - 69,401,119 (-)NCBIHuRef
CHM1_11774,002,525 - 74,040,340 (-)NCBICHM1_1
T2T-CHM13v2.01776,834,659 - 76,872,295 (-)NCBIT2T-CHM13v2.0
Acox1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911116,062,714 - 116,089,605 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11116,062,714 - 116,089,871 (-)EnsemblGRCm39 Ensembl
GRCm3811116,171,883 - 116,199,045 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11116,171,888 - 116,199,045 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711116,033,202 - 116,060,359 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611115,987,978 - 116,015,135 (-)NCBIMGSCv36mm8
Celera11127,936,007 - 127,963,704 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1180.96NCBI
Acox1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555066,286,648 - 6,312,716 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555066,286,824 - 6,309,764 (+)NCBIChiLan1.0ChiLan1.0
ACOX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21991,985,727 - 92,022,709 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11796,810,438 - 96,847,726 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01769,890,817 - 69,928,342 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11775,441,856 - 75,479,568 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1775,445,923 - 75,479,571 (-)Ensemblpanpan1.1panPan2
ACOX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.194,658,692 - 4,682,667 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl94,658,090 - 4,679,096 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha95,338,792 - 5,363,123 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.095,328,698 - 5,353,076 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl95,328,746 - 5,392,641 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.195,368,568 - 5,392,890 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.095,478,345 - 5,502,565 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.095,538,510 - 5,562,844 (+)NCBIUU_Cfam_GSD_1.0
Acox1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056025,272,135 - 5,296,650 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365941,112,565 - 1,140,228 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365941,115,607 - 1,140,085 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACOX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl125,439,361 - 5,479,546 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1125,450,913 - 5,479,550 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2125,472,406 - 5,484,941 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACOX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11645,706,009 - 45,745,564 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1645,706,360 - 45,740,247 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607716,459,017 - 16,498,942 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acox1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248015,846,729 - 5,867,427 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248015,844,824 - 5,867,439 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Acox1
82 total Variants

Predicted Target Of
Summary Value
Count of predictions:698
Count of miRNA genes:249
Interacting mature miRNAs:297
Transcripts:ENSRNOT00000042372, ENSRNOT00000046754
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 59 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093223816107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat

1 to 10 of 59 rows
RH128790  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210101,406,255 - 101,406,439 (+)MAPPERmRatBN7.2
Rnor_6.010104,723,058 - 104,723,241NCBIRnor6.0
Rnor_5.010103,562,380 - 103,562,563UniSTSRnor5.0
RGSC_v3.410106,280,501 - 106,280,684UniSTSRGSC3.4
Celera1099,979,557 - 99,979,740UniSTS
Cytogenetic Map10q32.3UniSTS
PMC199556P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210101,412,196 - 101,412,286 (+)MAPPERmRatBN7.2
Rnor_6.010104,728,999 - 104,729,088NCBIRnor6.0
Rnor_5.010103,556,533 - 103,556,622UniSTSRnor5.0
RGSC_v3.410106,286,442 - 106,286,531UniSTSRGSC3.4
Celera1099,985,472 - 99,985,561UniSTS
Cytogenetic Map10q32.3UniSTS
PMC21059P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210101,406,415 - 101,407,050 (+)MAPPERmRatBN7.2
Rnor_6.010104,723,218 - 104,723,852NCBIRnor6.0
Rnor_5.010103,561,769 - 103,562,403UniSTSRnor5.0
RGSC_v3.410106,280,661 - 106,281,295UniSTSRGSC3.4
Celera1099,979,717 - 99,980,351UniSTS
Cytogenetic Map10q32.3UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 16 of 16 rows
RefSeq Transcripts NM_001414015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_017340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC085743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB872989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB882851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB894180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC930398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC940260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC951589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J02752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J02753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 16 of 16 rows

Ensembl Acc Id: ENSRNOT00000042372   ⟹   ENSRNOP00000051538
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10101,406,197 - 101,431,223 (-)Ensembl
Rnor_6.0 Ensembl10104,724,534 - 104,748,003 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000046754   ⟹   ENSRNOP00000042132
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10101,406,198 - 101,431,227 (-)Ensembl
Rnor_6.0 Ensembl10104,722,958 - 104,748,050 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103476   ⟹   ENSRNOP00000083504
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10101,406,198 - 101,418,993 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108949   ⟹   ENSRNOP00000087983
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10101,406,197 - 101,431,232 (-)Ensembl
RefSeq Acc Id: NM_001414015   ⟹   NP_001400944
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810101,905,083 - 101,930,136 (-)NCBI
mRatBN7.210101,406,197 - 101,431,252 (-)NCBI
RefSeq Acc Id: NM_017340   ⟹   NP_059036
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810101,905,083 - 101,930,136 (-)NCBI
mRatBN7.210101,406,197 - 101,431,252 (-)NCBI
Rnor_6.010104,724,534 - 104,748,003 (-)NCBI
Rnor_5.010103,537,761 - 103,561,087 (+)NCBI
RGSC_v3.410106,281,977 - 106,319,382 (-)RGD
Celera1099,981,033 - 100,004,515 (-)RGD
Sequence:
RefSeq Acc Id: XM_063269680   ⟹   XP_063125750
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810101,905,083 - 101,929,676 (-)NCBI
RefSeq Acc Id: NP_059036   ⟸   NM_017340
- Peptide Label: isoform 2
- UniProtKB: P11354 (UniProtKB/Swiss-Prot),   P07872 (UniProtKB/Swiss-Prot),   A6HKU7 (UniProtKB/TrEMBL),   F1LQC1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000051538   ⟸   ENSRNOT00000042372
Ensembl Acc Id: ENSRNOP00000042132   ⟸   ENSRNOT00000046754
Ensembl Acc Id: ENSRNOP00000083504   ⟸   ENSRNOT00000103476
Ensembl Acc Id: ENSRNOP00000087983   ⟸   ENSRNOT00000108949
Acyl-CoA oxidase C-alpha1   Acyl-CoA oxidase C-terminal   Acyl-CoA oxidase/dehydrogenase middle   Acyl-coenzyme A oxidase N-terminal

Name Modeler Protein Id AA Range Protein Structure
AF-P07872-F1-model_v2 AlphaFold P07872 1-661 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13697908
Promoter ID:EPDNEW_R8432
Type:initiation region
Name:Acox1_1
Description:acyl-CoA oxidase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.010104,748,013 - 104,748,073EPDNEW


1 to 40 of 49 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-22621 BioCyc
BioCyc Pathway PWY-6061 [bile acid biosynthesis, neutral pathway] BioCyc
BioCyc Pathway Image PWY-6061 BioCyc
Ensembl Genes ENSRNOG00000008755 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000042372 ENTREZGENE
  ENSRNOT00000042372.7 UniProtKB/Swiss-Prot
  ENSRNOT00000046754 ENTREZGENE
  ENSRNOT00000046754.6 UniProtKB/Swiss-Prot
  ENSRNOT00000108949 ENTREZGENE
Gene3D-CATH 1.10.540.10 UniProtKB/Swiss-Prot
  2.40.110.10 UniProtKB/Swiss-Prot
  Butyryl-CoA Dehydrogenase, subunit A, domain 3 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7109722 IMAGE-MGC_LOAD
InterPro ACO UniProtKB/Swiss-Prot
  ACOX_C_alpha1 UniProtKB/Swiss-Prot
  Acyl-CoA_ox_N UniProtKB/Swiss-Prot
  Acyl-CoA_Oxase/DH_cen-dom UniProtKB/Swiss-Prot
  Acyl-CoA_Oxase/DH_mid-dom_sf UniProtKB/Swiss-Prot
  Acyl-CoA_oxidase UniProtKB/Swiss-Prot
  Acyl-CoA_oxidase_C UniProtKB/Swiss-Prot
  AcylCo_DH-like_C UniProtKB/Swiss-Prot
  AcylCoA_DH/ox_N_sf UniProtKB/Swiss-Prot
  AcylCoA_DH/oxidase_NM_dom UniProtKB/Swiss-Prot
KEGG Report rno:50681 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93508 IMAGE-MGC_LOAD
NCBI Gene 50681 ENTREZGENE
PANTHER PEROXISOMAL ACYL-COENZYME A OXIDASE 1 UniProtKB/Swiss-Prot
  PTHR10909 UniProtKB/Swiss-Prot
Pfam ACOX UniProtKB/Swiss-Prot
  ACOX_C_alpha1 UniProtKB/Swiss-Prot
  Acyl-CoA_dh_M UniProtKB/Swiss-Prot
  Acyl-CoA_ox_N UniProtKB/Swiss-Prot
PhenoGen Acox1 PhenoGen
PIRSF Acyl-CoA_oxidase UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000008755 RatGTEx
Superfamily-SCOP SSF47203 UniProtKB/Swiss-Prot
  SSF56645 UniProtKB/Swiss-Prot
UniProt A0A8I6A041 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A8D0 ENTREZGENE, UniProtKB/TrEMBL
  A6HKU5_RAT UniProtKB/TrEMBL
1 to 40 of 49 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Acox1  acyl-CoA oxidase 1  LOC100910385  peroxisomal acyl-coenzyme A oxidase 1-like  Data merged from RGD:6498976 737654 PROVISIONAL
2016-06-08 Acox1  acyl-CoA oxidase 1  Acox1  acyl-CoA oxidase 1, palmitoyl  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100910385  peroxisomal acyl-coenzyme A oxidase 1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2011-07-28 Acox1  acyl-CoA oxidase 1, palmitoyl  Acox1  acyl-Coenzyme A oxidase 1, palmitoyl  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Acox1  acyl-Coenzyme A oxidase 1, palmitoyl  RATACOA1  acyl-coA oxidase  Symbol and Name updated 1299863 APPROVED
2002-08-07 RATACOA1  acyl-coA oxidase      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_protein 661 amino acids  
gene_protein enzyme contains three polypeptide components of which two are derived from post-translational proteolytic cleavage of the full length transcript